ZNF274 | ENSG00000171606 | NCBI 10782

Details for: ZNF274

Gene ID: 10782

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ZNF274

Ensembl ID: ENSG00000171606

Description: zinc finger protein 274

Cell Significance Landscape

Display Count:

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Rna polymerase ii transcription
(R-HSA-73857)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Metal ion binding
(GO:0046872)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleolus
(GO:0005730)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

common myeloid progenitor CL0000049

CSI 9.63

rCSI 7.78%

PRS 78.74
squamous epithelial cell CL0000076

CSI 4.33

rCSI 10.29%

PRS 77.7
regular atrial cardiac myocyte CL0002129

CSI 4.14

rCSI 13.34%

PRS 73.54
differentiation-committed oligodendrocyte precursor CL4023059

CSI 4.01

rCSI 7.28%

PRS 67.78
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 3.86

rCSI 2.28%

PRS 91.56
CD4-positive, alpha-beta memory T cell CL0000897

CSI 3.74

rCSI 2.68%

PRS 88.99
ciliated epithelial cell CL0000067

CSI 3.65

rCSI 3.21%

PRS 65.28
unswitched memory B cell CL0000970

CSI 3.64

rCSI 3.06%

PRS 89.59
parietal epithelial cell CL1000452

CSI 3.62

rCSI 9.67%

PRS 67.88
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.61

rCSI 2.89%

PRS 90.87
kidney interstitial alternatively activated macrophage CL1000695

CSI 3.19

rCSI 8.32%

PRS 77.36
choroid plexus epithelial cell CL0000706

CSI 2.97

rCSI 4.87%

PRS 65.89
ON-bipolar cell CL0000749

CSI 2.91

rCSI 4.33%

PRS 76.9
vascular leptomeningeal cell CL4023051

CSI 2.71

rCSI 4.76%

PRS 69.8
immature B cell CL0000816

CSI 2.65

rCSI 1.97%

PRS 87.67
CD14-low, CD16-positive monocyte CL0002396

CSI 2.65

rCSI 2.04%

PRS 78.91
precursor B cell CL0000817

CSI 2.6

rCSI 2.27%

PRS 84.11
interneuron CL0000099

CSI 2.59

rCSI 5.2%

PRS 66.25
class switched memory B cell CL0000972

CSI 2.54

rCSI 1.89%

PRS 89.2
lung ciliated cell CL1000271

CSI 2.5

rCSI 2.89%

PRS 68.29
Kupffer cell CL0000091

CSI 2.44

rCSI 5.59%

PRS 77.45
naive T cell CL0000898

CSI 2.38

rCSI 1.66%

PRS 90.04
hematopoietic stem cell CL0000037

CSI 2.38

rCSI 1.58%

PRS 79.28
neural crest cell CL0011012

CSI 2.34

rCSI 1.85%

PRS 64.56
goblet cell CL0000160

CSI 2.27

rCSI 2.15%

PRS 75.59
perivascular cell CL4033054

CSI 2.26

rCSI 3.08%

PRS 81.07
alpha-beta T cell CL0000789

CSI 2.18

rCSI 2.55%

PRS 90.16
melanocyte CL0000148

CSI 2.17

rCSI 1.61%

PRS 69.65
Mueller cell CL0000636

CSI 2.17

rCSI 4.94%

PRS 67.88
mature B cell CL0000785

CSI 2.12

rCSI 1.84%

PRS 86.07
retina horizontal cell CL0000745

CSI 2.11

rCSI 3.21%

PRS 73.24
megakaryocyte-erythroid progenitor cell CL0000050

CSI 2.08

rCSI 1.88%

PRS 74.41
group 3 innate lymphoid cell CL0001071

CSI 2.05

rCSI 1.54%

PRS 82.38
retinal pigment epithelial cell CL0002586

CSI 2.05

rCSI 4.07%

PRS 72.59
myeloid leukocyte CL0000766

CSI 1.99

rCSI 1.84%

PRS 78.05
cerebral cortex GABAergic interneuron CL0010011

CSI 1.95

rCSI 5.77%

PRS 77.88
lung secretory cell CL1000272

CSI 1.93

rCSI 4.78%

PRS 76.05
hepatocyte CL0000182

CSI 1.9

rCSI 3.41%

PRS 75.81
pro-B cell CL0000826

CSI 1.9

rCSI 1.57%

PRS 78.9
rod bipolar cell CL0000751

CSI 1.9

rCSI 3.41%

PRS 69.77
BEST4+ enteroycte CL4030026

CSI 1.89

rCSI 2.35%

PRS 77.87
respiratory suprabasal cell CL4033048

CSI 1.89

rCSI 2.42%

