Details for: WNT7A

Gene ID: 7476

Symbol: WNT7A

Ensembl ID: ENSG00000154764

Description: Wnt family member 7A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3630
    Cell Significance Index: 198.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3013
    Cell Significance Index: 108.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2929
    Cell Significance Index: 7.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1306
    Cell Significance Index: 26.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1070
    Cell Significance Index: 145.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0160
    Cell Significance Index: 11.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0133
    Cell Significance Index: 0.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0123
    Cell Significance Index: 0.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0078
    Cell Significance Index: -3.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0087
    Cell Significance Index: -16.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0112
    Cell Significance Index: -17.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0116
    Cell Significance Index: -21.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0193
    Cell Significance Index: -12.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0213
    Cell Significance Index: -15.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0219
    Cell Significance Index: -16.6000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0241
    Cell Significance Index: -0.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0276
    Cell Significance Index: -4.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0281
    Cell Significance Index: -15.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0327
    Cell Significance Index: -4.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0362
    Cell Significance Index: -16.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0385
    Cell Significance Index: -0.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0403
    Cell Significance Index: -1.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0565
    Cell Significance Index: -16.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0691
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0814
    Cell Significance Index: -13.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0822
    Cell Significance Index: -5.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0840
    Cell Significance Index: -12.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0849
    Cell Significance Index: -16.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0958
    Cell Significance Index: -13.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1049
    Cell Significance Index: -12.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1153
    Cell Significance Index: -11.7800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1369
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1502
    Cell Significance Index: -17.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2021
    Cell Significance Index: -10.5300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2068
    Cell Significance Index: -3.2000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2306
    Cell Significance Index: -2.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2414
    Cell Significance Index: -16.2300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2616
    Cell Significance Index: -1.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2685
    Cell Significance Index: -5.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2769
    Cell Significance Index: -12.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2905
    Cell Significance Index: -12.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3040
    Cell Significance Index: -17.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3211
    Cell Significance Index: -12.1600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3316
    Cell Significance Index: -3.1500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.3374
    Cell Significance Index: -0.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3652
    Cell Significance Index: -11.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3741
    Cell Significance Index: -11.0200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3768
    Cell Significance Index: -5.2100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3810
    Cell Significance Index: -9.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3861
    Cell Significance Index: -12.6400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3910
    Cell Significance Index: -9.4700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4041
    Cell Significance Index: -12.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4042
    Cell Significance Index: -14.1600
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.4119
    Cell Significance Index: -4.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4132
    Cell Significance Index: -9.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4203
    Cell Significance Index: -8.3100
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.4319
    Cell Significance Index: -3.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4411
    Cell Significance Index: -9.5300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4659
    Cell Significance Index: -2.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4794
    Cell Significance Index: -22.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5124
    Cell Significance Index: -16.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5162
    Cell Significance Index: -18.9500
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.5164
    Cell Significance Index: -5.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5174
    Cell Significance Index: -5.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5188
    Cell Significance Index: -8.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5275
    Cell Significance Index: -27.4000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5354
    Cell Significance Index: -21.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5368
    Cell Significance Index: -15.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5510
    Cell Significance Index: -25.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5771
    Cell Significance Index: -16.4700
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.5803
    Cell Significance Index: -5.6300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6175
    Cell Significance Index: -13.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6266
    Cell Significance Index: -16.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6281
    Cell Significance Index: -16.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6435
    Cell Significance Index: -16.9200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.6475
    Cell Significance Index: -7.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6649
    Cell Significance Index: -16.9400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6680
    Cell Significance Index: -7.6500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.6684
    Cell Significance Index: -16.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6694
    Cell Significance Index: -18.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6747
    Cell Significance Index: -16.8300
  • Cell Name: lung interstitial macrophage (CL4033043)
    Fold Change: -0.6866
    Cell Significance Index: -6.6200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.6964
    Cell Significance Index: -14.1700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7152
    Cell Significance Index: -12.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7162
    Cell Significance Index: -20.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7315
    Cell Significance Index: -13.5200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7332
    Cell Significance Index: -14.7200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7472
    Cell Significance Index: -18.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7499
    Cell Significance Index: -12.5500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.7532
    Cell Significance Index: -10.0400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.7552
    Cell Significance Index: -15.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7600
    Cell Significance Index: -16.1300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7641
    Cell Significance Index: -14.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7894
    Cell Significance Index: -10.7700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7901
    Cell Significance Index: -16.4900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7924
    Cell Significance Index: -11.2800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.8038
    Cell Significance Index: -10.1800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.8206
    Cell Significance Index: -13.2900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.8211
    Cell Significance Index: -11.0800
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.8354
    Cell Significance Index: -5.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Wnt family member**: WNT7A is a member of the Wnt family of genes, which are known for their involvement in various cellular processes, including cell fate determination and signaling pathways. 2. **Significant expression**: WNT7A is significantly expressed in multiple cell types, including blood vessel endothelial cells, cardiac endothelial cells, and stem cells. 3. **Multiple signaling pathways**: WNT7A is involved in various signaling pathways, including the canonical Wnt signaling pathway, planar cell polarity pathway, and the Wnt ligand biogenesis and trafficking pathway. 4. **Cell fate determination**: WNT7A plays a role in determining cell fate, including cell proliferation, differentiation, and migration. **Pathways and Functions:** 1. **Canonical Wnt signaling pathway**: WNT7A is involved in the canonical Wnt signaling pathway, which regulates cell proliferation, differentiation, and migration. 2. **Planar cell polarity pathway**: WNT7A is also involved in the planar cell polarity pathway, which regulates cell polarity and the establishment of blood-brain barrier. 3. **Wnt ligand biogenesis and trafficking**: WNT7A is involved in the biogenesis and trafficking of Wnt ligands, which are essential for Wnt signaling. 4. **Cell polarity**: WNT7A regulates cell polarity, which is essential for the proper functioning of cells, including blood vessel endothelial cells and cardiac endothelial cells. 5. **Neurogenesis**: WNT7A is involved in neurogenesis, including the differentiation of cerebral cortex GABAergic interneurons and forebrain radial glial cells. **Clinical Significance:** 1. **Cancer**: Abnormal expression of WNT7A has been linked to various cancers, including breast cancer, colon cancer, and lung cancer. 2. **Cardiovascular disorders**: WNT7A has been implicated in cardiovascular disorders, including atherosclerosis and cardiac hypertrophy. 3. **Neurological conditions**: WNT7A has been linked to various neurological conditions, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 4. **Developmental disorders**: WNT7A has been implicated in developmental disorders, including Down syndrome and neural tube defects. 5. **Regenerative medicine**: WNT7A has potential applications in regenerative medicine, including the activation of skeletal muscle satellite cells and the maintenance of stem cell populations. In conclusion, WNT7A is a key player in various cellular processes, including cell fate determination, proliferation, differentiation, and migration. Its involvement in multiple signaling pathways and its significant expression in various cell types make it an important gene in understanding disease mechanisms and developing therapeutic strategies.

