Gene RPS21 - ENSG00000171858 | NCBI Gene ID: 6227

Details for: RPS21

Gene ID: 6227

Symbol: RPS21

Ensembl ID: ENSG00000171858

Description: ribosomal protein S21

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-HSA-72662)
Axon guidance
(R-HSA-422475)
Cap-dependent translation initiation
(R-HSA-72737)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eukaryotic translation elongation
(R-HSA-156842)
Eukaryotic translation initiation
(R-HSA-72613)
Eukaryotic translation termination
(R-HSA-72764)
Formation of a pool of free 40s subunits
(R-HSA-72689)
Formation of the ternary complex, and subsequently, the 43s complex
(R-HSA-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-HSA-72706)
Infectious disease
(R-HSA-5663205)
Influenza infection
(R-HSA-168255)
Influenza viral rna transcription and replication
(R-HSA-168273)
L13a-mediated translational silencing of ceruloplasmin expression
(R-HSA-156827)
Major pathway of rrna processing in the nucleolus and cytosol
(R-HSA-6791226)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Peptide chain elongation
(R-HSA-156902)
Regulation of expression of slits and robos
(R-HSA-9010553)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Ribosomal scanning and start codon recognition
(R-HSA-72702)
Rrna processing
(R-HSA-72312)
Rrna processing in the nucleus and cytosol
(R-HSA-8868773)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 modulates host translation machinery
(R-HSA-9735869)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 modulates host translation machinery
(R-HSA-9754678)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Selenoamino acid metabolism
(R-HSA-2408522)
Selenocysteine synthesis
(R-HSA-2408557)
Signaling by robo receptors
(R-HSA-376176)
Srp-dependent cotranslational protein targeting to membrane
(R-HSA-1799339)
Translation initiation complex formation
(R-HSA-72649)
Viral infection pathways
(R-HSA-9824446)
Viral mrna translation
(R-HSA-192823)
Cytoplasm
(GO:0005737)
Cytoplasmic translation
(GO:0002181)
Cytosol
(GO:0005829)
Cytosolic ribosome
(GO:0022626)
Cytosolic small ribosomal subunit
(GO:0022627)
Endonucleolytic cleavage in its1 to separate ssu-rrna from 5.8s rrna and lsu-rrna from tricistronic rrna transcript (ssu-rrna, 5.8s rrna, lsu-rrna)
(GO:0000447)
Endonucleolytic cleavage to generate mature 3'-end of ssu-rrna from (ssu-rrna, 5.8s rrna, lsu-rrna)
(GO:0000461)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Rough endoplasmic reticulum
(GO:0005791)
Small ribosomal subunit
(GO:0015935)
Structural constituent of ribosome
(GO:0003735)
Synapse
(GO:0045202)
Translation
(GO:0006412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 6.26
Marker Score: 30773.5
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 6.22
Marker Score: 4697
Cell Name: malignant cell (CL0001064)
Fold Change: 5.33
Marker Score: 71646
Cell Name: mature T cell (CL0002419)
Fold Change: 5.25
Marker Score: 52034
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 5.13
Marker Score: 8803
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 5.11
Marker Score: 10703
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 5.03
Marker Score: 3650
Cell Name: radial glial cell (CL0000681)
Fold Change: 5.03
Marker Score: 1853
Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 5.01
Marker Score: 2822.5
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 4.99
Marker Score: 7690
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 4.98
Marker Score: 2561
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.98
Marker Score: 169545
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 4.93
Marker Score: 3861
Cell Name: naive T cell (CL0000898)
Fold Change: 4.82
Marker Score: 3105
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.82
Marker Score: 15201
Cell Name: naive B cell (CL0000788)
Fold Change: 4.77
Marker Score: 4262
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.76
Marker Score: 251782
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 4.74
Marker Score: 2444.5
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.64
Marker Score: 13549
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 4.59
Marker Score: 24107
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.41
Marker Score: 246649
Cell Name: blood cell (CL0000081)
Fold Change: 4.36
Marker Score: 50639
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 4.34
Marker Score: 1036
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 4.32
Marker Score: 4802.5
Cell Name: mesodermal cell (CL0000222)
Fold Change: 4.27
Marker Score: 56299
Cell Name: elicited macrophage (CL0000861)
Fold Change: 4.26
Marker Score: 25890
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.25
Marker Score: 11910
Cell Name: memory T cell (CL0000813)
Fold Change: 4.2
Marker Score: 1807
Cell Name: germinal center B cell (CL0000844)
Fold Change: 4.19
Marker Score: 2548
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.17
Marker Score: 4030
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 4.16
Marker Score: 1353
Cell Name: papillary tips cell (CL1000597)
Fold Change: 4.16
Marker Score: 840
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.13
Marker Score: 9421
