No CSI details found for gene ID: 6406
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 931909807
Symbol: SEMG1_HUMAN
Name: Semenogelin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2912989
Title: Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa.
PubMed ID: 2912989
PubMed ID: 1517240
Title: Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20.
PubMed ID: 1517240
PubMed ID: 14629036
Title: Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.
PubMed ID: 14629036
PubMed ID: 11780052
Title: The DNA sequence and comparative analysis of human chromosome 20.
PubMed ID: 11780052
DOI: 10.1038/414865a
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14562960
Title: Reduced polymorphism in the chimpanzee semen coagulating protein, semenogelin I.
PubMed ID: 14562960
PubMed ID: 3972122
Title: Amino acid sequence of the predominant basic protein in human seminal plasma.
PubMed ID: 3972122
PubMed ID: 6698208
Title: Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity.
PubMed ID: 6698208
PubMed ID: 6422553
Title: Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity.
PubMed ID: 6422553
PubMed ID: 2757795
Title: Isolation and structure determination of two peptides occurring in human seminal plasma.
PubMed ID: 2757795
PubMed ID: 8444163
Title: Isolation and identification of N-terminally extended forms of 5-oxoprolylglutamylprolinamide (Glp-Glu-Pro-NH2), a thyrotropin-releasing-hormone (TRH)-like peptide present in human semen.
PubMed ID: 8444163
PubMed ID: 3889920
Title: Human seminal alpha inhibins: isolation, characterization, and structure.
PubMed ID: 3889920
PubMed ID: 10412373
Title: Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein.
PubMed ID: 10412373
PubMed ID: 15590901
Title: Association of eppin with semenogelin on human spermatozoa.
PubMed ID: 15590901
PubMed ID: 17567961
Title: Characterization of an eppin protein complex from human semen and spermatozoa.
PubMed ID: 17567961
PubMed ID: 19889947
Title: Analysis of recombinant human semenogelin as an inhibitor of human sperm motility.
PubMed ID: 19889947
Sequence Information:
- Length: 462
- Mass: 52131
- Checksum: 760F48EFCF2FA702
- Sequence:
MKPNIIFVLS LLLILEKQAA VMGQKGGSKG RLPSEFSQFP HGQKGQHYSG QKGKQQTESK GSFSIQYTYH VDANDHDQSR KSQQYDLNAL HKTTKSQRHL GGSQQLLHNK QEGRDHDKSK GHFHRVVIHH KGGKAHRGTQ NPSQDQGNSP SGKGISSQYS NTEERLWVHG LSKEQTSVSG AQKGRKQGGS QSSYVLQTEE LVANKQQRET KNSHQNKGHY QNVVEVREEH SSKVQTSLCP AHQDKLQHGS KDIFSTQDEL LVYNKNQHQT KNLNQDQQHG RKANKISYQS SSTEERRLHY GENGVQKDVS QSSIYSQTEE KAQGKSQKQI TIPSQEQEHS QKANKISYQS SSTEERRLHY GENGVQKDVS QRSIYSQTEK LVAGKSQIQA PNPKQEPWHG ENAKGESGQS TNREQDLLSH EQKGRHQHGS HGGLDIVIIE QEDDSDRHLA QHLNNDRNPL FT
Details Unavailable
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{
"geneID": 6406,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AL049767.12"
]
},
"genePos": {
"start": 45207033,
"end": 45209768
},
"orientation": true,
"symbol": "SEMG1",
"created": {
"$date": {
"$numberLong": "1738333349159"
}
},
"crossReference": {
"enseGeneID": "ENSG00000124233",
"enseRnaID": [
"ENST00000372781.4"
],
"enseProtID": [
"ENSP00000361867.3"
]
},
"chrom": {
"pos": "20",
"type": 1,
"loc": "20q13.12"
},
"desc": "semenogelin 1",
"geneType": 5,
"mim": [
{
"id": 182140,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-168256",
"term": "Immune System",
"cat": 10
},
{
"id": "R-HSA-392499",
"term": "Metabolism of proteins",
"cat": 10
},
{
"id": "R-HSA-168249",
"term": "Innate Immune System",
"cat": 11
},
{
"id": "R-HSA-977225",
"term": "Amyloid fiber formation",
"cat": 11
},
{
"id": "R-HSA-6803157",
"term": "Antimicrobial peptides",
"cat": 12
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
8665956,
15590901,
19889947,
28514442,
