Details for: SULT1E1

Gene ID: 6783

Symbol: SULT1E1

Ensembl ID: ENSG00000109193

Description: sulfotransferase family 1E member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 13.0392
    Cell Significance Index: 80.6700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 5.5105
    Cell Significance Index: 12.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.5596
    Cell Significance Index: 161.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.8147
    Cell Significance Index: 535.6500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 2.4941
    Cell Significance Index: 27.8800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8247
    Cell Significance Index: 24.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7628
    Cell Significance Index: 38.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7174
    Cell Significance Index: 15.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4926
    Cell Significance Index: 173.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2594
    Cell Significance Index: 36.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2273
    Cell Significance Index: 243.5700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.2220
    Cell Significance Index: 18.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1877
    Cell Significance Index: 71.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1038
    Cell Significance Index: 996.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0832
    Cell Significance Index: 107.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0729
    Cell Significance Index: 116.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0345
    Cell Significance Index: 8.2600
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.7926
    Cell Significance Index: 1.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7912
    Cell Significance Index: 19.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6376
    Cell Significance Index: 44.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4092
    Cell Significance Index: 14.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.4072
    Cell Significance Index: 6.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2518
    Cell Significance Index: 5.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2514
    Cell Significance Index: 111.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2503
    Cell Significance Index: 5.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.1901
    Cell Significance Index: -0.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1300
    Cell Significance Index: 3.2500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0774
    Cell Significance Index: 1.1600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0753
    Cell Significance Index: 0.7800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.0237
    Cell Significance Index: 0.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0230
    Cell Significance Index: 0.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0090
    Cell Significance Index: 0.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0046
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0069
    Cell Significance Index: -13.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0093
    Cell Significance Index: -17.2100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0093
    Cell Significance Index: -0.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0112
    Cell Significance Index: -17.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0127
    Cell Significance Index: -17.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0127
    Cell Significance Index: -0.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0142
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0170
    Cell Significance Index: -12.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0175
    Cell Significance Index: -13.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0193
    Cell Significance Index: -14.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0234
    Cell Significance Index: -12.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0250
    Cell Significance Index: -14.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0287
    Cell Significance Index: -0.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0334
    Cell Significance Index: -15.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0343
    Cell Significance Index: -1.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0352
    Cell Significance Index: -1.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0358
    Cell Significance Index: -0.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0369
    Cell Significance Index: -13.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0485
    Cell Significance Index: -13.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0557
    Cell Significance Index: -6.8500
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.0607
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0612
    Cell Significance Index: -12.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0626
    Cell Significance Index: -3.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0664
    Cell Significance Index: -13.3300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0683
    Cell Significance Index: -0.9700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0699
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0705
    Cell Significance Index: -12.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0950
    Cell Significance Index: -13.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0958
    Cell Significance Index: -13.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1021
    Cell Significance Index: -4.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1027
    Cell Significance Index: -1.7300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1055
    Cell Significance Index: -0.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1093
    Cell Significance Index: -7.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1111
    Cell Significance Index: -12.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1408
    Cell Significance Index: -14.3800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1504
    Cell Significance Index: -2.5300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1755
    Cell Significance Index: -1.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1997
    Cell Significance Index: -13.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2099
    Cell Significance Index: -7.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2106
    Cell Significance Index: -10.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2374
    Cell Significance Index: -6.3500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2600
    Cell Significance Index: -2.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2619
    Cell Significance Index: -16.1000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2697
    Cell Significance Index: -1.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2781
    Cell Significance Index: -8.1900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2876
    Cell Significance Index: -4.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2965
    Cell Significance Index: -16.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3115
    Cell Significance Index: -8.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3123
    Cell Significance Index: -7.8000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3175
    Cell Significance Index: -4.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3392
    Cell Significance Index: -9.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3506
    Cell Significance Index: -12.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3592
    Cell Significance Index: -16.8800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3757
    Cell Significance Index: -5.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3757
    Cell Significance Index: -16.6200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3804
    Cell Significance Index: -3.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3828
    Cell Significance Index: -13.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3946
    Cell Significance Index: -12.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4096
    Cell Significance Index: -13.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4129
    Cell Significance Index: -6.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4148
    Cell Significance Index: -5.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4187
    Cell Significance Index: -13.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4311
    Cell Significance Index: -10.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4386
    Cell Significance Index: -16.6100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.4446
    Cell Significance Index: -5.5000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.4563
    Cell Significance Index: -5.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SULT1E1 is a cytosolic enzyme that exhibits aryl sulfotransferase activity, enabling it to catalyze the sulfonation of small molecules. Its expression is widespread in various cell types, including mesangial cells, pulmonary interstitial fibroblasts, hepatoblasts, and granulocyte monocyte progenitor cells. The gene is highly conserved across species, suggesting its essential role in maintaining cellular homeostasis. **Pathways and Functions:** SULT1E1 is involved in several key metabolic and immune-related pathways, including: 1. **3'-phosphoadenosine 5'-phosphosulfate metabolic process:** SULT1E1 plays a critical role in the sulfonation of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a key donor molecule for sulfonation reactions. 2. **Aryl sulfotransferase activity:** SULT1E1 catalyzes the sulfonation of aryl groups, enabling the conjugation and detoxification of various compounds. 3. **Steroid metabolic process:** SULT1E1 is involved in the sulfonation of steroids, including estrone, which is crucial for regulating steroid hormone activity. 4. **Cytosolic sulfonation of small molecules:** SULT1E1 contributes to the sulfonation of various small molecules, including flavonoids and drugs, which is essential for their detoxification and regulation. **Clinical Significance:** The dysregulation of SULT1E1 has been implicated in various diseases, including: 1. **Cancer:** SULT1E1 overexpression has been observed in several types of cancer, suggesting its potential role as a tumor suppressor. 2. **Metabolic disorders:** SULT1E1 plays a crucial role in glucose metabolism, and its dysregulation has been linked to insulin resistance and type 2 diabetes. 3. **Immune system disorders:** SULT1E1 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis. In conclusion, SULT1E1 is a multifunctional enzyme that plays a critical role in maintaining metabolic homeostasis, regulating immune responses, and controlling the activity of various compounds. Further research is needed to elucidate the mechanisms underlying its dysregulation and to explore its therapeutic potential in treating various diseases. **References:** [List of relevant references] Note: The references provided are hypothetical and not actual references. In a real article, you would include relevant and peer-reviewed sources to support the discussion.

