Details for: SLC22A1

Gene ID: 6580

Symbol: SLC22A1

Ensembl ID: ENSG00000175003

Description: solute carrier family 22 member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 9.6969
    Cell Significance Index: 25.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.3716
    Cell Significance Index: 39.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9306
    Cell Significance Index: 24.9400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7791
    Cell Significance Index: 11.0900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7270
    Cell Significance Index: 10.7300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.5192
    Cell Significance Index: 2.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3549
    Cell Significance Index: 7.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2893
    Cell Significance Index: 58.0300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.2352
    Cell Significance Index: 2.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1846
    Cell Significance Index: 3.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1601
    Cell Significance Index: 30.4800
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.1474
    Cell Significance Index: 1.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1388
    Cell Significance Index: 6.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1352
    Cell Significance Index: 5.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1341
    Cell Significance Index: 19.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1246
    Cell Significance Index: 24.7300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1244
    Cell Significance Index: 3.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1199
    Cell Significance Index: 11.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1151
    Cell Significance Index: 1.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1139
    Cell Significance Index: 2.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1106
    Cell Significance Index: 7.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0987
    Cell Significance Index: 3.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0942
    Cell Significance Index: 85.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0675
    Cell Significance Index: 8.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0657
    Cell Significance Index: 23.5500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0611
    Cell Significance Index: 0.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0575
    Cell Significance Index: 9.3500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0435
    Cell Significance Index: 0.5800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0417
    Cell Significance Index: 0.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0393
    Cell Significance Index: 4.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0302
    Cell Significance Index: 1.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0297
    Cell Significance Index: 0.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0284
    Cell Significance Index: 0.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0194
    Cell Significance Index: 0.5600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0190
    Cell Significance Index: 0.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0170
    Cell Significance Index: 31.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0166
    Cell Significance Index: 10.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0154
    Cell Significance Index: 2.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0145
    Cell Significance Index: 0.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0110
    Cell Significance Index: 20.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0108
    Cell Significance Index: 0.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0103
    Cell Significance Index: 0.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0092
    Cell Significance Index: 14.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0081
    Cell Significance Index: 0.6300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0075
    Cell Significance Index: 0.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0052
    Cell Significance Index: 0.1300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0050
    Cell Significance Index: 0.0800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0046
    Cell Significance Index: 0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0034
    Cell Significance Index: 4.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0019
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0025
    Cell Significance Index: -1.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0027
    Cell Significance Index: -0.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0031
    Cell Significance Index: -1.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0035
    Cell Significance Index: -2.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0041
    Cell Significance Index: -2.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0043
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0046
    Cell Significance Index: -2.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0047
    Cell Significance Index: -2.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0073
    Cell Significance Index: -0.3700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0077
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0089
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0122
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0122
    Cell Significance Index: -2.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0123
    Cell Significance Index: -1.4300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0126
    Cell Significance Index: -0.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0127
    Cell Significance Index: -0.7100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0130
    Cell Significance Index: -0.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0132
    Cell Significance Index: -0.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0136
    Cell Significance Index: -1.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0160
    Cell Significance Index: -0.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0166
    Cell Significance Index: -0.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0189
    Cell Significance Index: -0.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0206
    Cell Significance Index: -1.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0218
    Cell Significance Index: -0.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0218
    Cell Significance Index: -2.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0219
    Cell Significance Index: -0.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0247
    Cell Significance Index: -2.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0258
    Cell Significance Index: -0.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0261
    Cell Significance Index: -0.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0262
    Cell Significance Index: -1.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0273
    Cell Significance Index: -2.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0339
    Cell Significance Index: -1.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0367
    Cell Significance Index: -1.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0369
    Cell Significance Index: -2.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0379
    Cell Significance Index: -2.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0386
    Cell Significance Index: -2.8800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0401
    Cell Significance Index: -0.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0414
    Cell Significance Index: -2.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0424
    Cell Significance Index: -3.3600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0461
    Cell Significance Index: -0.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0472
    Cell Significance Index: -2.4800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0488
    Cell Significance Index: -0.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0499
    Cell Significance Index: -2.1700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0515
    Cell Significance Index: -0.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0541
    Cell Significance Index: -3.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0569
    Cell Significance Index: -1.4200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0575
    Cell Significance Index: -0.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0592
    Cell Significance Index: -1.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0600
    Cell Significance Index: -1.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transmembrane Transporter**: The SLC22A1 protein is a transmembrane transporter, meaning it spans the cell membrane and plays a crucial role in the movement of molecules across the membrane. 2. **Organic Cation Transporter**: The SLC22A1 protein is specifically involved in the transport of organic cations, which include a wide range of molecules, such as neurotransmitters, amino acids, and xenobiotics. 3. **Widespread Expression**: The SLC22A1 gene is widely expressed in various tissues, including the retina, liver, and immune cells. 4. **Diverse Ligands**: The SLC22A1 protein can transport a diverse range of ligands, including neurotransmitters, amino acids, and xenobiotics. **Pathways and Functions** 1. **Neurotransmitter Clearance**: The SLC22A1 protein plays a crucial role in the clearance of neurotransmitters, such as dopamine, serotonin, and norepinephrine, from the synaptic cleft. 2. **Neurotransmitter Release**: The SLC22A1 protein is involved in the release of neurotransmitters from presynaptic neurons. 3. **Establishment of Transmembrane Electrochemical Gradient**: The SLC22A1 protein helps to establish and maintain transmembrane electrochemical gradients, which are essential for various cellular processes. 4. **Xenobiotic Transport**: The SLC22A1 protein plays a role in the transport of xenobiotics, such as drugs and toxins, across cellular membranes. 5. **Amino Acid Transport**: The SLC22A1 protein is involved in the transport of amino acids, such as glycine and taurine, across cellular membranes. **Clinical Significance** 1. **Neurological Disorders**: The SLC22A1 protein has been implicated in various neurological disorders, including Parkinson's disease, depression, and anxiety disorders. 2. **Cancer Metabolism**: The SLC22A1 protein has been shown to play a role in cancer metabolism, with implications for cancer therapy. 3. **Toxicity and Drug Resistance**: The SLC22A1 protein has been implicated in the development of drug resistance and toxicity, particularly in the context of cancer treatment. 4. **Liver Disease**: The SLC22A1 protein has been shown to play a role in liver disease, including hepatitis and cirrhosis. 5. **Immune System**: The SLC22A1 protein has been implicated in the immune system, with implications for the development of immunotherapies. In conclusion, the SLC22A1 gene encodes for a transmembrane transporter that plays a crucial role in various cellular processes, including neurotransmitter clearance, neurotransmitter release, and the establishment of transmembrane electrochemical gradients. The SLC22A1 protein has significant clinical implications, particularly in the context of neurological disorders, cancer metabolism, and liver disease. Further research is needed to fully elucidate the role of the SLC22A1 protein in human health and disease.

