Details for: PROX1

Gene ID: 5629

Symbol: PROX1

Ensembl ID: ENSG00000117707

Description: prospero homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 5.7317
    Cell Significance Index: 96.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.1711
    Cell Significance Index: 629.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.0657
    Cell Significance Index: 160.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.3934
    Cell Significance Index: 160.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.8319
    Cell Significance Index: 27.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.7591
    Cell Significance Index: 47.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4693
    Cell Significance Index: 159.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4545
    Cell Significance Index: 89.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.4444
    Cell Significance Index: 34.6400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.4271
    Cell Significance Index: 11.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1656
    Cell Significance Index: 89.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1618
    Cell Significance Index: 135.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.8998
    Cell Significance Index: 1223.5200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.8468
    Cell Significance Index: 8.8400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.8297
    Cell Significance Index: 8.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8174
    Cell Significance Index: 155.5600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.7119
    Cell Significance Index: 8.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5970
    Cell Significance Index: 41.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5820
    Cell Significance Index: 32.6600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5149
    Cell Significance Index: 7.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4750
    Cell Significance Index: 731.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3332
    Cell Significance Index: 32.9600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3208
    Cell Significance Index: 7.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3001
    Cell Significance Index: 4.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2905
    Cell Significance Index: 104.2100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.2731
    Cell Significance Index: 3.0900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.2485
    Cell Significance Index: 3.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2017
    Cell Significance Index: 139.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1244
    Cell Significance Index: 5.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1241
    Cell Significance Index: 228.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1227
    Cell Significance Index: 4.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1138
    Cell Significance Index: 1.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0989
    Cell Significance Index: 5.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0187
    Cell Significance Index: 13.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0174
    Cell Significance Index: 0.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0052
    Cell Significance Index: 0.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0045
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0094
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0128
    Cell Significance Index: -24.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0133
    Cell Significance Index: -5.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0273
    Cell Significance Index: -4.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0274
    Cell Significance Index: -15.4800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0296
    Cell Significance Index: -0.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0336
    Cell Significance Index: -0.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0355
    Cell Significance Index: -26.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0390
    Cell Significance Index: -24.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0429
    Cell Significance Index: -19.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0455
    Cell Significance Index: -9.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0456
    Cell Significance Index: -24.9200
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0497
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0506
    Cell Significance Index: -5.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0525
    Cell Significance Index: -10.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0760
    Cell Significance Index: -9.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0787
    Cell Significance Index: -22.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1193
    Cell Significance Index: -16.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1380
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1621
    Cell Significance Index: -18.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1715
    Cell Significance Index: -24.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1793
    Cell Significance Index: -3.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1921
    Cell Significance Index: -24.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1984
    Cell Significance Index: -23.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2002
    Cell Significance Index: -25.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2240
    Cell Significance Index: -4.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2381
    Cell Significance Index: -24.3200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2522
    Cell Significance Index: -2.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2565
    Cell Significance Index: -26.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2691
    Cell Significance Index: -9.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2766
    Cell Significance Index: -21.9100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2775
    Cell Significance Index: -6.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2920
    Cell Significance Index: -8.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3160
    Cell Significance Index: -23.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3417
    Cell Significance Index: -24.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3622
    Cell Significance Index: -9.3100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3765
    Cell Significance Index: -4.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3843
    Cell Significance Index: -24.2200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.3959
    Cell Significance Index: -2.2800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4028
    Cell Significance Index: -12.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4042
    Cell Significance Index: -24.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4171
    Cell Significance Index: -19.6100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4264
    Cell Significance Index: -22.2100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4634
    Cell Significance Index: -9.1200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4730
    Cell Significance Index: -11.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5043
    Cell Significance Index: -13.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5254
    Cell Significance Index: -23.2400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5311
    Cell Significance Index: -6.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5323
    Cell Significance Index: -24.8200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.5337
    Cell Significance Index: -2.0100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.5810
    Cell Significance Index: -4.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6084
    Cell Significance Index: -17.4400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.6100
    Cell Significance Index: -6.5400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6136
    Cell Significance Index: -17.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6237
    Cell Significance Index: -18.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6344
    Cell Significance Index: -13.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6517
    Cell Significance Index: -24.6800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.6629
    Cell Significance Index: -9.4200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.6871
    Cell Significance Index: -5.8400
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.7032
    Cell Significance Index: -8.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7236
    Cell Significance Index: -25.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional regulation**: PROX1 acts as a transcriptional regulator, influencing the expression of target genes involved in cell differentiation, proliferation, and survival. 2. **Cell-type specificity**: PROX1 is highly expressed in specific cell types, such as lens epithelial cells, hepatoblasts, and chromaffin cells, indicating its role in tissue-specific development and function. 3. **Tissue patterning**: PROX1 is involved in the development and patterning of various tissues, including the lens, pancreas, liver, and kidney. 4. **Signaling pathways**: PROX1 interacts with various signaling pathways, including the Wnt/β-catenin and Notch signaling pathways, to regulate cell fate decisions and tissue development. 5. **Disease association**: Mutations in the PROX1 gene have been associated with various developmental disorders, including congenital heart defects, cardiovascular disease, and diabetes. **Pathways and Functions** 1. **Cell differentiation**: PROX1 regulates the differentiation of various cell types, including lens epithelial cells, hepatoblasts, and chromaffin cells. 2. **Tissue patterning**: PROX1 is involved in the development and patterning of tissues, including the lens, pancreas, liver, and kidney. 3. **Signaling pathways**: PROX1 interacts with various signaling pathways, including the Wnt/β-catenin and Notch signaling pathways, to regulate cell fate decisions and tissue development. 4. **Gene regulation**: PROX1 regulates the expression of target genes involved in cell differentiation, proliferation, and survival. 5. **Circadian rhythm**: PROX1 is involved in the regulation of the circadian rhythm, influencing the expression of clock genes and maintaining circadian oscillations. **Clinical Significance** 1. **Congenital heart defects**: Mutations in the PROX1 gene have been associated with congenital heart defects, highlighting its role in cardiac development and function. 2. **Cardiovascular disease**: PROX1 has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 3. **Diabetes**: Mutations in the PROX1 gene have been associated with diabetes, suggesting its role in pancreatic development and function. 4. **Cancer**: PROX1 has been implicated in the development and progression of various cancers, including pancreatic cancer and hepatocellular carcinoma. 5. **Therapeutic applications**: Understanding the role of PROX1 in disease development and progression may lead to the development of novel therapeutic strategies, including targeted therapies and gene therapy approaches. In conclusion, PROX1 is a critical transcription factor involved in the development and differentiation of various cell types and tissues in the body. Its role in tissue patterning, signaling pathways, and gene regulation highlights its importance in maintaining cellular identity and function. Mutations in the PROX1 gene have been associated with various developmental disorders and diseases, emphasizing the need for further research into its function and therapeutic applications.

