Details for: TRGJP1

Gene ID: 6971

Symbol: TRGJP1

Ensembl ID: ENSG00000211692

Description: T cell receptor gamma joining P1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.3874
    Cell Significance Index: 57.8300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.8552
    Cell Significance Index: 12.4700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.7875
    Cell Significance Index: 9.9500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.5856
    Cell Significance Index: 7.6900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0887
    Cell Significance Index: 1.3000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0395
    Cell Significance Index: 0.8000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.0126
    Cell Significance Index: 0.1100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0049
    Cell Significance Index: -0.1300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0079
    Cell Significance Index: -0.0900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0082
    Cell Significance Index: -0.0800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0118
    Cell Significance Index: -0.2300
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0141
    Cell Significance Index: -0.1100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0161
    Cell Significance Index: -0.2100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0161
    Cell Significance Index: -0.1100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0184
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0195
    Cell Significance Index: -0.2400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0205
    Cell Significance Index: -0.1500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0228
    Cell Significance Index: -0.3900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0230
    Cell Significance Index: -0.2700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0232
    Cell Significance Index: -0.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0253
    Cell Significance Index: -0.4200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0264
    Cell Significance Index: -0.2700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0270
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0286
    Cell Significance Index: -0.3800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0296
    Cell Significance Index: -0.4800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0296
    Cell Significance Index: -0.3900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0303
    Cell Significance Index: -0.3300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0311
    Cell Significance Index: -0.3500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0325
    Cell Significance Index: -0.3600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0330
    Cell Significance Index: -0.3600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0331
    Cell Significance Index: -0.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0336
    Cell Significance Index: -0.4000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0336
    Cell Significance Index: -0.4100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0338
    Cell Significance Index: -0.4000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0341
    Cell Significance Index: -0.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0346
    Cell Significance Index: -0.6400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0369
    Cell Significance Index: -0.4000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0390
    Cell Significance Index: -0.3900
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0391
    Cell Significance Index: -0.4200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0396
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0415
    Cell Significance Index: -0.3900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0417
    Cell Significance Index: -0.3400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0442
    Cell Significance Index: -0.4000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0469
    Cell Significance Index: -0.4100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0489
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0512
    Cell Significance Index: -0.5400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0516
    Cell Significance Index: -0.4800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0533
    Cell Significance Index: -0.4100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0539
    Cell Significance Index: -0.6400
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0541
    Cell Significance Index: -0.5300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0542
    Cell Significance Index: -0.6400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0548
    Cell Significance Index: -0.6300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0551
    Cell Significance Index: -0.6100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0563
    Cell Significance Index: -0.3600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0569
    Cell Significance Index: -0.6600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0577
    Cell Significance Index: -0.5900
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0577
    Cell Significance Index: -0.4700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0580
    Cell Significance Index: -0.4800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0594
    Cell Significance Index: -0.6400
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.0604
    Cell Significance Index: -0.5900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0624
    Cell Significance Index: -0.6300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0636
    Cell Significance Index: -0.5600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0649
    Cell Significance Index: -0.6400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0691
    Cell Significance Index: -0.3700
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0738
    Cell Significance Index: -0.7700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0761
    Cell Significance Index: -0.7600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0769
    Cell Significance Index: -0.7800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0779
    Cell Significance Index: -0.6700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0803
    Cell Significance Index: -0.7200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0877
    Cell Significance Index: -0.7100
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0890
    Cell Significance Index: -0.7300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0894
    Cell Significance Index: -0.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1040
    Cell Significance Index: -1.0000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1084
    Cell Significance Index: -0.9200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1188
    Cell Significance Index: -1.0600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1284
    Cell Significance Index: -0.7000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1326
    Cell Significance Index: -1.0600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1375
    Cell Significance Index: -1.0700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1411
    Cell Significance Index: -1.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRGJP1 is a gene that encodes a protein involved in the regulation of immune responses and epithelial homeostasis. The gene is significantly expressed in various cell types, including lymphocytes, goblet cells, neoplastic cells, and intestinal epithelial cells. This widespread expression suggests that TRGJP1 plays a crucial role in maintaining immune homeostasis and epithelial integrity. **Pathways and Functions:** TRGJP1 is involved in several key pathways that regulate immune responses and epithelial homeostasis. These include: 1. **T cell receptor signaling:** TRGJP1 is a component of the T cell receptor (TCR) complex, which plays a critical role in the recognition of antigens and the activation of immune responses. 2. **Epithelial barrier function:** TRGJP1 is also expressed in epithelial cells, where it contributes to the maintenance of the epithelial barrier function and the regulation of immune responses. 3. **Inflammation and immune regulation:** TRGJP1 has been shown to modulate inflammation and immune responses by regulating the expression of cytokines and other immune-related genes. **Functions:** The functions of TRGJP1 are multifaceted and involve the regulation of immune responses, epithelial homeostasis, and inflammation. Some of the key functions of TRGJP1 include: 1. **Antigen recognition and presentation:** TRGJP1 plays a role in the recognition of antigens by T cells and the presentation of antigens to other immune cells. 2. **Epithelial barrier function:** TRGJP1 contributes to the maintenance of the epithelial barrier function by regulating the expression of tight junction proteins and other epithelial markers. 3. **Immune regulation:** TRGJP1 modulates inflammation and immune responses by regulating the expression of cytokines and other immune-related genes. **Clinical Significance:** The clinical significance of TRGJP1 is an area of active research, with implications for the treatment of various diseases. Some of the key clinical applications of TRGJP1 include: 1. **Autoimmune diseases:** TRGJP1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where dysregulation of immune responses and epithelial homeostasis contributes to disease progression. 2. **Cancer:** TRGJP1 has been shown to be overexpressed in certain types of cancer, where it contributes to tumor progression and metastasis. 3. **Inflammatory bowel disease:** TRGJP1 has been implicated in the pathogenesis of inflammatory bowel disease (IBD), where dysregulation of immune responses and epithelial homeostasis contributes to disease progression. In conclusion, TRGJP1 is a gene with a complex role in immune response and epithelial homeostasis. Further research is needed to fully elucidate the functions of TRGJP1 and its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.