Details for: UCN

Gene ID: 7349

Symbol: UCN

Ensembl ID: ENSG00000163794

Description: urocortin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 34.0737
    Cell Significance Index: -5.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.5801
    Cell Significance Index: -5.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.7552
    Cell Significance Index: -4.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.3311
    Cell Significance Index: -5.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.3533
    Cell Significance Index: -5.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.6351
    Cell Significance Index: -1.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5072
    Cell Significance Index: 96.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3471
    Cell Significance Index: 34.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2653
    Cell Significance Index: 239.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2581
    Cell Significance Index: 51.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1767
    Cell Significance Index: 19.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1713
    Cell Significance Index: 27.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1642
    Cell Significance Index: 9.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1030
    Cell Significance Index: 36.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0785
    Cell Significance Index: 4.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0749
    Cell Significance Index: 5.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0642
    Cell Significance Index: 1.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0614
    Cell Significance Index: 12.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0559
    Cell Significance Index: 1.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0469
    Cell Significance Index: 5.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0336
    Cell Significance Index: 2.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0310
    Cell Significance Index: 21.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0216
    Cell Significance Index: 1.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0190
    Cell Significance Index: 0.8600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.0149
    Cell Significance Index: 0.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0133
    Cell Significance Index: 0.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0066
    Cell Significance Index: 12.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0047
    Cell Significance Index: 2.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0046
    Cell Significance Index: 0.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0044
    Cell Significance Index: 0.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0041
    Cell Significance Index: 0.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0037
    Cell Significance Index: 0.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0033
    Cell Significance Index: 0.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0033
    Cell Significance Index: 1.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0010
    Cell Significance Index: -0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0028
    Cell Significance Index: -0.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0049
    Cell Significance Index: -3.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0051
    Cell Significance Index: -0.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0051
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -4.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0078
    Cell Significance Index: -4.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0084
    Cell Significance Index: -0.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0088
    Cell Significance Index: -4.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0093
    Cell Significance Index: -0.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0112
    Cell Significance Index: -2.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0112
    Cell Significance Index: -0.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0117
    Cell Significance Index: -0.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0119
    Cell Significance Index: -3.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0129
    Cell Significance Index: -0.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0138
    Cell Significance Index: -0.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0140
    Cell Significance Index: -2.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0144
    Cell Significance Index: -1.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0204
    Cell Significance Index: -0.3500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0249
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0255
    Cell Significance Index: -5.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0268
    Cell Significance Index: -3.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0272
    Cell Significance Index: -0.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0283
    Cell Significance Index: -2.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0293
    Cell Significance Index: -3.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0333
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0335
    Cell Significance Index: -3.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0340
    Cell Significance Index: -0.9500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0364
    Cell Significance Index: -0.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0418
    Cell Significance Index: -2.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0419
    Cell Significance Index: -4.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0448
    Cell Significance Index: -2.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0485
    Cell Significance Index: -3.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0490
    Cell Significance Index: -5.1000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0492
    Cell Significance Index: -0.6900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0512
    Cell Significance Index: -0.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0542
    Cell Significance Index: -1.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0574
    Cell Significance Index: -1.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0580
    Cell Significance Index: -0.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0585
    Cell Significance Index: -1.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0647
    Cell Significance Index: -3.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0681
    Cell Significance Index: -2.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0731
    Cell Significance Index: -4.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0733
    Cell Significance Index: -2.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0769
    Cell Significance Index: -1.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0773
    Cell Significance Index: -1.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0801
    Cell Significance Index: -2.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0835
    Cell Significance Index: -2.9300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0865
    Cell Significance Index: -1.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0872
    Cell Significance Index: -1.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0942
    Cell Significance Index: -2.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0996
    Cell Significance Index: -2.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1040
    Cell Significance Index: -2.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1062
    Cell Significance Index: -3.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1081
    Cell Significance Index: -3.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1165
    Cell Significance Index: -3.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1174
    Cell Significance Index: -1.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1203
    Cell Significance Index: -3.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1205
    Cell Significance Index: -4.9400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1315
    Cell Significance Index: -3.3600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1319
    Cell Significance Index: -1.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Peptide Hormone**: Urocortin is a member of the corticotropin-releasing hormone (CRH) family, which consists of six peptides: urocortin I, II, III, IV, V, and VI. Urocortin II is the most well-studied isoform, which is widely expressed in the brain and peripheral tissues. 2. **Receptor Binding**: Urocortin II binds to two receptors: CRHR1 and CRHR2. These receptors are G-protein coupled receptors that mediate various physiological responses, including stress response, appetite regulation, and social behavior. 3. **Expression in Immune Cells**: Urocortin is significantly expressed in various immune cells, including goblet cells, GABAergic interneurons, and intestinal epithelial cells. This suggests a potential role for urocortin in modulating immune responses. **Pathways and Functions:** 1. **Stress Response**: Urocortin is involved in the stress response, regulating the hypothalamic-pituitary-adrenal (HPA) axis. It stimulates the release of corticotropin-releasing hormone (CRH), which in turn activates the HPA axis, leading to the release of cortisol and other glucocorticoids. 2. **Appetite Regulation**: Urocortin regulates appetite by modulating the activity of the hypothalamus, which is involved in energy homeostasis. Urocortin II stimulates appetite, while CRHR1 and CRHR2 receptors inhibit appetite. 3. **Social Behavior**: Urocortin is involved in social behavior, regulating fear response and anxiety. Urocortin II stimulates the release of oxytocin, which is involved in social bonding and attachment. 4. **Immune Response**: Urocortin is involved in modulating immune responses, including the regulation of cytokine production, inflammation, and immune cell activation. **Clinical Significance:** 1. **Mood Disorders**: Alterations in urocortin expression and function have been linked to mood disorders, including depression and anxiety. 2. **Obesity**: Urocortin dysregulation has been implicated in obesity, as it regulates appetite and energy homeostasis. 3. **Autoimmune Diseases**: Urocortin has been shown to modulate immune responses, and alterations in urocortin expression have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Cancer**: Urocortin has been shown to regulate tumor growth and metastasis, and alterations in urocortin expression have been linked to cancer progression. In conclusion, urocortin is a multifaceted peptide hormone that plays a crucial role in various physiological processes, including stress response, appetite regulation, and social behavior. Its dysregulation has been implicated in various diseases, including mood disorders, obesity, autoimmune diseases, and cancer. Further research is needed to fully understand the immunological significance of urocortin and its potential therapeutic applications.

