Details for: FGF17

Gene ID: 8822

Symbol: FGF17

Ensembl ID: ENSG00000158815

Description: fibroblast growth factor 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.5620
    Cell Significance Index: -6.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.7813
    Cell Significance Index: 170.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2180
    Cell Significance Index: 26.6700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1817
    Cell Significance Index: 28.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8761
    Cell Significance Index: 18.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7636
    Cell Significance Index: 219.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7154
    Cell Significance Index: 136.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5493
    Cell Significance Index: 54.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4937
    Cell Significance Index: 99.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4577
    Cell Significance Index: 413.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3515
    Cell Significance Index: 126.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2615
    Cell Significance Index: 42.5300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2224
    Cell Significance Index: 1.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2083
    Cell Significance Index: 5.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2065
    Cell Significance Index: 22.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1921
    Cell Significance Index: 132.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1591
    Cell Significance Index: 5.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1058
    Cell Significance Index: 7.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0567
    Cell Significance Index: 3.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0250
    Cell Significance Index: 1.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0206
    Cell Significance Index: 1.0800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0193
    Cell Significance Index: 0.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0185
    Cell Significance Index: 0.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0157
    Cell Significance Index: 0.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0146
    Cell Significance Index: 0.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0137
    Cell Significance Index: 2.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0042
    Cell Significance Index: 0.1200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0018
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0024
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0074
    Cell Significance Index: -5.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0080
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0082
    Cell Significance Index: -5.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0082
    Cell Significance Index: -0.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0083
    Cell Significance Index: -6.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0095
    Cell Significance Index: -5.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0102
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0102
    Cell Significance Index: -6.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0132
    Cell Significance Index: -5.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0158
    Cell Significance Index: -0.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0175
    Cell Significance Index: -0.9100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0211
    Cell Significance Index: -3.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0236
    Cell Significance Index: -4.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0240
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0295
    Cell Significance Index: -6.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0323
    Cell Significance Index: -3.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0334
    Cell Significance Index: -0.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0399
    Cell Significance Index: -4.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0450
    Cell Significance Index: -5.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0458
    Cell Significance Index: -6.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0469
    Cell Significance Index: -5.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0481
    Cell Significance Index: -6.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0542
    Cell Significance Index: -1.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0561
    Cell Significance Index: -1.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0624
    Cell Significance Index: -0.6800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0651
    Cell Significance Index: -0.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0659
    Cell Significance Index: -6.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0659
    Cell Significance Index: -2.1000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0665
    Cell Significance Index: -0.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0774
    Cell Significance Index: -2.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0794
    Cell Significance Index: -3.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0798
    Cell Significance Index: -6.3200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0812
    Cell Significance Index: -6.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0817
    Cell Significance Index: -6.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0834
    Cell Significance Index: -1.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0847
    Cell Significance Index: -1.8300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0847
    Cell Significance Index: -1.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0849
    Cell Significance Index: -2.7800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0852
    Cell Significance Index: -1.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0854
    Cell Significance Index: -2.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0893
    Cell Significance Index: -1.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0908
    Cell Significance Index: -3.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1039
    Cell Significance Index: -5.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1046
    Cell Significance Index: -6.7500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1083
    Cell Significance Index: -2.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1155
    Cell Significance Index: -5.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1157
    Cell Significance Index: -2.4000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1272
    Cell Significance Index: -1.2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1279
    Cell Significance Index: -1.5500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1376
    Cell Significance Index: -1.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1378
    Cell Significance Index: -4.7900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1387
    Cell Significance Index: -1.7500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1484
    Cell Significance Index: -2.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1552
    Cell Significance Index: -4.0800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1604
    Cell Significance Index: -2.2000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1727
    Cell Significance Index: -6.3400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1790
    Cell Significance Index: -3.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1812
    Cell Significance Index: -4.9300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1853
    Cell Significance Index: -5.8600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1914
    Cell Significance Index: -1.5800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1956
    Cell Significance Index: -3.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1964
    Cell Significance Index: -5.6300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2044
    Cell Significance Index: -3.0800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2065
    Cell Significance Index: -3.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2079
    Cell Significance Index: -5.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** FGF17 is a secreted protein that belongs to the fibroblast growth factor family. 2. **Expression:** The gene is significantly expressed in various cell types, including conventional dendritic cells, neuroendocrine cells, and hematopoietic stem cells. 3. **Signaling Pathways:** FGF17 is involved in multiple signaling pathways, including those mediated by FGFRs, insulin receptor signaling cascades, and MAPK family signaling cascades. 4. **Functions:** FGF17 regulates cell proliferation, differentiation, migration, and survival, and has been implicated in various biological processes, including cell-cell signaling, morphogenesis, and tissue development. **Pathways and Functions:** FGF17 is involved in various signaling pathways, including: 1. **FGFR Signaling Pathway:** FGF17 binds to FGFRs, triggering a cascade of downstream signaling events that regulate cell proliferation, differentiation, and migration. 2. **Insulin Receptor Signaling Cascade:** FGF17 interacts with the insulin receptor, modulating insulin signaling and influencing glucose metabolism. 3. **MAPK Family Signaling Cascades:** FGF17 activates MAPK family kinases, which regulate cell proliferation, differentiation, and survival. 4. **Cell Migration:** FGF17 regulates cell migration by modulating the activity of various signaling proteins, including Rho GTPases and PI3K/AKT. **Clinical Significance:** 1. **Cancer:** FGF17 has been implicated in various cancers, including colorectal, breast, and lung cancer, where it promotes tumor growth, invasion, and metastasis. 2. **Neurological Disorders:** FGF17 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, where it regulates neuronal survival and migration. 3. **Immune System:** FGF17 plays a role in immune system development and function, influencing the differentiation and function of immune cells, including dendritic cells and T cells. In conclusion, FGF17 is a multifaceted gene involved in various biological processes, including cell signaling, differentiation, and migration. Its dysregulation has been implicated in various diseases, including cancer and neurological disorders. Further research is needed to fully understand the mechanisms by which FGF17 regulates biological processes and to explore its therapeutic potential in disease treatment.