Genular Protein ID: 1257423890

Symbol: PROX1_HUMAN

Name: Prospero homeobox protein 1

UniProtKB Accession Codes:

Q92786 A6NK29 A8K2B1 Q5SW76 Q8TB91

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 76 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8812486

Title: Structure and chromosomal localization of the human homeobox gene Prox 1.

PubMed ID: 8812486

DOI: 10.1006/geno.1996.0392

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22733308

Title: Transcription factor PROX1: its role in development and cancer.

PubMed ID: 22733308

DOI: 10.1007/s10555-012-9390-8

PubMed ID: 23723244

Title: Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation.

PubMed ID: 23723244

DOI: 10.1093/nar/gkt447

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 22733734

Title: Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples.

PubMed ID: 22733734

DOI: 10.1073/pnas.1203013109

Sequence Information:

  • Length: 737
  • Mass: 83203
  • Checksum: D243CEB421B313CA
  • Sequence:
    • MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS EQDVEYSVVQ 
HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN MNKNGGTEPS FQASGLSSTG 
SEVHQEDICS NSSRDSPPEC LSPFGRPTMS QFDMDRLCDE HLRAKRARVE NIIRGMSHSP 
SVALRGNENE REMAPQSVSP RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK 
QQLEDMQKQL RQLQEKFYQI YDSTDSENDE DGNLSEDSMR SEILDARAQD SVGRSDNEMC 
ELDPGQFIDR ARALIREQEM AENKPKREGN NKERDHGPNS LQPEGKHLAE TLKQELNTAM 
SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH NFHTANQRLQ CFGDVIIPNP 
LDTFGNVQMA SSTDQTEALP LVVRKNSSDQ SASGPAAGGH HQPLHQSPLS ATTGFTTSTF 
RHPFPLPLMA YPFQSPLGAP SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP 
AHPPSTAEGL SLSLIKSECG DLQDMSEISP YSGSAMQEGL SPNHLKKAKL MFFYTRYPSS 
NMLKTYFSDV KFNRCITSQL IKWFSNFREF YYIQMEKYAR QAINDGVTST EELSITRDCE 
LYRALNMHYN KANDFEVPER FLEVAQITLR EFFNAIIAGK DVDPSWKKAI YKVICKLDSE 
VPEIFKSPNC LQELLHE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.