Details for: RENBP

Gene ID: 5973

Symbol: RENBP

Ensembl ID: ENSG00000102032

Description: renin binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 51.2391
    Cell Significance Index: -7.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 21.3883
    Cell Significance Index: -5.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.0858
    Cell Significance Index: -8.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 18.6180
    Cell Significance Index: -8.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 16.9523
    Cell Significance Index: -8.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5777
    Cell Significance Index: -8.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8146
    Cell Significance Index: -7.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1084
    Cell Significance Index: -8.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9510
    Cell Significance Index: -4.2700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7632
    Cell Significance Index: 9.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4545
    Cell Significance Index: 86.4900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3749
    Cell Significance Index: 6.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3366
    Cell Significance Index: 8.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2209
    Cell Significance Index: 14.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2196
    Cell Significance Index: 6.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1981
    Cell Significance Index: 178.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1489
    Cell Significance Index: 14.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1471
    Cell Significance Index: 8.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1194
    Cell Significance Index: 3.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1128
    Cell Significance Index: 1.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1102
    Cell Significance Index: 5.7400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1058
    Cell Significance Index: 11.5100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1027
    Cell Significance Index: 0.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0832
    Cell Significance Index: 13.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0517
    Cell Significance Index: 3.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0449
    Cell Significance Index: 5.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0211
    Cell Significance Index: 14.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0162
    Cell Significance Index: 1.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0110
    Cell Significance Index: 20.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0079
    Cell Significance Index: 0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0055
    Cell Significance Index: 10.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0043
    Cell Significance Index: 2.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0038
    Cell Significance Index: 0.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0031
    Cell Significance Index: 0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0026
    Cell Significance Index: 3.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0014
    Cell Significance Index: 0.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0003
    Cell Significance Index: 0.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0003
    Cell Significance Index: -0.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0004
    Cell Significance Index: -0.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0037
    Cell Significance Index: -1.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0073
    Cell Significance Index: -5.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0084
    Cell Significance Index: -0.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0103
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0106
    Cell Significance Index: -0.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0131
    Cell Significance Index: -7.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0131
    Cell Significance Index: -5.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0132
    Cell Significance Index: -7.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0135
    Cell Significance Index: -8.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0147
    Cell Significance Index: -0.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0152
    Cell Significance Index: -1.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0186
    Cell Significance Index: -3.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0218
    Cell Significance Index: -1.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0235
    Cell Significance Index: -1.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0270
    Cell Significance Index: -0.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0276
    Cell Significance Index: -5.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0284
    Cell Significance Index: -3.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0293
    Cell Significance Index: -8.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0312
    Cell Significance Index: -4.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0410
    Cell Significance Index: -5.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0419
    Cell Significance Index: -8.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0454
    Cell Significance Index: -5.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0477
    Cell Significance Index: -5.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0492
    Cell Significance Index: -8.4000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0556
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0594
    Cell Significance Index: -6.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0641
    Cell Significance Index: -5.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0657
    Cell Significance Index: -4.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0667
    Cell Significance Index: -6.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0916
    Cell Significance Index: -4.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0937
    Cell Significance Index: -3.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1077
    Cell Significance Index: -6.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1085
    Cell Significance Index: -5.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1119
    Cell Significance Index: -8.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1142
    Cell Significance Index: -6.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1226
    Cell Significance Index: -5.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1257
    Cell Significance Index: -3.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1260
    Cell Significance Index: -8.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1301
    Cell Significance Index: -2.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1364
    Cell Significance Index: -6.8900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1388
    Cell Significance Index: -1.1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1523
    Cell Significance Index: -2.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1542
    Cell Significance Index: -5.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1610
    Cell Significance Index: -4.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1639
    Cell Significance Index: -2.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1683
    Cell Significance Index: -3.5900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1807
    Cell Significance Index: -3.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1851
    Cell Significance Index: -2.9700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1893
    Cell Significance Index: -3.7400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1945
    Cell Significance Index: -1.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2007
    Cell Significance Index: -3.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2104
    Cell Significance Index: -7.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2130
    Cell Significance Index: -4.5200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2154
    Cell Significance Index: -1.7200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2191
    Cell Significance Index: -1.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2236
    Cell Significance Index: -8.2100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2310
    Cell Significance Index: -3.2300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2330
    Cell Significance Index: -5.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RENBP is a protein-coding gene that encodes for the N-acylglucosamine 2-epimerase enzyme. It is characterized by its ability to bind renin, a key enzyme in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure. RENBP is also involved in various post-translational modifications, including glycosylation, which is essential for protein function and stability. The gene's expression is widespread, with significant levels detected in immune cells, enterocytes, and neurons. **Pathways and Functions:** RENBP is involved in multiple pathways, including: 1. **Asparagine N-linked Glycosylation**: RENBP is essential for the proper glycosylation of proteins, which is crucial for protein function and stability. 2. **Biosynthesis of n-glycan precursors**: RENBP participates in the synthesis of dolichol lipid-linked oligosaccharides (LO), which are precursors to n-glycans. 3. **Carbohydrate metabolic processes**: RENBP is involved in the metabolism of carbohydrates, including the breakdown of N-acetylglucosamine and N-acetylmannosamine. 4. **Endopeptidase inhibitor activity**: RENBP can inhibit endopeptidases, which are enzymes that break down proteins. 5. **Regulation of blood pressure**: RENBP's interaction with renin suggests its role in regulating blood pressure through the RAAS pathway. **Clinical Significance:** RENBP's involvement in various cellular processes and its expression in multiple cell types make it a potential candidate for involvement in various diseases. Some potential clinical implications of RENBP include: 1. **Hypertension**: Alterations in RENBP expression or function may contribute to the development of hypertension. 2. **Immune disorders**: RENBP's role in immune regulation suggests its involvement in autoimmune diseases or immune-related disorders. 3. **Neurological disorders**: RENBP's expression in neurons and its potential involvement in neuronal function make it a potential candidate for involvement in neurological disorders, such as Alzheimer's disease. In conclusion, RENBP is a multifaceted gene that plays a critical role in various cellular processes, including protein modification, immune regulation, and metabolic pathways. Its clinical significance is evident, and further research is needed to fully understand its role in human disease.

