Details for: PRRG1

Gene ID: 5638

Symbol: PRRG1

Ensembl ID: ENSG00000130962

Description: proline rich and Gla domain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.4135
    Cell Significance Index: -20.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2305
    Cell Significance Index: -20.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0557
    Cell Significance Index: 211.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8716
    Cell Significance Index: 101.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8049
    Cell Significance Index: 726.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7932
    Cell Significance Index: 22.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7536
    Cell Significance Index: 34.1600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6490
    Cell Significance Index: 10.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6312
    Cell Significance Index: 226.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4949
    Cell Significance Index: 53.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4707
    Cell Significance Index: 76.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4655
    Cell Significance Index: 35.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4265
    Cell Significance Index: 9.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4226
    Cell Significance Index: 25.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3848
    Cell Significance Index: 9.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3357
    Cell Significance Index: 18.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3143
    Cell Significance Index: 11.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2828
    Cell Significance Index: 12.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2819
    Cell Significance Index: 14.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2505
    Cell Significance Index: 17.3200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2072
    Cell Significance Index: 2.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1935
    Cell Significance Index: 105.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1620
    Cell Significance Index: 9.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1537
    Cell Significance Index: 15.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1385
    Cell Significance Index: 17.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1345
    Cell Significance Index: 24.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1093
    Cell Significance Index: 3.8400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1076
    Cell Significance Index: 74.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0644
    Cell Significance Index: 8.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0642
    Cell Significance Index: 12.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0497
    Cell Significance Index: 21.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0030
    Cell Significance Index: 0.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0109
    Cell Significance Index: -0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0112
    Cell Significance Index: -21.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0140
    Cell Significance Index: -10.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0157
    Cell Significance Index: -28.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0182
    Cell Significance Index: -28.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0207
    Cell Significance Index: -28.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0247
    Cell Significance Index: -18.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0269
    Cell Significance Index: -20.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0335
    Cell Significance Index: -21.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0383
    Cell Significance Index: -21.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0427
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0467
    Cell Significance Index: -29.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0516
    Cell Significance Index: -23.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0623
    Cell Significance Index: -12.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0714
    Cell Significance Index: -8.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0965
    Cell Significance Index: -12.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1119
    Cell Significance Index: -23.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1137
    Cell Significance Index: -11.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1151
    Cell Significance Index: -19.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1153
    Cell Significance Index: -14.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1357
    Cell Significance Index: -6.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1543
    Cell Significance Index: -22.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1600
    Cell Significance Index: -5.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1602
    Cell Significance Index: -4.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1603
    Cell Significance Index: -11.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1726
    Cell Significance Index: -9.0600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1748
    Cell Significance Index: -2.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2083
    Cell Significance Index: -21.6900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2111
    Cell Significance Index: -3.0700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2479
    Cell Significance Index: -3.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2662
    Cell Significance Index: -21.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2751
    Cell Significance Index: -20.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2967
    Cell Significance Index: -12.9000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3194
    Cell Significance Index: -1.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3297
    Cell Significance Index: -22.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3361
    Cell Significance Index: -8.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3368
    Cell Significance Index: -21.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3492
    Cell Significance Index: -10.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3689
    Cell Significance Index: -22.6200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4054
    Cell Significance Index: -12.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4244
    Cell Significance Index: -5.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4343
    Cell Significance Index: -14.2200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.4394
    Cell Significance Index: -2.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4573
    Cell Significance Index: -16.0200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4645
    Cell Significance Index: -4.9800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.4861
    Cell Significance Index: -6.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4934
    Cell Significance Index: -13.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5312
    Cell Significance Index: -13.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5459
    Cell Significance Index: -10.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5563
    Cell Significance Index: -20.4200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5714
    Cell Significance Index: -9.8800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5726
    Cell Significance Index: -11.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5906
    Cell Significance Index: -8.9000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5906
    Cell Significance Index: -9.3700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5928
    Cell Significance Index: -7.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5999
    Cell Significance Index: -17.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6046
    Cell Significance Index: -21.0100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6331
    Cell Significance Index: -15.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6631
    Cell Significance Index: -17.4400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.6669
    Cell Significance Index: -13.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6790
    Cell Significance Index: -14.6700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6999
    Cell Significance Index: -13.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7006
    Cell Significance Index: -18.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7224
    Cell Significance Index: -18.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7272
    Cell Significance Index: -5.9300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7488
    Cell Significance Index: -16.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7491
    Cell Significance Index: -12.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRRG1 is a gene that encodes a protein with a unique structure, comprising a proline-rich and Gla domain. The Gla domain is a calcium-binding motif that is often associated with proteins involved in calcium signaling and homeostasis. The proline-rich domain, on the other hand, is a characteristic feature of several proteins involved in cell adhesion and signaling. The combination of these domains suggests that PRRG1 may play a role in regulating calcium-dependent signaling pathways. **Pathways and Functions:** PRRG1 is significantly expressed in cells involved in neuronal function and development, including cerebral cortex endothelial cells, oligodendrocytes, and glutamatergic cortical neurons. The expression of PRRG1 in these cells suggests that it may be involved in regulating calcium-dependent signaling pathways, which are essential for neuronal function and synaptic plasticity. Specifically, PRRG1 may play a role in: 1. **Calcium signaling:** The Gla domain of PRRG1 is likely involved in binding calcium ions, which could regulate calcium-dependent signaling pathways in these cells. 2. **Cell adhesion:** The proline-rich domain of PRRG1 may be involved in cell adhesion and signaling, potentially regulating the interactions between neurons and their environment. 3. **Neurotransmission:** PRRG1 may also play a role in regulating neurotransmission, particularly in glutamatergic cortical neurons, which are involved in excitatory neurotransmission. **Clinical Significance:** While the functional significance of PRRG1 remains unclear, its expression in various cell types and tissues suggests that it may play a role in several neurological and immunological disorders. For example: 1. **Neurological disorders:** Alterations in calcium signaling and cell adhesion pathways have been implicated in several neurological disorders, including Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. PRRG1 may play a role in these disorders, particularly in regulating calcium-dependent signaling pathways. 2. **Immunological disorders:** PRRG1 is also expressed in cells involved in immune responses, including extravillous trophoblasts and renal alpha-intercalated cells. Alterations in PRRG1 expression or function may contribute to immunological disorders, such as autoimmune diseases or transplant rejection. In conclusion, while the functional significance of PRRG1 remains unclear, its widespread expression in various cell types and tissues suggests that it may play a role in regulating calcium-dependent signaling pathways, cell adhesion, and neurotransmission. Further research is needed to elucidate the role of PRRG1 in neurological and immunological disorders.

