Details for: PANK1

Gene ID: 53354

Symbol: PANK1

Ensembl ID: ENSG00000152782

Description: pantothenate kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.3841
    Cell Significance Index: -12.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.6223
    Cell Significance Index: -12.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.0703
    Cell Significance Index: -11.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.4327
    Cell Significance Index: -11.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.5357
    Cell Significance Index: -12.9900
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 6.0519
    Cell Significance Index: 7.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3071
    Cell Significance Index: -13.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7383
    Cell Significance Index: 120.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4491
    Cell Significance Index: 287.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0078
    Cell Significance Index: 77.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.9884
    Cell Significance Index: 14.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8359
    Cell Significance Index: 37.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8037
    Cell Significance Index: 87.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7980
    Cell Significance Index: 17.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7750
    Cell Significance Index: 13.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7595
    Cell Significance Index: 152.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7426
    Cell Significance Index: 670.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7249
    Cell Significance Index: 20.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5403
    Cell Significance Index: 53.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5395
    Cell Significance Index: 87.7400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.5273
    Cell Significance Index: 3.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4932
    Cell Significance Index: 7.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4159
    Cell Significance Index: 23.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4037
    Cell Significance Index: 47.0500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3853
    Cell Significance Index: 9.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3448
    Cell Significance Index: 123.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3325
    Cell Significance Index: 22.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3230
    Cell Significance Index: 223.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2920
    Cell Significance Index: 42.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2545
    Cell Significance Index: 5.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2371
    Cell Significance Index: 8.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2220
    Cell Significance Index: 9.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2216
    Cell Significance Index: 5.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2134
    Cell Significance Index: 40.6100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2129
    Cell Significance Index: 6.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1961
    Cell Significance Index: 5.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1580
    Cell Significance Index: 3.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0977
    Cell Significance Index: 0.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0910
    Cell Significance Index: 49.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0887
    Cell Significance Index: 1.3100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0711
    Cell Significance Index: 1.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0706
    Cell Significance Index: 1.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0696
    Cell Significance Index: 1.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0678
    Cell Significance Index: 3.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0618
    Cell Significance Index: 11.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0548
    Cell Significance Index: 1.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0418
    Cell Significance Index: 2.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0350
    Cell Significance Index: 1.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0320
    Cell Significance Index: 14.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0297
    Cell Significance Index: 18.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0286
    Cell Significance Index: 53.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0192
    Cell Significance Index: 8.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0185
    Cell Significance Index: 13.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0170
    Cell Significance Index: 1.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0019
    Cell Significance Index: 0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0053
    Cell Significance Index: -8.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0058
    Cell Significance Index: -0.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0067
    Cell Significance Index: -0.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0143
    Cell Significance Index: -10.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0173
    Cell Significance Index: -12.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0221
    Cell Significance Index: -12.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0244
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0247
    Cell Significance Index: -15.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0297
    Cell Significance Index: -4.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0367
    Cell Significance Index: -10.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0438
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0489
    Cell Significance Index: -8.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0513
    Cell Significance Index: -6.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0514
    Cell Significance Index: -1.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0528
    Cell Significance Index: -1.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0681
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0700
    Cell Significance Index: -14.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0763
    Cell Significance Index: -6.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0812
    Cell Significance Index: -9.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0825
    Cell Significance Index: -4.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0897
    Cell Significance Index: -4.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0936
    Cell Significance Index: -2.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1007
    Cell Significance Index: -13.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1036
    Cell Significance Index: -3.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1097
    Cell Significance Index: -11.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1219
    Cell Significance Index: -2.4100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1321
    Cell Significance Index: -1.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1355
    Cell Significance Index: -2.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1414
    Cell Significance Index: -8.6700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1603
    Cell Significance Index: -5.1100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1628
    Cell Significance Index: -2.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1633
    Cell Significance Index: -5.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1778
    Cell Significance Index: -13.2500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1843
    Cell Significance Index: -3.1000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1844
    Cell Significance Index: -1.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1917
    Cell Significance Index: -5.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1951
    Cell Significance Index: -2.0200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1999
    Cell Significance Index: -1.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2055
    Cell Significance Index: -13.2600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2065
    Cell Significance Index: -4.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2085
    Cell Significance Index: -5.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2110
    Cell Significance Index: -7.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2120
    Cell Significance Index: -13.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PANK1 is a cytosolic enzyme that belongs to the kinase family, characterized by its ability to phosphorylate pantothenate, a precursor molecule in the biosynthesis of CoA. The enzyme exhibits a high degree of specificity, with a strong affinity for pantothenate, which is essential for its catalytic activity. PANK1 is predominantly expressed in cells involved in hematopoiesis, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and mucosal type mast cells. Its expression is also observed in other cell types, such as ciliated cells of the bronchus, sebaceous gland cells, and cardiac muscle myoblasts. **Pathways and Functions:** PANK1 is intimately involved in the biosynthesis of CoA, a molecule that plays a central role in various metabolic pathways. The enzyme catalyzes the phosphorylation of pantothenate, which is then converted into CoA through a series of biochemical reactions. This process is essential for the production of acetyl-CoA, a key intermediate in the citric acid cycle, fatty acid synthesis, and the metabolism of various vitamins and cofactors. PANK1's dysregulation can lead to impaired CoA biosynthesis, resulting in metabolic disorders, such as impaired energy production and fatty acid synthesis. **Clinical Significance:** Dysregulation of PANK1 has been implicated in various human diseases, including: 1. **Neurodegenerative disorders:** PANK1 mutations have been associated with Niemann-Pick disease type A, a rare genetic disorder characterized by the accumulation of sphingomyelin in cells, leading to neurodegeneration and cognitive impairment. 2. **Metabolic disorders:** Impaired PANK1 activity has been linked to metabolic disorders, such as impaired energy production and fatty acid synthesis, which can contribute to the development of obesity, type 2 diabetes, and other metabolic diseases. 3. **Cancer:** PANK1 expression has been observed in certain types of cancer, including breast cancer and leukemia, suggesting its potential role in tumorigenesis and cancer progression. 4. **Cardiovascular disease:** PANK1's involvement in the biosynthesis of CoA may also contribute to the development of cardiovascular disease, particularly in relation to impaired energy production and fatty acid synthesis. In conclusion, PANK1 is a crucial enzyme that plays a vital role in the biosynthesis of CoA, a molecule essential for various metabolic processes. Its dysregulation has been linked to various human diseases, highlighting the importance of understanding its function and regulation in maintaining cellular homeostasis. Further research is necessary to elucidate the mechanisms underlying PANK1's role in human disease and to identify potential therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 3487891113

