Details for: SRC

Gene ID: 6714

Symbol: SRC

Ensembl ID: ENSG00000197122

Description: SRC proto-oncogene, non-receptor tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 118.6793
    Cell Significance Index: -18.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 72.7202
    Cell Significance Index: -18.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 36.2763
    Cell Significance Index: -18.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.3500
    Cell Significance Index: -15.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.9803
    Cell Significance Index: -18.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.1374
    Cell Significance Index: -19.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7351
    Cell Significance Index: -18.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.8526
    Cell Significance Index: 38.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6870
    Cell Significance Index: 139.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.4079
    Cell Significance Index: -5.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2619
    Cell Significance Index: 250.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1750
    Cell Significance Index: 33.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1004
    Cell Significance Index: 23.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0764
    Cell Significance Index: 117.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0219
    Cell Significance Index: 61.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9979
    Cell Significance Index: 45.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7354
    Cell Significance Index: 132.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7344
    Cell Significance Index: 19.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6713
    Cell Significance Index: 134.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6308
    Cell Significance Index: 17.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6240
    Cell Significance Index: 9.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6197
    Cell Significance Index: 42.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5718
    Cell Significance Index: 70.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5549
    Cell Significance Index: 5.1100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.4701
    Cell Significance Index: 3.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2824
    Cell Significance Index: 7.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2818
    Cell Significance Index: 6.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2698
    Cell Significance Index: 186.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2687
    Cell Significance Index: 96.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2362
    Cell Significance Index: 5.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1771
    Cell Significance Index: 17.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1770
    Cell Significance Index: 2.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1768
    Cell Significance Index: 8.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1742
    Cell Significance Index: 33.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1737
    Cell Significance Index: 6.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1311
    Cell Significance Index: 18.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0769
    Cell Significance Index: 42.0100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0762
    Cell Significance Index: 1.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0574
    Cell Significance Index: 25.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0530
    Cell Significance Index: 9.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0445
    Cell Significance Index: 40.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0266
    Cell Significance Index: 1.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0246
    Cell Significance Index: 3.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0202
    Cell Significance Index: 1.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0202
    Cell Significance Index: 38.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0121
    Cell Significance Index: 0.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0078
    Cell Significance Index: 12.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0065
    Cell Significance Index: 11.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0011
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0052
    Cell Significance Index: -2.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0081
    Cell Significance Index: -5.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0162
    Cell Significance Index: -11.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0178
    Cell Significance Index: -13.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0210
    Cell Significance Index: -15.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0211
    Cell Significance Index: -3.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0312
    Cell Significance Index: -17.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0366
    Cell Significance Index: -22.8800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0378
    Cell Significance Index: -1.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0465
    Cell Significance Index: -1.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0496
    Cell Significance Index: -5.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0521
    Cell Significance Index: -15.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0554
    Cell Significance Index: -1.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0768
    Cell Significance Index: -0.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0787
