Gene RPS4X - ENSG00000198034 | NCBI Gene ID: 6191

Details for: RPS4X

Gene ID: 6191

Symbol: RPS4X

Ensembl ID: ENSG00000198034

Description: ribosomal protein S4 X-linked

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Membrane
(GO:0016020)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of translation
(GO:0045727)
Protein binding
(GO:0005515)
Ribonucleoprotein complex
(GO:1990904)
Ribosomal small subunit biogenesis
(GO:0042274)
Ribosome
(GO:0005840)
Rna binding
(GO:0003723)
Rrna binding
(GO:0019843)
Small-subunit processome
(GO:0032040)
Small ribosomal subunit
(GO:0015935)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 7.36
Marker Score: 4148
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 6.11
Marker Score: 4781
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 6.09
Marker Score: 4596
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 6.04
Marker Score: 29668
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.69
Marker Score: 11918
Cell Name: malignant cell (CL0001064)
Fold Change: 5.52
Marker Score: 74214
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.42
Marker Score: 3929
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 5.41
Marker Score: 7052
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.37
Marker Score: 15668
Cell Name: mature T cell (CL0002419)
Fold Change: 5.32
Marker Score: 52672
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.3
Marker Score: 1954
Cell Name: acinar cell (CL0000622)
Fold Change: 5.29
Marker Score: 3730.5
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 5.27
Marker Score: 2710
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 5.19
Marker Score: 3662
Cell Name: naive T cell (CL0000898)
Fold Change: 5.18
Marker Score: 3334.5
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.16
Marker Score: 8849
Cell Name: theca cell (CL0000503)
Fold Change: 5.12
Marker Score: 3668
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 5.1
Marker Score: 4342.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 5.06
Marker Score: 172087
Cell Name: naive B cell (CL0000788)
Fold Change: 5.01
Marker Score: 4470
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.88
Marker Score: 7520
Cell Name: endocardial cell (CL0002350)
Fold Change: 4.88
Marker Score: 2756
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.85
Marker Score: 15314
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.75
Marker Score: 251135
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 4.65
Marker Score: 2399.5
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.63
Marker Score: 24325
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.56
Marker Score: 1089
Cell Name: memory T cell (CL0000813)
Fold Change: 4.51
Marker Score: 1939
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 4.51
Marker Score: 3429
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.5
Marker Score: 59300
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.44
Marker Score: 1442
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.43
Marker Score: 4926
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 4.38
Marker Score: 11746
Cell Name: blood cell (CL0000081)
Fold Change: 4.34
Marker Score: 50497
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.34
Marker Score: 2642
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.33
Marker Score: 11950
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.32
Marker Score: 241372
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 4.29
Marker Score: 2289
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.28
Marker Score: 25992
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 4.26
Marker Score: 17773
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.23
Marker Score: 10338
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 4.23
Marker Score: 15027
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.22
Marker Score: 11844
Cell Name: endothelial cell (CL0000115)
Fold Change: 4.22
Marker Score: 3781
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.21
Marker Score: 4065
Cell Name: club cell (CL0000158)
Fold Change: 4.2
Marker Score: 4902
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.2
Marker Score: 2461
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.17
Marker Score: 31048
Cell Name: granulocyte (CL0000094)
Fold Change: 4.16
Marker Score: 1866
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.15
Marker Score: 9453
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.13
Marker Score: 10500
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 4.12
Marker Score: 26827
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.11
Marker Score: 10026
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4.1
Marker Score: 3218
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 4.1
Marker Score: 2914
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.08
Marker Score: 17510
Cell Name: supporting cell (CL0000630)
Fold Change: 4.08
Marker Score: 7667
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4.08
Marker Score: 3478
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.07
Marker Score: 6000
Cell Name: chondrocyte (CL0000138)
Fold Change: 4.05
Marker Score: 1822
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 4.04
Marker Score: 926
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.99
Marker Score: 3928
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.98
Marker Score: 4253
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 3.98
Marker Score: 4915
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.97
Marker Score: 9894.5
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.95
Marker Score: 1039
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.94
Marker Score: 9932
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.94
Marker Score: 25122
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.93
Marker Score: 3710
Cell Name: glial cell (CL0000125)
Fold Change: 3.92
Marker Score: 4310
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.92
Marker Score: 3209
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.92
Marker Score: 3439
Cell Name: stromal cell (CL0000499)
Fold Change: 3.91
Marker Score: 4584
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.9
Marker Score: 2626
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.9
Marker Score: 3439
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.89
Marker Score: 4700
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 3.88
Marker Score: 2008
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.87
Marker Score: 4276
Cell Name: reticular cell (CL0000432)
Fold Change: 3.86
Marker Score: 1410
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.86
Marker Score: 1096
Cell Name: taste receptor cell (CL0000209)
Fold Change: 3.85
Marker Score: 3323
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.85
Marker Score: 3616
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.82
Marker Score: 1077
Cell Name: fibroblast (CL0000057)
Fold Change: 3.8
Marker Score: 3674
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.8
Marker Score: 3158
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.8
Marker Score: 1734
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.8
Marker Score: 4083
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.78
Marker Score: 1245
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.78
Marker Score: 3361
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.77
Marker Score: 33073
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.77
Marker Score: 1074
Cell Name: memory B cell (CL0000787)
Fold Change: 3.75
Marker Score: 2839
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 3.75
Marker Score: 5448
Cell Name: immature B cell (CL0000816)
Fold Change: 3.75
Marker Score: 2482
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.74
Marker Score: 992
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.73
Marker Score: 3788
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 3.72
Marker Score: 1856
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.72
Marker Score: 3316
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.72
Marker Score: 24170
Cell Name: connective tissue cell (CL0002320)
Fold Change: 3.71
Marker Score: 962

