Details for: TGM3

Gene ID: 7053

Symbol: TGM3

Ensembl ID: ENSG00000125780

Description: transglutaminase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.6136
    Cell Significance Index: 282.8600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.6544
    Cell Significance Index: 17.6200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 1.7176
    Cell Significance Index: 25.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7114
    Cell Significance Index: 77.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0756
    Cell Significance Index: 30.0600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.8339
    Cell Significance Index: 1.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8211
    Cell Significance Index: 81.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7328
    Cell Significance Index: 661.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5693
    Cell Significance Index: 12.1300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.5175
    Cell Significance Index: 6.5000
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.4951
    Cell Significance Index: 0.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4467
    Cell Significance Index: 48.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4373
    Cell Significance Index: 71.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3744
    Cell Significance Index: 9.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3463
    Cell Significance Index: 9.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2938
    Cell Significance Index: 17.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2594
    Cell Significance Index: 17.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2290
    Cell Significance Index: 4.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2192
    Cell Significance Index: 41.7200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2068
    Cell Significance Index: 1.6800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0899
    Cell Significance Index: 1.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0626
    Cell Significance Index: 12.4300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0505
    Cell Significance Index: 1.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0408
    Cell Significance Index: 0.7000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0374
    Cell Significance Index: 0.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0307
    Cell Significance Index: 13.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0281
    Cell Significance Index: 0.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0263
    Cell Significance Index: 5.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0240
    Cell Significance Index: 0.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0197
    Cell Significance Index: 10.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0119
    Cell Significance Index: 0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0082
    Cell Significance Index: 2.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0060
    Cell Significance Index: 0.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0050
    Cell Significance Index: 1.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0040
    Cell Significance Index: 0.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0028
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0014
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0018
    Cell Significance Index: -1.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0025
    Cell Significance Index: -1.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0037
    Cell Significance Index: -0.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0052
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0054
    Cell Significance Index: -0.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0078
    Cell Significance Index: -0.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0080
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0086
    Cell Significance Index: -1.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0100
    Cell Significance Index: -1.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0107
    Cell Significance Index: -1.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0112
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0118
    Cell Significance Index: -1.3500
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: -0.0122
    Cell Significance Index: -0.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0123
    Cell Significance Index: -0.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0130
    Cell Significance Index: -1.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0133
    Cell Significance Index: -1.6400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0144
    Cell Significance Index: -0.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0154
    Cell Significance Index: -0.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0158
    Cell Significance Index: -1.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0195
    Cell Significance Index: -0.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0210
    Cell Significance Index: -0.9900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0216
    Cell Significance Index: -0.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0216
    Cell Significance Index: -1.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0222
    Cell Significance Index: -0.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0223
    Cell Significance Index: -0.7300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0228
    Cell Significance Index: -0.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0249
    Cell Significance Index: -1.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0250
    Cell Significance Index: -1.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0261
    Cell Significance Index: -0.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0274
    Cell Significance Index: -0.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0282
    Cell Significance Index: -1.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0288
    Cell Significance Index: -1.0100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0299
    Cell Significance Index: -0.4500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0305
    Cell Significance Index: -0.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0309
    Cell Significance Index: -0.7700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0317
    Cell Significance Index: -0.6500
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0351
    Cell Significance Index: -0.2600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0386
    Cell Significance Index: -0.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0388
    Cell Significance Index: -0.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0398
    Cell Significance Index: -0.8600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0420
    Cell Significance Index: -0.5600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0420
    Cell Significance Index: -0.6200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0422
    Cell Significance Index: -0.5100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0428
    Cell Significance Index: -0.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0435
    Cell Significance Index: -0.8600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0435
    Cell Significance Index: -0.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0441
    Cell Significance Index: -1.3000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0453
    Cell Significance Index: -0.9100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0462
    Cell Significance Index: -0.9800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0469
    Cell Significance Index: -0.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0492
    Cell Significance Index: -1.7100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.0500
    Cell Significance Index: -0.4300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0502
    Cell Significance Index: -0.3400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0513
    Cell Significance Index: -0.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0526
    Cell Significance Index: -1.3400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0527
    Cell Significance Index: -1.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0532
    Cell Significance Index: -1.2300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0539
    Cell Significance Index: -1.0600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0541
    Cell Significance Index: -0.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0551
    Cell Significance Index: -1.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0571
    Cell Significance Index: -1.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TGM3 is a calcium-dependent enzyme that catalyzes the gamma-glutamyl transfer reaction, which involves the transfer of a gamma-glutamyl moiety from glutamine to a lysine residue in target proteins. This reaction is essential for various cellular processes, including protein cross-linking, peptide modification, and cellular differentiation. TGM3 is primarily expressed in epithelial cells, including those of the skin, gut, and respiratory tract, as well as in immune cells, such as innate lymphoid cells and granulocytes. **Pathways and Functions:** TGM3 is involved in several cellular pathways, including: 1. **Hair follicle morphogenesis**: TGM3 plays a crucial role in the development and maintenance of hair follicles by regulating the expression of key genes involved in hair growth. 2. **Keratinization**: TGM3 is essential for the process of keratinization, which involves the transformation of epithelial cells into keratinocytes, a process critical for skin barrier function. 3. **Immune cell development**: TGM3 is expressed in immature innate lymphoid cells and granulocytes, where it regulates the development and function of these cells. 4. **Cellular differentiation**: TGM3 is involved in the differentiation of various cell types, including epithelial cells, immune cells, and cardiac endothelial cells. **Clinical Significance:** TGM3 has been implicated in several diseases, including: 1. **Autoimmune diseases**: TGM3 has been linked to autoimmune diseases, such as psoriasis, where it plays a role in the pathogenesis of keratinocyte differentiation and immune cell function. 2. **Cancer**: TGM3 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumor progression and metastasis. 3. **Neurological disorders**: TGM3 has been implicated in neurological disorders, such as Alzheimer's disease, where it may play a role in the pathogenesis of amyloid-beta peptide aggregation. 4. **Cardiovascular disease**: TGM3 has been found to be associated with cardiovascular disease, where it may contribute to the development of atherosclerosis and cardiac remodeling. In conclusion, TGM3 is a multifaceted enzyme that plays a crucial role in various cellular processes, including protein modification, cross-linking, and cellular differentiation. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the functions and pathogenic mechanisms of TGM3.