    Cell Significance Index: -8.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0789
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0910
    Cell Significance Index: -10.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0992
    Cell Significance Index: -12.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1013
    Cell Significance Index: -7.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1018
    Cell Significance Index: -7.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1024
    Cell Significance Index: -21.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1312
    Cell Significance Index: -6.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1397
    Cell Significance Index: -16.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1461
    Cell Significance Index: -15.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1493
    Cell Significance Index: -4.2800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1546
    Cell Significance Index: -1.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1899
    Cell Significance Index: -2.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1920
    Cell Significance Index: -10.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1935
    Cell Significance Index: -14.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1971
    Cell Significance Index: -12.7200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2031
    Cell Significance Index: -3.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2054
    Cell Significance Index: -9.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2076
    Cell Significance Index: -16.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2080
    Cell Significance Index: -9.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2294
    Cell Significance Index: -4.2400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2675
    Cell Significance Index: -4.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2783
    Cell Significance Index: -17.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2853
    Cell Significance Index: -4.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2907
    Cell Significance Index: -10.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2980
    Cell Significance Index: -9.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3060
    Cell Significance Index: -10.0200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3086
    Cell Significance Index: -12.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3129
    Cell Significance Index: -6.5500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3339
    Cell Significance Index: -8.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3443
    Cell Significance Index: -12.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3828
    Cell Significance Index: -8.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3939
    Cell Significance Index: -8.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3945
    Cell Significance Index: -10.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3987
    Cell Significance Index: -14.6400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4063
    Cell Significance Index: -8.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Proto-oncogene**: The SRC gene is classified as a proto-oncogene, which means it has the potential to become an oncogene when mutated or overexpressed. 2. **Non-receptor tyrosine kinase**: SRC is a non-receptor tyrosine kinase, meaning it catalyzes the phosphorylation of tyrosine residues on target proteins without the need for ligand binding. 3. **Diverse signaling pathways**: SRC is involved in numerous signaling pathways, including the Ras/Raf/MAPK pathway, PI3K/AKT pathway, and MAPK/ERK pathway, among others. 4. **Cellular localization**: SRC is primarily localized to the cytoplasm and membrane, where it interacts with various signaling partners and substrates. **Pathways and Functions:** 1. **Ras/Raf/MAPK pathway**: SRC is a key component of the Ras/Raf/MAPK signaling pathway, which regulates cell growth, differentiation, and survival. 2. **PI3K/AKT pathway**: SRC also interacts with the PI3K/AKT pathway, influencing cell survival, proliferation, and metabolism. 3. **MAPK/ERK pathway**: SRC is involved in the MAPK/ERK pathway, which regulates cell growth, differentiation, and migration. 4. **Adhesion and migration**: SRC plays a crucial role in cell adhesion and migration, influencing the behavior of cells in different tissues and organs. 5. **Immune system**: SRC is significantly expressed in immune cells, where it regulates the function of T cells, B cells, and dendritic cells. 6. **Cancer**: SRC is often overexpressed or mutated in various types of cancer, including breast, lung, and colon cancer, promoting tumor growth and metastasis. **Clinical Significance:** 1. **Cancer therapy**: SRC inhibitors have been developed as potential cancer therapies, targeting the SRC kinase activity and its downstream signaling pathways. 2. **Inflammatory diseases**: SRC has been implicated in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis and atherosclerosis, where it regulates the function of immune cells and endothelial cells. 3. **Neurological disorders**: SRC has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it regulates the function of neurons and glial cells. 4. **Cardiovascular disease**: SRC has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac arrhythmias, where it regulates the function of endothelial cells and smooth muscle cells. In conclusion, the SRC proto-oncogene is a complex player in cellular signaling, influencing various physiological and pathological processes. Its involvement in multiple signaling pathways and its significant expression in different cell types make it an attractive target for cancer therapy and other diseases.

