Details for: LEFTY2

Gene ID: 7044

Symbol: LEFTY2

Ensembl ID: ENSG00000143768

Description: left-right determination factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 8.3976
    Cell Significance Index: -2.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 5.0338
    Cell Significance Index: -2.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.9757
    Cell Significance Index: 85.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.1803
    Cell Significance Index: 133.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3614
    Cell Significance Index: 29.5000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.8102
    Cell Significance Index: 4.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6238
    Cell Significance Index: 118.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4571
    Cell Significance Index: 45.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3894
    Cell Significance Index: 10.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3606
    Cell Significance Index: 325.6100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.3557
    Cell Significance Index: 2.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3540
    Cell Significance Index: 7.5400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3060
    Cell Significance Index: 4.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2359
    Cell Significance Index: 38.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2343
    Cell Significance Index: 25.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2103
    Cell Significance Index: 28.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1554
    Cell Significance Index: 9.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1295
    Cell Significance Index: 8.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0699
    Cell Significance Index: 0.7600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.0636
    Cell Significance Index: 0.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0403
    Cell Significance Index: 2.5400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0384
    Cell Significance Index: 0.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0370
    Cell Significance Index: 0.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0196
    Cell Significance Index: 0.8900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.0136
    Cell Significance Index: 0.1300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0064
    Cell Significance Index: 0.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0009
    Cell Significance Index: 0.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0009
    Cell Significance Index: 0.1200
  • Cell Name: myoblast (CL0000056)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0024
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0028
    Cell Significance Index: -2.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0032
    Cell Significance Index: -1.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0033
    Cell Significance Index: -1.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0037
    Cell Significance Index: -2.3300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0047
    Cell Significance Index: -2.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0051
    Cell Significance Index: -0.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0052
    Cell Significance Index: -1.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0053
    Cell Significance Index: -0.1100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0067
    Cell Significance Index: -0.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0069
    Cell Significance Index: -1.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0075
    Cell Significance Index: -1.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0080
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0086
    Cell Significance Index: -1.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0093
    Cell Significance Index: -1.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0100
    Cell Significance Index: -0.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0101
    Cell Significance Index: -0.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0103
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0109
    Cell Significance Index: -1.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0114
    Cell Significance Index: -1.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0114
    Cell Significance Index: -0.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0120
    Cell Significance Index: -1.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0122
    Cell Significance Index: -0.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0129
    Cell Significance Index: -1.5900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0130
    Cell Significance Index: -0.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0146
    Cell Significance Index: -0.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0148
    Cell Significance Index: -2.1500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0179
    Cell Significance Index: -0.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0199
    Cell Significance Index: -0.5600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0202
    Cell Significance Index: -0.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0213
    Cell Significance Index: -2.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0231
    Cell Significance Index: -1.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0246
    Cell Significance Index: -1.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0251
    Cell Significance Index: -1.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0255
    Cell Significance Index: -0.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0269
    Cell Significance Index: -0.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0296
    Cell Significance Index: -2.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0314
    Cell Significance Index: -2.1100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0369
    Cell Significance Index: -0.4300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0371
    Cell Significance Index: -0.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0377
    Cell Significance Index: -1.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0381
    Cell Significance Index: -2.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0398
    Cell Significance Index: -2.5700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0448
    Cell Significance Index: -0.5700
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0449
    Cell Significance Index: -0.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0451
    Cell Significance Index: -1.5800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0460
    Cell Significance Index: -0.6700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0463
    Cell Significance Index: -0.6100
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0472
    Cell Significance Index: -0.4800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0482
    Cell Significance Index: -1.7700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0490
    Cell Significance Index: -0.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0531
    Cell Significance Index: -2.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0534
    Cell Significance Index: -1.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0534
    Cell Significance Index: -1.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0558
    Cell Significance Index: -1.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0559
    Cell Significance Index: -1.8300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0562
    Cell Significance Index: -0.3800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0575
    Cell Significance Index: -0.8900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0576
    Cell Significance Index: -0.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0581
    Cell Significance Index: -1.8500
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0589
    Cell Significance Index: -0.5300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0593
    Cell Significance Index: -0.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0599
    Cell Significance Index: -2.0800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0603
    Cell Significance Index: -0.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LEFTY2 is a secreted protein that belongs to the left-right determination factor family. It is primarily expressed in various cell types, including uterine smooth muscle cells, conventional dendritic cells, intestinal crypt stem cells, and decidual cells. LEFTY2 plays a dual role in development, acting as an anti-angiogenic factor to inhibit vessel formation and promote left-right asymmetry. In the context of the immune system, LEFTY2 has been shown to regulate T cell and dendritic cell function, influencing the development of immune tolerance and autoimmune diseases. **Pathways and Functions:** LEFTY2 is involved in several signaling pathways, including: 1. **Nodal signaling pathway:** LEFTY2 acts as a negative regulator of the nodal signaling pathway, which is critical for left-right asymmetry development and organogenesis. 2. **Cytokine activity:** LEFTY2 modulates cytokine production, influencing the balance between pro-inflammatory and anti-inflammatory responses. 3. **Growth factor activity:** LEFTY2 interacts with growth factors, such as TGF-β, to regulate cell proliferation, differentiation, and survival. 4. **Signaling by nodal:** LEFTY2 inhibits the activity of the nodal receptor, preventing excessive signaling and promoting proper left-right development. LEFTY2's functions in the immune system include: 1. **Immune tolerance:** LEFTY2 promotes immune tolerance by regulating T cell and dendritic cell function, preventing autoimmune diseases. 2. **Antitumor activity:** LEFTY2 has been shown to inhibit tumor growth and metastasis by regulating angiogenesis and immune responses. 3. **Regulation of signaling by nodal:** LEFTY2 modulates nodal signaling, preventing excessive activation and promoting proper left-right development. **Clinical Significance:** LEFTY2's dysregulation has been implicated in various diseases, including: 1. **Autoimmune diseases:** LEFTY2's role in regulating immune tolerance and preventing autoimmune diseases makes it a potential therapeutic target for diseases such as rheumatoid arthritis and lupus. 2. **Cancer:** LEFTY2's antitumor activity and ability to regulate angiogenesis make it a promising candidate for cancer therapy. 3. **Developmental disorders:** LEFTY2's involvement in left-right asymmetry development and organogenesis highlights its potential role in congenital disorders, such as situs inversus. In conclusion, LEFTY2 is a multifunctional gene that plays a critical role in development, immune regulation, and disease. Further research is needed to fully understand its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 1935558302