Genular Protein ID: 652829074

Symbol: TGM3_HUMAN

Name: Protein-glutamine gamma-glutamyltransferase E

UniProtKB Accession Codes:

Q08188 A8K5N6 B2RCR6 D3DVX1 O95933 Q32ML9 Q32MM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 4 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8099584

Title: The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse.

PubMed ID: 8099584

DOI: 10.1016/s0021-9258(18)31442-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16565075

Title: Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.

PubMed ID: 16565075

DOI: 10.1074/jbc.m600694200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27866708

Title: Mutations in three genes encoding proteins involved in hair shaft formation cause uncombable hair syndrome.

PubMed ID: 27866708

DOI: 10.1016/j.ajhg.2016.10.004

PubMed ID: 11980702

Title: Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation.

PubMed ID: 11980702

DOI: 10.1093/emboj/21.9.2055

PubMed ID: 12679341

Title: Roles of calcium ions in the activation and activity of the transglutaminase 3 enzyme.

PubMed ID: 12679341

DOI: 10.1074/jbc.m301162200

Sequence Information:

  • Length: 693
  • Mass: 76632
  • Checksum: EAFAC0C9A8AA5FD6
  • Sequence:
    • MAALGVQSIN WQTAFNRQAH HTDKFSSQEL ILRRGQNFQV LMIMNKGLGS NERLEFIVST 
GPYPSESAMT KAVFPLSNGS SGGWSAVLQA SNGNTLTISI SSPASAPIGR YTMALQIFSQ 
GGISSVKLGT FILLFNPWLN VDSVFMGNHA EREEYVQEDA GIIFVGSTNR IGMIGWNFGQ 
FEEDILSICL SILDRSLNFR RDAATDVASR NDPKYVGRVL SAMINSNDDN GVLAGNWSGT 
YTGGRDPRSW NGSVEILKNW KKSGFSPVRY GQCWVFAGTL NTALRSLGIP SRVITNFNSA 
HDTDRNLSVD VYYDPMGNPL DKGSDSVWNF HVWNEGWFVR SDLGPSYGGW QVLDATPQER 
SQGVFQCGPA SVIGVREGDV QLNFDMPFIF AEVNADRITW LYDNTTGKQW KNSVNSHTIG 
RYISTKAVGS NARMDVTDKY KYPEGSDQER QVFQKALGKL KPNTPFAATS SMGLETEEQE 
PSIIGKLKVA GMLAVGKEVN LVLLLKNLSR DTKTVTVNMT AWTIIYNGTL VHEVWKDSAT 
MSLDPEEEAE HPIKISYAQY EKYLKSDNMI RITAVCKVPD ESEVVVERDI ILDNPTLTLE 
VLNEARVRKP VNVQMLFSNP LDEPVRDCVL MVEGSGLLLG NLKIDVPTLG PKEGSRVRFD 
ILPSRSGTKQ LLADFSCNKF PAIKAMLSID VAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.