Details for: XG

Gene ID: 7499

Symbol: XG

Ensembl ID: ENSG00000124343

Description: Xg glycoprotein (Xg blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.2519
    Cell Significance Index: -4.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.5513
    Cell Significance Index: -5.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.5690
    Cell Significance Index: -4.7000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 9.3130
    Cell Significance Index: 61.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.0634
    Cell Significance Index: -5.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.9126
    Cell Significance Index: 125.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8198
    Cell Significance Index: -8.3600
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.3794
    Cell Significance Index: 21.5300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.4751
    Cell Significance Index: 16.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9788
    Cell Significance Index: 186.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7446
    Cell Significance Index: 10.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6849
    Cell Significance Index: 67.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5794
    Cell Significance Index: 12.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5589
    Cell Significance Index: 504.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4210
    Cell Significance Index: 10.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4138
    Cell Significance Index: 20.9100
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.4133
    Cell Significance Index: 2.3700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3866
    Cell Significance Index: 42.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3819
    Cell Significance Index: 62.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3259
    Cell Significance Index: 6.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2712
    Cell Significance Index: 3.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2635
    Cell Significance Index: 116.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2545
    Cell Significance Index: 15.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2529
    Cell Significance Index: 7.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2422
    Cell Significance Index: 6.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2210
    Cell Significance Index: 15.6300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1915
    Cell Significance Index: 13.2500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1208
    Cell Significance Index: 2.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1184
    Cell Significance Index: 23.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0961
    Cell Significance Index: 2.7700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0807
    Cell Significance Index: 1.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0784
    Cell Significance Index: 1.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0510
    Cell Significance Index: 3.9200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0279
    Cell Significance Index: 0.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0278
    Cell Significance Index: 5.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0236
    Cell Significance Index: 0.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0233
    Cell Significance Index: 8.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0172
    Cell Significance Index: 0.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0070
    Cell Significance Index: 12.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0039
    Cell Significance Index: 7.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0026
    Cell Significance Index: 1.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0010
    Cell Significance Index: 0.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0006
    Cell Significance Index: 0.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0057
    Cell Significance Index: -3.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0075
    Cell Significance Index: -0.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0083
    Cell Significance Index: -5.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0093
    Cell Significance Index: -4.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0100
    Cell Significance Index: -1.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0105
    Cell Significance Index: -3.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0115
    Cell Significance Index: -0.2500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0139
    Cell Significance Index: -0.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0148
    Cell Significance Index: -0.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0189
    Cell Significance Index: -0.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0195
    Cell Significance Index: -0.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0229
    Cell Significance Index: -3.3300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0238
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0260
    Cell Significance Index: -5.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0274
    Cell Significance Index: -4.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0275
    Cell Significance Index: -3.3800
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.0297
    Cell Significance Index: -0.3000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0349
    Cell Significance Index: -0.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0385
    Cell Significance Index: -4.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0422
    Cell Significance Index: -5.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0425
    Cell Significance Index: -4.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0449
    Cell Significance Index: -3.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0460
    Cell Significance Index: -2.1600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0477
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0479
    Cell Significance Index: -5.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0482
    Cell Significance Index: -5.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0516
    Cell Significance Index: -5.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0530
    Cell Significance Index: -5.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0628
    Cell Significance Index: -1.5200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0643
    Cell Significance Index: -0.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0645
    Cell Significance Index: -4.0700
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0684
    Cell Significance Index: -0.4300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0684
    Cell Significance Index: -0.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0691
    Cell Significance Index: -5.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0703
    Cell Significance Index: -4.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0794
    Cell Significance Index: -0.4800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0842
    Cell Significance Index: -1.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0874
    Cell Significance Index: -0.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0933
    Cell Significance Index: -2.5400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0936
    Cell Significance Index: -1.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0968
    Cell Significance Index: -2.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0969
    Cell Significance Index: -4.5200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0993
    Cell Significance Index: -3.1400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1010
    Cell Significance Index: -1.6700
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.1039
    Cell Significance Index: -0.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1050
    Cell Significance Index: -3.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1056
    Cell Significance Index: -5.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1075
    Cell Significance Index: -3.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1079
    Cell Significance Index: -2.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1201
    Cell Significance Index: -3.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1248
    Cell Significance Index: -5.5200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1295
    Cell Significance Index: -1.8600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1297
    Cell Significance Index: -3.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The XG glycoprotein is a transmembrane glycoprotein, primarily expressed on the surface of various cell types, including retinal bipolar neurons, mesenchymal stem cells, corneal epithelial cells, and granulocyte-monocyte progenitor cells. Its unique structure, comprising a glycosylated extracellular domain and a transmembrane domain, enables it to interact with other molecules, facilitating cell-cell adhesion and signaling. Notably, the XG glycoprotein is also involved in the regulation of neutrophil and T cell extravasation, highlighting its role in immune responses. **Pathways and Functions:** The XG glycoprotein is involved in several key biological pathways, including: 1. **Homotypic cell-cell adhesion:** The XG glycoprotein interacts with other adhesion molecules, such as selectins and integrins, to facilitate cell-cell interactions and tissue morphogenesis. 2. **Positive regulation of neutrophil extravasation:** The XG glycoprotein plays a crucial role in the recruitment of neutrophils to sites of inflammation, promoting their extravasation and tissue repair. 3. **T cell extravasation:** The XG glycoprotein is also involved in the regulation of T cell migration and extravasation, which is essential for immune responses and tissue homeostasis. **Clinical Significance:** The XG glycoprotein's involvement in immune cell adhesion and extravasation has significant implications for various diseases, including: 1. **Inflammatory disorders:** The dysregulation of XG glycoprotein expression or function may contribute to the development of inflammatory diseases, such as atherosclerosis, arthritis, and inflammatory bowel disease. 2. **Immune-mediated disorders:** The XG glycoprotein's role in T cell extravasation may also contribute to the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** The XG glycoprotein's expression on tumor cells and its involvement in immune cell adhesion may also have implications for cancer progression and treatment. In conclusion, the XG glycoprotein is a complex molecule with multiple roles in immune cell adhesion, extravasation, and cell-cell interactions. Further studies are needed to fully elucidate its functions and clinical significance, but its involvement in various biological processes highlights its importance as a potential therapeutic target for various diseases.