Genular Protein ID: 736371549

Symbol: TMG1_HUMAN

Name: Transmembrane gamma-carboxyglutamic acid protein 1

UniProtKB Accession Codes:

O14668 B2R7A3 C9JXL7 D3DWA9 Q5JT66

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 5 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9256434

Title: Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins.

PubMed ID: 9256434

DOI: 10.1073/pnas.94.17.9058

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 218
  • Mass: 24947
  • Checksum: 26538A61AB0AEB98
  • Sequence:
    • MGRVFLTGEK ANSILKRYPR ANGFFEEIRQ GNIERECKEE FCTFEEAREA FENNEKTKEF 
WSTYTKAQQG ESNRGSDWFQ FYLTFPLIFG LFIILLVIFL IWRCFLRNKT RRQTVTEGHI 
PFPQHLNIIT PPPPPDEVFD SSGLSPGFLG YVVGRSDSVS TRLSNCDPPP TYEEATGQVN 
LQRSETEPHL DPPPEYEDIV NSNSASAIPM VPVVTTIK

Genular Protein ID: 4163078259

Symbol: Q8NEK6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NEK6

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 2 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 266
  • Mass: 30151
  • Checksum: 175768D24D635351
  • Sequence:
    • VRSRFLAPAR LGRNRSAQAR RAARRTASSG AGPAGIIIQG RARNHKKTWG RVFLTGEKAN 
SILKRYPRAN GFFEEIRQGN IERECKEEFC TFEEAREAFE NNEKTKEFWS TYTKAQQGES 
NRGSDWFQFY LTFPLIFGLF IILLVIFLIW RCFLRNKTRR QTVTEGHIPF PQHLNIITPP 
PPPDEVFDSS GLSPGFLGYV VGRSDSVSTR LSNCDPPPTY EEATGQVNLQ RSETEPHLDP 
PPEYEDIVNS NSASAIPMVP VVTTIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.