Genular Protein ID: 2327385454

Symbol: SRC_HUMAN

Name: Proto-oncogene c-Src

UniProtKB Accession Codes:

P12931 E1P5V4 Q76P87 Q86VB9 Q9H5A8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 3 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 48 DrugCentral 1 EC 4 ELM 1 EMBL 25 Ensembl 12 EvolutionaryTrace 1 GO 100 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 73 PDBsum 73 PIR 1 PRINTS 3 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 68 RefSeq 7 Rhea 12 SASBDB 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3299057

Title: DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes.

PubMed ID: 3299057

DOI: 10.1128/mcb.7.5.1978-1983.1987

PubMed ID: 2582238

Title: Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-src.

PubMed ID: 2582238

DOI: 10.1128/mcb.5.5.1122-1129.1985

PubMed ID: 2681803

Title: Neuron-specific splicing of C-SRC RNA in human brain.

PubMed ID: 2681803

DOI: 10.1002/jnr.490240113

PubMed ID: 2581127

Title: Isolation of duplicated human c-src genes located on chromosomes 1 and 20.

PubMed ID: 2581127

DOI: 10.1128/mcb.5.4.831-838.1985

PubMed ID: 6273838

Title: Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).

PubMed ID: 6273838

DOI: 10.1073/pnas.78.10.6013

PubMed ID: 3093483

Title: Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.

PubMed ID: 3093483

DOI: 10.1016/s0021-9258(18)67084-x

PubMed ID: 2498394

Title: pp60c-src activation in human colon carcinoma.

PubMed ID: 2498394

DOI: 10.1172/jci114113

PubMed ID: 1691439

Title: Identification of a novel neuronal C-SRC exon expressed in human brain.

PubMed ID: 1691439

DOI: 10.1128/mcb.10.5.2035-2040.1990

PubMed ID: 8319227

Title: Expression of alternatively spliced src messenger RNAs related to neuronal differentiation in human neuroblastomas.

PubMed ID: 8319227

PubMed ID: 7525268

Title: Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.

PubMed ID: 7525268

DOI: 10.1002/j.1460-2075.1994.tb06800.x

PubMed ID: 7929427

Title: Cdc2-mediated modulation of pp60c-src activity.

PubMed ID: 7929427

DOI: 10.1016/s0021-9258(18)47102-5

PubMed ID: 7853507

Title: Highly specific antibody to Rous sarcoma virus src gene product recognizes nuclear and nucleolar antigens in human cells.

PubMed ID: 7853507

DOI: 10.1128/jvi.69.3.1699-1713.1995

PubMed ID: 7478590

Title: Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas.

PubMed ID: 7478590

PubMed ID: 8759729

Title: Physical and functional association of Fc mu receptor on human natural killer cells with the zeta- and Fc epsilon RI gamma-chains and with src family protein tyrosine kinases.

PubMed ID: 8759729

PubMed ID: 8755529

Title: Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.

PubMed ID: 8755529

DOI: 10.1073/pnas.93.15.7644

PubMed ID: 9571170

Title: Butein, a specific protein tyrosine kinase inhibitor.

PubMed ID: 9571170

DOI: 10.1006/bbrc.1998.8452

PubMed ID: 9584165

Title: RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells.

PubMed ID: 9584165

DOI: 10.1128/mcb.18.6.3245

PubMed ID: 9924018

Title: Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

PubMed ID: 9924018

DOI: 10.1126/science.283.5402.655

PubMed ID: 10753943

Title: beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.

PubMed ID: 10753943

DOI: 10.1074/jbc.275.15.11312

PubMed ID: 10747847

Title: Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.

PubMed ID: 10747847

DOI: 10.1074/jbc.c000085200

PubMed ID: 11389730

Title: Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm.

PubMed ID: 11389730

DOI: 10.1046/j.1432-1327.2001.02230.x

PubMed ID: 11152665

Title: The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin.

PubMed ID: 11152665

DOI: 10.1074/jbc.c000754200

PubMed ID: 11279199

Title: The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1.

PubMed ID: 11279199

DOI: 10.1074/jbc.m101375200

PubMed ID: 11518702

Title: The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.

PubMed ID: 11518702

DOI: 10.1074/jbc.m101546200

PubMed ID: 12091389

Title: Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.

PubMed ID: 12091389

DOI: 10.1074/jbc.m204367200

PubMed ID: 12415108

Title: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.

PubMed ID: 12415108

DOI: 10.1073/pnas.192569699

PubMed ID: 19666546

Title:

PubMed ID: 19666546

DOI: 10.1073/pnas.0908685106

PubMed ID: 12615910

Title: Regulation of cytochrome c oxidase activity by c-Src in osteoclasts.

PubMed ID: 12615910

DOI: 10.1083/jcb.200209098

PubMed ID: 12925710

Title: EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.

