Details for: PSG4

Gene ID: 5672

Symbol: PSG4

Ensembl ID: ENSG00000243137

Description: pregnancy specific beta-1-glycoprotein 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 5.45
    Marker Score: 17464
  • Cell Name: glial cell (CL0000125)
    Fold Change: 4.72
    Marker Score: 5194.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.79
    Marker Score: 5259
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.57
    Marker Score: 10248
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.36
    Marker Score: 2379
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.99
    Marker Score: 645
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2208
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.48
    Marker Score: 1473
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.42
    Marker Score: 9155.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.23
    Marker Score: 1174
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 504
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.03
    Marker Score: 989
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 490
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1286
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.69
    Marker Score: 1114
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.38
    Marker Score: 164
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.37
    Marker Score: 529
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.37
    Marker Score: 517
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.33
    Marker Score: 343
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.31
    Marker Score: 334
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.28
    Marker Score: 1361
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.27
    Marker Score: 339
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.26
    Marker Score: 253
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.25
    Marker Score: 608.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.22
    Marker Score: 195
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.2
    Marker Score: 338
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.19
    Marker Score: 1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.18
    Marker Score: 2871
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.18
    Marker Score: 516.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.17
    Marker Score: 165
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.16
    Marker Score: 173
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.16
    Marker Score: 131
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.15
    Marker Score: 85
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.15
    Marker Score: 275
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.14
    Marker Score: 286
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.13
    Marker Score: 293
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.12
    Marker Score: 495
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.12
    Marker Score: 61
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 110
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.11
    Marker Score: 52
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.11
    Marker Score: 92
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.1
    Marker Score: 311
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1
    Marker Score: 80
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1
    Marker Score: 177
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.1
    Marker Score: 153
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1
    Marker Score: 109
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1
    Marker Score: 238
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1
    Marker Score: 196
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.1
    Marker Score: 240
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.09
    Marker Score: 801
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.09
    Marker Score: 5706
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.09
    Marker Score: 113
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.09
    Marker Score: 17
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 93
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.08
    Marker Score: 93
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.08
    Marker Score: 180
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.07
    Marker Score: 689
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.07
    Marker Score: 33
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.07
    Marker Score: 24

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Other Information

**Key characteristics:** - It is a glycoprotein with a molecular weight of approximately 120 kDa. - It is expressed exclusively in the human placenta during pregnancy. - It is involved in the regulation of immune responses and the maintenance of pregnancy. **Pathways and functions:** - PSG4 is involved in the regulation of cell adhesion and migration. - It is a key regulator of the placenta-fetal interface. - It is involved in the regulation of angiogenesis and the formation of new blood vessels. - It is involved in the regulation of immune cell migration and function. - It is involved in the regulation of inflammation. **Clinical significance:** - Mutations in PSG4 have been linked to placental abruption, preterm labor, and other pregnancy complications. - PSG4 is a potential therapeutic target for pregnancy-related diseases. - It is a promising target for the development of new diagnostic tests and therapeutic interventions for pregnancy-related diseases. **Additional information:** - PSG4 is a member of the PSG (pregnancy-specific glycoproteins) family of glycoproteins. - It is expressed in high levels in the blood of pregnant women. - It is also expressed in the placenta, fetal membranes, and umbilical cord blood. - It is a highly conserved protein, with a similar protein found in other mammals.

Genular Protein ID: 2859803209

Symbol: PSG4_HUMAN

Name: Pregnancy-specific beta-1-glycoprotein 4

UniProtKB Accession Codes:

Q00888 E7EX79 Q13047 Q13048 Q15234 Q15240 Q9UQ76

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1690992

Title: The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed.

PubMed ID: 1690992

DOI: 10.1016/0006-291x(90)92103-7

PubMed ID: 2346490

Title:

PubMed ID: 2346490

PubMed ID: 2271648

Title: Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit.

PubMed ID: 2271648

DOI: 10.1021/bi00496a009

PubMed ID: 1922019

Title: Characterization of new members of the pregnancy-specific beta 1-glycoprotein family.