PRS 80.25
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.82

rCSI 4.71%

PRS 71.89
activated type II NK T cell CL0000931

CSI 1.82

rCSI 2.04%

PRS 89.68
mononuclear phagocyte CL0000113

CSI 1.79

rCSI 3.95%

PRS 80.49
granulocyte monocyte progenitor cell CL0000557

CSI 1.78

rCSI 1.54%

PRS 80.72
ionocyte CL0005006

CSI 1.77

rCSI 1.89%

PRS 77.47
ependymal cell CL0000065

CSI 1.76

rCSI 3.56%

PRS 54.76
activated CD4-positive, alpha-beta T cell CL0000896

CSI 1.72

rCSI 1.59%

PRS 91.16
cerebral cortex endothelial cell CL1001602

CSI 1.66

rCSI 2.88%

PRS 67.6
extravillous trophoblast CL0008036

CSI 1.65

rCSI 2.04%

PRS 74.28
peripheral nervous system neuron CL2000032

CSI 1.63

rCSI 2.22%

PRS 67.79
retinal rod cell CL0000604

CSI 1.63

rCSI 2.87%

PRS 72.43
chondrocyte CL0000138

CSI 1.63

rCSI 2.59%

PRS 69.33
keratinocyte CL0000312

CSI 1.63

rCSI 1.36%

PRS 79.76
neuroblast (sensu Vertebrata) CL0000031

CSI 1.6

rCSI 2.05%

PRS 72.82
cardiac endothelial cell CL0010008

CSI 1.55

rCSI 6.26%

PRS 76.01
astrocyte of the cerebral cortex CL0002605

CSI 1.55

rCSI 3.47%

PRS 58.8
hepatic stellate cell CL0000632

CSI 1.54

rCSI 5.78%

PRS 68.72
amacrine cell CL0000561

CSI 1.52

rCSI 4.41%

PRS 65.68
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.51

rCSI 2.14%

PRS 73.25
retinal cone cell CL0000573

CSI 1.5

rCSI 2.41%

PRS 66.24
VIP GABAergic cortical interneuron CL4023016

CSI 1.46

rCSI 1.75%

PRS 58.03
erythrocyte CL0000232

CSI 1.45

rCSI 3.29%

PRS 77.77
cardiac muscle cell CL0000746

CSI 1.28

rCSI 1.84%

PRS 66.09
podocyte CL0000653

CSI 1.22

rCSI 5.43%

PRS 76.98
blood vessel smooth muscle cell CL0019018

CSI 1.19

rCSI 9.65%

PRS 70.16
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.19

rCSI 3.4%

PRS 92.75
retinal bipolar neuron CL0000748

CSI 1.17

rCSI 2.18%

PRS 64.54
helper T cell CL0000912

CSI 1.12

rCSI 1.58%

PRS 76.81
fibroblast of cardiac tissue CL0002548

CSI 1.11

rCSI 5.33%

PRS 76.58
lymphoid lineage restricted progenitor cell CL0000838

CSI 1.11

rCSI 4.32%

PRS 92.07
transitional stage B cell CL0000818

CSI 1.06

rCSI 3.48%

PRS 92.79
neural progenitor cell CL0011020

CSI 1.03

rCSI 4.55%

PRS 65.13
enteric smooth muscle cell CL0002504

CSI 1.02

rCSI 1.45%

PRS 77.7
sst GABAergic cortical interneuron CL4023017

CSI 0.97

rCSI 1.25%

PRS 59.31
kidney connecting tubule epithelial cell CL1000768

CSI 0.93

rCSI 2.35%

PRS 66.7
regular ventricular cardiac myocyte CL0002131

CSI 0.83

rCSI 5.18%

PRS 68.05
follicular B cell CL0000843

CSI 0.81

rCSI 2.94%

PRS 91.61
forebrain radial glial cell CL0013000

CSI 0.81

rCSI 2.58%

PRS 79.13
megakaryocyte CL0000556

CSI 0.74

rCSI 3.19%

PRS 83.14
L6b glutamatergic cortical neuron CL4023038

CSI 0.73

rCSI 2.27%

PRS 59.84
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.66

rCSI 1.6%

PRS 56.15
myeloid lineage restricted progenitor cell CL0000839

CSI 0.58

rCSI 2.97%

PRS 91.83

