Details for: ST14

Gene ID: 6768

Symbol: ST14

Ensembl ID: ENSG00000149418

Description: ST14 transmembrane serine protease matriptase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 98.4923
    Cell Significance Index: -15.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.4392
    Cell Significance Index: -15.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 22.7414
    Cell Significance Index: -15.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.4173
    Cell Significance Index: -15.3100
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 9.9565
    Cell Significance Index: 75.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 7.1803
    Cell Significance Index: 107.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7879
    Cell Significance Index: -15.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 5.3716
    Cell Significance Index: 154.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 4.8541
    Cell Significance Index: 220.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.8560
    Cell Significance Index: 200.3100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.1394
    Cell Significance Index: 31.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.3641
    Cell Significance Index: 257.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2749
    Cell Significance Index: 61.9200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.8673
    Cell Significance Index: 7.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.8043
    Cell Significance Index: 41.6900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.8005
    Cell Significance Index: 25.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6723
    Cell Significance Index: 15.4000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.5480
    Cell Significance Index: 3.4900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.4688
    Cell Significance Index: 9.0900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.4090
    Cell Significance Index: 15.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3444
    Cell Significance Index: 37.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.2402
    Cell Significance Index: 43.5800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.2309
    Cell Significance Index: 7.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1340
    Cell Significance Index: 619.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0491
    Cell Significance Index: 947.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0419
    Cell Significance Index: 187.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0067
    Cell Significance Index: 21.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9143
    Cell Significance Index: 42.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7929
    Cell Significance Index: 102.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7648
    Cell Significance Index: 94.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7094
    Cell Significance Index: 52.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6413
    Cell Significance Index: 20.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.6397
    Cell Significance Index: -1.4000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.5833
    Cell Significance Index: 6.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5632
    Cell Significance Index: 26.4700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.5458
    Cell Significance Index: 5.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5262
    Cell Significance Index: 100.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5245
    Cell Significance Index: 51.8800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.5141
    Cell Significance Index: 5.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4304
    Cell Significance Index: 190.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2951
    Cell Significance Index: 20.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2846
    Cell Significance Index: 7.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2560
    Cell Significance Index: 2.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2299
    Cell Significance Index: 27.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1892
    Cell Significance Index: 30.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1835
    Cell Significance Index: 31.3400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.1819
    Cell Significance Index: 0.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1445
    Cell Significance Index: 10.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0508
    Cell Significance Index: 10.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0138
    Cell Significance Index: 10.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0115
    Cell Significance Index: 8.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0005
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0050
    Cell Significance Index: -9.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0100
    Cell Significance Index: -18.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0122
    Cell Significance Index: -18.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0145
    Cell Significance Index: -19.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0183
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0185
    Cell Significance Index: -2.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0208
    Cell Significance Index: -7.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0210
    Cell Significance Index: -4.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0222
    Cell Significance Index: -0.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0235
    Cell Significance Index: -14.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0244
    Cell Significance Index: -0.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0262
    Cell Significance Index: -14.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0270
    Cell Significance Index: -16.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0351
    Cell Significance Index: -0.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0372
    Cell Significance Index: -16.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0405
    Cell Significance Index: -11.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0633
    Cell Significance Index: -7.3800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0758
    Cell Significance Index: -0.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0782
    Cell Significance Index: -3.9500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0784
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0814
    Cell Significance Index: -17.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0863
    Cell Significance Index: -11.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0949
    Cell Significance Index: -13.8000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0956
    Cell Significance Index: -0.7900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0973
    Cell Significance Index: -1.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1120
    Cell Significance Index: -2.8800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1314
    Cell Significance Index: -5.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1378
    Cell Significance Index: -17.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1477
    Cell Significance Index: -15.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1639
    Cell Significance Index: -3.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1701
    Cell Significance Index: -5.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1768
    Cell Significance Index: -10.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1893
    Cell Significance Index: -14.9900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2035
    Cell Significance Index: -1.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2067
    Cell Significance Index: -5.5300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2086
    Cell Significance Index: -2.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2109
    Cell Significance Index: -16.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2243
    Cell Significance Index: -15.0800
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.2249
    Cell Significance Index: -1.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2359
    Cell Significance Index: -15.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2480
    Cell Significance Index: -12.9200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2596
    Cell Significance Index: -1.8000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2697
    Cell Significance Index: -6.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2882
    Cell Significance Index: -10.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2919
    Cell Significance Index: -17.9400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.3168
    Cell Significance Index: -4.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3562
    Cell Significance Index: -18.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ST14 is a member of the type II transmembrane serine protease family, characterized by its unique structure and enzymatic activity. Its serine protease domain is capable of cleaving a wide range of substrates, including proteins, peptides, and lipids, thereby modulating various cellular processes. ST14 is predominantly expressed in epithelial cells, where it is often associated with the apical membrane, suggesting its role in regulating cellular polarity and morphology. **Pathways and Functions:** ST14's involvement in various biological processes can be attributed to its serine protease activity, which is implicated in several signaling pathways, including: 1. **Keratinization and Epithelial Differentiation:** ST14 plays a crucial role in regulating keratinocyte differentiation, a process essential for maintaining skin integrity. The enzyme's activity is required for the proper formation of the cornified envelope, a complex structure composed of keratin filaments that provides mechanical strength to the skin. 2. **Neural Tube Closure:** ST14 is essential for the closure of the neural tube, a critical process in embryonic development. The enzyme's proteolytic activity is required for the degradation of extracellular matrix proteins, allowing for the proper closure of the neural tube. 3. **Immune Regulation:** ST14 has been shown to modulate immune responses by regulating the activity of various immune cells, including T cells and dendritic cells. The enzyme's proteolytic activity can influence the processing and presentation of antigens, thereby impacting immune tolerance and inflammation. 4. **Proteolysis and Catabolism:** ST14's serine protease activity is also involved in the degradation of extracellular matrix proteins, a process essential for tissue remodeling and repair. **Clinical Significance:** Dysregulation of ST14's activity has been implicated in various diseases, including: 1. **Cancer:** ST14's role in tumorigenesis has been highlighted, with its expression often associated with cancer progression and metastasis. 2. **Autoimmune Disorders:** ST14's involvement in immune regulation has led to its investigation as a potential therapeutic target for autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Skin Disorders:** ST14's role in keratinization and epithelial differentiation has led to its investigation as a potential therapeutic target for skin disorders, such as psoriasis and acne. In conclusion, ST14 is a multifunctional transmembrane serine protease that plays a critical role in regulating various biological processes, including keratinization, neural tube closure, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2039433587

