Details for: GSDME

Gene ID: 1687

Symbol: GSDME

Ensembl ID: ENSG00000105928

Description: gasdermin E

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 3.9
    Marker Score: 4860
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.79
    Marker Score: 4296
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.99
    Marker Score: 7834
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.87
    Marker Score: 2304
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.53
    Marker Score: 1364
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.37
    Marker Score: 1652.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.35
    Marker Score: 2360
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2319
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.11
    Marker Score: 1494
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.03
    Marker Score: 15458
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.01
    Marker Score: 250
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71809
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.99
    Marker Score: 37525
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15389
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 644
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.92
    Marker Score: 735
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.89
    Marker Score: 1453
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.88
    Marker Score: 2406
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.87
    Marker Score: 359
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.84
    Marker Score: 4975
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.83
    Marker Score: 3594
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.82
    Marker Score: 379
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.79
    Marker Score: 727
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.78
    Marker Score: 5189
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 594.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.78
    Marker Score: 518.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.76
    Marker Score: 7183
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.76
    Marker Score: 6537
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.76
    Marker Score: 1166
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.75
    Marker Score: 5775
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.72
    Marker Score: 4341
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2983
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.7
    Marker Score: 385
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.69
    Marker Score: 1307
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.69
    Marker Score: 25334
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.68
    Marker Score: 1607
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.68
    Marker Score: 6996
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.66
    Marker Score: 2744
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.65
    Marker Score: 535
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.63
    Marker Score: 1150
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.62
    Marker Score: 653
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.61
    Marker Score: 195
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.58
    Marker Score: 2249
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.58
    Marker Score: 5482
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 275
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.57
    Marker Score: 825
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.57
    Marker Score: 6426
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 347
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.51
    Marker Score: 10232
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.51
    Marker Score: 299
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.5
    Marker Score: 2037
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.49
    Marker Score: 610.5
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.49
    Marker Score: 154
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.47
    Marker Score: 649
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.46
    Marker Score: 1228
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.45
    Marker Score: 27679
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.45
    Marker Score: 144
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.44
    Marker Score: 473
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.42
    Marker Score: 210.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.42
    Marker Score: 276
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.42
    Marker Score: 130
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.38
    Marker Score: 1469
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 378
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.37
    Marker Score: 1719
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.37
    Marker Score: 753
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 151
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.35
    Marker Score: 173
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.35
    Marker Score: 911
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.34
    Marker Score: 598
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.33
    Marker Score: 95
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.33
    Marker Score: 132
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 87
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.33
    Marker Score: 6941
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.32
    Marker Score: 325
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.31
    Marker Score: 845
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.31
    Marker Score: 2299
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.31
    Marker Score: 492
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.3
    Marker Score: 124
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3
    Marker Score: 652
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.29
    Marker Score: 122
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.29
    Marker Score: 541
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.29
    Marker Score: 71
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.28
    Marker Score: 805
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.28
    Marker Score: 73

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Other Information

**Key characteristics:** - GSDME is a protein of the cytochrome c family, which are a group of proteins that are involved in the regulation of apoptosis. - It is expressed in a wide range of cell types, including retinal ganglion cells, enterocytes, placental villous trophoblast, B-2 B cells, and germ cells. - GSDME is a key regulator of inflammation and cell death. - It is activated by a variety of stimuli, including damage to cells, infection, and cytokines. - Once activated, GSDME triggers a cascade of events that lead to the death of the cell. **Pathways and functions:** - GSDME is involved in the regulation of apoptosis, a process that is essential for the removal of damaged or unwanted cells. - It is also involved in the regulation of cell death in response to inflammation and infection. - GSDME is a key regulator of tumor growth and metastasis. - It is also involved in the regulation of the immune response. **Clinical significance:** - Mutations in GSDME have been linked to a number of human diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. - GSDME inhibitors are being investigated as a potential treatment for these diseases.

Genular Protein ID: 3009622475

Symbol: GSDME_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60443 A4D156 B2RAX9 B3KT05 O14590 Q08AQ8 Q9UBV3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 17 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 4 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9771715

Title: Nonsyndromic hearing impairment is associated with a mutation in DFNA5.

