Details for: SEMG1

Gene ID: 6406

Symbol: SEMG1

Ensembl ID: ENSG00000124233

Description: semenogelin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 3.0619
    Cell Significance Index: 39.6200
  • Cell Name: mast cell (CL0000097)
    Fold Change: 2.9081
    Cell Significance Index: 38.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.5277
    Cell Significance Index: 52.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.0892
    Cell Significance Index: 34.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8701
    Cell Significance Index: 18.5300
  • Cell Name: sperm (CL0000019)
    Fold Change: 0.5671
    Cell Significance Index: 1.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4727
    Cell Significance Index: 10.2400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2135
    Cell Significance Index: 3.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1905
    Cell Significance Index: 2.8700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.1730
    Cell Significance Index: 1.0700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1513
    Cell Significance Index: 1.8400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0937
    Cell Significance Index: 1.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0511
    Cell Significance Index: 1.1800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0454
    Cell Significance Index: 0.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0339
    Cell Significance Index: 2.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0070
    Cell Significance Index: 0.1900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0060
    Cell Significance Index: 0.0800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0031
    Cell Significance Index: 0.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0026
    Cell Significance Index: -1.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0034
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0046
    Cell Significance Index: -0.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0060
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0075
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0078
    Cell Significance Index: -0.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0080
    Cell Significance Index: -1.4500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0093
    Cell Significance Index: -0.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0109
    Cell Significance Index: -1.5000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0116
    Cell Significance Index: -0.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0120
    Cell Significance Index: -0.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0169
    Cell Significance Index: -0.8800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0191
    Cell Significance Index: -0.2500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0226
    Cell Significance Index: -0.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0235
    Cell Significance Index: -0.4300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0239
    Cell Significance Index: -0.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0245
    Cell Significance Index: -0.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0269
    Cell Significance Index: -0.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0288
    Cell Significance Index: -1.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0294
    Cell Significance Index: -0.9400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0296
    Cell Significance Index: -0.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0296
    Cell Significance Index: -0.7400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0302
    Cell Significance Index: -0.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0314
    Cell Significance Index: -0.4500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0319
    Cell Significance Index: -0.5500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0336
    Cell Significance Index: -0.3900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0350
    Cell Significance Index: -0.4800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0391
    Cell Significance Index: -0.4600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0434
    Cell Significance Index: -0.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0443
    Cell Significance Index: -0.9400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0446
    Cell Significance Index: -0.5300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0457
    Cell Significance Index: -0.5400
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0525
    Cell Significance Index: -0.7200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0546
    Cell Significance Index: -0.6500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0564
    Cell Significance Index: -0.6500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0607
    Cell Significance Index: -0.6400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0609
    Cell Significance Index: -0.8900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0627
    Cell Significance Index: -0.9700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0649
    Cell Significance Index: -0.4500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0653
    Cell Significance Index: -0.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0661
    Cell Significance Index: -0.7200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0668
    Cell Significance Index: -0.8900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0679
    Cell Significance Index: -0.8200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0682
    Cell Significance Index: -0.7300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0686
    Cell Significance Index: -0.9000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0686
    Cell Significance Index: -0.7200
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0702
    Cell Significance Index: -0.6600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0708
    Cell Significance Index: -0.4700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0741
    Cell Significance Index: -0.8200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0771
    Cell Significance Index: -1.0700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0775
    Cell Significance Index: -0.7500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0776
    Cell Significance Index: -0.8800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0793
    Cell Significance Index: -0.8100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0797
    Cell Significance Index: -0.9700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0817
    Cell Significance Index: -0.9400
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0817
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0830
    Cell Significance Index: -1.0500
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0843
    Cell Significance Index: -0.9300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0852
    Cell Significance Index: -0.8400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0853
    Cell Significance Index: -1.1600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0865
    Cell Significance Index: -1.0800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0865
    Cell Significance Index: -0.9500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0868
    Cell Significance Index: -1.0300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0875
    Cell Significance Index: -1.0800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0881
    Cell Significance Index: -0.9600
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0909
    Cell Significance Index: -0.9100
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0918
    Cell Significance Index: -0.8200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0920
    Cell Significance Index: -1.0700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0921
    Cell Significance Index: -0.9400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0922
    Cell Significance Index: -1.0100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0924
    Cell Significance Index: -0.6600
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0931
    Cell Significance Index: -0.8500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0947
    Cell Significance Index: -0.8000
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0962
    Cell Significance Index: -0.8700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0967
    Cell Significance Index: -1.1600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0980
    Cell Significance Index: -0.9200
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0982
    Cell Significance Index: -0.9000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1004
    Cell Significance Index: -1.1400
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.1007
    Cell Significance Index: -0.8500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1015
    Cell Significance Index: -1.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SEMG1 is a serine protease inhibitor (serpin) that belongs to the serine protease inhibitor family (SERPIN). It is a member of the SEMG family, which also includes SEMG2 and SEMG3. SEMG1 is characterized by its ability to bind to and inhibit serine proteases, which are enzymes involved in various cellular processes, including protein metabolism and immune response. SEMG1 is also known for its role in the formation of amyloid fibers, which are protein aggregates that can be associated with various diseases. **Pathways and Functions** SEMG1 is involved in several biological pathways, including: 1. **Amyloid fiber formation**: SEMG1 is involved in the formation of amyloid fibers, which are protein aggregates that can be associated with various diseases. 2. **Antibacterial humoral response**: SEMG1 is involved in the regulation of the antibacterial humoral response, which is the body's defense against bacterial infections. 3. **Antimicrobial humoral immune response mediated by antimicrobial peptide**: SEMG1 is involved in the regulation of the antimicrobial humoral immune response mediated by antimicrobial peptides, which are small proteins that have antimicrobial properties. 4. **Coagulation**: SEMG1 is involved in the regulation of coagulation, which is the process by which the blood forms clots to stop bleeding. 5. **Protein metabolism**: SEMG1 is involved in the regulation of protein metabolism, which is the process by which cells synthesize and degrade proteins. 6. **Negative regulation of calcium ion import**: SEMG1 is involved in the negative regulation of calcium ion import, which is the process by which cells regulate the influx of calcium ions. 7. **Negative regulation of flagellated sperm motility**: SEMG1 is involved in the negative regulation of flagellated sperm motility, which is the process by which sperm cells move through the reproductive tract. **Clinical Significance** SEMG1 has been implicated in several diseases, including: 1. **Reproductive disorders**: SEMG1 has been implicated in reproductive disorders, including infertility and reproductive tract infections. 2. **Immune system disorders**: SEMG1 has been implicated in immune system disorders, including autoimmune diseases and immunodeficiency disorders. 3. **Neurological disorders**: SEMG1 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: SEMG1 has been implicated in cancer, including various types of cancer, such as breast cancer and prostate cancer. Overall, SEMG1 is a protein that plays a crucial role in various biological processes, including protein metabolism, immune response, and reproduction. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the functions and regulation of SEMG1.

