Details for: MASP1

Gene ID: 5648

Symbol: MASP1

Ensembl ID: ENSG00000127241

Description: MBL associated serine protease 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.0120
    Cell Significance Index: -8.1300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 5.4221
    Cell Significance Index: 80.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.7712
    Cell Significance Index: 46.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.9717
    Cell Significance Index: 29.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8278
    Cell Significance Index: 63.5300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.6892
    Cell Significance Index: 4.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6629
    Cell Significance Index: 131.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6107
    Cell Significance Index: 30.8600
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.5674
    Cell Significance Index: 3.3500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.4955
    Cell Significance Index: 4.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3927
    Cell Significance Index: 7.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3655
    Cell Significance Index: 42.5900
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.1895
    Cell Significance Index: 1.1900
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.1694
    Cell Significance Index: 0.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1478
    Cell Significance Index: 18.9500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0674
    Cell Significance Index: 0.4000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0509
    Cell Significance Index: 0.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0246
    Cell Significance Index: 0.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0187
    Cell Significance Index: 2.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0069
    Cell Significance Index: 3.0300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0031
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0041
    Cell Significance Index: -7.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0054
    Cell Significance Index: -3.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0066
    Cell Significance Index: -12.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0080
    Cell Significance Index: -12.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0096
    Cell Significance Index: -12.9900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0123
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0130
    Cell Significance Index: -9.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0131
    Cell Significance Index: -9.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0135
    Cell Significance Index: -10.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0140
    Cell Significance Index: -8.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0173
    Cell Significance Index: -9.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0189
    Cell Significance Index: -10.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0221
    Cell Significance Index: -10.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0232
    Cell Significance Index: -8.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0276
    Cell Significance Index: -7.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0282
    Cell Significance Index: -5.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0283
    Cell Significance Index: -2.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0289
    Cell Significance Index: -5.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0534
    Cell Significance Index: -11.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0576
    Cell Significance Index: -8.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0617
    Cell Significance Index: -7.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0707
    Cell Significance Index: -9.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0771
    Cell Significance Index: -13.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0789
    Cell Significance Index: -1.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0801
    Cell Significance Index: -2.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0880
    Cell Significance Index: -9.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0944
    Cell Significance Index: -10.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0950
    Cell Significance Index: -4.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1089
    Cell Significance Index: -2.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1205
    Cell Significance Index: -9.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1236
    Cell Significance Index: -9.2100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1245
    Cell Significance Index: -1.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1256
    Cell Significance Index: -3.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1400
    Cell Significance Index: -6.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1559
    Cell Significance Index: -8.1200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1665
    Cell Significance Index: -2.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1688
    Cell Significance Index: -4.3400
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1692
    Cell Significance Index: -1.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1724
    Cell Significance Index: -2.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1868
    Cell Significance Index: -10.4800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1960
    Cell Significance Index: -3.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2002
    Cell Significance Index: -9.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2056
    Cell Significance Index: -10.8000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2065
    Cell Significance Index: -2.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2071
    Cell Significance Index: -6.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2085
    Cell Significance Index: -10.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2200
    Cell Significance Index: -9.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2250
    Cell Significance Index: -5.4500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2267
    Cell Significance Index: -2.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2295
    Cell Significance Index: -8.0400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2376
    Cell Significance Index: -0.9000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2380
    Cell Significance Index: -8.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2512
    Cell Significance Index: -7.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2569
    Cell Significance Index: -9.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2603
    Cell Significance Index: -8.2900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.2605
    Cell Significance Index: -1.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2773
    Cell Significance Index: -10.1800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2801
    Cell Significance Index: -5.7000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2804
    Cell Significance Index: -4.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2852
    Cell Significance Index: -7.5000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2947
    Cell Significance Index: -7.3500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.2951
    Cell Significance Index: -4.0800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2992
    Cell Significance Index: -2.7200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3088
    Cell Significance Index: -4.4300
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.3128
    Cell Significance Index: -3.6200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3190
    Cell Significance Index: -10.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3208
    Cell Significance Index: -9.4500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3214
    Cell Significance Index: -5.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3252
    Cell Significance Index: -6.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3281
    Cell Significance Index: -11.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3416
    Cell Significance Index: -7.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3431
    Cell Significance Index: -9.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3439
    Cell Significance Index: -9.2000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3522
    Cell Significance Index: -5.0100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3539
    Cell Significance Index: -6.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3622
    Cell Significance Index: -9.8600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3684
    Cell Significance Index: -9.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3706
    Cell Significance Index: -9.2600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3836
    Cell Significance Index: -5.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Lectin Pathway of Complement Activation:** MASP1 is a serine protease that is activated by the lectin pathway, which recognizes carbohydrate structures on the surface of pathogens. 2. **C1q-Dependent Activation:** MASP1 is activated by C1q, a protein that binds to the Fc region of IgM antibodies, leading to the activation of the complement cascade. 3. **Protein Binding:** MASP1 binds to various proteins, including C4b, C2b, and factor B, to form the C3 convertase, which cleaves C3 into C3a and C3b. 4. **Serine Protease Activity:** MASP1 possesses serine protease activity, which is essential for cleaving and activating C4 and C2 into C4b and C2b, respectively. 5. **Cellular Expression:** MASP1 is expressed in various cells, including enterocytes, dendritic cells, and hepatocytes, which are involved in immune surveillance and recognition of pathogens. **Pathways and Functions:** 1. **Lectin Pathway of Complement Activation:** MASP1 is involved in the lectin pathway, which recognizes carbohydrate structures on the surface of pathogens, leading to the activation of the complement cascade. 2. **Complement Activation:** MASP1 activates the complement cascade by cleaving C4 and C2 into C4b and C2b, respectively, which leads to the formation of the C3 convertase. 3. **Immune Response:** MASP1 plays a crucial role in the immune response by recognizing and eliminating pathogens, including viruses like SARS-CoV-2. 4. **Viral Infection:** MASP1 is activated by SARS-CoV-2, leading to the activation of the complement cascade and the elimination of the virus. 5. **Innate Immunity:** MASP1 is involved in the innate immune response, which provides the first line of defense against pathogens. **Clinical Significance:** 1. **SARS-CoV-2 Infection:** MASP1 is activated by SARS-CoV-2, leading to the activation of the complement cascade and the elimination of the virus. 2. **Infectious Diseases:** MASP1 plays a crucial role in the immune response against infectious diseases, including viral infections. 3. **Immunodeficiency:** Dysregulation of the lectin pathway, including MASP1, has been implicated in immunodeficiency diseases, such as primary immunodeficiency disorders. 4. **Cancer:** MASP1 has been implicated in cancer progression, where it contributes to tumor cell invasion and metastasis. 5. **Therapeutic Applications:** MASP1 inhibitors have been explored as potential therapeutic agents for treating autoimmune diseases, such as systemic lupus erythematosus, and other inflammatory conditions. In conclusion, MASP1 is a critical component of the lectin pathway of complement activation, which plays a pivotal role in the immune response against pathogens, including viruses like SARS-CoV-2. Its dysregulation has been implicated in various diseases, including immunodeficiency disorders, cancer, and autoimmune diseases, highlighting the importance of MASP1 in maintaining immune homeostasis.

