Details for: RNF112

Gene ID: 7732

Symbol: RNF112

Ensembl ID: ENSG00000128482

Description: ring finger protein 112

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3212
    Cell Significance Index: 42.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2807
    Cell Significance Index: 27.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8063
    Cell Significance Index: 23.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5580
    Cell Significance Index: 24.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5393
    Cell Significance Index: 36.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5329
    Cell Significance Index: 20.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5317
    Cell Significance Index: 106.6500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.4715
    Cell Significance Index: 6.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4685
    Cell Significance Index: 89.1600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.3885
    Cell Significance Index: 2.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3466
    Cell Significance Index: 5.9400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3406
    Cell Significance Index: 235.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2708
    Cell Significance Index: 26.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2304
    Cell Significance Index: 208.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2271
    Cell Significance Index: 81.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1622
    Cell Significance Index: 3.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1485
    Cell Significance Index: 9.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1470
    Cell Significance Index: 23.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1380
    Cell Significance Index: 15.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1374
    Cell Significance Index: 6.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1213
    Cell Significance Index: 2.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1174
    Cell Significance Index: 2.5700
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1151
    Cell Significance Index: 1.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1026
    Cell Significance Index: 6.1600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0715
    Cell Significance Index: 0.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0545
    Cell Significance Index: 3.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0344
    Cell Significance Index: 0.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0065
    Cell Significance Index: 0.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0017
    Cell Significance Index: 0.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0002
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0044
    Cell Significance Index: -1.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0064
    Cell Significance Index: -0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0068
    Cell Significance Index: -9.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0123
    Cell Significance Index: -8.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0129
    Cell Significance Index: -9.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0132
    Cell Significance Index: -8.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0133
    Cell Significance Index: -7.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0159
    Cell Significance Index: -9.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0169
    Cell Significance Index: -9.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0233
    Cell Significance Index: -6.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0332
    Cell Significance Index: -6.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0368
    Cell Significance Index: -1.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0401
    Cell Significance Index: -7.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0456
    Cell Significance Index: -9.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0490
    Cell Significance Index: -7.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0501
    Cell Significance Index: -1.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0522
    Cell Significance Index: -7.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0552
    Cell Significance Index: -9.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0560
    Cell Significance Index: -2.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0564
    Cell Significance Index: -6.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0620
    Cell Significance Index: -7.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0666
    Cell Significance Index: -8.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0694
    Cell Significance Index: -1.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0727
    Cell Significance Index: -1.4600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0730
    Cell Significance Index: -1.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0795
    Cell Significance Index: -8.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0833
    Cell Significance Index: -9.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0854
    Cell Significance Index: -8.7200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0891
    Cell Significance Index: -1.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0916
    Cell Significance Index: -7.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0985
    Cell Significance Index: -1.4100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1006
    Cell Significance Index: -5.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1009
    Cell Significance Index: -2.1800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1101
    Cell Significance Index: -1.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1157
    Cell Significance Index: -8.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1202
    Cell Significance Index: -4.2100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1203
    Cell Significance Index: -1.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1285
    Cell Significance Index: -7.2100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1290
    Cell Significance Index: -2.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1296
    Cell Significance Index: -6.7300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1511
    Cell Significance Index: -1.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1514
    Cell Significance Index: -7.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1519
    Cell Significance Index: -9.8000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1559
    Cell Significance Index: -3.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1689
    Cell Significance Index: -4.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1730
    Cell Significance Index: -8.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1736
    Cell Significance Index: -2.9100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1911
    Cell Significance Index: -2.2300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2068
    Cell Significance Index: -1.9600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2152
    Cell Significance Index: -3.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2174
    Cell Significance Index: -7.9800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2175
    Cell Significance Index: -3.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2194
    Cell Significance Index: -5.6400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2262
    Cell Significance Index: -4.7200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2356
    Cell Significance Index: -3.1400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2507
    Cell Significance Index: -3.6000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2602
    Cell Significance Index: -6.5000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2718
    Cell Significance Index: -5.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2742
    Cell Significance Index: -7.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2858
    Cell Significance Index: -7.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2894
    Cell Significance Index: -5.7700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2907
    Cell Significance Index: -7.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2917
    Cell Significance Index: -7.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2961
    Cell Significance Index: -5.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2962
    Cell Significance Index: -6.2000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2978
    Cell Significance Index: -9.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNF112 is a 275-amino acid protein containing a RING finger domain, which is essential for its E3 ubiquitin ligase activity. It is highly expressed in various tissues, including the immune system, and is involved in the regulation of multiple cellular processes. RNF112 has been implicated in the ubiquitination and degradation of several proteins, including tumor suppressors, transcription factors, and signaling molecules. **Pathways and Functions:** RNF112 is involved in various cellular pathways, including: 1. **Ubiquitin-proteasome pathway**: RNF112 regulates the degradation of proteins by the ubiquitin-proteasome pathway, which is crucial for maintaining protein homeostasis and cell cycle regulation. 2. **Cell cycle regulation**: RNF112 is involved in the regulation of the cell cycle, particularly during the G1 to G0 transition, which is essential for cellular differentiation and proliferation. 3. **Immune regulation**: RNF112 is highly expressed in immune cells, including conventional dendritic cells, granulocyte monocyte progenitor cells, and innate lymphoid cells. It regulates the function of these cells by targeting specific proteins for degradation. 4. **Neuronal differentiation**: RNF112 is also involved in the regulation of neuronal differentiation, particularly in the development of glutamatergic cortical neurons. **Clinical Significance:** Dysregulation of RNF112 has been implicated in various diseases, including: 1. **Cancer**: RNF112 is often downregulated in cancer cells, leading to the accumulation of oncogenic proteins and tumorigenesis. 2. **Neurodegenerative diseases**: RNF112 mutations have been associated with neurodegenerative diseases, such as Alzheimer's disease and frontotemporal dementia. 3. **Inflammatory disorders**: RNF112 is involved in the regulation of immune responses, and its dysregulation can contribute to the development of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. In conclusion, RNF112 is a multifaceted protein that plays a crucial role in immune regulation, cellular differentiation, and disease pathogenesis. Its dysregulation can contribute to various diseases, highlighting the importance of understanding its role in maintaining cellular homeostasis and immune function. Further research is needed to fully elucidate the mechanisms by which RNF112 regulates cellular processes and its implications in human disease.

