Details for: TNFSF11

Gene ID: 8600

Symbol: TNFSF11

Ensembl ID: ENSG00000120659

Description: TNF superfamily member 11

Associated with

  • Cytokine signaling in immune system
    (R-HSA-1280215)
  • Immune system
    (R-HSA-168256)
  • Tnfr2 non-canonical nf-kb pathway
    (R-HSA-5668541)
  • Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
    (R-HSA-5676594)
  • Tnfs bind their physiological receptors
    (R-HSA-5669034)
  • Bone resorption
    (GO:0045453)
  • Calcium-mediated signaling
    (GO:0019722)
  • Calcium ion homeostasis
    (GO:0055074)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to leukemia inhibitory factor
    (GO:1990830)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytokine activity
    (GO:0005125)
  • Cytoplasm
    (GO:0005737)
  • Erk1 and erk2 cascade
    (GO:0070371)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Jnk cascade
    (GO:0007254)
  • Mammary gland alveolus development
    (GO:0060749)
  • Mammary gland epithelial cell proliferation
    (GO:0033598)
  • Monocyte chemotaxis
    (GO:0002548)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Ossification
    (GO:0001503)
  • Osteoclast development
    (GO:0036035)
  • Osteoclast differentiation
    (GO:0030316)
  • Osteoclast proliferation
    (GO:0002158)
  • Paracrine signaling
    (GO:0038001)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of bone resorption
    (GO:0045780)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of corticotropin-releasing hormone secretion
    (GO:0051466)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of fever generation by positive regulation of prostaglandin secretion
    (GO:0071812)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of homotypic cell-cell adhesion
    (GO:0034112)
  • Positive regulation of intracellular signal transduction
    (GO:1902533)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of map kinase activity
    (GO:0043406)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of osteoclast development
    (GO:2001206)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of t cell activation
    (GO:0050870)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Tooth eruption
    (GO:0044691)
  • Tumor necrosis factor-mediated signaling pathway
    (GO:0033209)
  • Tumor necrosis factor receptor binding
    (GO:0005164)
  • Tumor necrosis factor receptor superfamily binding
    (GO:0032813)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 4.9485
    Cell Significance Index: 173.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 4.6652
    Cell Significance Index: 96.7800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 3.3678
    Cell Significance Index: -1.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 3.0523
    Cell Significance Index: -1.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.3685
    Cell Significance Index: 59.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.0509
    Cell Significance Index: 125.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4780
    Cell Significance Index: 32.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3160
    Cell Significance Index: 42.1500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1791
    Cell Significance Index: 28.5600
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.8033
    Cell Significance Index: 7.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5912
    Cell Significance Index: 112.5200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.5222
    Cell Significance Index: 3.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4449
    Cell Significance Index: 44.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3728
    Cell Significance Index: 7.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3420
    Cell Significance Index: 308.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3404
    Cell Significance Index: 4.8800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.3250
    Cell Significance Index: 2.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2379
    Cell Significance Index: 25.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2327
    Cell Significance Index: 37.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1896
    Cell Significance Index: 5.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1704
    Cell Significance Index: 10.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1237
    Cell Significance Index: 8.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1026
    Cell Significance Index: 7.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0991
    Cell Significance Index: 35.5500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0910
    Cell Significance Index: 1.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0795
    Cell Significance Index: 1.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0477
    Cell Significance Index: 1.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0376
    Cell Significance Index: 26.0200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0159
    Cell Significance Index: 0.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0139
    Cell Significance Index: 0.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0124
    Cell Significance Index: 1.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0077
    Cell Significance Index: 0.9100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0048
    Cell Significance Index: 0.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0046
    Cell Significance Index: 0.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0044
    Cell Significance Index: 0.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0025
    Cell Significance Index: 1.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0022
    Cell Significance Index: 0.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0012
    Cell Significance Index: 0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0010
    Cell Significance Index: -0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0010
    Cell Significance Index: -1.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0015
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0018
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0019
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0019
    Cell Significance Index: -1.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0021
    Cell Significance Index: -0.1000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0031
    Cell Significance Index: -1.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0041
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0050
    Cell Significance Index: -0.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0071
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0075
    Cell Significance Index: -1.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0083
    Cell Significance Index: -1.5100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0088
    Cell Significance Index: -0.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0092
    Cell Significance Index: -1.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0120
    Cell Significance Index: -1.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0122
    Cell Significance Index: -1.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0123
    Cell Significance Index: -1.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0127
    Cell Significance Index: -1.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0164
    Cell Significance Index: -0.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0180
    Cell Significance Index: -1.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0194
    Cell Significance Index: -1.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0196
    Cell Significance Index: -0.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0214
    Cell Significance Index: -1.0100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0216
    Cell Significance Index: -0.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0225
    Cell Significance Index: -1.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0231
    Cell Significance Index: -1.4900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0239
    Cell Significance Index: -0.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0251
    Cell Significance Index: -1.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0267
    Cell Significance Index: -1.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0288
    Cell Significance Index: -1.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0289
    Cell Significance Index: -1.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0298
    Cell Significance Index: -0.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0312
    Cell Significance Index: -1.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0318
    Cell Significance Index: -0.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0320
    Cell Significance Index: -0.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0328
    Cell Significance Index: -1.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0328
    Cell Significance Index: -1.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0352
    Cell Significance Index: -0.4800
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0353
    Cell Significance Index: -0.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0355
    Cell Significance Index: -1.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0361
    Cell Significance Index: -0.7800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0363
    Cell Significance Index: -0.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0373
    Cell Significance Index: -0.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0423
    Cell Significance Index: -2.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0429
    Cell Significance Index: -1.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0433
    Cell Significance Index: -0.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0436
    Cell Significance Index: -1.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0439
    Cell Significance Index: -1.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0440
    Cell Significance Index: -0.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0445
    Cell Significance Index: -0.8800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0445
    Cell Significance Index: -1.1100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0450
    Cell Significance Index: -0.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0456
    Cell Significance Index: -1.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0466
    Cell Significance Index: -1.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0467
    Cell Significance Index: -1.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TNFSF11 shares structural similarities with other TNF family members, featuring a type II transmembrane region, a short extracellular domain, and a long intracellular domain. The protein is highly conserved across species, suggesting its importance in evolutionarily conserved biological processes. TNFSF11 is primarily expressed in cells that participate in immune responses, inflammation, and tissue remodeling, highlighting its role in regulating these processes. **Pathways and Functions** TNFSF11 functions through binding to the TNFR2 receptor, triggering a signaling cascade that activates various downstream pathways. These pathways include: 1. **Bone resorption**: TNFSF11 stimulates osteoclast differentiation and activation, leading to bone resorption and calcium ion homeostasis. 2. **Immune response**: TNFSF11 promotes immune cell activation, proliferation, and survival, contributing to the regulation of immune responses and inflammation. 3. **Cell proliferation**: TNFSF11 can stimulate the proliferation of epithelial cells, including those in the mammary gland and intestinal crypts. 4. **Cytokine signaling**: TNFSF11 interacts with other cytokines and growth factors to regulate immune responses and inflammation. **Clinical Significance** TNFSF11 plays a critical role in various diseases, including: 1. **Osteoporosis**: Dysregulation of TNFSF11 and TNFR2 can contribute to osteoporosis, a condition characterized by decreased bone density and increased risk of fractures. 2. **Rheumatoid arthritis**: TNFSF11 has been implicated in the pathogenesis of rheumatoid arthritis, a chronic autoimmune disorder characterized by joint inflammation and bone erosion. 3. **Inflammatory bowel disease**: TNFSF11 may contribute to the development and progression of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. 4. **Cancer**: TNFSF11 has been shown to promote the proliferation and survival of certain cancer cells, suggesting its potential role in cancer development and progression. In conclusion, TNFSF11 is a critical regulator of immune responses, inflammation, and tissue remodeling, playing a significant role in various diseases. Further research is needed to fully understand the mechanisms by which TNFSF11 regulates biological processes and to develop therapeutic strategies targeting this cytokine for the treatment of diseases associated with its dysregulation.