Genular Protein ID: 931909807

Symbol: SEMG1_HUMAN

Name: Semenogelin-1

UniProtKB Accession Codes:

P04279 Q53ZV0 Q53ZV1 Q53ZV2 Q6X4I9 Q6Y809 Q6Y822 Q6Y823 Q86U64 Q96QM3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 16 Ensembl 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2912989

Title: Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa.

PubMed ID: 2912989

DOI: 10.1016/s0021-9258(18)94272-9

PubMed ID: 1517240

Title: Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20.

PubMed ID: 1517240

DOI: 10.1016/s0021-9258(19)37155-8

PubMed ID: 14629036

Title: Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.

PubMed ID: 14629036

DOI: 10.1007/s00239-003-2474-x

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14562960

Title: Reduced polymorphism in the chimpanzee semen coagulating protein, semenogelin I.

PubMed ID: 14562960

DOI: 10.1007/s00239-002-2463-0

PubMed ID: 3972122

Title: Amino acid sequence of the predominant basic protein in human seminal plasma.

PubMed ID: 3972122

DOI: 10.1016/0014-5793(85)81179-0

PubMed ID: 6698208

Title: Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity.

PubMed ID: 6698208

DOI: 10.1016/0014-5793(84)80840-6

PubMed ID: 6422553

Title: Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity.

PubMed ID: 6422553

DOI: 10.1126/science.6422553

PubMed ID: 2757795

Title: Isolation and structure determination of two peptides occurring in human seminal plasma.

PubMed ID: 2757795

PubMed ID: 8444163

Title: Isolation and identification of N-terminally extended forms of 5-oxoprolylglutamylprolinamide (Glp-Glu-Pro-NH2), a thyrotropin-releasing-hormone (TRH)-like peptide present in human semen.

PubMed ID: 8444163

DOI: 10.1111/j.1432-1033.1993.tb17629.x

PubMed ID: 3889920

Title: Human seminal alpha inhibins: isolation, characterization, and structure.

PubMed ID: 3889920

DOI: 10.1073/pnas.82.12.4041

PubMed ID: 10412373

Title: Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein.

PubMed ID: 10412373

DOI: 10.1007/s000180050346

PubMed ID: 15590901

Title: Association of eppin with semenogelin on human spermatozoa.

PubMed ID: 15590901

DOI: 10.1095/biolreprod.104.036483

PubMed ID: 17567961

Title: Characterization of an eppin protein complex from human semen and spermatozoa.

PubMed ID: 17567961

DOI: 10.1095/biolreprod.107.060194

PubMed ID: 19889947

Title: Analysis of recombinant human semenogelin as an inhibitor of human sperm motility.

PubMed ID: 19889947

DOI: 10.1095/biolreprod.109.081331

Sequence Information:

  • Length: 462
  • Mass: 52131
  • Checksum: 760F48EFCF2FA702
  • Sequence:
    • MKPNIIFVLS LLLILEKQAA VMGQKGGSKG RLPSEFSQFP HGQKGQHYSG QKGKQQTESK 
GSFSIQYTYH VDANDHDQSR KSQQYDLNAL HKTTKSQRHL GGSQQLLHNK QEGRDHDKSK 
GHFHRVVIHH KGGKAHRGTQ NPSQDQGNSP SGKGISSQYS NTEERLWVHG LSKEQTSVSG 
AQKGRKQGGS QSSYVLQTEE LVANKQQRET KNSHQNKGHY QNVVEVREEH SSKVQTSLCP 
AHQDKLQHGS KDIFSTQDEL LVYNKNQHQT KNLNQDQQHG RKANKISYQS SSTEERRLHY 
GENGVQKDVS QSSIYSQTEE KAQGKSQKQI TIPSQEQEHS QKANKISYQS SSTEERRLHY 
GENGVQKDVS QRSIYSQTEK LVAGKSQIQA PNPKQEPWHG ENAKGESGQS TNREQDLLSH 
EQKGRHQHGS HGGLDIVIIE QEDDSDRHLA QHLNNDRNPL FT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.