PubMed ID: 12925710

DOI: 10.1083/jcb.200302073

PubMed ID: 14632929

Title: Development and characterization of potent and specific peptide inhibitors of p60c-src protein tyrosine kinase using pseudosubstrate-based inhibitor design approach.

PubMed ID: 14632929

DOI: 10.1046/j.1399-3011.2003.00094.x

PubMed ID: 14585963

Title: Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions.

PubMed ID: 14585963

DOI: 10.1128/mcb.23.22.8019-8029.2003

PubMed ID: 15504032

Title: Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).

PubMed ID: 15504032

DOI: 10.1021/bi049295+

PubMed ID: 14963108

Title: Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc.

PubMed ID: 14963108

DOI: 10.1210/me.2003-0335

PubMed ID: 14661060

Title: Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.

PubMed ID: 14661060

DOI: 10.1038/sj.onc.1207298

PubMed ID: 15851033

Title: The C2 domain of PKCdelta is a phosphotyrosine binding domain.

PubMed ID: 15851033

DOI: 10.1016/j.cell.2005.02.019

PubMed ID: 16186108

Title: Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation.

PubMed ID: 16186108

DOI: 10.1074/jbc.m506921200

PubMed ID: 16619028

Title: Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression.

PubMed ID: 16619028

DOI: 10.1038/sj.emboj.7601085

PubMed ID: 16479011

Title: The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors.

PubMed ID: 16479011

DOI: 10.1128/mcb.26.5.1932-1947.2006

PubMed ID: 17202804

Title: Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5.

PubMed ID: 17202804

DOI: 10.1159/000098402

PubMed ID: 17293535

Title: Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation.

PubMed ID: 17293535

DOI: 10.1242/dev.02782

PubMed ID: 17525734

Title: p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.

PubMed ID: 17525734

DOI: 10.1038/sj.emboj.7601724

PubMed ID: 18586953

Title: EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src.

PubMed ID: 18586953

DOI: 10.1152/ajplung.90282.2008

PubMed ID: 18024423

Title: Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.

PubMed ID: 18024423

DOI: 10.1074/jbc.m706361200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18657504

Title: Regulation of estrogen rapid signaling through arginine methylation by PRMT1.

PubMed ID: 18657504

DOI: 10.1016/j.molcel.2008.05.025

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19665017

Title: The PDZ protein MPP2 interacts with c-Src in epithelial cells.

PubMed ID: 19665017

DOI: 10.1016/j.yexcr.2009.07.028

PubMed ID: 19419966

Title: The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.

PubMed ID: 19419966

DOI: 10.1074/jbc.m808233200

PubMed ID: 19307596

Title: Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle.

PubMed ID: 19307596

DOI: 10.1083/jcb.200810155

PubMed ID: 18936167

Title: New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.

PubMed ID: 18936167

DOI: 10.1128/mcb.01374-08

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21036157

Title: Heme controls the regulation of protein tyrosine kinases Jak2 and Src.

PubMed ID: 21036157

DOI: 10.1016/j.bbrc.2010.10.101

PubMed ID: 20100835

Title: Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.

PubMed ID: 20100835

DOI: 10.1074/jbc.m109.071381

PubMed ID: 20525694

Title: The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.

PubMed ID: 20525694

DOI: 10.1074/jbc.m109.091157

PubMed ID: 20534535

Title: Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.

PubMed ID: 20534535

DOI: 10.1073/pnas.0911714107

PubMed ID: 21309750

Title: The Cdc42-associated kinase ACK1 is not auto-inhibited but requires Src for activation.

PubMed ID: 21309750

DOI: 10.1042/bj20102156

PubMed ID: 21442427

Title: Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75).

PubMed ID: 21442427

DOI: 10.1007/s00018-011-0638-1

PubMed ID: 21460222

Title: PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis.

PubMed ID: 21460222

DOI: 10.1074/jbc.m110.175117

PubMed ID: 21411625

Title: A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src.

