Details for: SLC7A5

Gene ID: 8140

Symbol: SLC7A5

Ensembl ID: ENSG00000103257

Description: solute carrier family 7 member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 112.6361
    Cell Significance Index: -17.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.8292
    Cell Significance Index: -21.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.6663
    Cell Significance Index: -16.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.5223
    Cell Significance Index: -22.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0330
    Cell Significance Index: -18.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7146
    Cell Significance Index: -22.5500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1716
    Cell Significance Index: -9.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.1113
    Cell Significance Index: 86.9500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.5730
    Cell Significance Index: 22.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1803
    Cell Significance Index: 14.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1414
    Cell Significance Index: 80.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0347
    Cell Significance Index: 53.7500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.9389
    Cell Significance Index: 13.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8247
    Cell Significance Index: 22.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7319
    Cell Significance Index: 34.4000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.6484
    Cell Significance Index: 7.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5973
    Cell Significance Index: 17.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5482
    Cell Significance Index: 109.9700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4675
    Cell Significance Index: 92.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4333
    Cell Significance Index: 27.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4310
    Cell Significance Index: 11.5500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4131
    Cell Significance Index: 10.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4007
    Cell Significance Index: 143.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3846
    Cell Significance Index: 347.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3415
    Cell Significance Index: 33.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3398
    Cell Significance Index: 20.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3087
    Cell Significance Index: 33.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2838
    Cell Significance Index: 46.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2623
    Cell Significance Index: 49.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2449
    Cell Significance Index: 133.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2225
    Cell Significance Index: 5.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1776
    Cell Significance Index: 78.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1624
    Cell Significance Index: 249.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1256
    Cell Significance Index: 231.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1062
    Cell Significance Index: 2.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1045
    Cell Significance Index: 13.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0860
    Cell Significance Index: 5.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0794
    Cell Significance Index: 2.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0754
    Cell Significance Index: 4.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0726
    Cell Significance Index: 136.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0717
    Cell Significance Index: 8.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0635
    Cell Significance Index: 2.9600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0516
    Cell Significance Index: 0.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0463
    Cell Significance Index: 1.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0405
    Cell Significance Index: 27.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.0382
    Cell Significance Index: 1.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0256
    Cell Significance Index: 1.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0159
    Cell Significance Index: 2.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0089
    Cell Significance Index: 6.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0038
    Cell Significance Index: 0.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0038
    Cell Significance Index: 0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0082
    Cell Significance Index: -6.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0083
    Cell Significance Index: -11.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0084
    Cell Significance Index: -0.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0096
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0132
    Cell Significance Index: -8.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0182
    Cell Significance Index: -11.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0190
    Cell Significance Index: -10.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0305
    Cell Significance Index: -2.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0348
    Cell Significance Index: -1.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0406
    Cell Significance Index: -6.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0442
    Cell Significance Index: -12.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0538
    Cell Significance Index: -11.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0792
    Cell Significance Index: -10.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0832