Genular Protein ID: 226727044

Symbol: UCN1_HUMAN

Name: Urocortin

UniProtKB Accession Codes:

P55089 Q6FG64

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 4 Ensembl 1 EvolutionaryTrace 1 GO 46 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8612563

Title: Cloning and characterization of human urocortin.

PubMed ID: 8612563

DOI: 10.1210/endo.137.5.8612563

PubMed ID: 9628819

Title: The structures of the mouse and human urocortin genes (Ucn and UCN).

PubMed ID: 9628819

DOI: 10.1006/geno.1998.5292

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10690896

Title: The skin produces urocortin.

PubMed ID: 10690896

DOI: 10.1210/jcem.85.2.6381

PubMed ID: 15531481

Title: Urocortin 1 in colonic mucosa in patients with ulcerative colitis.

PubMed ID: 15531481

DOI: 10.1210/jc.2004-0195

PubMed ID: 18052377

Title: Common and divergent structural features of a series of corticotropin releasing factor-related peptides.

PubMed ID: 18052377

DOI: 10.1021/ja0760933

PubMed ID: 20966082

Title: Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor.

PubMed ID: 20966082

DOI: 10.1074/jbc.m110.186072

Sequence Information:

  • Length: 124
  • Mass: 13458
  • Checksum: 4F765DA75DDD4A5E
  • Sequence:
    • MRQAGRAALL AALLLLVQLC PGSSQRSPEA AGVQDPSLRW SPGARNQGGG ARALLLLLAE 
RFPRRAGPGR LGLGTAGERP RRDNPSLSID LTFHLLRTLL ELARTQSQRE RAEQNRIIFD 
SVGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.