Details for: TM4SF4

Gene ID: 7104

Symbol: TM4SF4

Ensembl ID: ENSG00000169903

Description: transmembrane 4 L six family member 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 4.05
    Marker Score: 6246
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.48
    Marker Score: 2452
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.16
    Marker Score: 1088
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.83
    Marker Score: 1055
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.57
    Marker Score: 8427
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.22
    Marker Score: 895
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.16
    Marker Score: 725
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.01
    Marker Score: 3808
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.89
    Marker Score: 1965
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.75
    Marker Score: 1038
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.54
    Marker Score: 1728
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.51
    Marker Score: 7253
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.5
    Marker Score: 3100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.46
    Marker Score: 6318
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.39
    Marker Score: 314
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.33
    Marker Score: 8522
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.21
    Marker Score: 6513
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.01
    Marker Score: 2062
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5333
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.92
    Marker Score: 265
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.8
    Marker Score: 547.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.77
    Marker Score: 740
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.75
    Marker Score: 354
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.74
    Marker Score: 384
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10988
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2908
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.69
    Marker Score: 672
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.64
    Marker Score: 685.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.64
    Marker Score: 139
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.63
    Marker Score: 158
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.63
    Marker Score: 301
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.62
    Marker Score: 235
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 385
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.56
    Marker Score: 243
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.55
    Marker Score: 554
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.54
    Marker Score: 141
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.53
    Marker Score: 526
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 316
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.51
    Marker Score: 140
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.49
    Marker Score: 119
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.48
    Marker Score: 127
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.43
    Marker Score: 106
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.39
    Marker Score: 821
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.38
    Marker Score: 379
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.37
    Marker Score: 194
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.33
    Marker Score: 106
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.32
    Marker Score: 152
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.31
    Marker Score: 115
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.3
    Marker Score: 162
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.29
    Marker Score: 74
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.28
    Marker Score: 91
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.28
    Marker Score: 86
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.28
    Marker Score: 87
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.26
    Marker Score: 248
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.26
    Marker Score: 603
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.25
    Marker Score: 195
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 112
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.25
    Marker Score: 156
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.22
    Marker Score: 93
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.22
    Marker Score: 100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.21
    Marker Score: 134
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.21
    Marker Score: 505
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.18
    Marker Score: 1216
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.18
    Marker Score: 2425
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.18
    Marker Score: 920
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 193
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.17
    Marker Score: 57
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.17
    Marker Score: 1054
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.16
    Marker Score: 90
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.16
    Marker Score: 253
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.16
    Marker Score: 98
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.15
    Marker Score: 88
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.15
    Marker Score: 104
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.15
    Marker Score: 43
  • Cell Name: GIP cell (CL0002278)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.14
    Marker Score: 47
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.13
    Marker Score: 473

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Other Information

**Key Characteristics:** TM4SF4 is a transmembrane protein composed of six L6 repeats, which are characteristic of the L6 family of proteins. The protein is heavily glycosylated, with N-glycans and O-glycans contributing to its overall structure and function. TM4SF4 is expressed in a wide range of cell types, including enterocytes, acinar cells, and pancreatic ductal cells, and is also found in primary sensory neurons and cardiac endothelial cells. The protein's ability to interact with other molecules, including ligands and receptors, suggests its involvement in cellular signaling and immune responses. **Pathways and Functions:** TM4SF4 is implicated in several cellular pathways, including: 1. **Tissue Regeneration:** TM4SF4 is involved in the regulation of tissue regeneration, particularly in the development and maintenance of epithelial tissues. The protein's expression in enterocytes, acinar cells, and pancreatic ductal cells suggests its role in maintaining the integrity of the epithelial barrier. 2. **Immune Function:** TM4SF4 is expressed in primary sensory neurons and cardiac endothelial cells, suggesting its involvement in immune responses and cellular signaling pathways. The protein's ability to interact with other molecules, including ligands and receptors, suggests its role in regulating immune responses. 3. **Cellular Signaling:** TM4SF4 is involved in cellular signaling pathways, including the regulation of cell proliferation, differentiation, and survival. The protein's expression in enterocytes and acinar cells suggests its role in regulating the development and maintenance of epithelial tissues. **Clinical Significance:** TM4SF4 has been implicated in several diseases, including: 1. **Inflammatory Bowel Disease (IBD):** TM4SF4 has been shown to play a role in the development and maintenance of the epithelial barrier in the gut, and its dysregulation has been implicated in IBD. 2. **Pancreatitis:** TM4SF4 has been shown to be involved in the regulation of pancreatic ductal cell function and the development of pancreatitis. 3. **Cardiovascular Disease:** TM4SF4 has been implicated in the regulation of immune responses and cellular signaling pathways in the cardiovascular system, and its dysregulation has been linked to cardiovascular disease. In conclusion, TM4SF4 is a crucial gene involved in tissue regeneration, immune function, and cellular signaling pathways. Its dysregulation has been implicated in several diseases, including IBD, pancreatitis, and cardiovascular disease. Further research is needed to fully elucidate the role of TM4SF4 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 405855231

Symbol: T4S4_HUMAN

Name: Transmembrane 4 L6 family member 4

UniProtKB Accession Codes:

P48230 B2RDA4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7665614

Title: A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation.

PubMed ID: 7665614

DOI: 10.1074/jbc.270.37.21907

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 202
  • Mass: 21396
  • Checksum: 402742A2F5F8598F
  • Sequence:
    • MCTGGCARCL GGTLIPLAFF GFLANILLFF PGGKVIDDND HLSQEIWFFG GILGSGVLMI 
FPALVFLGLK NNDCCGCCGN EGCGKRFAMF TSTIFAVVGF LGAGYSFIIS AISINKGPKC 
LMANSTWGYP FHDGDYLNDE ALWNKCREPL NVVPWNLTLF SILLVVGGIQ MVLCAIQVVN 
GLLGTLCGDC QCCGCCGGDG PV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.