Details for: KRT37

Gene ID: 8688

Symbol: KRT37

Ensembl ID: ENSG00000108417

Description: keratin 37

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.0387
    Cell Significance Index: 128.3800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.5216
    Cell Significance Index: 26.0100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.4080
    Cell Significance Index: 22.8100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.9600
    Cell Significance Index: 13.1700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.8818
    Cell Significance Index: 11.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2917
    Cell Significance Index: 3.9800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1118
    Cell Significance Index: 1.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0476
    Cell Significance Index: 2.4700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0261
    Cell Significance Index: 0.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0083
    Cell Significance Index: 1.1400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0047
    Cell Significance Index: 0.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0060
    Cell Significance Index: -0.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0062
    Cell Significance Index: -1.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0114
    Cell Significance Index: -2.0600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0124
    Cell Significance Index: -0.0900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0124
    Cell Significance Index: -0.3100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0145
    Cell Significance Index: -0.2900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0169
    Cell Significance Index: -2.0800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0172
    Cell Significance Index: -0.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0265
    Cell Significance Index: -1.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0354
    Cell Significance Index: -1.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0367
    Cell Significance Index: -0.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0375
    Cell Significance Index: -1.0200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0382
    Cell Significance Index: -0.7500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0385
    Cell Significance Index: -0.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0386
    Cell Significance Index: -1.2300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0421
    Cell Significance Index: -0.5500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0457
    Cell Significance Index: -0.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0483
    Cell Significance Index: -2.2700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0489
    Cell Significance Index: -0.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0492
    Cell Significance Index: -1.4500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0601
    Cell Significance Index: -0.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0643
    Cell Significance Index: -2.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0761
    Cell Significance Index: -1.0900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0804
    Cell Significance Index: -0.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0809
    Cell Significance Index: -2.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0820
    Cell Significance Index: -2.3500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0826
    Cell Significance Index: -1.0800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0898
    Cell Significance Index: -1.0600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0915
    Cell Significance Index: -0.9600
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0917
    Cell Significance Index: -0.9900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0919
    Cell Significance Index: -1.0100
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0961
    Cell Significance Index: -0.9200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0974
    Cell Significance Index: -1.0100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0994
    Cell Significance Index: -0.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1016
    Cell Significance Index: -0.9800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1025
    Cell Significance Index: -1.1100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1031
    Cell Significance Index: -1.1300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1106
    Cell Significance Index: -1.3000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1159
    Cell Significance Index: -1.3900
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1190
    Cell Significance Index: -1.3500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1196
    Cell Significance Index: -1.7000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1207
    Cell Significance Index: -1.4000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1223
    Cell Significance Index: -1.6800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1231
    Cell Significance Index: -1.3200
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.1232
    Cell Significance Index: -1.1600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1239
    Cell Significance Index: -1.6300
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.1293
    Cell Significance Index: -1.0900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1297
    Cell Significance Index: -1.9700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1320
    Cell Significance Index: -1.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1321
    Cell Significance Index: -1.9800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1334
    Cell Significance Index: -1.3800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1343
    Cell Significance Index: -1.3900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1350
    Cell Significance Index: -2.1700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1356
    Cell Significance Index: -1.4400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1387
    Cell Significance Index: -1.8100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1387
    Cell Significance Index: -1.5500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1425
