Details for: SCGB1A1

Gene ID: 7356

Symbol: SCGB1A1

Ensembl ID: ENSG00000149021

Description: secretoglobin family 1A member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 4.95
    Marker Score: 6418
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.66
    Marker Score: 3979
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 3.33
    Marker Score: 914
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 3.27
    Marker Score: 1611
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.85
    Marker Score: 3323
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.85
    Marker Score: 5195
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.46
    Marker Score: 710
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.37
    Marker Score: 4093
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.37
    Marker Score: 2550
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.26
    Marker Score: 5746
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.21
    Marker Score: 1997
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.14
    Marker Score: 18626
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.13
    Marker Score: 3090
  • Cell Name: monocyte (CL0000576)
    Fold Change: 2.09
    Marker Score: 2712
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.03
    Marker Score: 5264
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.95
    Marker Score: 2153.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.91
    Marker Score: 2122
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.83
    Marker Score: 466
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.81
    Marker Score: 749
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.77
    Marker Score: 982
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.71
    Marker Score: 2366
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.68
    Marker Score: 798
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.54
    Marker Score: 1986
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.54
    Marker Score: 808.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.48
    Marker Score: 1779
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.41
    Marker Score: 406
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.41
    Marker Score: 4106
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.34
    Marker Score: 599
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.3
    Marker Score: 1600.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.29
    Marker Score: 802
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.28
    Marker Score: 1215
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.27
    Marker Score: 2409
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.25
    Marker Score: 1818
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.24
    Marker Score: 721
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.24
    Marker Score: 1996
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.24
    Marker Score: 2359.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.24
    Marker Score: 263
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.2
    Marker Score: 1338
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.2
    Marker Score: 500
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.18
    Marker Score: 687
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.15
    Marker Score: 6036
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.14
    Marker Score: 18294
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.12
    Marker Score: 680
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.1
    Marker Score: 752
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.06
    Marker Score: 944
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.05
    Marker Score: 6864
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71687
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47905
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.98
    Marker Score: 528
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30396
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.98
    Marker Score: 5942
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.96
    Marker Score: 292
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.94
    Marker Score: 1911
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.93
    Marker Score: 2639
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5292
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.93
    Marker Score: 619
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.92
    Marker Score: 632
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.91
    Marker Score: 786
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.9
    Marker Score: 2797
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.88
    Marker Score: 2309.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5256
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.86
    Marker Score: 22148
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.86
    Marker Score: 2067
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.85
    Marker Score: 859
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.84
    Marker Score: 1343
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.79
    Marker Score: 5854
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.77
    Marker Score: 532
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.75
    Marker Score: 172
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1189
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.74
    Marker Score: 488
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.74
    Marker Score: 520
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.74
    Marker Score: 216
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 708
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.71
    Marker Score: 390
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.7
    Marker Score: 170
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.7
    Marker Score: 186
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.69
    Marker Score: 1993.5
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.69
    Marker Score: 317
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.69
    Marker Score: 618
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.68
    Marker Score: 169
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.68
    Marker Score: 782
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.68
    Marker Score: 192
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.67
    Marker Score: 10526
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.66
    Marker Score: 266
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.66
    Marker Score: 552.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.65
    Marker Score: 811
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.65
    Marker Score: 171
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.64
    Marker Score: 160
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.64
    Marker Score: 160
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.61
    Marker Score: 238
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.61
    Marker Score: 481
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.61
    Marker Score: 357
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.6
    Marker Score: 152.5