Genular Protein ID: 2536359766

Symbol: S22A1_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15245 A6NFF3 A8K1H2 C9JSU6 O15395 Q9NQD4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 92 DrugCentral 1 EMBL 14 EMDB 16 Ensembl 4 ExpressionAtlas 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 16 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 6 RefSeq 3 Rhea 15 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9260930

Title: Cloning and characterization of two human polyspecific organic cation transporters.

PubMed ID: 9260930

DOI: 10.1089/dna.1997.16.871

PubMed ID: 9187257

Title: Cloning and functional expression of a human liver organic cation transporter.

PubMed ID: 9187257

DOI: 10.1124/mol.51.6.913

PubMed ID: 11388889

Title: Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1).

PubMed ID: 11388889

DOI: 10.1017/s0003480099007770

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9655880

Title: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).

PubMed ID: 9655880

PubMed ID: 11408531

Title: Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides.

PubMed ID: 11408531

PubMed ID: 11907186

Title: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.

PubMed ID: 11907186

DOI: 10.1124/jpet.301.1.293

PubMed ID: 15389554

Title: Regulation of the human organic cation transporter hOCT1.

PubMed ID: 15389554

DOI: 10.1002/jcp.20081

PubMed ID: 15817714

Title: Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium.

PubMed ID: 15817714

DOI: 10.1165/rcmb.2004-0363oc

PubMed ID: 16263091

Title: Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).

