Details for: MAS1L

Gene ID: 116511

Symbol: MAS1L

Ensembl ID: ENSG00000204687

Description: MAS1 proto-oncogene like, G protein-coupled receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1622
    Cell Significance Index: 1.8600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1597
    Cell Significance Index: 2.7300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.1315
    Cell Significance Index: 1.7200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0817
    Cell Significance Index: 0.8900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0087
    Cell Significance Index: 0.1100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0026
    Cell Significance Index: -0.0400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0074
    Cell Significance Index: -0.1200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0099
    Cell Significance Index: -0.1300
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0225
    Cell Significance Index: -0.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0239
    Cell Significance Index: -0.6100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0269
    Cell Significance Index: -0.2900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0277
    Cell Significance Index: -0.6700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0279
    Cell Significance Index: -0.5600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0296
    Cell Significance Index: -0.4300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0300
    Cell Significance Index: -0.5900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0316
    Cell Significance Index: -0.7700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0389
    Cell Significance Index: -0.4400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0406
    Cell Significance Index: -0.4400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0430
    Cell Significance Index: -0.5900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0486
    Cell Significance Index: -0.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0488
    Cell Significance Index: -0.7200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0497
    Cell Significance Index: -0.6000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0522
    Cell Significance Index: -0.6700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0523
    Cell Significance Index: -0.6700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0535
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0541
    Cell Significance Index: -0.5200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0542
    Cell Significance Index: -0.6400
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0543
    Cell Significance Index: -0.5700
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0553
    Cell Significance Index: -0.4900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0556
    Cell Significance Index: -0.7300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0583
    Cell Significance Index: -0.8500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0591
    Cell Significance Index: -0.7200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0597
    Cell Significance Index: -0.7200
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0597
    Cell Significance Index: -0.9600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0608
    Cell Significance Index: -0.6400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0611
    Cell Significance Index: -0.6100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0611
    Cell Significance Index: -0.6200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0620
    Cell Significance Index: -0.8100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0633
    Cell Significance Index: -0.9600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0635
    Cell Significance Index: -0.7500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0643
    Cell Significance Index: -0.8100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0655
    Cell Significance Index: -0.9000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0661
    Cell Significance Index: -0.5900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0663
    Cell Significance Index: -0.7900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0668
    Cell Significance Index: -0.7400
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0672
    Cell Significance Index: -0.6100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0689
    Cell Significance Index: -0.7700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0692
    Cell Significance Index: -0.9800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0709
    Cell Significance Index: -0.8500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0711
    Cell Significance Index: -0.7000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0719
    Cell Significance Index: -0.8500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0720
    Cell Significance Index: -0.6300
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0736
    Cell Significance Index: -0.8000
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.0739
    Cell Significance Index: -0.7300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0759
    Cell Significance Index: -0.8800
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.0766
    Cell Significance Index: -0.7100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0791
    Cell Significance Index: -0.9100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0804
    Cell Significance Index: -0.8100
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0807
    Cell Significance Index: -0.5800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0820
    Cell Significance Index: -0.8500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0822
    Cell Significance Index: -0.9700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0841
    Cell Significance Index: -0.7900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0852
    Cell Significance Index: -0.8700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0853
    Cell Significance Index: -1.2500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0861
    Cell Significance Index: -0.6700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0882
    Cell Significance Index: -0.9300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0901
    Cell Significance Index: -0.6700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0911
    Cell Significance Index: -1.2100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0919
    Cell Significance Index: -0.6100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0919
    Cell Significance Index: -0.6400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0923
    Cell Significance Index: -0.7800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1025
    Cell Significance Index: -1.2200
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1061
    Cell Significance Index: -1.2200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1098
    Cell Significance Index: -1.2400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1155
    Cell Significance Index: -1.2300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1213
    Cell Significance Index: -1.3800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1339
    Cell Significance Index: -1.4500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1400
    Cell Significance Index: -1.7200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1436
    Cell Significance Index: -1.2700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1457
    Cell Significance Index: -0.7800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1537
    Cell Significance Index: -0.9100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1630
    Cell Significance Index: -1.3200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1985
    Cell Significance Index: -2.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAS1L is a G protein-coupled receptor that belongs to the Mas-related G-protein coupled receptor (Mrg) family. It is characterized by its ability to activate G proteins, leading to downstream signaling cascades that regulate various cellular processes. The MAS1L gene is transcriptionally regulated by the angiotensin II receptor, a key component of the renin-angiotensin system (RAS). This suggests that MAS1L plays a role in the regulation of blood pressure and fluid balance, in addition to its immune-related functions. **Pathways and Functions:** MAS1L is involved in several signaling pathways, including: 1. **Angiotensin-activated signaling pathway**: MAS1L is activated by angiotensin II, a peptide hormone that regulates blood pressure and fluid balance. This activation leads to the activation of G proteins, which in turn regulate various downstream signaling cascades. 2. **G protein-coupled receptor activity**: MAS1L is a G protein-coupled receptor that activates G proteins, leading to the regulation of various cellular processes, including immune response and cell signaling. 3. **G protein-coupled receptor signaling pathway**: MAS1L is involved in the regulation of various cellular processes, including immune response, cell growth, and differentiation. The functions of MAS1L include: 1. **Immune regulation**: MAS1L is expressed in immune cells, including T cells, B cells, and plasma cells, where it regulates immune response and cell signaling. 2. **Cell signaling**: MAS1L is involved in the regulation of various cellular processes, including cell growth, differentiation, and survival. 3. **Tissue homeostasis**: MAS1L is expressed in epithelial cells, including goblet cells and intestinal crypt stem cells, where it regulates tissue homeostasis and maintenance. **Clinical Significance:** MAS1L has been implicated in several immune-related diseases, including: 1. **Autoimmune diseases**: MAS1L has been shown to regulate immune response and cell signaling in autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Inflammatory diseases**: MAS1L has been implicated in the regulation of inflammation and immune response in inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). 3. **Cancer**: MAS1L has been shown to regulate cell growth and differentiation in various types of cancer, including breast cancer and prostate cancer. In conclusion, the MAS1L gene is a multifunctional G protein-coupled receptor that plays a crucial role in immune regulation, cell signaling, and tissue homeostasis. Its clinical significance in immune-related diseases highlights the importance of further research into the mechanisms of MAS1L and its potential as a therapeutic target.

