Details for: LHX3

Gene ID: 8022

Symbol: LHX3

Ensembl ID: ENSG00000107187

Description: LIM homeobox 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 7.6184
    Cell Significance Index: -1.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 4.6719
    Cell Significance Index: -1.1900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 4.3941
    Cell Significance Index: 61.7200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.7800
    Cell Significance Index: 13.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 0.9692
    Cell Significance Index: -1.2000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.8125
    Cell Significance Index: 13.1600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.5647
    Cell Significance Index: 3.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.4672
    Cell Significance Index: 6.6900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.3655
    Cell Significance Index: 3.2200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.2466
    Cell Significance Index: 2.4400
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.2319
    Cell Significance Index: 1.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1358
    Cell Significance Index: 1.8500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1229
    Cell Significance Index: 1.4900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.0771
    Cell Significance Index: 0.7300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0755
    Cell Significance Index: 1.0600
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.0630
    Cell Significance Index: 0.4900
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: 0.0499
    Cell Significance Index: 0.6100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0495
    Cell Significance Index: 0.7100
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: 0.0295
    Cell Significance Index: 0.3600
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: 0.0225
    Cell Significance Index: 0.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0071
    Cell Significance Index: 0.3300
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.0061
    Cell Significance Index: 0.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0057
    Cell Significance Index: 2.5400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.2500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0013
    Cell Significance Index: -0.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0017
    Cell Significance Index: -0.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0017
    Cell Significance Index: -0.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0018
    Cell Significance Index: -0.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0021
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0031
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0034
    Cell Significance Index: -0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0042
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0043
    Cell Significance Index: -0.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0052
    Cell Significance Index: -1.0300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0064
    Cell Significance Index: -0.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0073
    Cell Significance Index: -0.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0077
    Cell Significance Index: -1.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0087
    Cell Significance Index: -0.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0100
    Cell Significance Index: -0.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0121
    Cell Significance Index: -0.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0127
    Cell Significance Index: -0.3400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0190
    Cell Significance Index: -0.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0197
    Cell Significance Index: -0.9300
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.0204
    Cell Significance Index: -0.2500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0216
    Cell Significance Index: -0.1500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0221
    Cell Significance Index: -0.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0247
    Cell Significance Index: -0.6300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0248
    Cell Significance Index: -0.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0253
    Cell Significance Index: -0.7300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0256
    Cell Significance Index: -0.3200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0260
    Cell Significance Index: -0.6000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0269
    Cell Significance Index: -0.5300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0270
    Cell Significance Index: -0.3700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0278
    Cell Significance Index: -0.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0283
    Cell Significance Index: -0.9000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0284
    Cell Significance Index: -0.3000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0289
    Cell Significance Index: -0.3900
  • Cell Name: diffuse bipolar 6 cell (CL4033032)
    Fold Change: -0.0294
    Cell Significance Index: -0.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0301
    Cell Significance Index: -0.8600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0329
    Cell Significance Index: -0.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0346
    Cell Significance Index: -0.7200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0350
    Cell Significance Index: -0.4600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0354
    Cell Significance Index: -0.3700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0356
    Cell Significance Index: -0.7100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0371
    Cell Significance Index: -0.4800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0373
    Cell Significance Index: -0.5300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0374
    Cell Significance Index: -0.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0380
