**Key characteristics:**
* TRGJP1 is a protein found in humans and other mammals.
* It is a transmembrane protein with a molecular weight of approximately 180 kDa.
* It is expressed in a wide range of cell types, including lymphocytes, goblet cells, neoplastic cells, abnormal cells, absorptive cells, intestinal crypt stem cells, transit amplifying cells, brush cells, intestinal epithelial cells, and natural killer cells.
* It is a key regulator of T cell activation and differentiation.
* It interacts with the CD28 protein, which is expressed on the surface of T cells.
* It is involved in the regulation of T cell responses to antigens.
**Pathways and functions:**
* TRGJP1 is involved in the regulation of T cell activation and differentiation.
* It is expressed in lymphoid tissues, where it is important for the development and maintenance of T cell populations.
* It is also expressed in non-lymphoid tissues, where it helps to regulate immune responses.
* TRGJP1 is involved in the regulation of the activation of naive T cells.
* It is a key regulator of the development of effector T cells, such as cytotoxic T cells and helper T cells.
* It is also involved in the regulation of regulatory T cells.
**Clinical significance:**
* Mutations in TRGJP1 have been linked to several human diseases, including immune disorders and cancer.
* In one study, mutations in TRGJP1 were found in a significant proportion of patients with autoimmune disorders, such as rheumatoid arthritis and lupus.
* These mutations were associated with a loss-of-function of TRGJP1, which led to an inability of T cells to recognize antigens and activate.
* This resulted in the development of autoimmune diseases.
**Conclusion:**
TRGJP1 is a critical protein that plays a crucial role in the regulation of T cell activation and differentiation. Mutations in TRGJP1 have been linked to several human diseases, highlighting its importance in maintaining immune homeostasis.
Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