PubMed ID: 9771715

DOI: 10.1038/2503

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9523727

Title: Characterization of a gene that is inversely correlated with estrogen receptor expression (ICERE-1) in breast carcinomas.

PubMed ID: 9523727

DOI: 10.1046/j.1432-1327.1998.2520169.x

PubMed ID: 16897187

Title: The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage.

PubMed ID: 16897187

DOI: 10.1007/s10038-006-0004-6

PubMed ID: 18223688

Title: Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma.

PubMed ID: 18223688

DOI: 10.1038/sj.onc.1211021

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21522185

Title: The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein.

PubMed ID: 21522185

DOI: 10.1038/ejhg.2011.63

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 19911014

Title: Evidence for a founder mutation causing DFNA5 hearing loss in East Asians.

PubMed ID: 19911014

DOI: 10.1038/jhg.2009.114

PubMed ID: 24506266

Title: A DFNA5 mutation identified in Japanese families with autosomal dominant hereditary hearing loss.

PubMed ID: 24506266

DOI: 10.1111/ahg.12053

PubMed ID: 26236191

Title: The deafness gene DFNA5 induces programmed cell death through mitochondria and MAPK-related pathways.

PubMed ID: 26236191

DOI: 10.3389/fncel.2015.00231

PubMed ID: 27281216

Title: Pore-forming activity and structural autoinhibition of the gasdermin family.

PubMed ID: 27281216

DOI: 10.1038/nature18590

PubMed ID: 28459430

Title: Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.

PubMed ID: 28459430

DOI: 10.1038/nature22393

PubMed ID: 28045099

Title: Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.

PubMed ID: 28045099

DOI: 10.1038/ncomms14128

PubMed ID: 32188940

Title: Gasdermin E suppresses tumour growth by activating anti-tumour immunity.

PubMed ID: 32188940

DOI: 10.1038/s41586-020-2071-9

PubMed ID: 32820063

Title: Succination inactivates gasdermin D and blocks pyroptosis.

PubMed ID: 32820063

DOI: 10.1126/science.abb9818

PubMed ID: 31953257

Title: Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome.

PubMed ID: 31953257

DOI: 10.1126/sciimmunol.aax7969

PubMed ID: 33852854

Title: Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.

PubMed ID: 33852854

DOI: 10.1016/j.celrep.2021.108998

PubMed ID: 35972780

Title: Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME.

PubMed ID: 35972780

DOI: 10.7554/elife.73792

PubMed ID: 35594856

Title: Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells.

PubMed ID: 35594856

DOI: 10.1016/j.molcel.2022.04.033

Sequence Information:

  • Length: 496
  • Mass: 54555
  • Checksum: A407C9AC31AA716B
  • Sequence:
    • MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD 
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK 
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC 
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK 
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA 
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL 
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL 
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL 
LCITLNGLCA LGREHS

Genular Protein ID: 3181522926

Symbol: A4FVA8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A4FVA8

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Genevisible 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 437
  • Mass: 47735
  • Checksum: EA17AC93616AAF9B
  • Sequence:
    • PTLPERPRHL PVVVESDFVK YEGKFANHVS GTLETALGKV KLNLGGSSRV ESQSSFGTLR 
KQEVDLQQLI RDSAERTINL RNPVLQQVLE GRNEVLCVLT QKITTMQKCV ISEHMQVEEK 
CGGIVGIQTK TVQVSATEDG NVTKDSNVVL EIPAATTIAY GVIELYVKLD GQFEFCLLRG 
KQGGFENKKR IDSVYLDPLV FREFAFIDMP DAAHGISSQD GPLSVLKQAT LLLERNFHPF 
AELPEPQQTA LSDIFQAVLF DDELLMVLEP VCDDLVSGLS PTVAVLGELK PRQQQDLVAF 
LQLVGCSLQG GCPGPEDAGS KQLFMTAYFL VSALAEMPDS AAALLGTCCK LQIIPTLCHL 
LRALSDDGVS DLEDPTLTPL KDTERFGIVQ RLFASADISL ERLKSSVKAV ILKDSKVFPL 
LLCITLNGLC ALGREHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.