Details for: GSDME

Gene ID: 1687

Symbol: GSDME

Ensembl ID: ENSG00000105928

Description: gasdermin E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.6308
    Cell Significance Index: -16.3500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 21.6746
    Cell Significance Index: 335.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7626
    Cell Significance Index: 79.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2921
    Cell Significance Index: 245.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7614
    Cell Significance Index: 20.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6545
    Cell Significance Index: 590.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6128
    Cell Significance Index: 60.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5367
    Cell Significance Index: 87.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5155
    Cell Significance Index: 103.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4295
    Cell Significance Index: 12.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4253
    Cell Significance Index: 26.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4136
    Cell Significance Index: 8.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3820
    Cell Significance Index: 9.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3693
    Cell Significance Index: 73.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3037
    Cell Significance Index: 41.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2917
    Cell Significance Index: 31.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2584
    Cell Significance Index: 92.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2418
    Cell Significance Index: 167.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2310
    Cell Significance Index: 5.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2254
    Cell Significance Index: 13.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2195
    Cell Significance Index: 31.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1917
    Cell Significance Index: 13.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1910
    Cell Significance Index: 9.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1764
    Cell Significance Index: 6.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1637
    Cell Significance Index: 7.2400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1533
    Cell Significance Index: 2.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1078
    Cell Significance Index: 165.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0856
    Cell Significance Index: 15.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0794
    Cell Significance Index: 2.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0725
    Cell Significance Index: 133.6300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0677
    Cell Significance Index: 0.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0388
    Cell Significance Index: 4.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0342
    Cell Significance Index: 3.9900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0326
    Cell Significance Index: 1.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0275
    Cell Significance Index: 15.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0253
    Cell Significance Index: 0.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0137
    Cell Significance Index: 0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0103
    Cell Significance Index: 14.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0077
    Cell Significance Index: 14.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0076
    Cell Significance Index: 0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0025
    Cell Significance Index: 1.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0143
    Cell Significance Index: -6.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0149
    Cell Significance Index: -6.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0160
    Cell Significance Index: -10.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0190
    Cell Significance Index: -0.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0196
    Cell Significance Index: -1.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0197
    Cell Significance Index: -14.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0218
    Cell Significance Index: -16.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0278
    Cell Significance Index: -7.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0281
    Cell Significance Index: -1.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0283
    Cell Significance Index: -15.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0292
    Cell Significance Index: -18.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0365
    Cell Significance Index: -4.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0423
    Cell Significance Index: -4.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0603
    Cell Significance Index: -3.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0605
    Cell Significance Index: -1.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0664
    Cell Significance Index: -5.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0686
    Cell Significance Index: -3.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0690
    Cell Significance Index: -7.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0699
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0799
    Cell Significance Index: -16.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0893
    Cell Significance Index: -15.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0932
    Cell Significance Index: -12.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1026
    Cell Significance Index: -1.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1043
    Cell Significance Index: -1.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1115
    Cell Significance Index: -13.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1432
    Cell Significance Index: -14.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1462
    Cell Significance Index: -2.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1511
    Cell Significance Index: -11.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1553
    Cell Significance Index: -10.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1560
    Cell Significance Index: -11.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1820
    Cell Significance Index: -8.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2012
    Cell Significance Index: -4.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2043
    Cell Significance Index: -15.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2238
    Cell Significance Index: -14.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2240
    Cell Significance Index: -7.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2404
    Cell Significance Index: -5.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2410
    Cell Significance Index: -6.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2596
    Cell Significance Index: -5.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2609
    Cell Significance Index: -13.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2659
    Cell Significance Index: -8.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2770
    Cell Significance Index: -7.7400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2822
    Cell Significance Index: -3.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2843
    Cell Significance Index: -11.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2921
    Cell Significance Index: -6.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3015
    Cell Significance Index: -6.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3078
    Cell Significance Index: -14.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3080
    Cell Significance Index: -9.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3171
    Cell Significance Index: -11.1100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3196
    Cell Significance Index: -5.0700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3199
    Cell Significance Index: -3.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3208
    Cell Significance Index: -9.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3297
    Cell Significance Index: -8.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3343
    Cell Significance Index: -5.6000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3377
    Cell Significance Index: -8.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3570
    Cell Significance Index: -7.0600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3598
    Cell Significance Index: -2.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3997
    Cell Significance Index: -9.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4074
    Cell Significance Index: -6.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4255
    Cell Significance Index: -15.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GSDME is a transmembrane protein that spans the plasma membrane, with a wide pore channel activity. It is characterized by its ability to bind to phosphatidylinositol-4,5-bisphosphate (PIP2) and cardiolipin, which are essential components of the mitochondrial outer membrane. GSDME is also involved in the regulation of innate immune responses, particularly in the context of TNF signaling. Its expression is upregulated in response to TNF, and it is involved in the activation of the NF-κB pathway, which is a key regulator of immune responses. **Pathways and Functions:** GSDME is involved in several key pathways, including: 1. **Apoptosis and Pyroptosis:** GSDME is a key regulator of pyroptosis, a form of programmed cell death that is mediated by the activation of the inflammasome complex. It is also involved in the regulation of apoptosis, particularly in the context of TNF signaling. 2. **TNF Signaling:** GSDME is a positive regulator of TNF signaling, and its expression is upregulated in response to TNF. It is involved in the activation of the NF-κB pathway, which is a key regulator of immune responses. 3. **Innate Immunity:** GSDME is involved in the regulation of innate immune responses, particularly in the context of TNF signaling. It is also involved in the regulation of the release of apoptotic factors from the mitochondria. 4. **Regulation of TLR:** GSDME is involved in the regulation of Toll-like receptor (TLR) signaling, particularly in the context of endogenous ligands. **Clinical Significance:** GSDME has significant clinical implications, particularly in the context of immune-mediated disorders. Its dysregulation has been implicated in several diseases, including: 1. **Autoimmune Disorders:** GSDME dysregulation has been implicated in several autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. 2. **Infectious Diseases:** GSDME is involved in the regulation of innate immune responses, particularly in the context of TNF signaling. Its dysregulation has been implicated in several infectious diseases, including sepsis and tuberculosis. 3. **Cancer:** GSDME is involved in the regulation of apoptosis and pyroptosis, particularly in the context of tumor necrosis factor signaling. Its dysregulation has been implicated in several types of cancer, including breast cancer and lung cancer. In conclusion, GSDME is a complex protein that plays a crucial role in regulating immune responses and cellular death. Its dysregulation has significant clinical implications, particularly in the context of immune-mediated disorders. Further research is needed to fully understand the mechanisms by which GSDME regulates immune responses and to identify potential therapeutic targets for the treatment of diseases associated with GSDME dysregulation.