32296183,
33961781
],
"cat": 0
},
{
"id": "GO:0008270",
"term": "zinc ion binding",
"pubMed": [
15563730
],
"cat": 0
},
{
"id": "GO:0007320",
"term": "insemination",
"pubMed": [
2912989
],
"cat": 1
},
{
"id": "GO:0019731",
"term": "antibacterial humoral response",
"pubMed": [
18714013
],
"cat": 1
},
{
"id": "GO:0031640",
"term": "killing of cells of another organism",
"pubMed": [
18314226
],
"cat": 1
},
{
"id": "GO:0048240",
"term": "sperm capacitation",
"cat": 1
},
{
"id": "GO:0050817",
"term": "coagulation",
"pubMed": [
8665956
],
"cat": 1
},
{
"id": "GO:0061844",
"term": "antimicrobial humoral immune response mediated by antimicrobial peptide",
"pubMed": [
18314226
],
"cat": 1
},
{
"id": "GO:0090281",
"term": "negative regulation of calcium ion import",
"pubMed": [
22075473
],
"cat": 1
},
{
"id": "GO:1900005",
"term": "positive regulation of serine-type endopeptidase activity",
"pubMed": [
15563730
],
"cat": 1
},
{
"id": "GO:1901318",
"term": "negative regulation of flagellated sperm motility",
"pubMed": [
22075473
],
"cat": 1
},
{
"id": "GO:1901318",
"term": "negative regulation of flagellated sperm motility",
"pubMed": [
19889947
],
"cat": 1
},
{
"id": "GO:0005576",
"term": "extracellular region",
"cat": 2
},
{
"id": "GO:0005615",
"term": "extracellular space",
"pubMed": [
2912989,
8665951,
8665956,
17567961,
18314226,
18714013
],
"cat": 2
},
{
"id": "GO:0005615",
"term": "extracellular space",
"pubMed": [
1517240
],
"cat": 2
},
{
"id": "GO:0005634",
"term": "nucleus",
"pubMed": [
21630459
],
"cat": 2
},
{
"id": "GO:0032991",
"term": "protein-containing complex",
"pubMed": [
17567961
],
"cat": 2
},
{
"id": "GO:0070062",
"term": "extracellular exosome",
"pubMed": [
23533145
],
"cat": 2
}
],
"geneRelations": [
{
"type": 1,
"similarGenes": [
"6407"
]
}
],
"protein": [
{
"symbol": "SEMG1_HUMAN",
"name": "Semenogelin-1",
"accession": [
"P04279",
"Q53ZV0",
"Q53ZV1",
"Q53ZV2",
"Q6X4I9",
"Q6Y809",
"Q6Y822",
"Q6Y823",
"Q86U64",
"Q96QM3"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"J04440",
"Z47556",
"M81650",
"AY256465",
"AY256466",
"AY256467",
"AY256468",
"AY256469",
"BT007177",
"AL049767",
"CH471077",
"BC007096",
"BC055416",
"AY174423",
"AY174424",
"AY174437"
],
"CCDS": [
"CCDS13345.1"
],
"PIR": [
"B43412"
],
"RefSeq": [
"NP_002998.1"
],
"PDB": [
"7ZRF",
"7ZRO",
"8BOO",
"8BVZ"
],
"PDBsum": [
"7ZRF",
"7ZRO",
"8BOO",
"8BVZ"
],
"AlphaFoldDB": [
"P04279"
],
"SMR": [
"P04279"
],
"BioGRID": [
"112306"
],
"IntAct": [
"P04279"
],
"MINT": [
"P04279"
],
"STRING": [
"9606.ENSP00000361867"
],
"DrugBank": [
"DB01593",
"DB14487",
"DB14533",
"DB14548"
],
"iPTMnet": [
"P04279"
],
"PhosphoSitePlus": [
"P04279"
],
"BioMuta": [
"SEMG1"
],
"DMDM": [
"134426"
],
"jPOST": [
"P04279"
],
"MassIVE": [
"P04279"
],
"PaxDb": [
"9606-ENSP00000361867"
],
"PeptideAtlas": [
"P04279"
],
"ProteomicsDB": [
"51699",
"51700"
],
"Pumba": [
"P04279"
],
"Antibodypedia": [
"12686"
],
"DNASU": [
"6406"
],
"Ensembl": [
"ENST00000372781.4"
],
"KEGG": [
"hsa:6406"
],
"MANE-Select": [
"ENST00000372781.4"
],
"UCSC": [
"uc002xni.3"
],
"AGR": [
"HGNC:10742"
],
"CTD": [
"6406"
],
"DisGeNET": [
"6406"
],
"GeneCards": [
"SEMG1"
],
"HGNC": [
"HGNC:10742"
],
"HPA": [
"ENSG00000124233"
],
"MIM": [
"182140"
],
"neXtProt": [
"NX_P04279"
],
"OpenTargets": [
"ENSG00000124233"
],
"PharmGKB": [
"PA35664"
],
"VEuPathDB": [
"HostDB:ENSG00000124233"
],
"eggNOG": [
"ENOG502T80H"
],
"GeneTree": [
"ENSGT00940000162560"
],
"HOGENOM": [
"CLU_034710_0_0_1"
],
"InParanoid": [
"P04279"
],
"OMA": [
"QRHNYDR"
],
"OrthoDB": [
"4729048at2759"
],
"PhylomeDB": [
"P04279"
],
"TreeFam": [
"TF342360"
],
"PathwayCommons": [
"P04279"
],
"Reactome": [
"R-HSA-6803157",
"R-HSA-977225"
],
"SignaLink": [
"P04279"
],