Symbol: LFTY2_HUMAN

Name: Left-right determination factor 2

UniProtKB Accession Codes:

O00292 B3KNH4 B4E332 E9PDM4 O75611 Q5TE89 Q8NBQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9153275

Title: Detection of ebaf, a novel human gene of the transforming growth factor beta superfamily association of gene expression with endometrial bleeding.

PubMed ID: 9153275

DOI: 10.1172/jci119415

PubMed ID: 10053005

Title: Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.

PubMed ID: 10053005

DOI: 10.1086/302289

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 366
  • Mass: 40920
  • Checksum: 63A416CAE30F7A39
  • Sequence:
    • MWPLWLCWAL WVLPLAGPGA ALTEEQLLGS LLRQLQLSEV PVLDRADMEK LVIPAHVRAQ 
YVVLLRRSHG DRSRGKRFSQ SFREVAGRFL ASEASTHLLV FGMEQRLPPN SELVQAVLRL 
FQEPVPKAAL HRHGRLSPRS AQARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKAFDV 
TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL 
DLRDYGAQGD CDPEAPMTEG TRCCRQEMYI DLQGMKWAKN WVLEPPGFLA YECVGTCQQP 
PEALAFNWPF LGPRQCIASE TASLPMIVSI KEGGRTRPQV VSLPNMRVQK CSCASDGALV 
PRRLQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.