Details for: PSG6

Gene ID: 5675

Symbol: PSG6

Ensembl ID: ENSG00000170848

Description: pregnancy specific beta-1-glycoprotein 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.6412
    Cell Significance Index: 28.0600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.7157
    Cell Significance Index: 9.8200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3138
    Cell Significance Index: 1.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2000
    Cell Significance Index: 5.3400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0811
    Cell Significance Index: 0.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0612
    Cell Significance Index: 3.8600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0475
    Cell Significance Index: 0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0238
    Cell Significance Index: 4.7800
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.0053
    Cell Significance Index: 0.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0030
    Cell Significance Index: 1.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0012
    Cell Significance Index: -1.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0033
    Cell Significance Index: -0.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0046
    Cell Significance Index: -2.9100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0063
    Cell Significance Index: -2.8800
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0069
    Cell Significance Index: -0.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0087
    Cell Significance Index: -1.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0103
    Cell Significance Index: -0.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0110
    Cell Significance Index: -2.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0124
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0149
    Cell Significance Index: -1.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0161
    Cell Significance Index: -0.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0169
    Cell Significance Index: -3.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0181
    Cell Significance Index: -2.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0183
    Cell Significance Index: -0.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0193
    Cell Significance Index: -1.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0193
    Cell Significance Index: -0.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0197
    Cell Significance Index: -2.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0208
    Cell Significance Index: -1.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0213
    Cell Significance Index: -2.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0220
    Cell Significance Index: -0.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0224
    Cell Significance Index: -0.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0248
    Cell Significance Index: -0.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0250
    Cell Significance Index: -3.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0256
    Cell Significance Index: -0.9700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0262
    Cell Significance Index: -0.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0282
    Cell Significance Index: -0.9900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0321
    Cell Significance Index: -0.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0331
    Cell Significance Index: -2.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0332
    Cell Significance Index: -2.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0371
    Cell Significance Index: -1.0100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0378
    Cell Significance Index: -0.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0382
    Cell Significance Index: -1.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0384
    Cell Significance Index: -2.1600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0405
    Cell Significance Index: -0.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0436
    Cell Significance Index: -1.1200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0483
    Cell Significance Index: -0.5900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0508
    Cell Significance Index: -0.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0520
    Cell Significance Index: -1.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0528
    Cell Significance Index: -1.1400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0531
    Cell Significance Index: -0.6700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0543
    Cell Significance Index: -0.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0570
    Cell Significance Index: -2.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0579
    Cell Significance Index: -1.0700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0600
    Cell Significance Index: -1.2200
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0609
    Cell Significance Index: -0.7200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0650
    Cell Significance Index: -0.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0673
    Cell Significance Index: -1.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0685
    Cell Significance Index: -1.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0700
    Cell Significance Index: -1.4600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0711
    Cell Significance Index: -2.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0714
    Cell Significance Index: -1.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0744
    Cell Significance Index: -3.0500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0756
    Cell Significance Index: -0.5200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0757
    Cell Significance Index: -0.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0777
    Cell Significance Index: -1.6500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0778
    Cell Significance Index: -0.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0805
    Cell Significance Index: -1.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0807
    Cell Significance Index: -1.6200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0829
    Cell Significance Index: -1.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0836
    Cell Significance Index: -2.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0861
    Cell Significance Index: -1.7000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0878
    Cell Significance Index: -1.0600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0881
    Cell Significance Index: -0.9200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0890
    Cell Significance Index: -0.5600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0945
    Cell Significance Index: -1.1800
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.0953
    Cell Significance Index: -1.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0972
    Cell Significance Index: -1.6800
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0982
    Cell Significance Index: -0.9400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1001
    Cell Significance Index: -1.0700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1013
    Cell Significance Index: -0.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1026
    Cell Significance Index: -2.9400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1026
    Cell Significance Index: -1.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1038
    Cell Significance Index: -2.4900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1043
    Cell Significance Index: -1.2000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1046
    Cell Significance Index: -1.1300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1093
    Cell Significance Index: -2.1800
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1122
    Cell Significance Index: -1.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1123
    Cell Significance Index: -2.7200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1125
    Cell Significance Index: -1.6400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1130
    Cell Significance Index: -1.2000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1159
    Cell Significance Index: -1.4600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1212
    Cell Significance Index: -1.5900
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1231
    Cell Significance Index: -1.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1242
    Cell Significance Index: -1.5400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1254
    Cell Significance Index: -2.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-specific expression**: PSG6 is expressed in a wide range of cell types, including glial cells, amacrine cells, retinal ganglion cells, Mueller cells, erythrocytes, and plasma cells. 2. **Cell surface localization**: PSG6 is localized to the cell surface, where it interacts with various receptors and ligands, modulating immune responses and cell signaling. 3. **Protein tyrosine kinase binding**: PSG6 interacts with protein tyrosine kinases (PTKs), which are essential for regulating cell growth, differentiation, and survival. 4. **Regulation of immune system processes**: PSG6 is involved in regulating immune responses, including B-cell differentiation, activation, and proliferation. **Pathways and Functions:** 1. **Cell surface interactions at the vascular wall**: PSG6 interacts with endothelial cells, modulating vascular permeability and inflammation. 2. **Hemostasis**: PSG6 is involved in regulating blood clotting and preventing excessive bleeding. 3. **Signal transduction**: PSG6 interacts with PTKs, initiating signaling cascades that regulate cell growth, differentiation, and survival. 4. **Regulation of immune system processes**: PSG6 modulates B-cell differentiation, activation, and proliferation, influencing immune responses and preventing autoimmune diseases. **Clinical Significance:** The dysregulation of PSG6 has been implicated in various diseases, including: 1. **Autoimmune disorders**: PSG6 dysfunction may contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Pregnancy complications**: Alterations in PSG6 expression have been linked to pregnancy-related complications, including preeclampsia and gestational diabetes. 3. **Neurological disorders**: PSG6 may play a role in regulating immune responses in the central nervous system, influencing the pathogenesis of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's disease. In conclusion, PSG6 is a multifunctional protein that plays a critical role in regulating immune responses, cell signaling, and tissue homeostasis. Further research is needed to fully elucidate the mechanisms by which PSG6 influences disease pathways and to develop therapeutic strategies targeting this protein.