Genular Protein ID: 3009622475

Symbol: GSDME_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60443 A4D156 B2RAX9 B3KT05 O14590 Q08AQ8 Q9UBV3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 ExpressionAtlas 1 GO 18 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 4 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9771715

Title: Nonsyndromic hearing impairment is associated with a mutation in DFNA5.

PubMed ID: 9771715

DOI: 10.1038/2503

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9523727

Title: Characterization of a gene that is inversely correlated with estrogen receptor expression (ICERE-1) in breast carcinomas.

PubMed ID: 9523727

DOI: 10.1046/j.1432-1327.1998.2520169.x

PubMed ID: 16897187

Title: The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage.

PubMed ID: 16897187

DOI: 10.1007/s10038-006-0004-6

PubMed ID: 18223688

Title: Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma.

PubMed ID: 18223688

DOI: 10.1038/sj.onc.1211021

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21522185

Title: The DFNA5 gene, responsible for hearing loss and involved in cancer, encodes a novel apoptosis-inducing protein.

PubMed ID: 21522185

DOI: 10.1038/ejhg.2011.63

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 19911014

Title: Evidence for a founder mutation causing DFNA5 hearing loss in East Asians.

PubMed ID: 19911014

DOI: 10.1038/jhg.2009.114

PubMed ID: 24506266

Title: A DFNA5 mutation identified in Japanese families with autosomal dominant hereditary hearing loss.

PubMed ID: 24506266

DOI: 10.1111/ahg.12053

PubMed ID: 26236191

Title: The deafness gene DFNA5 induces programmed cell death through mitochondria and MAPK-related pathways.