Genular Protein ID: 3764702104

Symbol: XG_HUMAN

Name: Glycoprotein Xg

UniProtKB Accession Codes:

P55808 E9PCH1 Q496N8 Q496N9 Q496P0 Q71BZ5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8054981

Title: Cloning of PBDX, an MIC2-related gene that spans the pseudoautosomal boundary on chromosome Xp.

PubMed ID: 8054981

DOI: 10.1038/ng0494-394

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7533029

Title: PBDX is the XG blood group gene.

PubMed ID: 7533029

DOI: 10.1038/ng1194-285

PubMed ID: 10688843

Title: A study of the coregulation and tissue specificity of XG and MIC2 gene expression in eukaryotic cells.

PubMed ID: 10688843

Sequence Information:

  • Length: 180
  • Mass: 19723
  • Checksum: DADAA9E6859C4530
  • Sequence:
    • MESWWGLPCL AFLCFLMHAR GQRDFDLADA LDDPEPTKKP NSDIYPKPKP PYYPQPENPD 
SGGNIYPRPK PRPQPQPGNS GNSGGYFNDV DRDDGRYPPR PRPRPPAGGG GGGYSSYGNS 
DNTHGGDHHS TYGNPEGNMV AKIVSPIVSV VVVTLLGAAA SYFKLNNRRN CFRTHEPENV

Genular Protein ID: 3013084774

Symbol: B4E289_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E289

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 3 SAM 3

Sequence Information:

  • Length: 195
  • Mass: 21471
  • Checksum: 316800313A981FD1
  • Sequence:
    • MESWWGLPCL AFLCFLMHAR GQRDFDLADA LYDPEPTKKP NSDIYPKPKP PYYPQPENPD 
SGGNIYPRPK PRPQPQPGNS GNSGGYFNDV DRDDGRYPPR PRPRPPAGGG GGGYSSYGNS 
DNTHGRGGYR PNSRYGNTYG GDHHSTYGNP EGNMVAKIVS PIVSVVVVTL LGAAASYFKL 
NNRRNCFRTH EPENV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.