    Cell Significance Index: -0.8200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0386
    Cell Significance Index: -0.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0396
    Cell Significance Index: -1.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0402
    Cell Significance Index: -0.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0411
    Cell Significance Index: -0.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0412
    Cell Significance Index: -1.1000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0427
    Cell Significance Index: -0.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0429
    Cell Significance Index: -1.0400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0435
    Cell Significance Index: -0.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0438
    Cell Significance Index: -0.8800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0441
    Cell Significance Index: -0.6700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0446
    Cell Significance Index: -0.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0454
    Cell Significance Index: -1.0900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0454
    Cell Significance Index: -0.6900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0463
    Cell Significance Index: -0.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0465
    Cell Significance Index: -0.9200
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0473
    Cell Significance Index: -0.6000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0473
    Cell Significance Index: -0.6900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0475
    Cell Significance Index: -0.4500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0497
    Cell Significance Index: -0.4100
  • Cell Name: OFFx cell (CL4033036)
    Fold Change: -0.0502
    Cell Significance Index: -0.5700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0504
    Cell Significance Index: -0.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0505
    Cell Significance Index: -0.8500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0506
    Cell Significance Index: -0.7200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0521
    Cell Significance Index: -0.9000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0526
    Cell Significance Index: -0.6600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0528
    Cell Significance Index: -0.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0534
    Cell Significance Index: -1.0500
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0534
    Cell Significance Index: -0.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor Function:** LHX3 is a transcription factor that regulates gene expression by binding to specific DNA sequences and interacting with RNA polymerase II. 2. **Developmental Expression:** LHX3 is expressed in various cell types during development, including the central nervous system, inner ear, lung, and placenta. 3. **Immune System Development:** LHX3 is involved in the development of immune cells, such as oligodendrocyte precursor cells and intestinal crypt stem cells of the colon. 4. **Cell Differentiation:** LHX3 regulates the differentiation of various cell types, including neurons, glial cells, and goblet cells. 5. **Apoptosis Regulation:** LHX3 is involved in the regulation of apoptotic processes, including the negative regulation of apoptotic processes. **Pathways and Functions:** 1. **Animal Organ Morphogenesis:** LHX3 regulates the development of various organs, including the inner ear, lung, and placenta. 2. **Apoptotic Process:** LHX3 negatively regulates apoptotic processes, promoting cell survival and preventing programmed cell death. 3. **Axon Guidance:** LHX3 regulates the guidance of motor neuron axons during development. 4. **Chromatin Regulation:** LHX3 interacts with chromatin to regulate gene expression. 5. **Dna-binding Transcription Activator Activity:** LHX3 acts as a transcription activator, regulating gene expression by binding to specific DNA sequences. 6. **Inner Ear Development:** LHX3 is involved in the development of the inner ear, regulating the differentiation of inner ear cells. 7. **Lung Development:** LHX3 regulates the development of the lung, promoting the differentiation of lung cells. 8. **Medial Motor Column Neuron Differentiation:** LHX3 regulates the differentiation of medial motor column neurons during development. 9. **Motor Neuron Axon Guidance:** LHX3 regulates the guidance of motor neuron axons during development. 10. **Negative Regulation of Apoptotic Process:** LHX3 negatively regulates apoptotic processes, promoting cell survival. 11. **Nervous System Development:** LHX3 regulates the development of the nervous system, including the central nervous system and peripheral nervous system. 12. **Neuron Differentiation:** LHX3 regulates the differentiation of neurons, including the differentiation of motor neurons and interneurons. 13. **Prolactin Secreting Cell Differentiation:** LHX3 regulates the differentiation of prolactin-secreting cells. 14. **Regulation of Expression of Slits and Robos:** LHX3 regulates the expression of Slits and Robos, which are involved in axon guidance and neuronal development. 15. **Spinal Cord Association Neuron Differentiation:** LHX3 regulates the differentiation of spinal cord association neurons during development. **Clinical Significance:** 1. **Immune System Disorders:** LHX3 dysregulation may contribute to immune system disorders, such as autoimmune diseases and immunodeficiencies. 2. **Neurological Disorders:** LHX3 dysregulation may contribute to neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer:** LHX3 dysregulation may contribute to cancer, including the development of tumors and cancer progression. 4. **Developmental Disorders:** LHX3 dysregulation may contribute to developmental disorders, such as congenital heart defects and birth defects. In conclusion, LHX3 is a critical regulator of developmental processes and immune function, and its dysregulation may contribute to various diseases and disorders. Further research is necessary to fully understand the complex functions of LHX3 and its role in human disease.

