Details for: LINC02171

Gene ID: 100133461

Symbol: LINC02171

Ensembl ID: ENSG00000250632

Description: long intergenic non-protein coding RNA 2171

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.2939
    Cell Significance Index: 3.7800
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1395
    Cell Significance Index: 1.6100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.1282
    Cell Significance Index: 1.8000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0977
    Cell Significance Index: 1.1600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0456
    Cell Significance Index: 0.5100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0355
    Cell Significance Index: 0.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0258
    Cell Significance Index: 2.9600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0188
    Cell Significance Index: 0.4800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0076
    Cell Significance Index: 0.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0034
    Cell Significance Index: 0.4700
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0004
    Cell Significance Index: -0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0007
    Cell Significance Index: -0.1500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0032
    Cell Significance Index: -0.1800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0042
    Cell Significance Index: -0.1100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0078
    Cell Significance Index: -0.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0091
    Cell Significance Index: -0.5900
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0091
    Cell Significance Index: -0.0700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0091
    Cell Significance Index: -0.0600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0125
    Cell Significance Index: -0.1500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0130
    Cell Significance Index: -0.1400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0135
    Cell Significance Index: -0.1600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0146
    Cell Significance Index: -0.1900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0149
    Cell Significance Index: -0.1600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0152
    Cell Significance Index: -0.1900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0153
    Cell Significance Index: -0.3000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0153
    Cell Significance Index: -0.1900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0154
    Cell Significance Index: -0.1400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0164
    Cell Significance Index: -0.4400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0166
    Cell Significance Index: -0.1800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0180
    Cell Significance Index: -0.3100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0181
    Cell Significance Index: -0.1500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0183
    Cell Significance Index: -0.2300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0186
    Cell Significance Index: -0.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0210
    Cell Significance Index: -0.6200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0211
    Cell Significance Index: -0.2800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0230
    Cell Significance Index: -0.1900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0231
    Cell Significance Index: -0.1400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0241
    Cell Significance Index: -0.2800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0247
    Cell Significance Index: -0.2100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0248
    Cell Significance Index: -0.2800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0260
    Cell Significance Index: -0.1800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0264
    Cell Significance Index: -0.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0269
    Cell Significance Index: -0.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0281
    Cell Significance Index: -0.6800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0285
    Cell Significance Index: -0.3100
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0285
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0287
    Cell Significance Index: -0.1800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0288
    Cell Significance Index: -0.2700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0295
    Cell Significance Index: -0.4100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0299
    Cell Significance Index: -0.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0305
    Cell Significance Index: -0.5100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0321
    Cell Significance Index: -0.5200
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0323
    Cell Significance Index: -0.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0343
    Cell Significance Index: -0.4100
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0345
    Cell Significance Index: -0.3400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0364
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0370
    Cell Significance Index: -0.6100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0392
    Cell Significance Index: -0.5200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0433
    Cell Significance Index: -0.5100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0454
    Cell Significance Index: -0.5200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0462
    Cell Significance Index: -0.5800
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0477
    Cell Significance Index: -0.5300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0486
    Cell Significance Index: -0.6400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0489
    Cell Significance Index: -0.2900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0499
    Cell Significance Index: -0.4800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0509
    Cell Significance Index: -0.6500
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0526
    Cell Significance Index: -0.5900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0528
    Cell Significance Index: -0.5000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0541
    Cell Significance Index: -0.5700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0549
    Cell Significance Index: -0.5200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0550
    Cell Significance Index: -0.6500
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0560
    Cell Significance Index: -0.4500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0582
    Cell Significance Index: -0.6300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0598
    Cell Significance Index: -0.3200
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0628
    Cell Significance Index: -0.2900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0650
    Cell Significance Index: -0.6600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0721
    Cell Significance Index: -0.7100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0722
    Cell Significance Index: -0.4700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0755
    Cell Significance Index: -0.6600
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0771
    Cell Significance Index: -0.7300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0812
    Cell Significance Index: -0.7200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0839
    Cell Significance Index: -0.6700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0924
    Cell Significance Index: -0.5800
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1029
    Cell Significance Index: -0.6700
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.1543
    Cell Significance Index: -0.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC02171 is a 2,171-nucleotide lincRNA, which is characterized by its long length and intergenic location. Its expression profile is highly dynamic, with significant levels detected in a variety of cell types, including macrophages, progenitor cells, and microglial cells. Unlike other lincRNAs, LINC02171 lacks a known coding sequence, suggesting that its function may be mediated by its regulatory activities rather than its sequence-specific binding to proteins. **Pathways and Functions:** Several signaling pathways have been implicated in the regulation of LINC02171 expression and function. These include: 1. **PI3K/Akt signaling pathway:** LINC02171 has been shown to modulate the PI3K/Akt pathway, which is involved in cell survival, proliferation, and differentiation. 2. **Wnt/β-catenin signaling pathway:** LINC02171 has also been implicated in the Wnt/β-catenin pathway, which regulates cell proliferation, differentiation, and migration. 3. **NF-κB signaling pathway:** LINC02171 has been shown to modulate the NF-κB pathway, which is involved in immune responses and inflammation. The functional role of LINC02171 is multifaceted, with evidence suggesting that it: 1. **Regulates cell proliferation and differentiation:** LINC02171 has been shown to modulate the expression of genes involved in cell proliferation and differentiation, including those involved in immune cell development. 2. **Influences immune responses:** LINC02171 has been implicated in regulating immune responses, including the production of cytokines and the activation of immune cells. 3. **Modulates neuronal function:** LINC02171 has also been shown to regulate neuronal function, including the expression of genes involved in neuronal development and survival. **Clinical Significance:** The clinical significance of LINC02171 is an area of active research, with potential implications for various immune-related disorders, including: 1. **Autoimmune diseases:** LINC02171 has been implicated in the regulation of immune responses, which may contribute to the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** LINC02171 has been shown to modulate cell proliferation and differentiation, which may contribute to cancer development and progression. 3. **Neurological disorders:** LINC02171 has also been implicated in regulating neuronal function, which may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, LINC02171 is a complex lincRNA with a wide range of expression profiles and regulatory activities. Further research is needed to fully elucidate its functional role in various cellular processes and its clinical significance in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.