Details for: SLC5A3

Gene ID: 6526

Symbol: SLC5A3

Ensembl ID: ENSG00000198743

Description: solute carrier family 5 member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.1571
    Cell Significance Index: -30.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 9.5412
    Cell Significance Index: 98.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.9734
    Cell Significance Index: -24.4900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.9855
    Cell Significance Index: 52.9700
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.3429
    Cell Significance Index: 12.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9931
    Cell Significance Index: 54.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9880
    Cell Significance Index: 1795.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.7943
    Cell Significance Index: 183.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4687
    Cell Significance Index: 159.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4605
    Cell Significance Index: 66.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3742
    Cell Significance Index: 36.1400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.2770
    Cell Significance Index: 22.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2613
    Cell Significance Index: 75.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1233
    Cell Significance Index: 613.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0372
    Cell Significance Index: 53.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8983
    Cell Significance Index: 180.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8636
    Cell Significance Index: 18.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7573
    Cell Significance Index: 52.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.7518
    Cell Significance Index: 37.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7214
    Cell Significance Index: 20.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6045
    Cell Significance Index: 216.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5664
    Cell Significance Index: 69.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5537
    Cell Significance Index: 99.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5016
    Cell Significance Index: 64.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4588
    Cell Significance Index: 336.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4148
    Cell Significance Index: 56.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3929
    Cell Significance Index: 24.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2816
    Cell Significance Index: 45.8000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.2544
    Cell Significance Index: 5.3100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2403
    Cell Significance Index: 4.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2396
    Cell Significance Index: 5.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2386
    Cell Significance Index: 13.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2334
    Cell Significance Index: 10.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1915
    Cell Significance Index: 84.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1695
    Cell Significance Index: 32.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1663
    Cell Significance Index: 16.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1606
    Cell Significance Index: 7.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1539
    Cell Significance Index: 18.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1535
    Cell Significance Index: 2.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1384
    Cell Significance Index: 10.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1176
    Cell Significance Index: 73.4500
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.0982
    Cell Significance Index: 0.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0942
    Cell Significance Index: 16.0800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.0875
    Cell Significance Index: 1.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0591
    Cell Significance Index: 2.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0517
    Cell Significance Index: 1.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0368
    Cell Significance Index: 56.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0303
    Cell Significance Index: 0.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0285
    Cell Significance Index: 52.6200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0187
    Cell Significance Index: 0.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0137
    Cell Significance Index: 0.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0088
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0136
    Cell Significance Index: -25.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0175
    Cell Significance Index: -13.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0180
    Cell Significance Index: -24.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0253
    Cell Significance Index: -14.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0269
    Cell Significance Index: -3.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0357
    Cell Significance Index: -1.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0385
    Cell Significance Index: -2.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0390
    Cell Significance Index: -24.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0409
    Cell Significance Index: -8.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0592
    Cell Significance Index: -4.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0594
    Cell Significance Index: -0.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0644
    Cell Significance Index: -29.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0849
    Cell Significance Index: -9.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0958
    Cell Significance Index: -11.1600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0983
    Cell Significance Index: -2.0000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1051
    Cell Significance Index: -0.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1141
    Cell Significance Index: -3.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1302
    Cell Significance Index: -2.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1363
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1395
    Cell Significance Index: -15.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1783
    Cell Significance Index: -4.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1785
    Cell Significance Index: -25.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1788
    Cell Significance Index: -11.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1880
    Cell Significance Index: -14.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2014
    Cell Significance Index: -15.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2065
    Cell Significance Index: -10.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2252
    Cell Significance Index: -5.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2779
    Cell Significance Index: -28.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2999
    Cell Significance Index: -6.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3186
    Cell Significance Index: -10.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3252
    Cell Significance Index: -19.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3454
    Cell Significance Index: -5.7800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4206
    Cell Significance Index: -7.2500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4384
    Cell Significance Index: -3.5000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4770
    Cell Significance Index: -6.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4895
    Cell Significance Index: -15.5900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.5268
    Cell Significance Index: -9.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5404
    Cell Significance Index: -18.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5729
    Cell Significance Index: -12.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5748
    Cell Significance Index: -16.9300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5778
    Cell Significance Index: -7.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6015
    Cell Significance Index: -22.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6130
    Cell Significance Index: -15.6600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6595
    Cell Significance Index: -13.0400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6606
    Cell Significance Index: -10.4800
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.6738
    Cell Significance Index: -7.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6934
    Cell Significance Index: -13.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: SLC5A3 is a transmembrane protein with 12 transmembrane domains, allowing it to transport sugars and other molecules across cell membranes. 2. **Function**: The primary function of SLC5A3 is to facilitate the transport of glucose and myo-inositol into cells, while also contributing to the transport of other sugars and molecules. 3. **Expression**: SLC5A3 is widely expressed in various tissues, including the kidney, trachea, and brain, with significant expression in epithelial cells of the kidney and trachea. 4. **Regulation**: The gene's expression is regulated by various factors, including transcription factors and post-translational modifications. **Pathways and Functions** 1. **Glucose Homeostasis**: SLC5A3 plays a critical role in maintaining glucose homeostasis by facilitating the transport of glucose into cells, particularly in the kidney and brain. 2. **Myo-inositol Metabolism**: The gene is involved in the transport of myo-inositol, a precursor to inositol phosphates, which are essential for various cellular processes, including signaling pathways and neurotransmission. 3. **Electrolyte Balance**: SLC5A3 contributes to the transport of sodium ions across cell membranes, helping to maintain electrolyte balance and regulate fluid balance. 4. **Cellular Signaling**: The gene's involvement in the transport of sugars and other molecules contributes to cellular signaling pathways, including those involved in glucose metabolism and myo-inositol signaling. **Clinical Significance** 1. **Diabetes**: Alterations in SLC5A3 expression have been linked to diabetes, highlighting the gene's importance in glucose homeostasis. 2. **Neurological Disorders**: The gene's role in myo-inositol metabolism and glucose homeostasis makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Kidney Disease**: SLC5A3 dysfunction has been implicated in kidney disease, particularly in the development of diabetic nephropathy. 4. **Cancer**: The gene's expression in various cancer types, including glioblastoma and colon cancer, suggests its potential role in cancer progression and metastasis. In conclusion, the SLC5A3 gene plays a critical role in maintaining glucose homeostasis, myo-inositol metabolism, and electrolyte balance, and its dysfunction has been implicated in various diseases, including diabetes, neurological disorders, kidney disease, and cancer. Further research is needed to fully elucidate the gene's mechanisms and potential therapeutic applications.

