Details for: SFTPB

Gene ID: 6439

Symbol: SFTPB

Ensembl ID: ENSG00000168878

Description: surfactant protein B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 19.2683
    Cell Significance Index: 42.3800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.7197
    Cell Significance Index: -5.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 14.7126
    Cell Significance Index: 11136.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.2425
    Cell Significance Index: -5.9600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 3.2571
    Cell Significance Index: 26.9400
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.2762
    Cell Significance Index: 13.6400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.3824
    Cell Significance Index: 14.2600
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.6607
    Cell Significance Index: 2.7500
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.6480
    Cell Significance Index: 6.9400
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.4964
    Cell Significance Index: 3.6000
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.3427
    Cell Significance Index: 3.1800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2899
    Cell Significance Index: 1.8900
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.2760
    Cell Significance Index: 2.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2676
    Cell Significance Index: 13.9400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.1043
    Cell Significance Index: 1.0200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0809
    Cell Significance Index: 0.9000
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.0609
    Cell Significance Index: 0.2900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.0330
    Cell Significance Index: 0.3100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.0261
    Cell Significance Index: 0.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0033
    Cell Significance Index: 0.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0027
    Cell Significance Index: 0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0024
    Cell Significance Index: -3.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0028
    Cell Significance Index: -3.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0035
    Cell Significance Index: -1.9200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0044
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0050
    Cell Significance Index: -1.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0066
    Cell Significance Index: -2.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0075
    Cell Significance Index: -2.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0091
    Cell Significance Index: -0.9300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0163
    Cell Significance Index: -0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0166
    Cell Significance Index: -2.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0169
    Cell Significance Index: -2.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0171
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0206
    Cell Significance Index: -4.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0218
    Cell Significance Index: -3.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0227
    Cell Significance Index: -2.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0236
    Cell Significance Index: -2.4600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0237
    Cell Significance Index: -0.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0265
    Cell Significance Index: -0.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0266
    Cell Significance Index: -1.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0277
    Cell Significance Index: -3.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0297
    Cell Significance Index: -5.3500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0307
    Cell Significance Index: -0.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0327
    Cell Significance Index: -2.5100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0343
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0346
    Cell Significance Index: -3.9600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0382
    Cell Significance Index: -0.2000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0394
    Cell Significance Index: -0.3900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0442
    Cell Significance Index: -0.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0466
    Cell Significance Index: -5.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0475
    Cell Significance Index: -1.2200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0486
    Cell Significance Index: -0.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0504
    Cell Significance Index: -3.1000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0512
    Cell Significance Index: -0.5400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0516
    Cell Significance Index: -0.3500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0566
    Cell Significance Index: -0.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0577
    Cell Significance Index: -2.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0595
    Cell Significance Index: -2.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0597
    Cell Significance Index: -3.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0648
    Cell Significance Index: -2.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0650
    Cell Significance Index: -4.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0669
    Cell Significance Index: -2.1300
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0672
    Cell Significance Index: -0.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0710
    Cell Significance Index: -2.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0740
    Cell Significance Index: -3.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0754
    Cell Significance Index: -1.2700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0766
    Cell Significance Index: -0.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0766
    Cell Significance Index: -3.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0769
    Cell Significance Index: -1.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0819
    Cell Significance Index: -0.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0832
    Cell Significance Index: -2.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0859
    Cell Significance Index: -3.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0879
    Cell Significance Index: -2.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0880
    Cell Significance Index: -3.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0918
    Cell Significance Index: -4.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0934
    Cell Significance Index: -2.3300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0935
    Cell Significance Index: -1.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0947
    Cell Significance Index: -2.7900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0949
    Cell Significance Index: -1.4200
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0984
    Cell Significance Index: -1.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0993
    Cell Significance Index: -4.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1003
    Cell Significance Index: -2.8900
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1024
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.1025
    Cell Significance Index: -0.9500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1050
    Cell Significance Index: -1.8100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1057
    Cell Significance Index: -2.1500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1061
    Cell Significance Index: -2.6500
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1080
    Cell Significance Index: -1.3300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1092
    Cell Significance Index: -1.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1126
    Cell Significance Index: -2.3900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1153
    Cell Significance Index: -1.6800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1163
    Cell Significance Index: -2.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1183
    Cell Significance Index: -1.9800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1185
    Cell Significance Index: -2.5600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1193
    Cell Significance Index: -1.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression**: SFTPB is primarily expressed in the epithelial cells of the lower respiratory tract, including alveolar epithelial cells, type II pneumocytes, and bronchial epithelial cells. 2. **Function**: SFTPB is involved in the regulation of surfactant metabolism, particularly in the secretion of surfactant lipids by alveolar type II pneumocytes. 3. **Structure**: SFTPB is a small, secreted protein with a molecular weight of approximately 12 kDa, consisting of three cysteine-rich domains. 4. **Interactions**: SFTPB interacts with other surfactant-associated proteins, such as SFTPA1 and SFTPA3, to regulate surfactant function and stability. **Pathways and Functions** 1. **Surfactant Metabolism**: SFTPB is involved in the regulation of surfactant lipid secretion by alveolar type II pneumocytes, ensuring proper surfactant function and stability. 2. **Endoplasmic Reticulum Membrane**: SFTPB is synthesized in the endoplasmic reticulum and secreted to the alveoli through the multivesicular body pathway. 3. **Lysosome and Multivesicular Body**: SFTPB is degraded by lysosomal enzymes, regulating surfactant lipid metabolism. 4. **Protein Binding**: SFTPB interacts with other surfactant-associated proteins and lipids to regulate surfactant function and stability. **Clinical Significance** Dysregulation of SFTPB has been implicated in various respiratory diseases, including: 1. **Respiratory Distress Syndrome (RDS)**: Defects in SFTPB have been associated with RDS, a condition characterized by impaired surfactant function and lung collapse. 2. **Surfactant Metabolic Disorders**: Defects in SFTPB have also been linked to surfactant metabolic disorders, such as Subacute Respiratory Distress Syndrome (SRDS) and Respiratory Distress Syndrome (RDS). 3. **Cystic Fibrosis**: SFTPB has been shown to interact with other cystic fibrosis-related proteins, suggesting a potential role in the pathogenesis of this disease. In summary, SFTPB plays a critical role in regulating surfactant metabolism and function in the lung, and its dysregulation has been implicated in various respiratory diseases. Further research is needed to elucidate the mechanisms of SFTPB dysfunction and develop effective therapeutic strategies for these diseases.

