Details for: PDCL2

Gene ID: 132954

Symbol: PDCL2

Ensembl ID: ENSG00000163440

Description: phosducin like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.6400
    Cell Significance Index: -4.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3377
    Cell Significance Index: 2.5500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3029
    Cell Significance Index: 4.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0955
    Cell Significance Index: 2.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0909
    Cell Significance Index: 2.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0799
    Cell Significance Index: 1.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0642
    Cell Significance Index: 0.9200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0091
    Cell Significance Index: 0.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0023
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0015
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0021
    Cell Significance Index: -1.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0023
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0046
    Cell Significance Index: -2.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0056
    Cell Significance Index: -8.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -7.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0061
    Cell Significance Index: -1.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0072
    Cell Significance Index: -1.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0075
    Cell Significance Index: -1.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0088
    Cell Significance Index: -4.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0096
    Cell Significance Index: -3.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0120
    Cell Significance Index: -2.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0137
    Cell Significance Index: -6.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0172
    Cell Significance Index: -2.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0198
    Cell Significance Index: -4.1800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0202
    Cell Significance Index: -0.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0257
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0309
    Cell Significance Index: -3.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0329
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0386
    Cell Significance Index: -4.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0432
    Cell Significance Index: -4.4100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0493
    Cell Significance Index: -0.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0521
    Cell Significance Index: -5.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0564
    Cell Significance Index: -1.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0638
    Cell Significance Index: -3.9200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0641
    Cell Significance Index: -0.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0653
    Cell Significance Index: -1.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0692
    Cell Significance Index: -4.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0782
    Cell Significance Index: -0.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0938
    Cell Significance Index: -4.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0955
    Cell Significance Index: -7.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0962
    Cell Significance Index: -11.3400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0976
    Cell Significance Index: -1.4600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0985
    Cell Significance Index: -2.4600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1038
    Cell Significance Index: -1.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1062
    Cell Significance Index: -3.7200
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1097
    Cell Significance Index: -1.0500
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1104
    Cell Significance Index: -1.2200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1113
    Cell Significance Index: -1.5600
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1125
    Cell Significance Index: -1.4400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1182
    Cell Significance Index: -0.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1183
    Cell Significance Index: -2.5900
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.1184
    Cell Significance Index: -1.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1200
    Cell Significance Index: -4.1700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1201
    Cell Significance Index: -1.2100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1220
    Cell Significance Index: -0.8100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1243
    Cell Significance Index: -2.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1260
    Cell Significance Index: -1.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1283
    Cell Significance Index: -7.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1314
    Cell Significance Index: -5.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1359
    Cell Significance Index: -4.4500
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1371
    Cell Significance Index: -1.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1396
    Cell Significance Index: -4.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1418
    Cell Significance Index: -3.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1423
    Cell Significance Index: -3.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1511
    Cell Significance Index: -4.4500
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1514
    Cell Significance Index: -1.6000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1520
    Cell Significance Index: -1.2000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1530
    Cell Significance Index: -2.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1550
    Cell Significance Index: -5.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1693
    Cell Significance Index: -4.8300
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1803
    Cell Significance Index: -2.2200
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.1804
    Cell Significance Index: -1.9700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1899
    Cell Significance Index: -4.0600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1908
    Cell Significance Index: -4.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1910
    Cell Significance Index: -5.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1936
    Cell Significance Index: -5.0900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1943
    Cell Significance Index: -2.0100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1945
    Cell Significance Index: -4.9600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1971
    Cell Significance Index: -1.2200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2020
    Cell Significance Index: -3.4300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2020
    Cell Significance Index: -4.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2110
    Cell Significance Index: -5.0600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2180
    Cell Significance Index: -4.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2197
    Cell Significance Index: -4.4100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2250
    Cell Significance Index: -3.7900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.2275
    Cell Significance Index: -1.3100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2304
    Cell Significance Index: -2.9600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2307
    Cell Significance Index: -4.5400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2319
    Cell Significance Index: -5.0100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2339
    Cell Significance Index: -2.9600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2374
    Cell Significance Index: -2.7600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2386
    Cell Significance Index: -3.4900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2417
    Cell Significance Index: -4.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2462
    Cell Significance Index: -4.1200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2545
    Cell Significance Index: -1.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2550
    Cell Significance Index: -9.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** PDCL2 is significantly expressed in a wide range of cell types, including progenitor cells, germ cells, granulocyte-monocyte progenitor cells, goblet cells, plasma cells, oogonial cells, early T lineage precursors, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and absorptive cells. 2. **Protein Structure:** PDCL2 is a member of the phosducin-like protein family, which consists of four conserved domains: an N-terminal domain, a central domain, a C-terminal domain, and a C-terminal extension. 3. **Functional Implications:** PDCL2 has been implicated in protein folding, cell migration, and signaling pathways, suggesting its potential role in cellular processes such as development, differentiation, and disease progression. **Pathways and Functions:** 1. **Protein Folding:** PDCL2 has been shown to interact with chaperone proteins, such as Hsp90, and play a role in protein folding and degradation, thereby regulating protein homeostasis. 2. **Cell Migration:** PDCL2 has been implicated in cell migration, which is crucial for development, tissue homeostasis, and disease progression. PDCL2 may regulate cell migration by interacting with cytoskeletal proteins and signaling molecules. 3. **Signaling Pathways:** PDCL2 has been shown to interact with signaling molecules, such as G-proteins and kinases, and modulate signaling pathways involved in cell proliferation, differentiation, and survival. **Clinical Significance:** 1. **Developmental Disorders:** PDCL2 expression abnormalities have been implicated in developmental disorders, such as autism spectrum disorder, schizophrenia, and neurodevelopmental disorders. 2. **Cancer:** PDCL2 overexpression has been observed in various types of cancer, including breast cancer, lung cancer, and colon cancer, suggesting its potential role in tumorigenesis and cancer progression. 3. **Neurological Disorders:** PDCL2 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, highlighting its potential role in neurodegenerative diseases. 4. **Immunological Disorders:** PDCL2 expression abnormalities have been observed in immunological disorders, such as multiple sclerosis and rheumatoid arthritis, suggesting its potential role in immune system dysregulation. In conclusion, PDCL2 is a multifunctional protein with far-reaching implications in human development, disease progression, and immune system dysregulation. Further studies are necessary to elucidate the mechanisms underlying PDCL2's functions and to explore its therapeutic potential in various diseases.

Genular Protein ID: 3247180718

Symbol: PDCL2_HUMAN

Name: Phosducin-like protein 2

UniProtKB Accession Codes:

Q8N4E4 A8MWA2 B9ZVQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19193988

Title: Structure of the thioredoxin-fold domain of human phosducin-like protein 2.

PubMed ID: 19193988

DOI: 10.1107/s1744309108037342

Sequence Information:

  • Length: 241
  • Mass: 28071
  • Checksum: F2F21C7252EE45CB
  • Sequence:
    • MQDPNEDTEW NDILRDFGIL PPKEESKDEI EEMVLRLQKE AMVKPFEKMT LAQLKEAEDE 
FDEEDMQAVE TYRKKRLQEW KALKKKQKFG ELREISGNQY VNEVTNAEED VWVIIHLYRS 
SIPMCLLVNQ HLSLLARKFP ETKFVKAIVN SCIQHYHDNC LPTIFVYKNG QIEAKFIGII 
ECGGINLKLE ELEWKLAEVG AIQTDLEENP RKDMVDMMVS SIRNTSIHDD SDSSNSDNDT 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.