    Cell Significance Index: -1.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0859
    Cell Significance Index: -10.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0894
    Cell Significance Index: -6.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0919
    Cell Significance Index: -10.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1010
    Cell Significance Index: -10.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1171
    Cell Significance Index: -3.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1192
    Cell Significance Index: -13.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1263
    Cell Significance Index: -16.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1628
    Cell Significance Index: -16.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1851
    Cell Significance Index: -2.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1884
    Cell Significance Index: -4.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1887
    Cell Significance Index: -5.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2108
    Cell Significance Index: -4.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2155
    Cell Significance Index: -13.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2287
    Cell Significance Index: -14.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2693
    Cell Significance Index: -21.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3007
    Cell Significance Index: -9.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3233
    Cell Significance Index: -14.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3265
    Cell Significance Index: -8.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3297
    Cell Significance Index: -18.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3426
    Cell Significance Index: -3.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3550
    Cell Significance Index: -5.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3645
    Cell Significance Index: -19.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3657
    Cell Significance Index: -6.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3762
    Cell Significance Index: -13.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3935
    Cell Significance Index: -14.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4228
    Cell Significance Index: -13.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4329
    Cell Significance Index: -3.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4416
    Cell Significance Index: -9.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4456
    Cell Significance Index: -14.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4540
    Cell Significance Index: -15.9100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4638
    Cell Significance Index: -6.8500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.4699
    Cell Significance Index: -2.9200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.5080
    Cell Significance Index: -7.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The LAT1 protein is a transmembrane transporter that utilizes the sodium gradient across the plasma membrane to transport large neutral amino acids. It is a heterodimeric protein composed of two subunits, LAT1 and LAT2, which are encoded by the SLC7A5 and SLC7A6 genes, respectively. The LAT1 protein has a high affinity for large neutral amino acids and is involved in the regulation of amino acid uptake and metabolism in various cells. It is also involved in the transport of other molecules, including inorganic cations, oligopeptides, and xenobiotics. **Pathways and Functions** The LAT1 protein is involved in various cellular pathways, including: 1. **Amino acid metabolism**: LAT1 is involved in the regulation of amino acid uptake and metabolism, including the transport of large neutral amino acids, such as leucine, isoleucine, valine, phenylalanine, and tryptophan. 2. **Immune response**: LAT1 is involved in the regulation of immune response, including the transport of amino acids that are essential for the production of cytokines and other immune molecules. 3. **Cellular proliferation**: LAT1 is involved in the regulation of cellular proliferation, including the transport of amino acids that are essential for cell growth and division. 4. **Neurotransmission**: LAT1 is involved in the regulation of neurotransmission, including the transport of amino acids that are essential for the synthesis and release of neurotransmitters. 5. **Hormone regulation**: LAT1 is involved in the regulation of hormone secretion, including the transport of amino acids that are essential for the synthesis and release of hormones. **Clinical Significance** Dysregulation of LAT1 has been implicated in various diseases, including: 1. **Cancer**: LAT1 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is involved in the regulation of amino acid metabolism and cellular proliferation. 2. **Neurodegenerative diseases**: LAT1 is involved in the regulation of neurotransmission and is implicated in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Diabetes**: LAT1 is involved in the regulation of glucose metabolism and is implicated in various forms of diabetes, including type 1 and type 2 diabetes. 4. **Infectious diseases**: LAT1 is involved in the regulation of immune response and is implicated in various infectious diseases, including HIV and tuberculosis. In conclusion, the SLC7A5 gene encodes for the LAT1 protein, which plays a crucial role in the transport of large neutral amino acids across the plasma membrane. The LAT1 protein is involved in various cellular pathways, including amino acid metabolism, immune response, cellular proliferation, neurotransmission, and hormone regulation. Dysregulation of LAT1 has been implicated in various diseases, including cancer, neurodegenerative diseases, diabetes, and infectious diseases.

