Details for: SCGB1A1

Gene ID: 7356

Symbol: SCGB1A1

Ensembl ID: ENSG00000149021

Description: secretoglobin family 1A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 32.1225
    Cell Significance Index: -13.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.6686
    Cell Significance Index: -13.0500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 9.9721
    Cell Significance Index: 102.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 8.3310
    Cell Significance Index: 6305.9400
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.9146
    Cell Significance Index: 8.6100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.9612
    Cell Significance Index: 12.1000
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.7225
    Cell Significance Index: 10.6600
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.6573
    Cell Significance Index: 13.7000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4899
    Cell Significance Index: 36.0900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.0082
    Cell Significance Index: 13.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6929
    Cell Significance Index: 85.2000
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.6573
    Cell Significance Index: 5.6600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.3367
    Cell Significance Index: 4.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1993
    Cell Significance Index: 35.9300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.1481
    Cell Significance Index: 1.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0663
    Cell Significance Index: 3.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0538
    Cell Significance Index: 29.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0428
    Cell Significance Index: 12.3200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0267
    Cell Significance Index: 0.1900
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.0235
    Cell Significance Index: 0.2300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0180
    Cell Significance Index: 0.2000
  • Cell Name: primary cultured cell (CL0000001)
    Fold Change: 0.0067
    Cell Significance Index: 0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0036
    Cell Significance Index: 1.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0038
    Cell Significance Index: -7.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0075
    Cell Significance Index: -0.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0089
    Cell Significance Index: -16.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0106
    Cell Significance Index: -16.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0166
    Cell Significance Index: -7.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0177
    Cell Significance Index: -11.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0183
    Cell Significance Index: -13.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0218
    Cell Significance Index: -13.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0236
    Cell Significance Index: -13.3300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0271
    Cell Significance Index: -0.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0317
    Cell Significance Index: -14.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0403
    Cell Significance Index: -8.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0522
    Cell Significance Index: -0.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0570
    Cell Significance Index: -11.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0586
    Cell Significance Index: -5.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0672
    Cell Significance Index: -9.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0715
    Cell Significance Index: -10.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0853
    Cell Significance Index: -14.5600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0861
    Cell Significance Index: -0.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0899
    Cell Significance Index: -4.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0905
    Cell Significance Index: -1.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0956
    Cell Significance Index: -9.9500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0983
    Cell Significance Index: -4.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0991
    Cell Significance Index: -11.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1292
    Cell Significance Index: -9.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1345
    Cell Significance Index: -15.4100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1432
    Cell Significance Index: -1.5600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1527
    Cell Significance Index: -1.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1579
    Cell Significance Index: -12.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1580
    Cell Significance Index: -5.8000
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.1605
    Cell Significance Index: -1.2600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1608
    Cell Significance Index: -1.3300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1659
    Cell Significance Index: -1.3100
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1738
    Cell Significance Index: -0.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1910
    Cell Significance Index: -12.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2100
    Cell Significance Index: -9.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2231
    Cell Significance Index: -13.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2336
    Cell Significance Index: -14.3200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2338
    Cell Significance Index: -2.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2359
    Cell Significance Index: -14.8700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.2370
    Cell Significance Index: -1.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2392
    Cell Significance Index: -13.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2598
    Cell Significance Index: -13.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2763
    Cell Significance Index: -7.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2783
    Cell Significance Index: -13.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2873
    Cell Significance Index: -12.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2929
    Cell Significance Index: -10.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3041
    Cell Significance Index: -13.7900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.3186
    Cell Significance Index: -1.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3368
    Cell Significance Index: -12.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3448
    Cell Significance Index: -11.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3498
    Cell Significance Index: -11.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3680
    Cell Significance Index: -9.4600
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: -0.3727
    Cell Significance Index: -2.4000
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: -0.3778
    Cell Significance Index: -2.7400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3784
    Cell Significance Index: -9.6400
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.3793
    Cell Significance Index: -3.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3820
    Cell Significance Index: -7.0600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3833
    Cell Significance Index: -9.5600
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.3938
    Cell Significance Index: -1.3700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3983
    Cell Significance Index: -3.0700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4001
    Cell Significance Index: -6.8400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.4011
    Cell Significance Index: -0.9000
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.4083
    Cell Significance Index: -0.7900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.4098
    Cell Significance Index: -3.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4298
    Cell Significance Index: -6.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4314
    Cell Significance Index: -15.1600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4337
    Cell Significance Index: -4.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4359
    Cell Significance Index: -12.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4535
    Cell Significance Index: -9.6300
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: -0.4574
    Cell Significance Index: -4.4900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4595
    Cell Significance Index: -9.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4619
    Cell Significance Index: -13.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4640
    Cell Significance Index: -13.3000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4748
    Cell Significance Index: -11.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SCGB1A1 gene is a non-coding gene that encodes for the uteroglobin protein. This protein is a secreted glycoprotein that is primarily expressed in the uterus during pregnancy. The SCGB1A1 gene is highly conserved across species, suggesting its evolutionary importance. The protein has been shown to possess anti-inflammatory properties, and its expression is regulated by various signaling pathways, including those involved in cytokine production and T cell proliferation. **Pathways and Functions:** The SCGB1A1 gene is involved in several key pathways, including: 1. **Negative regulation of interleukin-4, 5, and 13 production:** SCGB1A1 has been shown to inhibit the production of these pro-inflammatory cytokines, which are involved in the regulation of immune responses. 2. **Negative regulation of T cell proliferation:** The SCGB1A1 protein has been shown to inhibit T cell proliferation, which is a key step in the development of immune responses. 3. **Negative regulation of transcription by RNA polymerase II:** SCGB1A1 has been shown to inhibit the transcription of genes involved in inflammation, including those involved in cytokine production. 4. **Phospholipase A2 inhibitor activity:** The SCGB1A1 protein has been shown to possess phospholipase A2 inhibitor activity, which suggests its potential role in modulating inflammatory responses. 5. **Regulation of inflammatory response:** SCGB1A1 has been shown to regulate the inflammatory response by inhibiting the production of pro-inflammatory cytokines and promoting the production of anti-inflammatory cytokines. **Clinical Significance:** The SCGB1A1 gene has been implicated in various clinical conditions, including: 1. **Pregnancy complications:** SCGB1A1 has been shown to play a crucial role in regulating immune responses during pregnancy, and its dysregulation has been implicated in pregnancy complications, including preeclampsia and preterm labor. 2. **Asthma and chronic obstructive pulmonary disease (COPD):** SCGB1A1 has been shown to possess anti-inflammatory properties, and its expression has been found to be decreased in patients with asthma and COPD. 3. **Cancer:** SCGB1A1 has been shown to possess anti-tumor properties, and its expression has been found to be decreased in various types of cancer, including breast, lung, and colon cancer. In conclusion, the SCGB1A1 gene plays a crucial role in regulating immune responses, particularly in the context of pregnancy and inflammation. Its dysregulation has been implicated in various clinical conditions, including pregnancy complications, asthma, and cancer. Further research is needed to fully understand the mechanisms by which SCGB1A1 regulates immune responses and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 871660389