"BioGRID-ORCS": [
"6406"
],
"ChiTaRS": [
"SEMG1"
],
"GeneWiki": [
"Semenogelin_I"
],
"GenomeRNAi": [
"6406"
],
"Pharos": [
"P04279"
],
"PRO": [
"PR:P04279"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P04279"
],
"Bgee": [
"ENSG00000124233"
],
"GO": [
"GO:0070062",
"GO:0005576",
"GO:0005615",
"GO:0005634",
"GO:0032991",
"GO:0008270",
"GO:0019731",
"GO:0061844",
"GO:0050817",
"GO:0007320",
"GO:0031640",
"GO:0090281",
"GO:1901318",
"GO:1900005",
"GO:0048240"
],
"InterPro": [
"IPR008836"
],
"PANTHER": [
"PTHR10547:SF4",
"PTHR10547"
],
"Pfam": [
"PF05474"
]
},
"citations": [
{
"title": "Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa.",
"pubmedID": "2912989",
"doi": "10.1016\/s0021-9258(18)94272-9"
},
{
"title": "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20.",
"pubmedID": "1517240",
"doi": "10.1016\/s0021-9258(19)37155-8"
},
{
"title": "Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.",
"pubmedID": "14629036",
"doi": "10.1007\/s00239-003-2474-x"
},
{
"title": "The DNA sequence and comparative analysis of human chromosome 20.",
"pubmedID": "11780052",
"doi": "10.1038\/414865a"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101\/gr.2596504"
},
{
"title": "Reduced polymorphism in the chimpanzee semen coagulating protein, semenogelin I.",
"pubmedID": "14562960",
"doi": "10.1007\/s00239-002-2463-0"
},
{
"title": "Amino acid sequence of the predominant basic protein in human seminal plasma.",
"pubmedID": "3972122",
"doi": "10.1016\/0014-5793(85)81179-0"
},
{
"title": "Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity.",
"pubmedID": "6698208",
"doi": "10.1016\/0014-5793(84)80840-6"
},
{
"title": "Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity.",
"pubmedID": "6422553",
"doi": "10.1126\/science.6422553"
},
{
"title": "Isolation and structure determination of two peptides occurring in human seminal plasma.",
"pubmedID": "2757795"
},
{
"title": "Isolation and identification of N-terminally extended forms of 5-oxoprolylglutamylprolinamide (Glp-Glu-Pro-NH2), a thyrotropin-releasing-hormone (TRH)-like peptide present in human semen.",
"pubmedID": "8444163",
"doi": "10.1111\/j.1432-1033.1993.tb17629.x"
},
{
"title": "Human seminal alpha inhibins: isolation, characterization, and structure.",
"pubmedID": "3889920",
"doi": "10.1073\/pnas.82.12.4041"
},
{
"title": "Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein.",
"pubmedID": "10412373",
"doi": "10.1007\/s000180050346"
},
{
"title": "Association of eppin with semenogelin on human spermatozoa.",
"pubmedID": "15590901",
"doi": "10.1095\/biolreprod.104.036483"
},
{
"title": "Characterization of an eppin protein complex from human semen and spermatozoa.",
"pubmedID": "17567961",
"doi": "10.1095\/biolreprod.107.060194"
},
{
"title": "Analysis of recombinant human semenogelin as an inhibitor of human sperm motility.",
"pubmedID": "19889947",
"doi": "10.1095\/biolreprod.109.081331"
}
],
"sequence": {
"length": 462,
"mass": 52131,
"checksum": "760F48EFCF2FA702",
"modified": {
"$date": {
"$numberLong": "631152000000"
}
},
"version": 2,
"sequence": "MKPNIIFVLSLLLILEKQAAVMGQKGGSKGRLPSEFSQFPHGQKGQHYSGQKGKQQTESKGSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSKGHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHYQNVVEVREEHSSKVQTSLCPAHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHYGENGVQKDVSQSSIYSQTEEKAQGKSQKQITIPSQEQEHSQKANKISYQSSSTEERRLHYGENGVQKDVSQRSIYSQTEKLVAGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLDIVIIEQEDDSDRHLAQHLNNDRNPLFT"
},
"existence": 0,
"relevance": 1,
"proteinID": 931909807
}
],
"mRNAExpressions": {
"proteinAtlas": [
{
"l": "Granulocytes",
"c": "eosinophil",
"e": 26.9
}
]
},
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}