Details for: PLA2G4E AS1

Gene ID: 101928388

Symbol: PLA2G4E AS1

Ensembl ID: ENSG00000246740

Description: PLA2G4E antisense RNA 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.8123
    Cell Significance Index: 11.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2335
    Cell Significance Index: 2.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1515
    Cell Significance Index: 9.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1270
    Cell Significance Index: 3.6600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1153
    Cell Significance Index: 1.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1133
    Cell Significance Index: 2.4800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.1109
    Cell Significance Index: 1.3400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0993
    Cell Significance Index: 1.2600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0987
    Cell Significance Index: 1.2400
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.0773
    Cell Significance Index: 0.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0624
    Cell Significance Index: 2.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0456
    Cell Significance Index: 2.3700
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.0335
    Cell Significance Index: 0.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0310
    Cell Significance Index: 0.8300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0292
    Cell Significance Index: 0.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0274
    Cell Significance Index: 0.4100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0265
    Cell Significance Index: 0.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0227
    Cell Significance Index: 0.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0180
    Cell Significance Index: 0.4500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0158
    Cell Significance Index: 0.2000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0149
    Cell Significance Index: 0.4700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0148
    Cell Significance Index: 0.1800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0118
    Cell Significance Index: 0.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0077
    Cell Significance Index: 0.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0073
    Cell Significance Index: 1.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0062
    Cell Significance Index: 1.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0056
    Cell Significance Index: 1.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0055
    Cell Significance Index: 2.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0046
    Cell Significance Index: 0.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0031
    Cell Significance Index: 0.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0024
    Cell Significance Index: 0.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0023
    Cell Significance Index: 3.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0016
    Cell Significance Index: 0.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0016
    Cell Significance Index: 0.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0004
    Cell Significance Index: 0.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0001
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0001
    Cell Significance Index: -0.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0004
    Cell Significance Index: -0.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0005
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0007
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0010
    Cell Significance Index: -0.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0011
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0011
    Cell Significance Index: -0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0014
    Cell Significance Index: -0.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0018
    Cell Significance Index: -0.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0032
    Cell Significance Index: -0.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0034
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0038
    Cell Significance Index: -0.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0038
    Cell Significance Index: -0.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0041
    Cell Significance Index: -0.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0048
    Cell Significance Index: -0.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0050
    Cell Significance Index: -0.6500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0055
    Cell Significance Index: -0.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0062
    Cell Significance Index: -0.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0064
    Cell Significance Index: -0.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0073
    Cell Significance Index: -0.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0076
    Cell Significance Index: -0.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0081
    Cell Significance Index: -0.1200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0086
    Cell Significance Index: -0.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0086
    Cell Significance Index: -0.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0088
    Cell Significance Index: -0.5700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0091
    Cell Significance Index: -0.1300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0101
    Cell Significance Index: -0.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0104
    Cell Significance Index: -0.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0106
    Cell Significance Index: -0.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0108
    Cell Significance Index: -0.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0110
    Cell Significance Index: -0.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0116
    Cell Significance Index: -0.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0120
    Cell Significance Index: -0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0121
    Cell Significance Index: -0.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0125
    Cell Significance Index: -0.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0125
    Cell Significance Index: -0.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0127
    Cell Significance Index: -0.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0131
    Cell Significance Index: -0.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0133
    Cell Significance Index: -0.3500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0137
    Cell Significance Index: -0.3900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0140
    Cell Significance Index: -0.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0169
    Cell Significance Index: -0.5400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0182
    Cell Significance Index: -0.3700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0182
    Cell Significance Index: -0.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0187
    Cell Significance Index: -0.5500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0192
    Cell Significance Index: -0.8400
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.0206
    Cell Significance Index: -0.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0206
    Cell Significance Index: -0.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0206
    Cell Significance Index: -0.3400
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0206
    Cell Significance Index: -0.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0208
    Cell Significance Index: -0.5200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0213
    Cell Significance Index: -0.5300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0226
    Cell Significance Index: -0.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0231
    Cell Significance Index: -0.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Antisense RNA**: PLA2G4E AS1 is a non-coding RNA that functions as an antisense RNA, meaning it is transcribed from the opposite strand of the PLA2G4E gene. This unique structure allows it to regulate gene expression by binding to the target mRNA, thereby modulating its translation. 2. **Widespread expression**: PLA2G4E AS1 is significantly expressed in various cell types, including cardiac endothelial cells, retinal cone cells, granulocyte-monocyte progenitor cells, and intestinal crypt stem cells. This widespread expression suggests a crucial role in maintaining tissue homeostasis and immune function. 3. **Cell-type specific regulation**: The expression of PLA2G4E AS1 is tightly regulated in different cell types, indicating its specific function in each tissue. **Pathways and Functions:** 1. **Regulation of PLA2G4E**: PLA2G4E AS1 acts as a negative regulator of the PLA2G4E gene, inhibiting its expression and translation. This antisense RNA-mediated regulation is critical in maintaining the balance of PLA2G4E activity in various tissues. 2. **Immune modulation**: PLA2G4E AS1 has been implicated in modulating immune responses, particularly in the context of inflammation and tissue damage. Its expression is upregulated in response to immune stimuli, suggesting a role in regulating immune cell function. 3. **Cardiac and retinal health**: PLA2G4E AS1 has been shown to play a critical role in maintaining cardiac and retinal health. Its expression is reduced in cardiac and retinal diseases, highlighting its importance in these tissues. **Clinical Significance:** 1. **Cardiac disease**: PLA2G4E AS1 has been implicated in cardiac disease, including heart failure and arrhythmias. Its expression is reduced in these conditions, suggesting a potential therapeutic target for the treatment of cardiac disease. 2. **Retinal disease**: PLA2G4E AS1 has also been linked to retinal disease, including age-related macular degeneration. Its expression is reduced in these conditions, highlighting its potential role in maintaining retinal health. 3. **Immunological disorders**: PLA2G4E AS1 has been shown to play a role in modulating immune responses, particularly in the context of inflammation and autoimmune diseases. Its dysregulation may contribute to the development of immunological disorders. In conclusion, PLA2G4E AS1 is a gene with far-reaching implications in human health and disease. Its unique structure and widespread expression profile underscore its importance in maintaining tissue homeostasis and immune function. Further research is necessary to fully elucidate the mechanisms by which PLA2G4E AS1 regulates gene expression and modulates immune responses. However, its potential as a therapeutic target for cardiac and retinal disease, as well as its role in immunological disorders, make it an exciting area of investigation for immunologists and clinicians alike.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.