Hover over a box to see details here...

**Key characteristics:** * The protein is a ribosomal protein. * It is encoded by the RS4X_HUMAN gene. * It is significantly expressed in epithelial cell of exocrine pancreas, thyroid follicular cell, cord blood hematopoietic stem cell, myoepithelial cell of mammary gland, CD38-negative naive B cell, malignant cell, activated CD8-positive, alpha-beta T cell, uterine smooth muscle cell, NKp46-positive innate lymphoid cell, and human. **Pathways and functions:** * The protein is involved in axon guidance. It is a key factor in the formation of the neural tube. * It is involved in cellular responses to stimuli. It is expressed in cells that are exposed to environmental cues and that respond by changing their behavior or morphology. * It is involved in cellular responses to stress. It is expressed in cells that are exposed to stress factors such as heat, cold, or toxins. * It is involved in developmental biology. It is expressed in cells during development. * It is involved in disease. It is expressed in cells that are involved in the development of cancer. * It is involved in metabolism. It is involved in the metabolism of amino acids and derivatives, metabolism of proteins, and metabolism of RNA. **Clinical significance:** * Mutations in the RPS4X gene have been linked to a number of human diseases, including cancer and developmental disorders. * The protein is a potential target for therapy in cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S4

Genular Protein ID: 380179661

Symbol: RS4X_HUMAN

Name: 40S ribosomal protein S4

UniProtKB Accession Codes:

P62701 P12631 P12750 P27576 P55831 Q14727 Q6IPY4

Database IDs:

Citations:

PubMed ID: 2124517

Title: Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome.

PubMed ID: 2124517

DOI: 10.1016/0092-8674(90)90416-c

PubMed ID: 1795030

Title: Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene.

PubMed ID: 1795030

DOI: 10.1242/jcs.100.1.35

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 2829364

Title: Isolation of an abundantly expressed sequence from the human X chromosome by differential screening.

PubMed ID: 2829364

DOI: 10.1007/bf01535047

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

Length: 263
Mass: 29598
Checksum: 87200E545A8958B0
Sequence:

MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN RLKYALTGDE 
VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIDKTGENFR LIYDTKGRFA VHRITPEEAK 
YKLCKVRKIF VGTKGIPHLV THDARTIRYP DPLIKVNDTI QIDLETGKIT DFIKFDTGNL 
CMVTGGANLG RIGVITNRER HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR 
GKGIRLTIAE ERDKRLAAKQ SSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPS4X

Associated with

Cells (max top 100)

Other Information

Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. PubMed ID: 2124517

Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene. PubMed ID: 1795030

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Isolation of an abundantly expressed sequence from the human X chromosome by differential screening. PubMed ID: 2829364

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Molecular composition of IMP1 ribonucleoprotein granules. PubMed ID: 17289661

Initial characterization of the human central proteome. PubMed ID: 21269460

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Nucleolar maturation of the human small subunit processome. PubMed ID: 34516797