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [ZNF274](/details-gene/10782) is a protein-coding gene located on chromosome 19q13.43 that encodes Zinc Finger Protein 274, a Kruppel-type zinc finger protein. It functions as a DNA-binding transcription factor primarily involved in the negative regulation of gene expression and chromatin remodeling. A key aspect of its function involves recruiting the histone methyltransferase SETDB1 to the 3' ends of other zinc finger (ZNF) genes, thereby inducing transcriptional silencing through histone H3 lysine 9 trimethylation (H3K9me3) [Link](https://doi.org/10.1371/journal.pone.0015082). **Overall**, expression data highlights its highest significance in the [common myeloid progenitor](/details-cell/CL0000049), suggesting a crucial role in regulating myelopoiesis. It is also significantly expressed across a diverse range of cell types, including various epithelial, cardiac, neuronal precursor, and lymphoid cells. ## Cellular Roles and Expression Landscape The expression profile of [ZNF274](/details-gene/10782) indicates a role as a fundamental transcriptional regulator rather than a specific cell lineage marker. Its most significant expression is observed in the [common myeloid progenitor](/details-cell/CL0000049) (CSI: 9.63), which strongly suggests a foundational role in the commitment and differentiation of the myeloid lineage from hematopoietic stem cells. Beyond its role in hematopoiesis, [ZNF274](/details-gene/10782) shows significant expression in a wide array of differentiated cell types, underscoring its broad biological importance. These include: * **Epithelial Tissues:** High significance in [squamous epithelial cell](/details-cell/CL0000076) and [ciliated epithelial cell](/details-cell/CL0000067). * **Muscle and Nervous System:** Notable expression in [regular atrial cardiac myocyte](/details-cell/CL0002129) and [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059). * **Immune System:** Consistent significance across both adaptive and innate immune cells, including [central memory CD4-positive, alpha-beta T cell](/details-cell/CL0000904), [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897), [unswitched memory B cell](/details-cell/CL0000970), and [kidney interstitial alternatively activated macrophage](/details-cell/CL1000695). This widespread expression pattern, combined with its established localization to the nucleolus [Link](https://doi.org/10.1006/geno.2000.6140), is consistent with a role in maintaining cellular identity and genomic stability by regulating large cassettes of genes across multiple, distinct lineages. ## Pathways and Molecular Function The function of [ZNF274](/details-gene/10782) is deeply rooted in the regulation of transcription. This is reflected in its association with Reactome pathways such as [Gene expression (transcription)](https://reactome.org/content/detail/R-HSA-74160) and [Rna polymerase ii transcription](https://reactome.org/content/detail/R-HSA-73857). Gene Ontology (GO) annotations further clarify its mechanistic role: * **Biological Process:** It is primarily involved in [Negative regulation of transcription by rna polymerase ii](/details-cell/GO0000122) and [Chromatin remodeling](/details-cell/GO0006338). * **Molecular Function:** Its functions as a transcription factor are defined by its ability for [Sequence-specific dna binding](/details-cell/GO0043565) and [Chromatin binding](/details-cell/GO0003682). Critically, experimental evidence has demonstrated that [ZNF274](/details-gene/10782) serves as a molecular beacon, recruiting the SETDB1 enzyme to orchestrate the silencing of other ZNF genes [Link](https://doi.org/10.1371/journal.pone.0015082). This places [ZNF274](/details-gene/10782) as a master regulator within a complex network