Genular Protein ID: 3172669007

Symbol: LHX3_HUMAN

Name: LIM/homeobox protein Lhx3

UniProtKB Accession Codes:

Q9UBR4 Q5TB39 Q5TB40 Q9NZB5 Q9P0I8 Q9P0I9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10598593

Title: Differential activation of pituitary hormone genes by human Lhx3 isoforms with distinct DNA binding properties.

PubMed ID: 10598593

DOI: 10.1210/mend.13.12.0395

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15517599

Title: Serine/threonine/tyrosine phosphorylation of the LHX3 LIM-homeodomain transcription factor.

PubMed ID: 15517599

DOI: 10.1002/jcb.20287

PubMed ID: 21149718

Title: Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo.

PubMed ID: 21149718

DOI: 10.1073/pnas.1009501108

PubMed ID: 26612202

Title: Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.

PubMed ID: 26612202

DOI: 10.1093/hmg/ddv486

PubMed ID: 10835633

Title: Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency.

PubMed ID: 10835633

DOI: 10.1038/76041

PubMed ID: 17327381

Title: Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotation.

PubMed ID: 17327381

DOI: 10.1210/jc.2006-2177

PubMed ID: 28302169

Title: Two novel LHX3 mutations in patients with combined pituitary hormone deficiency including cervical rigidity and sensorineural hearing loss.

PubMed ID: 28302169

DOI: 10.1186/s12902-017-0164-8

Sequence Information:

  • Length: 397
  • Mass: 43358
  • Checksum: FB4A2E48C015C249
  • Sequence:
    • MLLETGLERD RARPGAAAVC TLGGTREIPL CAGCDQHILD RFILKALDRH WHSKCLKCSD 
CHTPLAERCF SRGESVYCKD DFFKRFGTKC AACQLGIPPT QVVRRAQDFV YHLHCFACVV 
CKRQLATGDE FYLMEDSRLV CKADYETAKQ REAEATAKRP RTTITAKQLE TLKSAYNTSP 
KPARHVREQL SSETGLDMRV VQVWFQNRRA KEKRLKKDAG RQRWGQYFRN MKRSRGGSKS 
DKDSVQEGQD SDAEVSFPDE PSLAEMGPAN GLYGSLGEPT QALGRPSGAL GNFSLEHGGL 
AGPEQYRELR PGSPYGVPPS PAAPQSLPGP QPLLSSLVYP DTSLGLVPSG APGGPPPMRV 
LAGNGPSSDL STGSSGGYPD FPASPASWLD EVDHAQF

Genular Protein ID: 314537252

Symbol: F1T0D9_HUMAN

Name: N/A

UniProtKB Accession Codes:

F1T0D9

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 2 Pfam 2 PhylomeDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 402
  • Mass: 43978
  • Checksum: 23B71558AC877672
  • Sequence:
    • MEARGELGPA RESAGGDLLL ALLARRADLR REIPLCAGCD QHILDRFILK ALDRHWHSKC 
LKCSDCHTPL AERCFSRGES VYCKDDFFKR FGTKCAACQL GIPPTQVVRR AQDFVYHLHC 
FACVVCKRQL ATGDEFYLME DSRLVCKADY ETAKQREAEA TAKRPRTTIT AKQLETLKSA 
YNTSPKPARH VREQLSSETG LDMRVVQVWF QNRRAKEKRL KKDAGRQRWG QYFRNMKRSR 
GGSKSDKDSV QEGQDSDAEV SFPDEPSLAE MGPANGLYGS LGEPTQALGR PSGALGNFSL 
EHGGLAGPEQ YRELRPGSPY GVPPSPAAPQ SLPGPQPLLS SLVYPDTSLG LVPSGAPGGP 
PPMRVLAGNG PSSDLSTGSS GGYPDFPASP ASWLDEVDHA QF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.