Details for: LEFTY2

Gene ID: 7044

Symbol: LEFTY2

Ensembl ID: ENSG00000143768

Description: left-right determination factor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.72
    Marker Score: 3537
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.2
    Marker Score: 1516
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.23
    Marker Score: 5310
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2
    Marker Score: 875
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4821
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.07
    Marker Score: 680
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1
    Marker Score: 1902
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.86
    Marker Score: 397
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 622
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.7
    Marker Score: 370
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.58
    Marker Score: 1189
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5
    Marker Score: 7866
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.47
    Marker Score: 285
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.47
    Marker Score: 124
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.44
    Marker Score: 256
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.44
    Marker Score: 1708
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.41
    Marker Score: 271
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 379
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.36
    Marker Score: 679
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 302
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.24
    Marker Score: 501
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.24
    Marker Score: 86
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 103
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 117
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.18
    Marker Score: 282.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.18
    Marker Score: 281
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.15
    Marker Score: 64
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.15
    Marker Score: 255
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.15
    Marker Score: 1687
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.15
    Marker Score: 105
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 149
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.14
    Marker Score: 366
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.13
    Marker Score: 51
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.13
    Marker Score: 73
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.12
    Marker Score: 97
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.12
    Marker Score: 236
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 79
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.11
    Marker Score: 113
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.11
    Marker Score: 134
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 120
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 70
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.1
    Marker Score: 55
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 112
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.09
    Marker Score: 130
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 80
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.08
    Marker Score: 89
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 42
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.08
    Marker Score: 34
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.07
    Marker Score: 94
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.07
    Marker Score: 449
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.07
    Marker Score: 75
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.07
    Marker Score: 158
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 57
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.07
    Marker Score: 394
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.06
    Marker Score: 127
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.06
    Marker Score: 77
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.06
    Marker Score: 150
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.06
    Marker Score: 26

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Other Information

**Key Characteristics:** LEFTY2 is a secreted protein that belongs to the left-right determination factor family. It is primarily expressed in various cell types, including uterine smooth muscle cells, conventional dendritic cells, intestinal crypt stem cells, and decidual cells. LEFTY2 plays a dual role in development, acting as an anti-angiogenic factor to inhibit vessel formation and promote left-right asymmetry. In the context of the immune system, LEFTY2 has been shown to regulate T cell and dendritic cell function, influencing the development of immune tolerance and autoimmune diseases. **Pathways and Functions:** LEFTY2 is involved in several signaling pathways, including: 1. **Nodal signaling pathway:** LEFTY2 acts as a negative regulator of the nodal signaling pathway, which is critical for left-right asymmetry development and organogenesis. 2. **Cytokine activity:** LEFTY2 modulates cytokine production, influencing the balance between pro-inflammatory and anti-inflammatory responses. 3. **Growth factor activity:** LEFTY2 interacts with growth factors, such as TGF-β, to regulate cell proliferation, differentiation, and survival. 4. **Signaling by nodal:** LEFTY2 inhibits the activity of the nodal receptor, preventing excessive signaling and promoting proper left-right development. LEFTY2's functions in the immune system include: 1. **Immune tolerance:** LEFTY2 promotes immune tolerance by regulating T cell and dendritic cell function, preventing autoimmune diseases. 2. **Antitumor activity:** LEFTY2 has been shown to inhibit tumor growth and metastasis by regulating angiogenesis and immune responses. 3. **Regulation of signaling by nodal:** LEFTY2 modulates nodal signaling, preventing excessive activation and promoting proper left-right development. **Clinical Significance:** LEFTY2's dysregulation has been implicated in various diseases, including: 1. **Autoimmune diseases:** LEFTY2's role in regulating immune tolerance and preventing autoimmune diseases makes it a potential therapeutic target for diseases such as rheumatoid arthritis and lupus. 2. **Cancer:** LEFTY2's antitumor activity and ability to regulate angiogenesis make it a promising candidate for cancer therapy. 3. **Developmental disorders:** LEFTY2's involvement in left-right asymmetry development and organogenesis highlights its potential role in congenital disorders, such as situs inversus. In conclusion, LEFTY2 is a multifunctional gene that plays a critical role in development, immune regulation, and disease. Further research is needed to fully understand its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 1935558302

Symbol: LFTY2_HUMAN

Name: Left-right determination factor 2

UniProtKB Accession Codes:

O00292 B3KNH4 B4E332 E9PDM4 O75611 Q5TE89 Q8NBQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9153275

Title: Detection of ebaf, a novel human gene of the transforming growth factor beta superfamily association of gene expression with endometrial bleeding.

PubMed ID: 9153275

DOI: 10.1172/jci119415

PubMed ID: 10053005

Title: Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.

PubMed ID: 10053005

DOI: 10.1086/302289

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 366
  • Mass: 40920
  • Checksum: 63A416CAE30F7A39
  • Sequence:
    • MWPLWLCWAL WVLPLAGPGA ALTEEQLLGS LLRQLQLSEV PVLDRADMEK LVIPAHVRAQ 
YVVLLRRSHG DRSRGKRFSQ SFREVAGRFL ASEASTHLLV FGMEQRLPPN SELVQAVLRL 
FQEPVPKAAL HRHGRLSPRS AQARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKAFDV 
TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL 
DLRDYGAQGD CDPEAPMTEG TRCCRQEMYI DLQGMKWAKN WVLEPPGFLA YECVGTCQQP 
PEALAFNWPF LGPRQCIASE TASLPMIVSI KEGGRTRPQV VSLPNMRVQK CSCASDGALV 
PRRLQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.