Details for: PRSS3

Gene ID: 5646

Symbol: PRSS3

Ensembl ID: ENSG00000010438

Description: serine protease 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.5978
    Cell Significance Index: -7.0000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 22.5757
    Cell Significance Index: -9.3000
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 19.9274
    Cell Significance Index: 151.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 9.8098
    Cell Significance Index: 360.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 7.5923
    Cell Significance Index: 1296.4300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 4.8300
    Cell Significance Index: 48.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.6975
    Cell Significance Index: 212.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0666
    Cell Significance Index: -8.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.9918
    Cell Significance Index: 44.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5793
    Cell Significance Index: 74.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9647
    Cell Significance Index: -4.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9430
    Cell Significance Index: 134.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 1.6123
    Cell Significance Index: 184.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6044
    Cell Significance Index: 35.1300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.4233
    Cell Significance Index: 12.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3571
    Cell Significance Index: 158.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2415
    Cell Significance Index: 122.8100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 1.1172
    Cell Significance Index: 15.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0263
    Cell Significance Index: 205.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9800
    Cell Significance Index: 58.8400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.9785
    Cell Significance Index: 2.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7887
    Cell Significance Index: 40.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5604
    Cell Significance Index: 11.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5261
    Cell Significance Index: 85.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4883
    Cell Significance Index: 15.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4426
    Cell Significance Index: 29.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4170
    Cell Significance Index: 79.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.4090
    Cell Significance Index: 10.2000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3859
    Cell Significance Index: 0.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3588
    Cell Significance Index: 103.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2586
    Cell Significance Index: 4.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2555
    Cell Significance Index: 7.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1642
    Cell Significance Index: 2.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1561
    Cell Significance Index: 5.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1555
    Cell Significance Index: 17.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1320
    Cell Significance Index: 5.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1262
    Cell Significance Index: 25.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1021
    Cell Significance Index: 1.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0959
    Cell Significance Index: 3.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0908
    Cell Significance Index: 32.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0760
    Cell Significance Index: 47.4300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.0568
    Cell Significance Index: 0.4000
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0509
    Cell Significance Index: 0.3700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0394
    Cell Significance Index: 0.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0348
    Cell Significance Index: 25.8000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0306
    Cell Significance Index: 0.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0237
    Cell Significance Index: 0.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0134
    Cell Significance Index: 2.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0120
    Cell Significance Index: 5.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0105
    Cell Significance Index: 0.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0069
    Cell Significance Index: 0.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0014
    Cell Significance Index: 2.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0014
    Cell Significance Index: 2.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0005
    Cell Significance Index: -0.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.5100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0092
    Cell Significance Index: -5.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0121
    Cell Significance Index: -8.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0137
    Cell Significance Index: -7.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0146
    Cell Significance Index: -3.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0167
    Cell Significance Index: -7.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0200
    Cell Significance Index: -0.4300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0366
    Cell Significance Index: -1.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0385
    Cell Significance Index: -5.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0422
    Cell Significance Index: -4.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0555
    Cell Significance Index: -1.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0560
    Cell Significance Index: -7.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0617
    Cell Significance Index: -0.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0630
    Cell Significance Index: -1.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0716
    Cell Significance Index: -7.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0730
    Cell Significance Index: -1.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0768
    Cell Significance Index: -9.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0841
    Cell Significance Index: -4.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0880
    Cell Significance Index: -0.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0893
    Cell Significance Index: -6.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1030
    Cell Significance Index: -3.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1066
    Cell Significance Index: -6.5500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1113
    Cell Significance Index: -2.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1121
    Cell Significance Index: -8.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1155
    Cell Significance Index: -8.6100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1209
    Cell Significance Index: -7.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1235
    Cell Significance Index: -7.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1261
    Cell Significance Index: -4.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1392
    Cell Significance Index: -7.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1404
    Cell Significance Index: -2.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1413
    Cell Significance Index: -4.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1530
    Cell Significance Index: -1.4500
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.1550
    Cell Significance Index: -0.9100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1595
    Cell Significance Index: -2.0200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1631
    Cell Significance Index: -1.7200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1652
    Cell Significance Index: -1.8000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1795
    Cell Significance Index: -1.1700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1796
    Cell Significance Index: -5.6800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1864
    Cell Significance Index: -4.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1935
    Cell Significance Index: -9.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1957
    Cell Significance Index: -9.2000
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.1958
    Cell Significance Index: -1.2100
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.2030
    Cell Significance Index: -2.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRSS3 is a serine protease that exhibits a high degree of specificity for the amino acids lysine and arginine. Its molecular weight is approximately 27 kDa, and it is produced as an inactive zymogen that requires activation to its active form. The trypsin-3 enzyme has a broad range of substrates, including proteins, peptides, and lipids, which highlights its potential role in various physiological and pathological processes. **Pathways and Functions:** PRSS3 is involved in several key pathways, including: 1. **Antimicrobial humoral response**: Trypsin-3 has been shown to exhibit antimicrobial activity against various microorganisms, including bacteria, viruses, and fungi. Its release from epithelial cells and neutrophils can help protect against infections. 2. **Digestion**: As a serine protease, trypsin-3 plays a crucial role in protein digestion, particularly in the breakdown of dietary proteins in the small intestine. 3. **Immune system**: PRSS3 is expressed in immune cells, such as double-negative thymocytes, and has been implicated in the regulation of immune responses, including the activation of neutrophils and the production of antimicrobial peptides. 4. **Neutrophil degranulation**: Trypsin-3 can facilitate the degranulation of neutrophils, releasing granules that contain antimicrobial peptides and proteins. **Clinical Significance:** PRSS3 has been associated with several diseases, including: 1. **Pancreatitis**: Mutations in the PRSS3 gene have been linked to chronic pancreatitis, a condition characterized by inflammation and scarring of the pancreas. 2. **Cystic fibrosis**: Variants of the PRSS3 gene have been identified in individuals with cystic fibrosis, a genetic disorder that affects the respiratory, digestive, and reproductive systems. 3. **Inflammatory bowel disease**: PRSS3 has been implicated in the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, where it may contribute to the activation of immune cells and the production of pro-inflammatory cytokines. In conclusion, the serine protease 3 gene (PRSS3) plays a vital role in the immune system, digestion, and various physiological processes. Its dysregulation has been linked to several diseases, highlighting the importance of further research into the mechanisms of PRSS3 and its potential therapeutic applications.

