Details for: OR2L5

Gene ID: 81466

Symbol: OR2L5

Ensembl ID: ENSG00000197454

Description: olfactory receptor family 2 subfamily L member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.1788
    Cell Significance Index: -3.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3661
    Cell Significance Index: 73.4400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1818
    Cell Significance Index: 2.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0911
    Cell Significance Index: 3.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0868
    Cell Significance Index: 31.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0825
    Cell Significance Index: 3.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0461
    Cell Significance Index: 3.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0285
    Cell Significance Index: 0.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0098
    Cell Significance Index: 0.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.3900
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0076
    Cell Significance Index: -0.3100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0077
    Cell Significance Index: -0.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0077
    Cell Significance Index: -0.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0078
    Cell Significance Index: -2.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0092
    Cell Significance Index: -4.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0099
    Cell Significance Index: -7.3300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0148
    Cell Significance Index: -8.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0178
    Cell Significance Index: -1.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0198
    Cell Significance Index: -0.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0208
    Cell Significance Index: -4.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0215
    Cell Significance Index: -1.3200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0271
    Cell Significance Index: -0.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0284
    Cell Significance Index: -0.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0285
    Cell Significance Index: -4.1400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0317
    Cell Significance Index: -0.4000
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0361
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0427
    Cell Significance Index: -9.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0458
    Cell Significance Index: -1.4600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0557
    Cell Significance Index: -0.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0583
    Cell Significance Index: -1.9100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0600
    Cell Significance Index: -0.6300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0611
    Cell Significance Index: -1.3200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0628
    Cell Significance Index: -1.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0691
    Cell Significance Index: -4.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0707
    Cell Significance Index: -1.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0788
    Cell Significance Index: -1.8900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0811
    Cell Significance Index: -0.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0811
    Cell Significance Index: -2.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0829
    Cell Significance Index: -1.6400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0844
    Cell Significance Index: -3.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0852
    Cell Significance Index: -1.4600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0906
    Cell Significance Index: -2.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0934
    Cell Significance Index: -4.3900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1020
    Cell Significance Index: -1.3600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1056
    Cell Significance Index: -1.3100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1189
    Cell Significance Index: -2.3400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1204
    Cell Significance Index: -1.6900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1234
    Cell Significance Index: -1.6200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1258
    Cell Significance Index: -2.5600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1280
    Cell Significance Index: -1.6600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1393
    Cell Significance Index: -3.4000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1429
    Cell Significance Index: -1.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1484
    Cell Significance Index: -2.1300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1491
    Cell Significance Index: -2.0500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1508
    Cell Significance Index: -1.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1524
    Cell Significance Index: -3.5200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1568
    Cell Significance Index: -2.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1570
    Cell Significance Index: -1.7100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1587
    Cell Significance Index: -1.3100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1588
    Cell Significance Index: -1.7900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1618
    Cell Significance Index: -2.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1641
    Cell Significance Index: -4.1800
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1684
    Cell Significance Index: -1.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1694
    Cell Significance Index: -3.7100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1703
    Cell Significance Index: -2.9500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1820
    Cell Significance Index: -3.6300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1828
    Cell Significance Index: -2.6200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1837
    Cell Significance Index: -4.4500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1875
    Cell Significance Index: -2.8100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1890
    Cell Significance Index: -2.5500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1903
    Cell Significance Index: -3.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1904
    Cell Significance Index: -3.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1938
    Cell Significance Index: -2.3100
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1961
    Cell Significance Index: -1.7000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1971
    Cell Significance Index: -3.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1985
    Cell Significance Index: -5.3000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2099
    Cell Significance Index: -2.5100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.2116
    Cell Significance Index: -3.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2127
    Cell Significance Index: -3.1400
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.2152
    Cell Significance Index: -2.6800
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.2171
    Cell Significance Index: -2.6800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2177
    Cell Significance Index: -1.5100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2187
    Cell Significance Index: -3.1400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2190
    Cell Significance Index: -2.6600
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.2220
    Cell Significance Index: -2.7900
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.2287
    Cell Significance Index: -2.3800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2289
    Cell Significance Index: -2.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2289
    Cell Significance Index: -3.8300
  • Cell Name: OFF parasol ganglion cell (CL4033051)
    Fold Change: -0.2296
    Cell Significance Index: -2.8900
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.2344
    Cell Significance Index: -2.4100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2359
    Cell Significance Index: -3.8200
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: -0.2367
    Cell Significance Index: -2.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2388
    Cell Significance Index: -3.7000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.2395
    Cell Significance Index: -3.0000
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.2400
    Cell Significance Index: -2.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR2L5 belongs to the olfactory receptor family, which is characterized by the presence of seven transmembrane domains and a G protein-coupled receptor (GPCR) structure. These receptors are expressed on the surface of olfactory sensory neurons, where they bind to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. OR2L5 is specifically expressed in various cell types, including progenitor cells, endothelial cells, and neurons in the cerebral cortex, forebrain, and spinal cord. **Pathways and Functions:** OR2L5 is involved in the detection of chemical stimuli involved in sensory perception of smell, specifically through the olfactory signaling pathway. The receptor binds to odorant molecules, which activates the G protein-coupled receptor activity, leading to a signaling cascade that activates downstream effectors, such as adenylyl cyclase, and ultimately triggers the perception of smell. OR2L5 also plays a role in the expression and translocation of olfactory receptors, which is essential for the development and maintenance of olfactory function. **Clinical Significance:** OR2L5 has been implicated in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. Studies have shown that altered expression of OR2L5 is associated with these conditions, suggesting a potential link between olfactory dysfunction and disease progression. Furthermore, OR2L5 has been identified as a potential therapeutic target for the treatment of these disorders, particularly in the context of olfactory dysfunction. **Implications for Immunology:** While OR2L5 is primarily associated with olfactory function, its role in the immune system is also noteworthy. The receptor has been shown to be expressed on certain immune cells, such as pericytes and endothelial cells, which suggests a potential role in modulating immune responses. Additionally, the olfactory signaling pathway has been shown to interact with other immune pathways, such as the Toll-like receptor (TLR) pathway, which may have implications for the development of immunotherapies. **Conclusion:** In conclusion, OR2L5 is a crucial component of the olfactory system, playing a vital role in the detection of chemical stimuli involved in sensory perception of smell. Its expression in various cell types and its involvement in the olfactory signaling pathway make it an important target for understanding the mechanisms of olfactory dysfunction and its association with neurological and psychiatric disorders. Further research is needed to fully elucidate the functions and significance of OR2L5, particularly in the context of immunology.

Genular Protein ID: 2068144193

Symbol: OR2L5_HUMAN

Name: Olfactory receptor 2L5

UniProtKB Accession Codes:

Q8NG80 Q6IF04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 312
  • Mass: 35648
  • Checksum: E04FEB775A902863
  • Sequence:
    • MENYNQTSTD FILLGLFPPS KIGLFLFILF VLIFLMALIG NLSMILLIFL DTHLHTPMYF 
LLSQLSLIDL NYISTIVPKM ASDFLYGNKS ISFIGCGIQS FFFMTFAGAE ALLLTSMAYD 
RYVAICFPLH YPIRMSKRMY VLMITGSWMI GSINSCAHTV YAFRIPYCKS RAINHFFCDV 
PAMLTLACTD TWVYEYTVFL SSTIFLVFPF TGIACSYGWV LLAVYRMHSA EGRKKAYSTC 
STHLTVVTFY YAPFAYTYLC PRSLRSLTED KVLAVFYTIL TPMLNPIIYS LRNKEVMGAL 
TRVIQNIFSV KM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.