Symbol: PANK1_HUMAN

Name: Pantothenate kinase 1

UniProtKB Accession Codes:

Q8TE04 A6NIP0 Q7RTX6 Q7Z495 Q8TBQ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11809413

Title: Cloning and characterization of a novel human pantothenate kinase gene.

PubMed ID: 11809413

DOI: 10.1016/s1357-2725(01)00114-5

PubMed ID: 14523052

Title: PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression.

PubMed ID: 14523052

DOI: 10.1194/jlr.m300279-jlr200

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11479594

Title: A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.

PubMed ID: 11479594

DOI: 10.1038/ng572

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23152917

Title: Compartmentalization of mammalian pantothenate kinases.

PubMed ID: 23152917

DOI: 10.1371/journal.pone.0049509

PubMed ID: 17631502

Title: Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.

PubMed ID: 17631502

DOI: 10.1074/jbc.m701915200

Sequence Information:

  • Length: 598
  • Mass: 64339
  • Checksum: 0A92115D5BEDFC4C
  • Sequence:
    • MLKLVGGGGG QDWACSVAGT SLGGEEAAFE VARPGDQGKA GGGSPGWGCA GIPDSAPGAG 
VLQAGAVGPA RGGQGAEEVG ESAGGGEERR VRHPQAPALR LLNRKPQGGS GEIKTPENDL 
QRGRLSRGPR TAPPAPGMGD RSGQQERSVP HSPGAPVGTS AAAVNGLLHN GFHPPPVQPP 
HVCSRGPVGG SDAAPQRLPL LPELQPQPLL PQHDSPAKKC RLRRRMDSGR KNRPPFPWFG 
MDIGGTLVKL VYFEPKDITA EEEQEEVENL KSIRKYLTSN TAYGKTGIRD VHLELKNLTM 
CGRKGNLHFI RFPSCAMHRF IQMGSEKNFS SLHTTLCATG GGAFKFEEDF RMIADLQLHK 
LDELDCLIQG LLYVDSVGFN GKPECYYFEN PTNPELCQKK PYCLDNPYPM LLVNMGSGVS 
ILAVYSKDNY KRVTGTSLGG GTFLGLCCLL TGCETFEEAL EMAAKGDSTN VDKLVKDIYG 
GDYERFGLQG SAVASSFGNM MSKEKRDSIS KEDLARATLV TITNNIGSIA RMCALNENID 
RVVFVGNFLR INMVSMKLLA YAMDFWSKGQ LKALFLEHEG YFGAVGALLE LFKMTDDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.