Genular Protein ID: 3618119017

Symbol: TRY3_HUMAN

Name: Trypsin-3

UniProtKB Accession Codes:

P35030 A8CED1 A8CED3 A9Z1Y4 E7ES07 F8W7P3 P15951 Q15665 Q5VXV0 Q6ISJ4 Q9UQV3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 1 EMBL 14 Ensembl 2 EvolutionaryTrace 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 5 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8294000

Title: Cloning of the cDNA encoding human brain trypsinogen and characterization of its product.

PubMed ID: 8294000

DOI: 10.1016/0378-1119(93)90460-k

PubMed ID: 2326201

Title: Nucleotide sequence of the human pancreatic trypsinogen III cDNA.

PubMed ID: 2326201

DOI: 10.1093/nar/18.6.1631

PubMed ID: 9099703

Title: Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance.

PubMed ID: 9099703

DOI: 10.1074/jbc.272.16.10573

PubMed ID: 19924134

Title: Keratinocytes synthesize enteropeptidase and multiple forms of trypsinogen during terminal differentiation.

PubMed ID: 19924134

DOI: 10.1038/jid.2009.364

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12021776

Title: Paneth cell trypsin is the processing enzyme for human defensin-5.

PubMed ID: 12021776

DOI: 10.1038/ni797

PubMed ID: 6698368

Title: Mesotrypsin: a new inhibitor-resistant protease from a zymogen in human pancreatic tissue and fluid.

PubMed ID: 6698368

PubMed ID: 14507909

Title: Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors.

PubMed ID: 14507909

DOI: 10.1074/jbc.m310301200

PubMed ID: 11827488

Title: Crystal structure reveals basis for the inhibitor resistance of human brain trypsin.

PubMed ID: 11827488

DOI: 10.1006/jmbi.2001.5305

PubMed ID: 18077447

Title: Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin.

PubMed ID: 18077447

DOI: 10.1074/jbc.m708268200

PubMed ID: 25301953

Title: Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.

PubMed ID: 25301953

DOI: 10.1074/jbc.m114.609560

PubMed ID: 27810896

Title: An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis.

PubMed ID: 27810896

DOI: 10.1074/jbc.m116.758417

Sequence Information:

  • Length: 304
  • Mass: 32529
  • Checksum: 4C4303C310B7BFFC
  • Sequence:
    • MCGPDDRCPA RWPGPGRAVK CGKGLAAARP GRVERGGAQR GGAGLELHPL LGGRTWRAAR 
DADGCEALGT VAVPFDDDDK IVGGYTCEEN SLPYQVSLNS GSHFCGGSLI SEQWVVSAAH 
CYKTRIQVRL GEHNIKVLEG NEQFINAAKI IRHPKYNRDT LDNDIMLIKL SSPAVINARV 
STISLPTTPP AAGTECLISG WGNTLSFGAD YPDELKCLDA PVLTQAECKA SYPGKITNSM 
FCVGFLEGGK DSCQRDSGGP VVCNGQLQGV VSWGHGCAWK NRPGVYTKVY NYVDWIKDTI 
AANS

Genular Protein ID: 3762080471

Symbol: Q7Z5F4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z5F4

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 7 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 Pfam 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 261
  • Mass: 28199
  • Checksum: 6B182C3BB9E7A5B3
  • Sequence:
    • MHMRETSGFT LKKGRSAPLV FHPPDALIAV PFDDDDKIVG GYTCEENSLP YQVSLNSGSH 
FCGGSLISEQ WVVSAAHCYK SRIQVRLGEH NIKVLEGNEQ FINAAKIIRH PKYNRDTLDN 
DIMLIKLSSP AVINARVSTI SLPTAPPAAG TECLISGWGN TLSSGADYPD ELKCLDAPVL 
TQAECKASYP GKITNSMFCV GFLEGGKDSC QGDSGGPVVC NGQLQGVVSW GHGCAWKNRP 
GVYTKVYNYV DWIKDTIAAN S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.