that controls the expression of a large family of transcription factors, thereby shaping the transcriptional landscape of the cell. ## Research Directions The widespread expression and critical regulatory function of [ZNF274](/details-gene/10782) present several avenues for future research. ### Testable Hypotheses 1. Given its exceptionally high significance in [common myeloid progenitor](/details-cell/CL0000049) cells, **[ZNF274](/details-gene/10782) is a critical gatekeeper for myeloid lineage commitment**. Its repressive function is likely required to silence genes associated with alternative hematopoietic fates (e.g., lymphoid or erythroid programs), thereby ensuring fidelity during myelopoiesis. 2. The broad expression of [ZNF274](/details-gene/10782) suggests that it **maintains cellular identity in differentiated tissues by constitutively repressing a specific subset of ZNF genes that would otherwise promote lineage plasticity or de-differentiation**. Loss of [ZNF274](/details-gene/10782) function in somatic cells could therefore contribute to cellular instability and diseases such as cancer. ### Proposed Experimental Approach To test the first hypothesis regarding the role of [ZNF274](/details-gene/10782) in myeloid differentiation, a CRISPR-Cas9-based loss-of-function study in primary human hematopoietic stem and progenitor cells (HSPCs) would be highly informative. CD34+ HSPCs could be isolated and subjected to [ZNF274](/details-gene/10782) knockout. These modified cells, alongside unedited controls, would then be cultured in media containing cytokines that promote myeloid differentiation (e.g., GM-CSF, M-CSF). The differentiation process would be monitored over time using multi-parameter flow cytometry to quantify the emergence of myeloid (CD33+, CD14+), erythroid (CD235a+), and lymphoid (CD19+) populations. A definitive result, such as a block in myelopoiesis or shunting towards an alternative lineage in the knockout cells, would be further investigated using single-cell RNA sequencing to identify the specific transcriptional programs, particularly other ZNF genes, that are de-repressed upon [ZNF274](/details-gene/10782) deletion. ### Therapeutic Potential As an intracellular DNA-binding protein, [ZNF274](/details-gene/10782) is a challenging target for conventional therapeutics like antibodies or small molecules. However, its role as a master epigenetic regulator suggests potential indirect therapeutic strategies. For instance, in malignancies characterized by blocked hematopoietic differentiation (e.g., acute myeloid leukemia), a loss of [ZNF274](/details-gene/10782) function could be a contributing factor. In such a context, therapeutic agents that enhance the activity of the H3K9me3-depositing machinery or inhibit antagonizing demethylases might partially restore the repressive state and promote differentiation. Conversely, if its overexpression leads to aberrant silencing of tumor suppressor genes, developing inhibitors against the ZNF274-SETDB1 protein-protein interaction could be a viable, albeit difficult, strategy. The broad expression of [ZNF274](/details-gene/10782) across many healthy tissues would, however, be a major consideration for potential on-target toxicity.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Neurotrophin receptor-interacting factor homolog
A0A0A0MR47_HUMAN

