Details for: DGAT1

Gene ID: 8694

Symbol: DGAT1

Ensembl ID: ENSG00000185000

Description: diacylglycerol O-acyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.1580
    Cell Significance Index: -18.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.6861
    Cell Significance Index: -18.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.4392
    Cell Significance Index: -18.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.1778
    Cell Significance Index: -22.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.5550
    Cell Significance Index: -18.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6940
    Cell Significance Index: -19.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.2722
    Cell Significance Index: -22.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9290
    Cell Significance Index: -19.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.4428
    Cell Significance Index: 156.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.5484
    Cell Significance Index: 55.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0698
    Cell Significance Index: -4.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.0228
    Cell Significance Index: 30.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6681
    Cell Significance Index: 48.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4549
    Cell Significance Index: 19.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0893
    Cell Significance Index: 75.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0653
    Cell Significance Index: 55.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9175
    Cell Significance Index: 99.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8432
    Cell Significance Index: 137.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7483
    Cell Significance Index: 148.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7049
    Cell Significance Index: 127.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6881
    Cell Significance Index: 17.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6804
    Cell Significance Index: 614.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5687
    Cell Significance Index: 19.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5330
    Cell Significance Index: 24.8500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5164
    Cell Significance Index: 4.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5055
    Cell Significance Index: 62.1600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.4451
    Cell Significance Index: 4.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4245
    Cell Significance Index: 9.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3784
    Cell Significance Index: 261.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3476
    Cell Significance Index: 69.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3299
    Cell Significance Index: 180.1600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2385
    Cell Significance Index: 1.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2358
    Cell Significance Index: 6.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2109
    Cell Significance Index: 28.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1715
    Cell Significance Index: 61.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1713
    Cell Significance Index: 32.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1639
    Cell Significance Index: 72.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1480
    Cell Significance Index: 9.3300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1189
    Cell Significance Index: 2.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1146
    Cell Significance Index: 5.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1135
    Cell Significance Index: 8.0300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1120
    Cell Significance Index: 7.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1102
    Cell Significance Index: 10.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0915
    Cell Significance Index: 2.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0721
    Cell Significance Index: 12.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0633
    Cell Significance Index: 7.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0517
    Cell Significance Index: 0.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0415
    Cell Significance Index: 1.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0366
    Cell Significance Index: 1.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0352
    Cell Significance Index: 4.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0328
    Cell Significance Index: 2.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0237
    Cell Significance Index: 0.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0019
    Cell Significance Index: 3.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0058
    Cell Significance Index: -4.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.2900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.0069
    Cell Significance Index: -0.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0070
    Cell Significance Index: -0.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0093
    Cell Significance Index: -14.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0117
    Cell Significance Index: -0.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0152
    Cell Significance Index: -20.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0200
    Cell Significance Index: -12.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0231
    Cell Significance Index: -17.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0288
    Cell Significance Index: -13.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0324
    Cell Significance Index: -18.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0368
    Cell Significance Index: -23.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0461
    Cell Significance Index: -1.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0558
    Cell Significance Index: -1.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0568
    Cell Significance Index: -6.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0602
    Cell Significance Index: -6.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0668
    Cell Significance Index: -4.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0732
    Cell Significance Index: -21.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0842
    Cell Significance Index: -9.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0963
    Cell Significance Index: -14.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1033
    Cell Significance Index: -21.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1417
    Cell Significance Index: -1.6100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1726
    Cell Significance Index: -1.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1726
    Cell Significance Index: -3.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1757
    Cell Significance Index: -18.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1784
    Cell Significance Index: -10.7100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2262
    Cell Significance Index: -0.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2304
    Cell Significance Index: -12.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2450
    Cell Significance Index: -15.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2547
    Cell Significance Index: -20.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2675
    Cell Significance Index: -5.6000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2722
    Cell Significance Index: -2.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2783
    Cell Significance Index: -9.6700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2837
    Cell Significance Index: -1.7600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2848
    Cell Significance Index: -14.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2862
    Cell Significance Index: -5.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3009
    Cell Significance Index: -13.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3023
    Cell Significance Index: -7.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3548
    Cell Significance Index: -9.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3557
    Cell Significance Index: -13.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3614
    Cell Significance Index: -11.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3658
    Cell Significance Index: -5.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3754
    Cell Significance Index: -12.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3851
    Cell Significance Index: -13.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3864
    Cell Significance Index: -8.2000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.3963
    Cell Significance Index: -2.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DGAT1 is a member of the diacylglycerol O-acyltransferase family, which catalyzes the acylation of diacylglycerol to form triglycerides and phospholipids. The enzyme exhibits high specificity for long-chain fatty acids, which are essential for energy storage and cellular membrane structure. DGAT1 has been implicated in various cellular processes, including: 1. **Triglyceride biosynthesis:** DGAT1 is a key enzyme in the synthesis of triglycerides, which are the primary form of energy storage in cells. 2. **Phospholipid biosynthesis:** DGAT1 also plays a crucial role in the synthesis of phospholipids, which are essential components of cellular membranes. 3. **Immune system regulation:** DGAT1 has been shown to modulate immune responses by regulating the production of lipid mediators, such as prostaglandins and leukotrienes. 4. **Cell signaling:** DGAT1 has been implicated in cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. **Pathways and Functions:** DGAT1 is involved in several key pathways, including: 1. **Acyl chain remodeling of DAG and TAG:** DGAT1 catalyzes the transfer of long-chain fatty acids to diacylglycerol (DAG) and triglycerides (TAG), which is essential for lipid homeostasis. 2. **Acyltransferase activity:** DGAT1 exhibits high specificity for long-chain fatty acids, which are essential for energy storage and cellular membrane structure. 3. **Diacylglycerol metabolic process:** DGAT1 is involved in the metabolism of diacylglycerol, which is a key regulator of cellular signaling pathways. 4. **Immune system regulation:** DGAT1 has been shown to modulate immune responses by regulating the production of lipid mediators. **Clinical Significance:** DGAT1 has been implicated in various diseases, including: 1. **Atherosclerosis:** DGAT1 has been shown to contribute to the development of atherosclerosis by regulating lipid metabolism and inflammation. 2. **Obesity:** DGAT1 has been implicated in obesity by regulating energy storage and lipid metabolism. 3. **Autoimmune diseases:** DGAT1 has been shown to modulate immune responses in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Cancer:** DGAT1 has been implicated in cancer by regulating lipid metabolism and cell signaling pathways. In conclusion, DGAT1 is a multifunctional enzyme that plays a crucial role in lipid metabolism, immune system regulation, and cell signaling. Further research is needed to fully understand the significance of DGAT1 in human disease and to develop novel therapeutic strategies targeting this enzyme.