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.13
Marker Score: 10085
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.11
Marker Score: 11350.5
Cell Name: taste receptor cell (CL0000209)
Fold Change: 4.1
Marker Score: 3540
Cell Name: acinar cell (CL0000622)
Fold Change: 4.08
Marker Score: 2881
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.08
Marker Score: 17491
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 4.04
Marker Score: 2368
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 4.04
Marker Score: 30056
Cell Name: type I NK T cell (CL0000921)
Fold Change: 4
Marker Score: 3135
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 3.99
Marker Score: 16623.5
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.99
Marker Score: 5869
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.98
Marker Score: 3920
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.98
Marker Score: 4247.5
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 3.96
Marker Score: 9657
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.94
Marker Score: 25694
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.93
Marker Score: 5118
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.92
Marker Score: 3346
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 3.88
Marker Score: 2950
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 3.86
Marker Score: 1015
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.85
Marker Score: 4021
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 3.83
Marker Score: 878
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.83
Marker Score: 3598
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.82
Marker Score: 2039
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.81
Marker Score: 10207
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 3.78
Marker Score: 2540
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 3.76
Marker Score: 2677
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.75
Marker Score: 3295
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.74
Marker Score: 3186
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.74
Marker Score: 3323.5
Cell Name: supporting cell (CL0000630)
Fold Change: 3.74
Marker Score: 7019
Cell Name: chondrocyte (CL0000138)
Fold Change: 3.71
Marker Score: 1671
Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.7
Marker Score: 4096.5
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 3.7
Marker Score: 1043
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.7
Marker Score: 24085
Cell Name: memory B cell (CL0000787)
Fold Change: 3.69
Marker Score: 2790
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.68
Marker Score: 3016
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.67
Marker Score: 3051
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 3.67
Marker Score: 1675
Cell Name: theca cell (CL0000503)
Fold Change: 3.66
Marker Score: 2622
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.65
Marker Score: 2767
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.65
Marker Score: 12959
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 3.65
Marker Score: 3701
Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 3.62
Marker Score: 1029
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.6
Marker Score: 1987
Cell Name: immature B cell (CL0000816)
Fold Change: 3.59
Marker Score: 2379
Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.59
Marker Score: 2063
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.57
Marker Score: 3835
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.55
Marker Score: 22663.5
Cell Name: lung macrophage (CL1001603)
Fold Change: 3.55
Marker Score: 4062
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.54
Marker Score: 2981
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 3.54
Marker Score: 3120
Cell Name: granulocyte (CL0000094)
Fold Change: 3.54
Marker Score: 1586
Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.53
Marker Score: 8017
Cell Name: mesothelial fibroblast (CL4023054)
Fold Change: 3.52
Marker Score: 1041
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.52
Marker Score: 20885
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.51
Marker Score: 1156.5
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.51
Marker Score: 2057
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.51
Marker Score: 1001
Cell Name: lung secretory cell (CL1000272)
Fold Change: 3.51
Marker Score: 3128
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 3.5
Marker Score: 928
Cell Name: late pro-B cell (CL0002048)
Fold Change: 3.5
Marker Score: 4128
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.5
Marker Score: 8707
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.5
Marker Score: 2526
Cell Name: stromal cell (CL0000499)
Fold Change: 3.5
Marker Score: 4095
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 3.49
Marker Score: 867
Cell Name: epithelial cell (CL0000066)
Fold Change: 3.48
Marker Score: 5540
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.47
Marker Score: 5685
Cell Name: S cone cell (CL0003050)
Fold Change: 3.46
Marker Score: 1041

Hover over a box to see details here...