Genular Protein ID: 513830716

Symbol: ZN274_HUMAN

Name: Neurotrophin receptor-interacting factor homolog

UniProtKB Accession Codes:

Q96GC6 Q53XU4 Q6MZG1 Q8WY37 Q8WY38 Q92969 Q9UII0 Q9UII1

Database IDs:

Citations:

PubMed ID: 10777669

Title: Identification and characterization of human ZNF274 cDNA, Which encodes a novel kruppel-type zinc-finger protein having nucleolar targeting ability.

PubMed ID: 10777669

DOI: 10.1006/geno.2000.6140

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10520746

Title: Computer sequence analysis of human highly conserved zinc finger modules.

PubMed ID: 10520746

DOI: 10.3109/10425179809072191

PubMed ID: 21170338

Title: ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes.

PubMed ID: 21170338

DOI: 10.1371/journal.pone.0015082

PubMed ID: 27029610

Title: ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment.

PubMed ID: 27029610

DOI: 10.1080/15592294.2016.1169351

Sequence Information:

Length: 653
Mass: 74177
Checksum: 8B91F51F4BEED925
Sequence:

MASRLPTAWS CEPVTFEDVT LGFTPEEWGL LDLKQKSLYR EVMLENYRNL VSVEHQLSKP 
DVVSQLEEAE DFWPVERGIP QDTIPEYPEL QLDPKLDPLP AESPLMNIEV VEVLTLNQEV 
AGPRNAQIQA LYAEDGSLSA DAPSEQVQQQ GKHPGDPEAA RQRFRQFRYK DMTGPREALD 
QLRELCHQWL QPKARSKEQI LELLVLEQFL GALPVKLRTW VESQHPENCQ EVVALVEGVT 
WMSEEEVLPA GQPAEGTTCC LEVTAQQEEK QEDAAICPVT VLPEEPVTFQ DVAVDFSREE 
WGLLGPTQRT EYRDVMLETF GHLVSVGWET TLENKELAPN SDIPEEEPAP SLKVQESSRD 
CALSSTLEDT LQGGVQEVQD TVLKQMESAQ EKDLPQKKHF DNRESQANSG ALDTNQVSLQ 
KIDNPESQAN SGALDTNQVL LHKIPPRKRL RKRDSQVKSM KHNSRVKIHQ KSCERQKAKE 
GNGCRKTFSR STKQITFIRI HKGSQVCRCS ECGKIFRNPR YFSVHKKIHT GERPYVCQDC 
GKGFVQSSSL TQHQRVHSGE RPFECQECGR TFNDRSAISQ HLRTHTGAKP YKCQDCGKAF 
RQSSHLIRHQ RTHTGERPYA CNKCGKAFTQ SSHLIGHQRT HNRTKRKKKQ PTS

Genular Protein ID: 622676161

Symbol: A0A0A0MR47_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MR47

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

Length: 611
Mass: 69351
Checksum: 85C702E2705D97DD
Sequence:

MLENYRNLVS VEHQLSKPDV VSQLEEAEDF WPVERGIPQD TIPEYPELQL DPKLDPLPAE 
SPLMNIEVVE VLTLNQEVAG PRNAQIQALY AEDGSLSADA PSEQVQQQGK HPGDPEAARQ 
RFRQFRYKDM TGPREALDQL RELCHQWLQP KARSKEQILE LLVLEQFLGA LPVKLRTWVE 
SQHPENCQEV VALVEGVTWM SEEEVLPAGQ PAEGTTCCLE VTAQQEEKQE DAAICPVTVL 
PEEPVTFQDV AVDFSREEWG LLGPTQRTEY RDVMLETFGH LVSVGWETTL ENKELAPNSD 
IPEEEPAPSL KVQESSRDCA LSSTLEDTLQ GGVQEVQDTV LKQMESAQEK DLPQKKHFDN 
RESQANSGAL DTNQVSLQKI DNPESQANSG ALDTNQVLLH KIPPRKRLRK RDSQVKSMKH 
NSRVKIHQKS CERQKAKEGN GCRKTFSRST KQITFIRIHK GSQVCRCSEC GKIFRNPRYF 
SVHKKIHTGE RPYVCQDCGK GFVQSSSLTQ HQRVHSGERP FECQECGRTF NDRSAISQHL 
RTHTGAKPYK CQDCGKAFRQ SSHLIRHQRT HTGERPYACN KCGKAFTQSS HLIGHQRTHN 
RTKRKKKQPT S

Details for: ZNF274

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification and characterization of human ZNF274 cDNA, Which encodes a novel kruppel-type zinc-finger protein having nucleolar targeting ability. PubMed ID: 10777669

Large-scale cDNA transfection screening for genes related to cancer development and progression. PubMed ID: 15498874

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Computer sequence analysis of human highly conserved zinc finger modules. PubMed ID: 10520746

ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes. PubMed ID: 21170338

ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment. PubMed ID: 27029610

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

PubMed ID: 10777669

PubMed ID: 15498874

PubMed ID: 17974005

PubMed ID: 15057824

PubMed ID: 15489334

PubMed ID: 10520746

PubMed ID: 21170338

PubMed ID: 27029610

PubMed ID: 11237011

PubMed ID: 15057824

PubMed ID: 15496913