PubMed ID: 26236191

DOI: 10.3389/fncel.2015.00231

PubMed ID: 27281216

Title: Pore-forming activity and structural autoinhibition of the gasdermin family.

PubMed ID: 27281216

DOI: 10.1038/nature18590

PubMed ID: 28459430

Title: Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.

PubMed ID: 28459430

DOI: 10.1038/nature22393

PubMed ID: 28045099

Title: Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death.

PubMed ID: 28045099

DOI: 10.1038/ncomms14128

PubMed ID: 32188940

Title: Gasdermin E suppresses tumour growth by activating anti-tumour immunity.

PubMed ID: 32188940

DOI: 10.1038/s41586-020-2071-9

PubMed ID: 32820063

Title: Succination inactivates gasdermin D and blocks pyroptosis.

PubMed ID: 32820063

DOI: 10.1126/science.abb9818

PubMed ID: 31953257

Title: Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome.

PubMed ID: 31953257

DOI: 10.1126/sciimmunol.aax7969

PubMed ID: 33852854

Title: Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases.

PubMed ID: 33852854

DOI: 10.1016/j.celrep.2021.108998

PubMed ID: 35972780

Title: Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME.

PubMed ID: 35972780

DOI: 10.7554/elife.73792

PubMed ID: 35594856

Title: Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells.

PubMed ID: 35594856

DOI: 10.1016/j.molcel.2022.04.033

PubMed ID: 36607699

Title: USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer.

PubMed ID: 36607699

DOI: 10.1158/0008-5472.can-22-1812

PubMed ID: 38599239

Title: ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.

PubMed ID: 38599239

DOI: 10.1038/s41586-024-07373-5

Sequence Information:

  • Length: 496
  • Mass: 54555
  • Checksum: A407C9AC31AA716B
  • Sequence:
    • MFAKATRNFL REVDADGDLI AVSNLNDSDK LQLLSLVTKK KRFWCWQRPK YQFLSLTLGD 
VLIEDQFPSP VVVESDFVKY EGKFANHVSG TLETALGKVK LNLGGSSRVE SQSSFGTLRK 
QEVDLQQLIR DSAERTINLR NPVLQQVLEG RNEVLCVLTQ KITTMQKCVI SEHMQVEEKC 
GGIVGIQTKT VQVSATEDGN VTKDSNVVLE IPAATTIAYG VIELYVKLDG QFEFCLLRGK 
QGGFENKKRI DSVYLDPLVF REFAFIDMPD AAHGISSQDG PLSVLKQATL LLERNFHPFA 
ELPEPQQTAL SDIFQAVLFD DELLMVLEPV CDDLVSGLSP TVAVLGELKP RQQQDLVAFL 
QLVGCSLQGG CPGPEDAGSK QLFMTAYFLV SALAEMPDSA AALLGTCCKL QIIPTLCHLL 
RALSDDGVSD LEDPTLTPLK DTERFGIVQR LFASADISLE RLKSSVKAVI LKDSKVFPLL 
LCITLNGLCA LGREHS

Genular Protein ID: 3181522926

Symbol: A4FVA8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A4FVA8

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 437
  • Mass: 47735
  • Checksum: EA17AC93616AAF9B
  • Sequence:
    • PTLPERPRHL PVVVESDFVK YEGKFANHVS GTLETALGKV KLNLGGSSRV ESQSSFGTLR 
KQEVDLQQLI RDSAERTINL RNPVLQQVLE GRNEVLCVLT QKITTMQKCV ISEHMQVEEK 
CGGIVGIQTK TVQVSATEDG NVTKDSNVVL EIPAATTIAY GVIELYVKLD GQFEFCLLRG 
KQGGFENKKR IDSVYLDPLV FREFAFIDMP DAAHGISSQD GPLSVLKQAT LLLERNFHPF 
AELPEPQQTA LSDIFQAVLF DDELLMVLEP VCDDLVSGLS PTVAVLGELK PRQQQDLVAF 
LQLVGCSLQG GCPGPEDAGS KQLFMTAYFL VSALAEMPDS AAALLGTCCK LQIIPTLCHL 
LRALSDDGVS DLEDPTLTPL KDTERFGIVQ RLFASADISL ERLKSSVKAV ILKDSKVFPL 
LLCITLNGLC ALGREHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.