Genular Protein ID: 1517436838

Symbol: TNF11_HUMAN

Name: Tumor necrosis factor ligand superfamily member 11

UniProtKB Accession Codes:

O14788 O14723 Q96Q17 Q9P2Q3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 45 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9367155

Title: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.

PubMed ID: 9367155

DOI: 10.1038/36593

PubMed ID: 9568710

Title: Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

PubMed ID: 9568710

DOI: 10.1016/s0092-8674(00)81569-x

PubMed ID: 10708588

Title: Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation.

PubMed ID: 10708588

DOI: 10.1006/bbrc.2000.2314

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9312132

Title: TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells.

PubMed ID: 9312132

DOI: 10.1074/jbc.272.40.25190

PubMed ID: 22664871

Title: Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin.

PubMed ID: 22664871

DOI: 10.4049/jimmunol.1103387

PubMed ID: 17632511

Title: Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.

PubMed ID: 17632511

DOI: 10.1038/ng2076

Sequence Information:

  • Length: 317
  • Mass: 35478
  • Checksum: 766176446348097F
  • Sequence:
    • MRRASRDYTK YLRGSEEMGG GPGAPHEGPL HAPPPPAPHQ PPAASRSMFV ALLGLGLGQV 
VCSVALFFYF RAQMDPNRIS EDGTHCIYRI LRLHENADFQ DTTLESQDTK LIPDSCRRIK 
QAFQGAVQKE LQHIVGSQHI RAEKAMVDGS WLDLAKRSKL EAQPFAHLTI NATDIPSGSH 
KVSLSSWYHD RGWAKISNMT FSNGKLIVNQ DGFYYLYANI CFRHHETSGD LATEYLQLMV 
YVTKTSIKIP SSHTLMKGGS TKYWSGNSEF HFYSINVGGF FKLRSGEEIS IEVSNPSLLD 
PDQDATYFGA FKVRDID

Genular Protein ID: 2033917018

Symbol: Q54A98_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q54A98

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 5 Gene3D 1 HOGENOM 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 PharmGKB 1 RefSeq 3 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14751235

Title: Regulation of osteoclastogenesis by three human RANKL isoforms expressed in NIH3T3 cells.

PubMed ID: 14751235

DOI: 10.1016/j.bbrc.2003.12.191

Sequence Information:

  • Length: 244
  • Mass: 27690
  • Checksum: C827590684B6B83C
  • Sequence:
    • MDPNRISEDG THCIYRILRL HENADFQDTT LESQDTKLIP DSCRRIKQAF QGAVQKELQH 
IVGSQHIRAE KAMVDGSWLD LAKRSKLEAQ PFAHLTINAT DIPSGSHKVS LSSWYHDRGW 
AKISNMTFSN GKLIVNQDGF YYLYANICFR HHETSGDLAT EYLQLMVYVT KTSIKIPSSH 
TLMKGGSTKY WSGNSEFHFY SINVGGFFKL RSGEEISIEV SNPSLLDPDQ DATYFGAFKV 
RDID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.