Details for: TM4SF4

Gene ID: 7104

Symbol: TM4SF4

Ensembl ID: ENSG00000169903

Description: transmembrane 4 L six family member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 34.8831
    Cell Significance Index: -14.3700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 8.2310
    Cell Significance Index: 31.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 6.3828
    Cell Significance Index: 95.6400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.2584
    Cell Significance Index: 32.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.1597
    Cell Significance Index: 53.2300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.3975
    Cell Significance Index: 18.1800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.0160
    Cell Significance Index: 18.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7235
    Cell Significance Index: 37.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3572
    Cell Significance Index: 39.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3378
    Cell Significance Index: 265.4900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.2190
    Cell Significance Index: 7.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2070
    Cell Significance Index: 119.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9923
    Cell Significance Index: 59.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9643
    Cell Significance Index: 156.8400
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.9381
    Cell Significance Index: 9.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7419
    Cell Significance Index: 15.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.5413
    Cell Significance Index: 61.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4891
    Cell Significance Index: 17.1900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3665
    Cell Significance Index: 5.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3497
    Cell Significance Index: 11.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2819
    Cell Significance Index: 30.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2606
    Cell Significance Index: 18.0300
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.1516
    Cell Significance Index: 0.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1234
    Cell Significance Index: 23.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1217
    Cell Significance Index: 12.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0618
    Cell Significance Index: 7.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0506
    Cell Significance Index: 27.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0391
    Cell Significance Index: 0.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0364
    Cell Significance Index: 6.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0340
    Cell Significance Index: 1.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0300
    Cell Significance Index: 27.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0187
    Cell Significance Index: 0.2600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0161
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0085
    Cell Significance Index: 1.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0034
    Cell Significance Index: 2.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0025
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0045
    Cell Significance Index: -0.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0052
    Cell Significance Index: -9.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0058
    Cell Significance Index: -3.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0069
    Cell Significance Index: -0.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0080
    Cell Significance Index: -10.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0111
    Cell Significance Index: -0.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0123
    Cell Significance Index: -0.6200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0150
    Cell Significance Index: -0.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0152
    Cell Significance Index: -9.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0161
    Cell Significance Index: -0.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0222
    Cell Significance Index: -7.9800
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0227
    Cell Significance Index: -0.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0231
    Cell Significance Index: -10.4900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0259
    Cell Significance Index: -0.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0310
    Cell Significance Index: -1.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0317
    Cell Significance Index: -5.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0352
    Cell Significance Index: -10.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0452
    Cell Significance Index: -9.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0467
    Cell Significance Index: -0.5300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0470
    Cell Significance Index: -0.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0498
    Cell Significance Index: -1.2800
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.0510
    Cell Significance Index: -0.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0516
    Cell Significance Index: -6.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0539
    Cell Significance Index: -7.8400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0541
    Cell Significance Index: -0.4800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0574
    Cell Significance Index: -0.9700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0577
    Cell Significance Index: -0.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0671
    Cell Significance Index: -9.2200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0775
    Cell Significance Index: -0.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0808
    Cell Significance Index: -10.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0854
    Cell Significance Index: -10.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0978
    Cell Significance Index: -10.1800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1160
    Cell Significance Index: -1.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1194
    Cell Significance Index: -3.2500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1208
    Cell Significance Index: -1.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1288
    Cell Significance Index: -8.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1308
    Cell Significance Index: -8.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1325
    Cell Significance Index: -8.3500
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1326
    Cell Significance Index: -1.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1358
    Cell Significance Index: -10.1200
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1404
    Cell Significance Index: -1.5700
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.1434
    Cell Significance Index: -1.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1490
    Cell Significance Index: -1.6200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1565
    Cell Significance Index: -8.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1603
    Cell Significance Index: -9.8500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1622
    Cell Significance Index: -2.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1622
    Cell Significance Index: -4.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1623
    Cell Significance Index: -4.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1687
    Cell Significance Index: -4.9700
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.1731
    Cell Significance Index: -1.0700
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.1814
    Cell Significance Index: -1.4100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1820
    Cell Significance Index: -1.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1862
    Cell Significance Index: -14.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1893
    Cell Significance Index: -3.1200
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.2085
    Cell Significance Index: -0.4800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2138
    Cell Significance Index: -2.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2140
    Cell Significance Index: -10.0600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2418
    Cell Significance Index: -1.5000
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.2459
    Cell Significance Index: -2.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2463
    Cell Significance Index: -13.8200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2476
    Cell Significance Index: -3.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TM4SF4 is a transmembrane protein composed of six L6 repeats, which are characteristic of the L6 family of proteins. The protein is heavily glycosylated, with N-glycans and O-glycans contributing to its overall structure and function. TM4SF4 is expressed in a wide range of cell types, including enterocytes, acinar cells, and pancreatic ductal cells, and is also found in primary sensory neurons and cardiac endothelial cells. The protein's ability to interact with other molecules, including ligands and receptors, suggests its involvement in cellular signaling and immune responses. **Pathways and Functions:** TM4SF4 is implicated in several cellular pathways, including: 1. **Tissue Regeneration:** TM4SF4 is involved in the regulation of tissue regeneration, particularly in the development and maintenance of epithelial tissues. The protein's expression in enterocytes, acinar cells, and pancreatic ductal cells suggests its role in maintaining the integrity of the epithelial barrier. 2. **Immune Function:** TM4SF4 is expressed in primary sensory neurons and cardiac endothelial cells, suggesting its involvement in immune responses and cellular signaling pathways. The protein's ability to interact with other molecules, including ligands and receptors, suggests its role in regulating immune responses. 3. **Cellular Signaling:** TM4SF4 is involved in cellular signaling pathways, including the regulation of cell proliferation, differentiation, and survival. The protein's expression in enterocytes and acinar cells suggests its role in regulating the development and maintenance of epithelial tissues. **Clinical Significance:** TM4SF4 has been implicated in several diseases, including: 1. **Inflammatory Bowel Disease (IBD):** TM4SF4 has been shown to play a role in the development and maintenance of the epithelial barrier in the gut, and its dysregulation has been implicated in IBD. 2. **Pancreatitis:** TM4SF4 has been shown to be involved in the regulation of pancreatic ductal cell function and the development of pancreatitis. 3. **Cardiovascular Disease:** TM4SF4 has been implicated in the regulation of immune responses and cellular signaling pathways in the cardiovascular system, and its dysregulation has been linked to cardiovascular disease. In conclusion, TM4SF4 is a crucial gene involved in tissue regeneration, immune function, and cellular signaling pathways. Its dysregulation has been implicated in several diseases, including IBD, pancreatitis, and cardiovascular disease. Further research is needed to fully elucidate the role of TM4SF4 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 405855231

Symbol: T4S4_HUMAN

Name: Transmembrane 4 L6 family member 4

UniProtKB Accession Codes:

P48230 B2RDA4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7665614

Title: A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation.

PubMed ID: 7665614

DOI: 10.1074/jbc.270.37.21907

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 202
  • Mass: 21396
  • Checksum: 402742A2F5F8598F
  • Sequence:
    • MCTGGCARCL GGTLIPLAFF GFLANILLFF PGGKVIDDND HLSQEIWFFG GILGSGVLMI 
FPALVFLGLK NNDCCGCCGN EGCGKRFAMF TSTIFAVVGF LGAGYSFIIS AISINKGPKC 
LMANSTWGYP FHDGDYLNDE ALWNKCREPL NVVPWNLTLF SILLVVGGIQ MVLCAIQVVN 
GLLGTLCGDC QCCGCCGGDG PV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.