Details for: TGM3

Gene ID: 7053

Symbol: TGM3

Ensembl ID: ENSG00000125780

Description: transglutaminase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1997
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.92
    Marker Score: 16564
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.49
    Marker Score: 3032
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.49
    Marker Score: 11603.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.27
    Marker Score: 2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.26
    Marker Score: 2612
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4819
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 1.07
    Marker Score: 3172
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1
    Marker Score: 414
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 647
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 395
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.6
    Marker Score: 675
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 467
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.58
    Marker Score: 212
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8905
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.56
    Marker Score: 326
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.54
    Marker Score: 326
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.52
    Marker Score: 593
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 166
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.5
    Marker Score: 4252
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.5
    Marker Score: 1448.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.48
    Marker Score: 404
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.4
    Marker Score: 245
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.39
    Marker Score: 1120
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.38
    Marker Score: 718
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 179
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 326.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.3
    Marker Score: 1994
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.29
    Marker Score: 281
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.29
    Marker Score: 70
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.27
    Marker Score: 122
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.25
    Marker Score: 112
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.25
    Marker Score: 112.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.25
    Marker Score: 844.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.24
    Marker Score: 117.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.23
    Marker Score: 103
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 116.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.22
    Marker Score: 1878
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.21
    Marker Score: 109
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.19
    Marker Score: 128
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.19
    Marker Score: 123.5
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.17
    Marker Score: 96
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 90
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 364
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.15
    Marker Score: 87
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.13
    Marker Score: 173
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1
    Marker Score: 74
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.09
    Marker Score: 118
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.09
    Marker Score: 40.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.09
    Marker Score: 75
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.08
    Marker Score: 61
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.08
    Marker Score: 34
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.08
    Marker Score: 53
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 87
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 74
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.07
    Marker Score: 39
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.07
    Marker Score: 21

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Other Information

**Key Characteristics:** TGM3 is a calcium-dependent enzyme that catalyzes the gamma-glutamyl transfer reaction, which involves the transfer of a gamma-glutamyl moiety from glutamine to a lysine residue in target proteins. This reaction is essential for various cellular processes, including protein cross-linking, peptide modification, and cellular differentiation. TGM3 is primarily expressed in epithelial cells, including those of the skin, gut, and respiratory tract, as well as in immune cells, such as innate lymphoid cells and granulocytes. **Pathways and Functions:** TGM3 is involved in several cellular pathways, including: 1. **Hair follicle morphogenesis**: TGM3 plays a crucial role in the development and maintenance of hair follicles by regulating the expression of key genes involved in hair growth. 2. **Keratinization**: TGM3 is essential for the process of keratinization, which involves the transformation of epithelial cells into keratinocytes, a process critical for skin barrier function. 3. **Immune cell development**: TGM3 is expressed in immature innate lymphoid cells and granulocytes, where it regulates the development and function of these cells. 4. **Cellular differentiation**: TGM3 is involved in the differentiation of various cell types, including epithelial cells, immune cells, and cardiac endothelial cells. **Clinical Significance:** TGM3 has been implicated in several diseases, including: 1. **Autoimmune diseases**: TGM3 has been linked to autoimmune diseases, such as psoriasis, where it plays a role in the pathogenesis of keratinocyte differentiation and immune cell function. 2. **Cancer**: TGM3 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it may contribute to tumor progression and metastasis. 3. **Neurological disorders**: TGM3 has been implicated in neurological disorders, such as Alzheimer's disease, where it may play a role in the pathogenesis of amyloid-beta peptide aggregation. 4. **Cardiovascular disease**: TGM3 has been found to be associated with cardiovascular disease, where it may contribute to the development of atherosclerosis and cardiac remodeling. In conclusion, TGM3 is a multifaceted enzyme that plays a crucial role in various cellular processes, including protein modification, cross-linking, and cellular differentiation. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the functions and pathogenic mechanisms of TGM3.

Genular Protein ID: 652829074

Symbol: TGM3_HUMAN

Name: Protein-glutamine gamma-glutamyltransferase E

UniProtKB Accession Codes:

Q08188 A8K5N6 B2RCR6 D3DVX1 O95933 Q32ML9 Q32MM0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 5 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 4 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8099584

Title: The deduced sequence of the novel protransglutaminase E (TGase3) of human and mouse.

PubMed ID: 8099584

DOI: 10.1016/s0021-9258(18)31442-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16565075

Title: Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.

PubMed ID: 16565075

DOI: 10.1074/jbc.m600694200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27866708

Title: Mutations in three genes encoding proteins involved in hair shaft formation cause uncombable hair syndrome.

PubMed ID: 27866708

DOI: 10.1016/j.ajhg.2016.10.004

PubMed ID: 11980702

Title: Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation.

PubMed ID: 11980702

DOI: 10.1093/emboj/21.9.2055

PubMed ID: 12679341

Title: Roles of calcium ions in the activation and activity of the transglutaminase 3 enzyme.

PubMed ID: 12679341

DOI: 10.1074/jbc.m301162200

Sequence Information:

  • Length: 693
  • Mass: 76632
  • Checksum: EAFAC0C9A8AA5FD6
  • Sequence:
    • MAALGVQSIN WQTAFNRQAH HTDKFSSQEL ILRRGQNFQV LMIMNKGLGS NERLEFIVST 
GPYPSESAMT KAVFPLSNGS SGGWSAVLQA SNGNTLTISI SSPASAPIGR YTMALQIFSQ 
GGISSVKLGT FILLFNPWLN VDSVFMGNHA EREEYVQEDA GIIFVGSTNR IGMIGWNFGQ 
FEEDILSICL SILDRSLNFR RDAATDVASR NDPKYVGRVL SAMINSNDDN GVLAGNWSGT 
YTGGRDPRSW NGSVEILKNW KKSGFSPVRY GQCWVFAGTL NTALRSLGIP SRVITNFNSA 
HDTDRNLSVD VYYDPMGNPL DKGSDSVWNF HVWNEGWFVR SDLGPSYGGW QVLDATPQER 
SQGVFQCGPA SVIGVREGDV QLNFDMPFIF AEVNADRITW LYDNTTGKQW KNSVNSHTIG 
RYISTKAVGS NARMDVTDKY KYPEGSDQER QVFQKALGKL KPNTPFAATS SMGLETEEQE 
PSIIGKLKVA GMLAVGKEVN LVLLLKNLSR DTKTVTVNMT AWTIIYNGTL VHEVWKDSAT 
MSLDPEEEAE HPIKISYAQY EKYLKSDNMI RITAVCKVPD ESEVVVERDI ILDNPTLTLE 
VLNEARVRKP VNVQMLFSNP LDEPVRDCVL MVEGSGLLLG NLKIDVPTLG PKEGSRVRFD 
ILPSRSGTKQ LLADFSCNKF PAIKAMLSID VAE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.