Genular Protein ID: 1576798815

Symbol: RENBP_HUMAN

Name: N-acylglucosamine 2-epimerase

UniProtKB Accession Codes:

P51606 B4DNZ3 Q96BI6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 3 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1723410

Title: Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif.

PubMed ID: 1723410

DOI: 10.1093/oxfordjournals.jbchem.a123609

PubMed ID: 9990133

Title: Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase.

PubMed ID: 9990133

DOI: 10.1093/oxfordjournals.jbchem.a022293

PubMed ID: 22692205

Title: Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid.

PubMed ID: 22692205

DOI: 10.1074/jbc.m112.363549

PubMed ID: 10502668

Title: Identification of cysteine-380 as the essential residue for the human N-acetyl-D-glucosamine 2-epimerase (renin binding protein).

PubMed ID: 10502668

DOI: 10.1093/oxfordjournals.jbchem.a022496

PubMed ID: 12499362

Title: GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism.

PubMed ID: 12499362

DOI: 10.1074/jbc.m212127200

Sequence Information:

  • Length: 427
  • Mass: 48831
  • Checksum: 40D5C485C30BE009
  • Sequence:
    • MSKGLPARQD MEKERETLQA WKERVGQELD RVVAFWMEHS HDQEHGGFFT CLGREGRVYD 
DLKYVWLQGR QVWMYCRLYR TFERFRHAQL LDAAKAGGEF LLRYARVAPP GKKCAFVLTR 
DGRPVKVQRT IFSECFYTMA MNELWRATGE VRYQTEAVEM MDQIVHWVQE DASGLGRPQL 
QGAPAAEPMA VPMMLLNLVE QLGEADEELA GKYAELGDWC ARRILQHVQR DGQAVLENVS 
EGGKELPGCL GRQQNPGHTL EAGWFLLRHC IRKGDPELRA HVIDKFLLLP FHSGWDPDHG 
GLFYFQDADN FCPTQLEWAM KLWWPHSEAM IAFLMGYSDS GDPVLLRLFY QVAEYTFRQF 
RDPEYGEWFG YLSREGKVAL SIKGGPFKGC FHVPRCLAMC EEMLGALLSR PAPAPSPAPT 
PACRGAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.