Genular Protein ID: 562611289

Symbol: MASP1_HUMAN

Name: Mannan-binding lectin serine protease 1

UniProtKB Accession Codes:

P48740 A8K542 A8K6M1 B4E2L7 O95570 Q68D21 Q8IUV8 Q96RS4 Q9UF09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 4 CPTAC 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 ComplexPortal 5 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 EMBL 14 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MEROPS 2 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 8 PathwayCommons 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 5 RefSeq 4 SABIO-RK 1 SIGNOR 1 SMART 4 SMR 1 SUPFAM 4 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8240317

Title: A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum.

PubMed ID: 8240317

DOI: 10.1006/bbrc.1993.2349

PubMed ID: 8018603

Title: Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein.

PubMed ID: 8018603

DOI: 10.1093/intimm/6.4.665

PubMed ID: 8921412

Title: Exon structure of the gene encoding the human mannose-binding protein-associated serine protease light chain: comparison with complement C1r and C1s genes.

PubMed ID: 8921412

DOI: 10.1093/intimm/8.9.1355

PubMed ID: 10475605

Title: Gene structure of the P100 serine-protease component of the human Ra-reactive factor.

PubMed ID: 10475605

DOI: 10.1016/s0161-5890(99)00070-x

PubMed ID: 11485744

Title: MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway.

PubMed ID: 11485744

DOI: 10.1016/s1074-7613(01)00161-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11290788

Title: Interaction properties of human mannan-binding lectin (MBL)-associated serine proteases-1 and -2, MBL-associated protein 19, and MBL.

PubMed ID: 11290788

DOI: 10.4049/jimmunol.166.8.5068

PubMed ID: 9367419

Title: Human serum mannose-binding lectin (MBL)-associated serine protease-1 (MASP-1): determination of levels in body fluids and identification of two forms in serum.