Genular Protein ID: 3621512970

Symbol: PSPB_HUMAN

Name: Pulmonary surfactant-associated protein B

UniProtKB Accession Codes:

P07988 Q96R04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 9 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3597440

Title: Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein.

PubMed ID: 3597440

DOI: 10.1016/s0021-9258(18)48005-2

PubMed ID: 2924687

Title: Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B.

PubMed ID: 2924687

DOI: 10.1089/dna.1.1989.8.75

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3035561

Title: cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe).

PubMed ID: 3035561

DOI: 10.1073/pnas.84.12.4007

PubMed ID: 3343343

Title: Use of human surfactant low molecular weight apoproteins in the reconstitution of surfactant biologic activity.

PubMed ID: 3343343

DOI: 10.1172/jci113391

PubMed ID: 1568474

Title: Human surfactant polypeptide SP-B. Disulfide bridges, C-terminal end, and peptide analysis of the airway form.

PubMed ID: 1568474

DOI: 10.1016/0014-5793(92)81239-i

PubMed ID: 10798379

Title: Conformational mapping of the N-terminal segment of surfactant protein B in lipid using 13C-enhanced Fourier transform infrared spectroscopy.

PubMed ID: 10798379

DOI: 10.1034/j.1399-3011.2000.00693.x

PubMed ID: 17845058

Title: Structure of mini-B, a functional fragment of surfactant protein B, in detergent micelles.

PubMed ID: 17845058

DOI: 10.1021/bi7011756

PubMed ID: 7491219

Title: Partial deficiency of surfactant protein B in an infant with chronic lung disease.

PubMed ID: 7491219

PubMed ID: 11076040

Title: Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP-B Thr131Ile with ARDS.

PubMed ID: 11076040

DOI: 10.1034/j.1399-0004.2000.580305.x

PubMed ID: 11063734

Title: Surfactant proteins A and B as interactive genetic determinants of neonatal respiratory distress syndrome.

PubMed ID: 11063734

DOI: 10.1093/hmg/9.18.2751

Sequence Information:

  • Length: 381
  • Mass: 42117
  • Checksum: 9FD7F66678A35153
  • Sequence:
    • MAESHLLQWL LLLLPTLCGP GTAAWTTSSL ACAQGPEFWC QSLEQALQCR ALGHCLQEVW 
GHVGADDLCQ ECEDIVHILN KMAKEAIFQD TMRKFLEQEC NVLPLKLLMP QCNQVLDDYF 
PLVIDYFQNQ TDSNGICMHL GLCKSRQPEP EQEPGMSDPL PKPLRDPLPD PLLDKLVLPV 
LPGALQARPG PHTQDLSEQQ FPIPLPYCWL CRALIKRIQA MIPKGALAVA VAQVCRVVPL 
VAGGICQCLA ERYSVILLDT LLGRMLPQLV CRLVLRCSMD DSAGPRSPTG EWLPRDSECH 
LCMSVTTQAG NSSEQAIPQA MLQACVGSWL DREKCKQFVE QHTPQLLTLV PRGWDAHTTC 
QALGVCGTMS SPLQCIHSPD L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.