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Other Information

**Key Characteristics:** The SCGB1A1 gene is a non-coding gene that encodes for the uteroglobin protein. This protein is a secreted glycoprotein that is primarily expressed in the uterus during pregnancy. The SCGB1A1 gene is highly conserved across species, suggesting its evolutionary importance. The protein has been shown to possess anti-inflammatory properties, and its expression is regulated by various signaling pathways, including those involved in cytokine production and T cell proliferation. **Pathways and Functions:** The SCGB1A1 gene is involved in several key pathways, including: 1. **Negative regulation of interleukin-4, 5, and 13 production:** SCGB1A1 has been shown to inhibit the production of these pro-inflammatory cytokines, which are involved in the regulation of immune responses. 2. **Negative regulation of T cell proliferation:** The SCGB1A1 protein has been shown to inhibit T cell proliferation, which is a key step in the development of immune responses. 3. **Negative regulation of transcription by RNA polymerase II:** SCGB1A1 has been shown to inhibit the transcription of genes involved in inflammation, including those involved in cytokine production. 4. **Phospholipase A2 inhibitor activity:** The SCGB1A1 protein has been shown to possess phospholipase A2 inhibitor activity, which suggests its potential role in modulating inflammatory responses. 5. **Regulation of inflammatory response:** SCGB1A1 has been shown to regulate the inflammatory response by inhibiting the production of pro-inflammatory cytokines and promoting the production of anti-inflammatory cytokines. **Clinical Significance:** The SCGB1A1 gene has been implicated in various clinical conditions, including: 1. **Pregnancy complications:** SCGB1A1 has been shown to play a crucial role in regulating immune responses during pregnancy, and its dysregulation has been implicated in pregnancy complications, including preeclampsia and preterm labor. 2. **Asthma and chronic obstructive pulmonary disease (COPD):** SCGB1A1 has been shown to possess anti-inflammatory properties, and its expression has been found to be decreased in patients with asthma and COPD. 3. **Cancer:** SCGB1A1 has been shown to possess anti-tumor properties, and its expression has been found to be decreased in various types of cancer, including breast, lung, and colon cancer. In conclusion, the SCGB1A1 gene plays a crucial role in regulating immune responses, particularly in the context of pregnancy and inflammation. Its dysregulation has been implicated in various clinical conditions, including pregnancy complications, asthma, and cancer. Further research is needed to fully understand the mechanisms by which SCGB1A1 regulates immune responses and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 871660389

Symbol: UTER_HUMAN

Name: Uteroglobin

UniProtKB Accession Codes:

P11684 B2R5F2 Q6FHH3 Q9UCM2 Q9UCM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3167058

Title: Amino-acid and cDNA nucleotide sequences of human Clara cell 10 kDa protein.

PubMed ID: 3167058

DOI: 10.1016/0167-4781(88)90129-7

PubMed ID: 7733299

Title: Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease.

PubMed ID: 7733299

DOI: 10.1152/ajplung.1995.268.4.l565

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1284526

Title: Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines.

PubMed ID: 1284526

DOI: 10.1093/hmg/1.6.371

PubMed ID: 1400743

Title: Simple and high-yield purification of urine protein 1 using immunoaffinity chromatography: evidence for the identity of urine protein 1 and human Clara cell 10-kilodalton protein.

PubMed ID: 1400743

DOI: 10.1016/0378-4347(92)80595-h

PubMed ID: 1395029

Title: Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions.

PubMed ID: 1395029

DOI: 10.1016/0009-8981(92)90122-7

PubMed ID: 11788998

Title: Newly identified proteins in human nasal lavage fluid from non-smokers and smokers using two-dimensional gel electrophoresis and peptide mass fingerprinting.

PubMed ID: 11788998

DOI: 10.1002/1615-9861(200201)2:1<112::aid-prot112>3.3.co;2-e

PubMed ID: 16423471

Title: Interaction of uteroglobin with lipocalin-1 receptor suppresses cancer cell motility and invasion.

PubMed ID: 16423471

DOI: 10.1016/j.gene.2005.10.027

PubMed ID: 23964685

Title: Expression, characterization and ligand specificity of lipocalin-1 interacting membrane receptor (LIMR).

PubMed ID: 23964685

DOI: 10.3109/09687688.2013.823018

PubMed ID: 7664082

Title: Structure of a human Clara cell phospholipid-binding protein-ligand complex at 1.9-A resolution.

PubMed ID: 7664082

DOI: 10.1038/nsb0894-538

Sequence Information:

  • Length: 91
  • Mass: 9994
  • Checksum: FE65ACA678F12ABD
  • Sequence:
    • MKLAVTLTLV TLALCCSSAS AEICPSFQRV IETLLMDTPS SYEAAMELFS PDQDMREAGA 
QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.