Genular Protein ID: 2531184587

Symbol: LAT1_HUMAN

Name: Large neutral amino acids transporter small subunit 1

UniProtKB Accession Codes:

Q01650 Q8IV97 Q9UBN8 Q9UP15 Q9UQC0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 12 DrugCentral 1 EMBL 8 EMDB 8 Ensembl 1 ExpressionAtlas 1 GO 54 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 20 SABIO-RK 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9751058

Title: Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family.

PubMed ID: 9751058

DOI: 10.1038/26246

PubMed ID: 10049700

Title: Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function.

PubMed ID: 10049700

DOI: 10.1006/bbrc.1999.0206

PubMed ID: 10072483

Title: Primary structure of the light chain of fusion regulatory protein-1/CD98/4F2 predicts a protein with multiple transmembrane domains that is almost identical to the amino acid transporter E16.

PubMed ID: 10072483

PubMed ID: 11557028

Title: Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines.

PubMed ID: 11557028

DOI: 10.1016/s0005-2736(01)00384-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1597461

Title: A novel transiently expressed, integral membrane protein linked to cell activation. Molecular cloning via the rapid degradation signal AUUUA.

PubMed ID: 1597461

DOI: 10.1016/s0021-9258(19)49906-7

PubMed ID: 10574970

Title: LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine.

PubMed ID: 10574970

DOI: 10.1074/jbc.274.49.34948

PubMed ID: 11389679

Title: Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta.

PubMed ID: 11389679

DOI: 10.1042/0264-6021:3560719

PubMed ID: 11564694

Title: Thyroid hormone transport by the heterodimeric human system L amino acid transporter.

PubMed ID: 11564694

DOI: 10.1210/endo.142.10.8418

PubMed ID: 11742812

Title: Expression and regulation of 4F2hc and hLAT1 in human trophoblasts.

PubMed ID: 11742812

DOI: 10.1152/ajpcell.2002.282.1.c196

PubMed ID: 12117417

Title: Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2.

PubMed ID: 12117417

DOI: 10.1042/bj20020841

PubMed ID: 12225859

Title: Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells.

PubMed ID: 12225859

DOI: 10.1016/s0005-2736(02)00516-3

PubMed ID: 12824232

Title: Identification and functional characterization of a Na+-independent large neutral amino acid transporter, LAT1, in human and rabbit cornea.

PubMed ID: 12824232

DOI: 10.1167/iovs.02-0907

PubMed ID: 16027961

Title: Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells.

PubMed ID: 16027961

DOI: 10.1007/s00726-005-0221-x

PubMed ID: 15769744

Title: Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols.

PubMed ID: 15769744

DOI: 10.1074/jbc.m413164200

PubMed ID: 16496379

Title: L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors.

PubMed ID: 16496379

DOI: 10.1002/ijc.21866

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18262359

Title: Functional characterization of tyrosine transport in fibroblast cells from healthy controls.

PubMed ID: 18262359

DOI: 10.1016/j.neulet.2008.01.028

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25998567

Title: LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.

PubMed ID: 25998567

DOI: 10.1038/ncomms8250

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30341327

Title: Hepatitis C Virus Modulates Solute carrier family 3 member 2 for Viral Propagation.

PubMed ID: 30341327

DOI: 10.1038/s41598-018-33861-6

PubMed ID: 30867591

Title: Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex.

PubMed ID: 30867591

DOI: 10.1038/s41586-019-1011-z

Sequence Information:

  • Length: 507
  • Mass: 55010
  • Checksum: 767F3C60B62C0F02
  • Sequence:
    • MAGAGPKRRA LAAPAAEEKE EAREKMLAAK SADGSAPAGE GEGVTLQRNI TLLNGVAIIV 
GTIIGSGIFV TPTGVLKEAG SPGLALVVWA ACGVFSIVGA LCYAELGTTI SKSGGDYAYM 
LEVYGSLPAF LKLWIELLII RPSSQYIVAL VFATYLLKPL FPTCPVPEEA AKLVACLCVL 
LLTAVNCYSV KAATRVQDAF AAAKLLALAL IILLGFVQIG KGDVSNLDPN FSFEGTKLDV 
GNIVLALYSG LFAYGGWNYL NFVTEEMINP YRNLPLAIII SLPIVTLVYV LTNLAYFTTL 
STEQMLSSEA VAVDFGNYHL GVMSWIIPVF VGLSCFGSVN GSLFTSSRLF FVGSREGHLP 
SILSMIHPQL LTPVPSLVFT CVMTLLYAFS KDIFSVINFF SFFNWLCVAL AIIGMIWLRH 
RKPELERPIK VNLALPVFFI LACLFLIAVS FWKTPVECGI GFTIILSGLP VYFFGVWWKN 
KPKWLLQGIF STTVLCQKLM QVVPQET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.