Symbol: UTER_HUMAN

Name: Uteroglobin

UniProtKB Accession Codes:

P11684 B2R5F2 Q6FHH3 Q9UCM2 Q9UCM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3167058

Title: Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein.

PubMed ID: 3167058

DOI: 10.1016/0167-4781(88)90129-7

PubMed ID: 7733299

Title: Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease.

PubMed ID: 7733299

DOI: 10.1152/ajplung.1995.268.4.l565

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1284526

Title: Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines.

PubMed ID: 1284526

DOI: 10.1093/hmg/1.6.371

PubMed ID: 1400743

Title: Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein.

PubMed ID: 1400743

DOI: 10.1016/0378-4347(92)80595-h

PubMed ID: 1395029

Title: Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions.

PubMed ID: 1395029

DOI: 10.1016/0009-8981(92)90122-7

PubMed ID: 11788998

Title: Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting.

PubMed ID: 11788998

DOI: 10.1002/1615-9861(200201)2:1<112::aid-prot112>3.3.co;2-e

PubMed ID: 16423471

Title: Interaction of uteroglobin with lipocalin-1 receptor suppresses cancer cell motility and invasion.

PubMed ID: 16423471

DOI: 10.1016/j.gene.2005.10.027

PubMed ID: 23964685

Title: Expression, characterization and ligand specificity of lipocalin-1 interacting membrane receptor (LIMR).

PubMed ID: 23964685

DOI: 10.3109/09687688.2013.823018

PubMed ID: 7664082

Title: Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9-A resolution.

PubMed ID: 7664082

DOI: 10.1038/nsb0894-538

Sequence Information:

  • Length: 91
  • Mass: 9994
  • Checksum: FE65ACA678F12ABD
  • Sequence:
    • MKLAVTLTLV TLALCCSSAS AEICPSFQRV IETLLMDTPS SYEAAMELFS PDQDMREAGA 
QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.