Genular Protein ID: 2418574417

Symbol: RN112_HUMAN

Name: RING finger protein 112

UniProtKB Accession Codes:

Q9ULX5 O60633 Q7Z5V9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10574464

Title: cDNA cloning of a human brain finger protein, BFP/ZNF179, a member of the RING finger protein family.

PubMed ID: 10574464

DOI: 10.1093/dnares/6.5.353

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8660987

Title: Chromosome mapping of human (ZNF179), mouse, and rat genes for brain finger protein (bfp), a member of the RING finger family.

PubMed ID: 8660987

DOI: 10.1006/geno.1996.0203

PubMed ID: 28684796

Title: Znf179 induces differentiation and growth arrest of human primary glioblastoma multiforme in a p53-dependent cell cycle pathway.

PubMed ID: 28684796

DOI: 10.1038/s41598-017-05305-0

Sequence Information:

  • Length: 631
  • Mass: 68298
  • Checksum: 770C4F33B1395954
  • Sequence:
    • MPRPALSVTS FCHRLGKRER KQSFMGNSGN SWSHTPFPKL ELGLGPQPMA PRELPTCSIC 
LERLRDPISL DCGHDFCIRC FSTHRLPGCE PPCCPECRKI CKQKRGLRSL GEKMKLLPQR 
PLPPALQETC PVRAEPLLLV RINASGGLIL RMGAINRCLK HPLARDTPVC LLAVLGEQHS 
GKSFLLNHLL QGLPGLESGE GGRPRGGEAS LQGCRWGANG LARGIWMWSH PFLLGKEGKK 
VAVFLVDTGD AMSPELSRET RIKLCALTTM LSSYQILSTS QELKDTDLDY LEMFVHVAEV 
MGKHYGMVPI QHLDLLVRDS SHPNKAGQGH VGNIFQRLSG RYPKVQELLQ GKRARCCLLP 
APGRRRMNQG HASPGDTDDD FRHLLGAYVS DVLSAAPQHA KSRCQGYWNE GRAVARGDRR 
LLTGQQLAQE IKNLSGWMGR TGPGFTSPDE MAAQLHDLRK VEAAKREFEE YVRQQDVATK 
RIFSALRVLP DTMRNLLSTQ KDAILARHGV ALLCKGRDQT LEALEAELQA TAKAFMDSYT 
MRFCGHLAAV GGAVGAGLMG LAGGVVGAGM AAAALAAEAG MVAAGAAVGA TGAAVVGGGV 
GAGLAATVGC MEKEEDERLL EGDREPLLQE E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.