Genular Protein ID: 121076670

Symbol: WNT7A_HUMAN

Name: Protein Wnt-7a

UniProtKB Accession Codes:

O00755 Q96H90 Q9Y560

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 2 Ensembl 1 EvolutionaryTrace 1 GO 73 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9161407

Title: Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25.

PubMed ID: 9161407

DOI: 10.1016/s0378-1119(96)00808-6

PubMed ID: 8893824

Title: Isolation, characterization and chromosomal assignment of the human WNT7A gene.

PubMed ID: 8893824

DOI: 10.1159/000134404

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8168088

Title: Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.

PubMed ID: 8168088

PubMed ID: 26902720

Title: Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/alpha-albumin.

PubMed ID: 26902720

DOI: 10.7554/elife.11621

PubMed ID: 30026314

Title: A molecular mechanism for Wnt ligand-specific signaling.

PubMed ID: 30026314

DOI: 10.1126/science.aat1178

PubMed ID: 25731175

Title: Notum deacylates Wnt proteins to suppress signalling activity.

PubMed ID: 25731175

DOI: 10.1038/nature14259

PubMed ID: 16826533

Title: Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome.

PubMed ID: 16826533

DOI: 10.1086/506332

PubMed ID: 17431918

Title: Al-Awadi/Raas-Rothschild syndrome: two new cases and review.

PubMed ID: 17431918

DOI: 10.1002/ajmg.a.31712

PubMed ID: 20949531

Title: A novel homozygous Arg222Trp missense mutation in WNT7A in two sisters with severe Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome.

PubMed ID: 20949531

DOI: 10.1002/ajmg.a.33673

PubMed ID: 21271649

Title: Al-Awadi-Raas-Rothschild (limb/pelvis/uterus-hypoplasia/aplasia) syndrome and WNT7A mutations: genetic homogeneity and nosological delineation.

PubMed ID: 21271649

DOI: 10.1002/ajmg.a.33793

PubMed ID: 27638328

Title: A novel missense mutation, p.(R102W) in WNT7A causes Al-Awadi Raas-Rothschild syndrome in a fetus.

PubMed ID: 27638328

DOI: 10.1016/j.ejmg.2016.09.009

PubMed ID: 26908622

Title: A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma.

PubMed ID: 26908622

DOI: 10.1093/hmg/ddw020

Sequence Information:

  • Length: 349
  • Mass: 39005
  • Checksum: 259EF506CFCD7AB0
  • Sequence:
    • MNRKARRCLG HLFLSLGMVY LRIGGFSSVV ALGASIICNK IPGLAPRQRA ICQSRPDAII 
VIGEGSQMGL DECQFQFRNG RWNCSALGER TVFGKELKVG SREAAFTYAI IAAGVAHAIT 
AACTQGNLSD CGCDKEKQGQ YHRDEGWKWG GCSADIRYGI GFAKVFVDAR EIKQNARTLM 
NLHNNEAGRK ILEENMKLEC KCHGVSGSCT TKTCWTTLPQ FRELGYVLKD KYNEAVHVEP 
VRASRNKRPT FLKIKKPLSY RKPMDTDLVY IEKSPNYCEE DPVTGSVGTQ GRACNKTAPQ 
ASGCDLMCCG RGYNTHQYAR VWQCNCKFHW CCYVKCNTCS ERTEMYTCK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.