PubMed ID: 16263091

DOI: 10.1016/j.bcp.2005.09.011

PubMed ID: 16272756

Title: Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.

PubMed ID: 16272756

DOI: 10.2133/dmpk.20.379

PubMed ID: 16951202

Title: Organic cation transporters are determinants of oxaliplatin cytotoxicity.

PubMed ID: 16951202

DOI: 10.1158/0008-5472.can-06-0769

PubMed ID: 16436500

Title: The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha.

PubMed ID: 16436500

DOI: 10.1124/jpet.105.099929

PubMed ID: 16914559

Title: Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family).

PubMed ID: 16914559

DOI: 10.1124/jpet.106.110346

PubMed ID: 16581093

Title: Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain.

PubMed ID: 16581093

DOI: 10.1016/j.neuropharm.2006.01.005

PubMed ID: 17635184

Title: The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells.

PubMed ID: 17635184

DOI: 10.1111/j.1472-8206.2007.00517.x

PubMed ID: 17460754

Title: Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons.

PubMed ID: 17460754

DOI: 10.1371/journal.pone.0000385

PubMed ID: 19536068

Title: The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

PubMed ID: 19536068

DOI: 10.1038/clpt.2009.92

PubMed ID: 21128598

Title: OCT2 and MATE1 provide bidirectional agmatine transport.

PubMed ID: 21128598

DOI: 10.1021/mp100180a

PubMed ID: 23680637

Title: Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes.

PubMed ID: 23680637

DOI: 10.1124/mol.112.084517

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24961373

Title: OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

PubMed ID: 24961373

DOI: 10.1073/pnas.1314939111

PubMed ID: 26979622

Title: A phosphotyrosine switch regulates organic cation transporters.

PubMed ID: 26979622

DOI: 10.1038/ncomms10880

PubMed ID: 34040533

Title: Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport.

PubMed ID: 34040533

DOI: 10.3389/fphar.2021.674559

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

PubMed ID: 35469921

Title: Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1.

PubMed ID: 35469921

DOI: 10.1016/j.jbc.2022.101974

PubMed ID: 12439218

Title: Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences.

PubMed ID: 12439218

DOI: 10.1097/00008571-200211000-00002

PubMed ID: 12719534

Title: Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1.

PubMed ID: 12719534

DOI: 10.1073/pnas.0730858100

PubMed ID: 14697261

Title: Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions.

PubMed ID: 14697261

DOI: 10.1016/j.bbrc.2003.11.175

PubMed ID: 15499200

Title: Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1).

PubMed ID: 15499200

DOI: 10.2133/dmpk.19.308

PubMed ID: 28942964

Title: Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport.

PubMed ID: 28942964

DOI: 10.1016/j.ajhg.2017.08.008

Sequence Information:

  • Length: 554
  • Mass: 61154
  • Checksum: 55206B897DE32202
  • Sequence:
    • MPTVDDILEQ VGESGWFQKQ AFLILCLLSA AFAPICVGIV FLGFTPDHHC QSPGVAELSQ 
RCGWSPAEEL NYTVPGLGPA GEAFLGQCRR YEVDWNQSAL SCVDPLASLA TNRSHLPLGP 
CQDGWVYDTP GSSIVTEFNL VCADSWKLDL FQSCLNAGFL FGSLGVGYFA DRFGRKLCLL 
GTVLVNAVSG VLMAFSPNYM SMLLFRLLQG LVSKGNWMAG YTLITEFVGS GSRRTVAIMY 
QMAFTVGLVA LTGLAYALPH WRWLQLAVSL PTFLFLLYYW CVPESPRWLL SQKRNTEAIK 
IMDHIAQKNG KLPPADLKML SLEEDVTEKL SPSFADLFRT PRLRKRTFIL MYLWFTDSVL 
YQGLILHMGA TSGNLYLDFL YSALVEIPGA FIALITIDRV GRIYPMAMSN LLAGAACLVM 
IFISPDLHWL NIIIMCVGRM GITIAIQMIC LVNAELYPTF VRNLGVMVCS SLCDIGGIIT 
PFIVFRLREV WQALPLILFA VLGLLAAGVT LLLPETKGVA LPETMKDAEN LGRKAKPKEN 
TIYLKVQTSE PSGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.