Genular Protein ID: 1324661678

Symbol: DGAT1_HUMAN

Name: ACAT-related gene product 1

UniProtKB Accession Codes:

O75907 B2RWQ2 D3DWL6 Q96BB8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 77 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 7 EMDB 6 Ensembl 2 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIRSF 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 36 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9756920

Title: Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes.

PubMed ID: 9756920

DOI: 10.1074/jbc.273.41.26765

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16214399

Title: Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1.

PubMed ID: 16214399

DOI: 10.1016/j.bbalip.2005.09.003

PubMed ID: 18768481

Title: Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption.

PubMed ID: 18768481

DOI: 10.1074/jbc.m800494200

PubMed ID: 28420705

Title: Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases.

PubMed ID: 28420705

DOI: 10.1194/jlr.m073445

PubMed ID: 23114594

Title: DGAT1 mutation is linked to a congenital diarrheal disorder.

PubMed ID: 23114594

DOI: 10.1172/jci64873

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32433611

Title: Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.

PubMed ID: 32433611

DOI: 10.1038/s41586-020-2289-6

PubMed ID: 32433610

Title: Structure and mechanism of human diacylglycerol O-acyltransferase 1.

PubMed ID: 32433610

DOI: 10.1038/s41586-020-2280-2

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

Sequence Information:

  • Length: 488
  • Mass: 55278
  • Checksum: 6574D5DBF15D6171
  • Sequence:
    • MGDRGSSRRR RTGSRPSSHG GGGPAAAEEE VRDAAAGPDV GAAGDAPAPA PNKDGDAGVG 
SGHWELRCHR LQDSLFSSDS GFSNYRGILN WCVVMLILSN ARLFLENLIK YGILVDPIQV 
VSLFLKDPYS WPAPCLVIAA NVFAVAAFQV EKRLAVGALT EQAGLLLHVA NLATILCFPA 
AVVLLVESIT PVGSLLALMA HTILFLKLFS YRDVNSWCRR ARAKAASAGK KASSAAAPHT 
VSYPDNLTYR DLYYFLFAPT LCYELNFPRS PRIRKRFLLR RILEMLFFTQ LQVGLIQQWM 
VPTIQNSMKP FKDMDYSRII ERLLKLAVPN HLIWLIFFYW LFHSCLNAVA ELMQFGDREF 
YRDWWNSESV TYFWQNWNIP VHKWCIRHFY KPMLRRGSSK WMARTGVFLA SAFFHEYLVS 
VPLRMFRLWA FTGMMAQIPL AWFVGRFFQG NYGNAAVWLS LIIGQPIAVL MYVHDYYVLN 
YEAPAAEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.