PubMed ID: 21411625

DOI: 10.1091/mbc.e10-09-0785

PubMed ID: 22801373

Title: Protein tyrosine phosphatase alpha phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.

PubMed ID: 22801373

DOI: 10.1128/mcb.00214-12

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22710723

Title: Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.

PubMed ID: 22710723

DOI: 10.1038/onc.2012.220

PubMed ID: 23564345

Title: Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.

PubMed ID: 23564345

DOI: 10.1073/pnas.1220659110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25501895

Title: c-Src mediated tyrosine phosphorylation of plakophilin 3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress.

PubMed ID: 25501895

DOI: 10.1007/s00441-014-2063-x

PubMed ID: 25731159

Title: A gp130-Src-YAP module links inflammation to epithelial regeneration.

PubMed ID: 25731159

DOI: 10.1038/nature14228

PubMed ID: 26936507

Title: A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.

PubMed ID: 26936507

DOI: 10.1126/scitranslmed.aad7666

PubMed ID: 28903391

Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.

PubMed ID: 28903391

DOI: 10.18632/oncotarget.18973

PubMed ID: 8672527

Title: Regulation, substrates and functions of src.

PubMed ID: 8672527

DOI: 10.1016/0304-419x(96)00003-0

PubMed ID: 9442882

Title: Cellular functions regulated by Src family kinases.

PubMed ID: 9442882

DOI: 10.1146/annurev.cellbio.13.1.513

PubMed ID: 11964124

Title: Novel regulation and function of Src tyrosine kinase.

PubMed ID: 11964124

DOI: 10.1007/s00018-002-8438-2

PubMed ID: 30862675

Title: Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication.

PubMed ID: 30862675

DOI: 10.1074/jbc.ra119.007656

PubMed ID: 31320558

Title: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.

PubMed ID: 31320558

DOI: 10.1126/science.aav0758

PubMed ID: 35927303

Title: Phosphorylation of OTUB1 at Tyr 26 stabilizes the mTORC1 component, Raptor.

PubMed ID: 35927303

DOI: 10.1038/s41418-022-01047-3

PubMed ID: 9024657

Title: Three-dimensional structure of the tyrosine kinase c-Src.

PubMed ID: 9024657

DOI: 10.1038/385595a0

PubMed ID: 9174343

Title: Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.

PubMed ID: 9174343

DOI: 10.1021/bi970019n

PubMed ID: 7532003

Title: Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.

PubMed ID: 7532003

DOI: 10.1021/bi00007a003

PubMed ID: 22888118

Title: Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.

PubMed ID: 22888118

DOI: 10.1093/jb/mvs085

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 536
  • Mass: 59835
  • Checksum: C1908084683E5DE8
  • Sequence:
    • MGSNKSKPKD ASQRRRSLEP AENVHGAGGG AFPASQTPSK PASADGHRGP SAAFAPAAAE 
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTEGD 
WWLAHSLSTG QTGYIPSNYV APSDSIQAEE WYFGKITRRE SERLLLNAEN PRGTFLVRES 
ETTKGAYCLS VSDFDNAKGL NVKHYKIRKL DSGGFYITSR TQFNSLQQLV AYYSKHADGL 
CHRLTTVCPT SKPQTQGLAK DAWEIPRESL RLEVKLGQGC FGEVWMGTWN GTTRVAIKTL 
KPGTMSPEAF LQEAQVMKKL RHEKLVQLYA VVSEEPIYIV TEYMSKGSLL DFLKGETGKY 
LRLPQLVDMA AQIASGMAYV ERMNYVHRDL RAANILVGEN LVCKVADFGL ARLIEDNEYT 
ARQGAKFPIK WTAPEAALYG RFTIKSDVWS FGILLTELTT KGRVPYPGMV NREVLDQVER 
GYRMPCPPEC PESLHDLMCQ CWRKEPEERP TFEYLQAFLE DYFTSTEPQY QPGENL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.