Genular Protein ID: 3025996816

Symbol: PSG6_HUMAN

Name: Pregnancy-specific beta-1-glycoprotein 6

UniProtKB Accession Codes:

Q00889 O75244 Q15224 Q15235 Q549K1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 2 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2783133

Title: cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver.

PubMed ID: 2783133

DOI: 10.1016/0006-291x(89)91105-4

PubMed ID: 2346748

Title: Characterization of cDNAs of the human pregnancy-specific beta-1-glycoprotein family, a new subfamily of the immunoglobulin gene superfamily.

PubMed ID: 2346748

DOI: 10.1021/bi00463a030

PubMed ID: 2271648

Title: Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit.

PubMed ID: 2271648

DOI: 10.1021/bi00496a009

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1690992

Title: The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed.

PubMed ID: 1690992

DOI: 10.1016/0006-291x(90)92103-7

PubMed ID: 10686536

Title: Evolution of the carcinoembryonic antigen family. structures of CGM9, CGM11 and pregnancy-specific glycoprotein promoters.

PubMed ID: 10686536

DOI: 10.1159/000030112

PubMed ID: 2537643

Title: Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons.

PubMed ID: 2537643

DOI: 10.1016/0006-291x(89)92821-0

PubMed ID: 2377620

Title: Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole.

PubMed ID: 2377620

DOI: 10.1073/pnas.87.15.5822

Sequence Information:

  • Length: 435
  • Mass: 48814
  • Checksum: D94D4B0884327C60
  • Sequence:
    • MGPLSAPPCT QHITWKGLLL TASLLNFWNL PTTAQVIIEA KPPKVSEGKD VLLLVHNLPQ 
NLTGYIWYKG QMTDLYHYIT SYVVHGQIIY GPAYSGRETV YSNASLLIQN VTQEDAGSYT 
LHIIKRGDGT GGVTGYFTVT LYSETPKPSI SSSNLNPREV MEAVRLICDP ETPDASYLWL 
LNGQNLPMTH RLQLSKTNRT LYLFGVTKYI AGPYECEIRN PVSASRSDPV TLNLLPKLPM 
PYITINNLNP REKKDVLAFT CEPKSRNYTY IWWLNGQSLP VSPRVKRPIE NRILILPSVT 
RNETGPYQCE IRDRYGGIRS NPVTLNVLYG PDLPRIYPSF TYYRSGENLD LSCFADSNPP 
AEYSWTINGK FQLSGQKLFI PQITTNHSGL YACSVRNSAT GKEISKSMIV KVSETASPQV 
TYAGPNTWFQ EILLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.