Symbol: ST14_HUMAN

Name: Suppressor of tumorigenicity 14 protein

UniProtKB Accession Codes:

Q9Y5Y6 Q9BS01 Q9H3S0 Q9HB36 Q9HCA3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 11 Gene3D 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PIRSF 1 PRINTS 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10373424

Title: Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity.

PubMed ID: 10373424

DOI: 10.1074/jbc.274.26.18231

PubMed ID: 10500122

Title: Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue.

PubMed ID: 10500122

DOI: 10.1073/pnas.96.20.11054

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10373425

Title: Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk.

PubMed ID: 10373425

DOI: 10.1074/jbc.274.26.18237

PubMed ID: 16007225

Title: Adhesion signaling by a novel mitotic substrate of src kinases.

PubMed ID: 16007225

DOI: 10.1038/sj.onc.1208582

PubMed ID: 16407223

Title: Protein interaction analysis of ST14 domains and their point and deletion mutants.

PubMed ID: 16407223

DOI: 10.1074/jbc.m510687200

PubMed ID: 18843291

Title: Ichthyosis, follicular atrophoderma, and hypotrichosis caused by mutations in ST14 is associated with impaired profilaggrin processing.

PubMed ID: 18843291

DOI: 10.1038/jid.2008.311

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 28710277

Title: Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization.

PubMed ID: 28710277

DOI: 10.1074/jbc.m117.775999

PubMed ID: 33732248

Title: Iripin-3, a New Salivary Protein Isolated From Ixodes ricinus Ticks, Displays Immunomodulatory and Anti-Hemostatic Properties In Vitro.

PubMed ID: 33732248

DOI: 10.3389/fimmu.2021.626200

PubMed ID: 36756125

Title: Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment <i>in vivo</i> while altering the levels of chemokines and adhesion molecules.

PubMed ID: 36756125

DOI: 10.3389/fimmu.2023.1116324

PubMed ID: 11696548

Title: Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase.

PubMed ID: 11696548

DOI: 10.1074/jbc.m109830200

PubMed ID: 17273967

Title: Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase.

PubMed ID: 17273967

DOI: 10.1086/512487

Sequence Information:

  • Length: 855
  • Mass: 94770
  • Checksum: 26143132C01F99C9
  • Sequence:
    • MGSDRARKGG GGPKDFGAGL KYNSRHEKVN GLEEGVEFLP VNNVKKVEKH GPGRWVVLAA 
VLIGLLLVLL GIGFLVWHLQ YRDVRVQKVF NGYMRITNEN FVDAYENSNS TEFVSLASKV 
KDALKLLYSG VPFLGPYHKE SAVTAFSEGS VIAYYWSEFS IPQHLVEEAE RVMAEERVVM 
LPPRARSLKS FVVTSVVAFP TDSKTVQRTQ DNSCSFGLHA RGVELMRFTT PGFPDSPYPA 
HARCQWALRG DADSVLSLTF RSFDLASCDE RGSDLVTVYN TLSPMEPHAL VQLCGTYPPS 
YNLTFHSSQN VLLITLITNT ERRHPGFEAT FFQLPRMSSC GGRLRKAQGT FNSPYYPGHY 
PPNIDCTWNI EVPNNQHVKV RFKFFYLLEP GVPAGTCPKD YVEINGEKYC GERSQFVVTS 
NSNKITVRFH SDQSYTDTGF LAEYLSYDSS DPCPGQFTCR TGRCIRKELR CDGWADCTDH 
SDELNCSCDA GHQFTCKNKF CKPLFWVCDS VNDCGDNSDE QGCSCPAQTF RCSNGKCLSK 
SQQCNGKDDC GDGSDEASCP KVNVVTCTKH TYRCLNGLCL SKGNPECDGK EDCSDGSDEK 
DCDCGLRSFT RQARVVGGTD ADEGEWPWQV SLHALGQGHI CGASLISPNW LVSAAHCYID 
DRGFRYSDPT QWTAFLGLHD QSQRSAPGVQ ERRLKRIISH PFFNDFTFDY DIALLELEKP 
AEYSSMVRPI CLPDASHVFP AGKAIWVTGW GHTQYGGTGA LILQKGEIRV INQTTCENLL 
PQQITPRMMC VGFLSGGVDS CQGDSGGPLS SVEADGRIFQ AGVVSWGDGC AQRNKPGVYT 
RLPLFRDWIK ENTGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.