Genular Protein ID: 1526083415

Symbol: ST1E1_HUMAN

Name: Sulfotransferase 1E1

UniProtKB Accession Codes:

P49888 Q8N6X5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 ChEBI 31 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 EC 1 EMBL 13 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 9 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8185618

Title: Human liver estrogen sulfotransferase: identification by cDNA cloning and expression.

PubMed ID: 8185618

DOI: 10.1006/bbrc.1994.1637

PubMed ID: 8530066

Title: Human estrogen sulfotransferase gene (STE): cloning, structure, and chromosomal localization.

PubMed ID: 8530066

DOI: 10.1006/geno.1995.1210

PubMed ID: 7779757

Title: Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase.

PubMed ID: 7779757

DOI: 10.1016/0960-0760(95)00015-r

PubMed ID: 10541560

Title: Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy.

PubMed ID: 10541560

DOI: 10.1093/molehr/5.11.995

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11006110

Title: Site-directed mutagenesis of the substrate-binding cleft of human estrogen sulfotransferase.

PubMed ID: 11006110

DOI: 10.1006/bbrc.2000.3473

PubMed ID: 19589875

Title: 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation.

PubMed ID: 19589875

DOI: 10.1124/dmd.108.025759

PubMed ID: 35165440

Title: A gut-derived metabolite alters brain activity and anxiety behaviour in mice.

PubMed ID: 35165440

DOI: 10.1038/s41586-022-04396-8

PubMed ID: 11884392

Title: Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction.

PubMed ID: 11884392

DOI: 10.1074/jbc.m111651200

PubMed ID: 12782487

Title: Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase.

PubMed ID: 12782487

DOI: 10.1289/ehp.6056

Sequence Information:

  • Length: 294
  • Mass: 35126
  • Checksum: 9EC8923D20757D57
  • Sequence:
    • MNSELDYYEK FEEVHGILMY KDFVKYWDNV EAFQARPDDL VIATYPKSGT TWVSEIVYMI 
YKEGDVEKCK EDVIFNRIPF LECRKENLMN GVKQLDEMNS PRIVKTHLPP ELLPASFWEK 
DCKIIYLCRN AKDVAVSFYY FFLMVAGHPN PGSFPEFVEK FMQGQVPYGS WYKHVKSWWE 
KGKSPRVLFL FYEDLKEDIR KEVIKLIHFL ERKPSEELVD RIIHHTSFQE MKNNPSTNYT 
TLPDEIMNQK LSPFMRKGIT GDWKNHFTVA LNEKFDKHYE QQMKESTLKF RTEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.