PubMed ID: 9367419

DOI: 10.1111/j.1365-2249.1997.tb08334.x

PubMed ID: 9087411

Title: A second serine protease associated with mannan-binding lectin that activates complement.

PubMed ID: 9087411

DOI: 10.1038/386506a0

PubMed ID: 10679061

Title: Complement-activating complex of ficolin and mannose-binding lectin-associated serine protease.

PubMed ID: 10679061

DOI: 10.4049/jimmunol.164.5.2281

PubMed ID: 10878362

Title: Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19.

PubMed ID: 10878362

DOI: 10.4049/jimmunol.165.2.878

PubMed ID: 10946292

Title: Proteolytic activities of two types of mannose-binding lectin-associated serine protease.

PubMed ID: 10946292

DOI: 10.4049/jimmunol.165.5.2637

PubMed ID: 11527969

Title: Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2.

PubMed ID: 11527969

DOI: 10.1074/jbc.m105934200

PubMed ID: 11907111

Title: Activation of the lectin complement pathway by H-ficolin (Hakata antigen).

PubMed ID: 11907111

DOI: 10.4049/jimmunol.168.7.3502

PubMed ID: 12421953

Title: Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2.

PubMed ID: 12421953

DOI: 10.4049/jimmunol.169.10.5735

PubMed ID: 12538697

Title: Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments.

PubMed ID: 12538697

DOI: 10.4049/jimmunol.170.3.1374

PubMed ID: 15034049

Title: Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2.

PubMed ID: 15034049

DOI: 10.4049/jimmunol.172.7.4342

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16554018

Title: Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5.

PubMed ID: 16554018

DOI: 10.1016/j.abb.2006.02.006

PubMed ID: 17182967

Title: Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway.

PubMed ID: 17182967

DOI: 10.1093/intimm/dxl131

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 20956340

Title: Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity.

PubMed ID: 20956340

DOI: 10.4049/jimmunol.1002185

PubMed ID: 18596036

Title: Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins.

PubMed ID: 18596036

DOI: 10.1074/jbc.m803551200

PubMed ID: 21258343

Title: Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome.

PubMed ID: 21258343

DOI: 10.1038/ng.757

PubMed ID: 26419238

Title: Novel MASP1 mutations are associated with an expanded phenotype in 3MC1 syndrome.

PubMed ID: 26419238

DOI: 10.1186/s13023-015-0345-3

PubMed ID: 28301481

Title: COLEC10 is mutated in 3MC patients and regulates early craniofacial development.

PubMed ID: 28301481

DOI: 10.1371/journal.pgen.1006679

Sequence Information:

  • Length: 699
  • Mass: 79247
  • Checksum: 5B37C7FB9F51FD1D
  • Sequence:
    • MRWLLLYYAL CFSLSKASAH TVELNNMFGQ IQSPGYPDSY PSDSEVTWNI TVPDGFRIKL 
YFMHFNLESS YLCEYDYVKV ETEDQVLATF CGRETTDTEQ TPGQEVVLSP GSFMSITFRS 
DFSNEERFTG FDAHYMAVDV DECKEREDEE LSCDHYCHNY IGGYYCSCRF GYILHTDNRT 
CRVECSDNLF TQRTGVITSP DFPNPYPKSS ECLYTIELEE GFMVNLQFED IFDIEDHPEV 
PCPYDYIKIK VGPKVLGPFC GEKAPEPIST QSHSVLILFH SDNSGENRGW RLSYRAAGNE 
CPELQPPVHG KIEPSQAKYF FKDQVLVSCD TGYKVLKDNV EMDTFQIECL KDGTWSNKIP 
TCKIVDCRAP GELEHGLITF STRNNLTTYK SEIKYSCQEP YYKMLNNNTG IYTCSAQGVW 
MNKVLGRSLP TCLPVCGLPK FSRKLMARIF NGRPAQKGTT PWIAMLSHLN GQPFCGGSLL 
GSSWIVTAAH CLHQSLDPED PTLRDSDLLS PSDFKIILGK HWRLRSDENE QHLGVKHTTL 
HPQYDPNTFE NDVALVELLE SPVLNAFVMP ICLPEGPQQE GAMVIVSGWG KQFLQRFPET 
LMEIEIPIVD HSTCQKAYAP LKKKVTRDMI CAGEKEGGKD ACAGDSGGPM VTLNRERGQW 
YLVGTVSWGD DCGKKDRYGV YSYIHHNKDW IQRVTGVRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.