Genular Protein ID: 719743606

Symbol: SC5A3_HUMAN

Name: Sodium/myo-inositol transporter 1

UniProtKB Accession Codes:

P53794 O43489

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 DMDM 1 DNASU 1 DrugBank 1 EMBL 3 Ensembl 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7789985

Title: The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21.

PubMed ID: 7789985

DOI: 10.1016/0888-7543(95)80052-n

PubMed ID: 9441750

Title: The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter.

PubMed ID: 9441750

DOI: 10.1006/geno.1997.5055

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 21679696

Title: H+/myo-inositol transporter genes, hmit-1.1 and hmit-1.2, have roles in the osmoprotective response in Caenorhabditis elegans.

PubMed ID: 21679696

DOI: 10.1016/j.bbrc.2011.06.001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24595108

Title: KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.

PubMed ID: 24595108

DOI: 10.1126/scisignal.2005025

PubMed ID: 27217553

Title: Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels.

PubMed ID: 27217553

DOI: 10.1073/pnas.1606348113

PubMed ID: 28793216

Title: SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore.

PubMed ID: 28793216

DOI: 10.1016/j.bpj.2017.06.055

Sequence Information:

  • Length: 718
  • Mass: 79664
  • Checksum: E83EFF81DBF567BB
  • Sequence:
    • MRAVLDTADI AIVALYFILV MCIGFFAMWK SNRSTVSGYF LAGRSMTWVA IGASLFVSNI 
GSEHFIGLAG SGAASGFAVG AWEFNALLLL QLLGWVFIPI YIRSGVYTMP EYLSKRFGGH 
RIQVYFAALS LILYIFTKLS VDLYSGALFI QESLGWNLYV SVILLIGMTA LLTVTGGLVA 
VIYTDTLQAL LMIIGALTLM IISIMEIGGF EEVKRRYMLA SPDVTSILLT YNLSNTNSCN 
VSPKKEALKM LRNPTDEDVP WPGFILGQTP ASVWYWCADQ VIVQRVLAAK NIAHAKGSTL 
MAGFLKLLPM FIIVVPGMIS RILFTDDIAC INPEHCMLVC GSRAGCSNIA YPRLVMKLVP 
VGLRGLMMAV MIAALMSDLD SIFNSASTIF TLDVYKLIRK SASSRELMIV GRIFVAFMVV 
ISIAWVPIIV EMQGGQMYLY IQEVADYLTP PVAALFLLAI FWKRCNEQGA FYGGMAGFVL 
GAVRLILAFA YRAPECDQPD NRPGFIKDIH YMYVATGLFW VTGLITVIVS LLTPPPTKEQ 
IRTTTFWSKK NLVVKENCSP KEEPYKMQEK SILRCSENNE TINHIIPNGK SEDSIKGLQP 
EDVNLLVTCR EEGNPVASLG HSEAETPVDA YSNGQAALMG EKERKKETDD GGRYWKFIDW 
FCGFKSKSLS KRSLRDLMEE EAVCLQMLEE TRQVKVILNI GLFAVCSLGI FMFVYFSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.