PubMed ID: 1922019

DOI: 10.1007/bf00230182

PubMed ID: 7794280

Title: Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants.

PubMed ID: 7794280

DOI: 10.1006/bbrc.1995.1862

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 2783133

Title: cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver.

PubMed ID: 2783133

DOI: 10.1016/0006-291x(89)91105-4

PubMed ID: 3180995

Title: Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen.

PubMed ID: 3180995

DOI: 10.1089/dna.1.1988.7.545

Sequence Information:

  • Length: 419
  • Mass: 47113
  • Checksum: 576BFB4CBA502CC2
  • Sequence:
    • MGPLSAPPCT QRITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ 
NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER VYSNASLLIQ NVTQEDAGSY 
TLHIIKRRDG TGGVTGHFTF TLHLETPKPS ISSSNLNPRE AMEAVILTCD PATPAASYQW 
WMNGQSLPMT HRLQLSKTNR TLFIFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLS 
KPYITINNLN PRENKDVLTF TCEPKSKNYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV 
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL YLSCFAESNP 
RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSIT VKVSDWILP

Genular Protein ID: 840493288

Symbol: Q6P520_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P520

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 419
  • Mass: 47090
  • Checksum: 9C8E9233BC418F78
  • Sequence:
    • MGPLSAPPCT HLITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ 
NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER VYSNASLLIQ NVTQEDAGSY 
TLHIIKRRDG TGGVTGHFTF TLHLETPKPS ISSSNLNPRE AMEAVILTCD PATPAASYQW 
WMNGQSLPMT HRLQLSKTNR TLFIFGVTKY IAGPYECEIR NPVSASRSDP VTLNLLPKLP 
KPYITINNLN PRENKDVLTF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV 
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL YLSCFAESNP 
RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSIT VKVSDWILP

Genular Protein ID: 1322565138

Symbol: B3KQL2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KQL2

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 326
  • Mass: 36770
  • Checksum: 63F8F7BCC7A4551C
  • Sequence:
    • MGPLSAPPCT HLITWKGVLL TASLLNFWNP PTTAQVTIEA QPPKVSEGKD VLLLVHNLPQ 
NLAGYIWYKG QMTYLYHYIT SYVVDGQRII YGPAYSGRER VYSNASLLIQ NVTQEDAGSY 
TLHIIKRRDG TGGVTGHFTF TLHPKLPKPY ITINNLNPRE NKDVLTFTCE PKSENYTYIW 
WLNGQSLPVS PRVKRPIENR ILILPNVTRN ETGPYQCEIR DRYGGIRSDP VTLNVLYGPD 
LPSIYPSFTY YRSGENLYLS CFAESNPRAQ YSWTINGKFQ LSGQKLSIPQ ITTKHSGLYA 
CSVRNSATGK ESSKSITVKV SDWILP

Genular Protein ID: 3423013844

Symbol: Q96QL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96QL5

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Gene3D 1 GenomeRNAi 1 InterPro 6 KEGG 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 RefSeq 4 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 419
  • Mass: 47045
  • Checksum: 0647F7FC7011D25F
  • Sequence:
    • MGTLSAPPCT QRIKWKGLLL TASLLNFWNL PTTAQVTIEA EPTKVSEGKD VLLLVHNLPQ 
NLTGYIWYKG QMRDLYHYIT SYVVDGEIII YGPAYGGRET AYSNASLLIQ NVTREDAGSY 
TLHIIKGDDG TRGVTGRFTF TLHLETPKPS ISSSNLNPRE TMEAVSLTCD PETPDASYLW 
WMNGQSLPMT HSLKLSETNR TLFLLGVTKY TAGPYECEIR NPVSASRSDP VTLNLLPKLS 
KPYITINNLN PRENKDVLTF TCEPKSENYT YIWWLNGQSL PVSPRVKRPI ENRILILPNV 
TRNETGPYQC EIRDRYGGIR SDPVTLNVLY GPDLPSIYPS FTYYRSGENL YLSCFAESNP 
RAQYSWTING KFQLSGQKLS IPQITTKHSG LYACSVRNSA TGKESSKSIT VKVSDWILP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.