**Key characteristics:** * The protein is a 40S ribosomal protein. * It is expressed in a variety of cell types. * It is involved in the initiation of protein synthesis. * It is a key regulator of protein synthesis. **Pathways and functions:** * The protein is involved in the initiation of protein synthesis by binding to the 5' cap of mRNA and promoting the binding of the ribosome to the start codon. * It is also involved in the regulation of protein synthesis by binding to the 3' polyadenylation signal of mRNA and promoting the release of the mRNA from the ribosome. * It is a key regulator of cell growth, differentiation, and metabolism. **Clinical significance:** * Mutations in the RPS21 gene have been linked to a number of human diseases, including cancer and neurodegenerative disorders. * Targeting RPS21 has been explored as a therapeutic strategy for these diseases. **Additional information:** * The human RPS21 gene is located on chromosome 15q21.1. * The protein is a glycoprotein with a molecular weight of approximately 45 kDa. * It is a member of the RPS21 family of ribosomal proteins.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

40S ribosomal protein S21

Genular Protein ID: 755992040

Symbol: RS21_HUMAN

Name: 40S ribosomal protein S21

UniProtKB Accession Codes:

P63220 P35265

Database IDs:

Citations:

PubMed ID: 8332502

Title: Primary structure of human ribosomal protein S21.

PubMed ID: 8332502

DOI: 10.1093/nar/21.12.2939

PubMed ID: 10900511

Title: Cloning and characterization of the human ribosomal protein S21 gene.

PubMed ID: 10900511

PubMed ID: 11875025

Title: The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.

PubMed ID: 11875025

DOI: 10.1101/gr.214202

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 9582194

Title: A map of 75 human ribosomal protein genes.

PubMed ID: 9582194

DOI: 10.1101/gr.8.5.509

PubMed ID: 8706699

Title: Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.

PubMed ID: 8706699

DOI: 10.1111/j.1432-1033.1996.0144u.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24524803

Title: A new system for naming ribosomal proteins.

PubMed ID: 24524803

DOI: 10.1016/j.sbi.2014.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 23636399

Title: Structures of the human and Drosophila 80S ribosome.

PubMed ID: 23636399

DOI: 10.1038/nature12104

PubMed ID: 25957688

Title: Structural snapshots of actively translating human ribosomes.

PubMed ID: 25957688

DOI: 10.1016/j.cell.2015.03.052

PubMed ID: 25901680

Title: Structure of the human 80S ribosome.

PubMed ID: 25901680

DOI: 10.1038/nature14427

Sequence Information:

Length: 83
Mass: 9111
Checksum: 6794AC1292A06BD3
Sequence:

MQNDAGEFVD LYVPRKCSAS NRIIGAKDHA SIQMNVAEVD KVTGRFNGQF KTYAICGAIR 
RMGESDDSIL RLAKADGIVS KNF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: RPS21

Associated with

Cells (max top 100)

Other Information

Primary structure of human ribosomal protein S21. PubMed ID: 8332502

Cloning and characterization of the human ribosomal protein S21 gene. PubMed ID: 10900511

The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. PubMed ID: 11875025

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

A map of 75 human ribosomal protein genes. PubMed ID: 9582194

Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. PubMed ID: 8706699

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

A new system for naming ribosomal proteins. PubMed ID: 24524803

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. PubMed ID: 25114211

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Structures of the human and Drosophila 80S ribosome. PubMed ID: 23636399

Structural snapshots of actively translating human ribosomes. PubMed ID: 25957688

Structure of the human 80S ribosome. PubMed ID: 25901680