Genular Protein ID: 3693309423

Symbol: MAS1L_HUMAN

Name: Mas-related G-protein coupled receptor MRG

UniProtKB Accession Codes:

P35410 Q5SUN5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 8 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1723144

Title: Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions.

PubMed ID: 1723144

DOI: 10.1210/mend-5-10-1477

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 378
  • Mass: 42411
  • Checksum: E08A606294B61474
  • Sequence:
    • MVWGKICWFS QRAGWTVFAE SQISLSCSLC LHSGDQEAQN PNLVSQLCGV FLQNETNETI 
HMQMSMAVGQ QALPLNIIAP KAVLVSLCGV LLNGTVFWLL CCGATNPYMV YILHLVAADV 
IYLCCSAVGF LQVTLLTYHG VVFFIPDFLA ILSPFSFEVC LCLLVAISTE RCVCVLFPIW 
YRCHRPKYTS NVVCTLIWGL PFCINIVKSL FLTYWKHVKA CVIFLKLSGL FHAILSLVMC 
VSSLTLLIRF LCCSQQQKAT RVYAVVQISA PMFLLWALPL SVAPLITDFK MFVTTSYLIS 
LFLIINSSAN PIIYFFVGSL RKKRLKESLR VILQRALADK PEVGRNKKAA GIDPMEQPHS 
TQHVENLLPR EHRVDVET

Genular Protein ID: 4071508174

Symbol: Q502V9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q502V9

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 RefSeq 1 RuleBase 1 SAM 3 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 378
  • Mass: 42387
  • Checksum: 8C9829D550041441
  • Sequence:
    • MVWGKICWFS QMAGWTVFAE SQISLSCSLC LHSGDQEAQN PNLVSQLCGV FLQNETDETI 
HMQMSMAVGQ QALPLNIIAP KAVLVSLCGV LLNGTVFWLL CCGATNPYMV YILHLVAADV 
IYLCCSAVGF LQVTLLTYHG VVFFIPDFLA ILSPFSFEVC LCLLVAISTE RCVCVLFPIW 
YRCHRPKYTS NVVCTLIWGL PFCINIVKSL FLTYWKHVKA CVIFLKLSGL FHAILSLVMC 
VSSLTLLIRF LCCSQQQKAT RVYAVVQISA PMFLLWALPL SVAPLITDFK MFVTTSYLIS 
LFLIINSSAN PIIYFFVGSL RKKRLKESLR VILQRALADK PEVGRNKKAA GIDPMEQPHS 
TQHVENLLPR EHRVDVET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.