Genular Protein ID: 2447084599

Symbol: FGF17_HUMAN

Name: Fibroblast growth factor 17

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9514906

Title: Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain.

PubMed ID: 9514906

DOI: 10.1006/bbrc.1998.8239

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 23643382

Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

PubMed ID: 23643382

DOI: 10.1016/j.ajhg.2013.04.008

Sequence Information:

  • Length: 216
  • Mass: 24891
  • Checksum: 2EE0288675220F4C
  • Sequence:
  • MGAARLLPNL TLCLQLLILC CQTQGENHPS PNFNQYVRDQ GAMTDQLSRR QIREYQLYSR 
    TSGKHVQVTG RRISATAEDG NKFAKLIVET DTFGSRVRIK GAESEKYICM NKRGKLIGKP 
    SGKSKDCVFT EIVLENNYTA FQNARHEGWF MAFTRQGRPR QASRSRQNQR EAHFIKRLYQ 
    GQLPFPNHAE KQKQFEFVGS APTRRTKRTR RPQPLT

Genular Protein ID: 3204623646

Symbol: A0A7U3JVY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 239
  • Mass: 27671
  • Checksum: 889CF24BF8DB6558
  • Sequence:
  • MAICPLHSAG QVACPHYIHL LTPLPWMDQW WCHPKQIDTI FPLVTAKGEN HPSPNFNQYV 
    RDQGAMTDQL SRRQIREYQL YSRTSGKHVQ VTGRRISATA EDGNKFAKLI VETDTFGSRV 
    RIKGAESEKY ICMNKRGKLI GKPSGKSKDC VFTEIVLENN YTAFQNARHE GWFMAFTRQG 
    RPRQASRSRQ NQREAHFIKR LYQGQLPFPN HAEKQKQFEF VGSAPTRRTK RTRRPQPLT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.