    Cell Significance Index: -1.8700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1431
    Cell Significance Index: -0.9000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1437
    Cell Significance Index: -1.7100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1478
    Cell Significance Index: -0.9800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1496
    Cell Significance Index: -2.1800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1509
    Cell Significance Index: -1.4300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1511
    Cell Significance Index: -0.9800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1512
    Cell Significance Index: -1.8400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1521
    Cell Significance Index: -1.2100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1529
    Cell Significance Index: -2.1200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1541
    Cell Significance Index: -1.9800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1544
    Cell Significance Index: -1.7100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1558
    Cell Significance Index: -1.8500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1588
    Cell Significance Index: -1.3100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1592
    Cell Significance Index: -2.0500
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1643
    Cell Significance Index: -1.1400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1677
    Cell Significance Index: -1.9300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1725
    Cell Significance Index: -1.8200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1736
    Cell Significance Index: -1.6300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1756
    Cell Significance Index: -2.1000
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.1757
    Cell Significance Index: -1.1000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1763
    Cell Significance Index: -1.8000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1779
    Cell Significance Index: -2.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1803
    Cell Significance Index: -1.8700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1847
    Cell Significance Index: -2.2700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1852
    Cell Significance Index: -1.1500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1867
    Cell Significance Index: -2.5400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1913
    Cell Significance Index: -2.2600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1918
    Cell Significance Index: -1.9600
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1918
    Cell Significance Index: -2.0100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1937
    Cell Significance Index: -2.2500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1938
    Cell Significance Index: -2.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KRT37 is a type I keratin, which is distinct from type II keratins, such as KRT5 and KRT14. Type I keratins are typically expressed in epithelial cells that require a more flexible cytoskeleton, such as those found in the skin and mucosa. KRT37 is specifically expressed in a range of cell types, including erythrocytes, double-negative thymocytes, and hematopoietic stem cells, highlighting its importance in the development and maintenance of epithelial tissues. The protein contains a characteristic keratin domain, which is essential for its function as a structural molecule. **Pathways and Functions:** KRT37 is involved in various cellular processes, including: 1. **Cytoskeleton organization**: KRT37 interacts with other keratins and intermediate filaments to form a stable cytoskeleton, which provides structural support and maintains cell shape. 2. **Epithelial cell differentiation**: KRT37 plays a crucial role in the differentiation of epithelial cells, particularly during keratinization, a process that involves the formation of the cornified envelope, a complex structure composed of cross-linked keratin filaments. 3. **Extracellular matrix interaction**: KRT37 interacts with the extracellular matrix, influencing cell adhesion and migration. 4. **Protein binding**: KRT37 interacts with other proteins, including keratins, intermediate filaments, and nuclear proteins, regulating various cellular processes. **Clinical Significance:** Dysregulation of KRT37 expression has been implicated in various diseases, including: 1. **Epidermolysis bullosa simplex** (EBS): A genetic disorder characterized by blistering skin lesions, resulting from mutations in the KRT37 gene. 2. **Keratinocyte disorders**: Abnormalities in KRT37 expression have been linked to various keratinocyte disorders, including ichthyosis and psoriasis. 3. **Cancer**: Altered expression of KRT37 has been observed in various types of cancer, including breast, lung, and colon cancer. 4. **Hematological disorders**: KRT37 is expressed in hematopoietic stem cells, and dysregulation of its expression has been implicated in hematological disorders, such as leukemia and lymphoma. In conclusion, KRT37 is a crucial component of the keratin family, playing a vital role in epithelial cell differentiation, development, and maintenance. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its function and clinical significance.

Genular Protein ID: 2543320871

Symbol: KRT37_HUMAN

Name: Keratin, type I cuticular Ha7

UniProtKB Accession Codes:

O76014

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9756910

Title: Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

PubMed ID: 9756910

DOI: 10.1074/jbc.273.41.26683

Sequence Information:

  • Length: 449
  • Mass: 49747
  • Checksum: E503974DFD8FCBAD
  • Sequence:
    • MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA HANRVRVGST 
PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL NGHEKETMKF LNDRLANYLE 
KVRQLEQENA ELETTLLERS KCHESTVCPD YQSYFRTIEE LQQKILCSKA ENARLIVQID 
NAKLAADDFR IKLESERSLH QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS 
NHEQEVKILR SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE 
GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE AEDRYGTELA 
QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE IATYRNLLES EDCKLPCNPC 
STPASCTSCP SCGPVTGGSP SGHGASMGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.