Details for: DMP1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: preosteoblast (CL0007010)
Fold Change: 1.2280
Cell Significance Index: 11.1500 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.7134
Cell Significance Index: 17.2800 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: 0.2942
Cell Significance Index: 3.9700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.2842
Cell Significance Index: 4.0700 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.2598
Cell Significance Index: 4.3700 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.2082
Cell Significance Index: 2.1300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1041
Cell Significance Index: 13.3500 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.0448
Cell Significance Index: 0.5800 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.0326
Cell Significance Index: 0.8300 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.0152
Cell Significance Index: 0.2600 - Cell Name: osteoblast (CL0000062)
Fold Change: 0.0144
Cell Significance Index: 0.1400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0056
Cell Significance Index: 3.8900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0003
Cell Significance Index: -0.6000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0006
Cell Significance Index: -1.1100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0011
Cell Significance Index: -1.7600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0013
Cell Significance Index: -0.9800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0014
Cell Significance Index: -1.0300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0025
Cell Significance Index: -0.7300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0026
Cell Significance Index: -1.6600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0026
Cell Significance Index: -0.5100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0027
Cell Significance Index: -1.5300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0032
Cell Significance Index: -1.1400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0042
Cell Significance Index: -1.9200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0045
Cell Significance Index: -0.9000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0046
Cell Significance Index: -0.2300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0056
Cell Significance Index: -0.2300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0075
Cell Significance Index: -1.3500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0094
Cell Significance Index: -1.6100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0102
Cell Significance Index: -0.1500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0116
Cell Significance Index: -1.1900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0128
Cell Significance Index: -1.5800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0147
Cell Significance Index: -1.6800 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.0178
Cell Significance Index: -0.2100 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0179
Cell Significance Index: -0.2900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0186
Cell Significance Index: -1.4300 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0217
Cell Significance Index: -0.2100 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0218
Cell Significance Index: -0.2800 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0219
Cell Significance Index: -0.3000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0260
Cell Significance Index: -1.4600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0262
Cell Significance Index: -1.7600 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.0280
Cell Significance Index: -0.4200 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -0.0287
Cell Significance Index: -0.2600 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0299
Cell Significance Index: -0.5900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0319
Cell Significance Index: -1.6600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0323
Cell Significance Index: -1.6800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0351
Cell Significance Index: -0.9400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0363
Cell Significance Index: -1.2700 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0364
Cell Significance Index: -0.5300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0370
Cell Significance Index: -0.8100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0375
Cell Significance Index: -1.6600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0397
Cell Significance Index: -1.3000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0404
Cell Significance Index: -1.9000 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.0405
Cell Significance Index: -0.3700 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.0406
Cell Significance Index: -0.4400 - Cell Name: microglial cell (CL0000129)
Fold Change: -0.0408
Cell Significance Index: -0.4800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0429
Cell Significance Index: -1.3700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0430
Cell Significance Index: -1.6300 - Cell Name: neutrophil (CL0000775)
Fold Change: -0.0448
Cell Significance Index: -0.5600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0497
Cell Significance Index: -1.0400 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.0506
Cell Significance Index: -0.8600 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0516
Cell Significance Index: -1.2900 - Cell Name: precursor cell (CL0011115)
Fold Change: -0.0541
Cell Significance Index: -0.4100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0553
Cell Significance Index: -1.3800 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.0557
Cell Significance Index: -0.7400 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0562
Cell Significance Index: -1.1200 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.0569
Cell Significance Index: -0.4100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0570
Cell Significance Index: -1.5000 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0585
Cell Significance Index: -1.8500 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0609
Cell Significance Index: -1.2700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0613
Cell Significance Index: -1.7500 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0620
Cell Significance Index: -1.3400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0638
Cell Significance Index: -1.8300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0645
Cell Significance Index: -1.3700 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.0647
Cell Significance Index: -0.7400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0648
Cell Significance Index: -1.7300 - Cell Name: mast cell (CL0000097)
Fold Change: -0.0669
Cell Significance Index: -0.8800 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0672
Cell Significance Index: -1.3500 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0673
Cell Significance Index: -0.7900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0690
Cell Significance Index: -1.4800 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0705
Cell Significance Index: -0.7300 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.0710
Cell Significance Index: -0.6000 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0711
Cell Significance Index: -1.4000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0713
Cell Significance Index: -1.4100 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0715
Cell Significance Index: -0.8700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0758
Cell Significance Index: -1.8500 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0765
Cell Significance Index: -1.0200 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.0768
Cell Significance Index: -0.8500 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.0777
Cell Significance Index: -0.8800 - Cell Name: progenitor cell (CL0011026)
Fold Change: -0.0781
Cell Significance Index: -0.8300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0793
Cell Significance Index: -1.3400 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0799
Cell Significance Index: -0.8700 - Cell Name: glial cell (CL0000125)
Fold Change: -0.0803
Cell Significance Index: -0.8800 - Cell Name: adipocyte (CL0000136)
Fold Change: -0.0818
Cell Significance Index: -1.0900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0821
Cell Significance Index: -1.9700 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.0829
Cell Significance Index: -1.1900 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0836
Cell Significance Index: -1.1600 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0841
Cell Significance Index: -1.2100 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.0846
Cell Significance Index: -1.3600 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0847
Cell Significance Index: -1.4700 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0853
Cell Significance Index: -1.1200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 1208259312
Symbol: DMP1_HUMAN
Name: Dentin matrix acidic phosphoprotein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9177774
Title: Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II.
PubMed ID: 9177774
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8586437
Title: Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21.
PubMed ID: 8586437
PubMed ID: 12615915
Title: Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store.
PubMed ID: 12615915
PubMed ID: 17033625
Title: DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.
PubMed ID: 17033625
DOI: 10.1038/ng1868
PubMed ID: 17033621
Title: Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.
PubMed ID: 17033621
DOI: 10.1038/ng1905
PubMed ID: 22582013
Title: Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.
PubMed ID: 22582013
Sequence Information:
- Length: 513
- Mass: 55782
- Checksum: 2C1FDE319A5D106F
- Sequence:
MKISILLMFL WGLSCALPVT RYQNNESEDS EEWKGHLAQA PTPPLESSES SEGSKVSSEE QANEDPSDST QSEEGLGSDD HQYIYRLAGG FSRSTGKGGD DKDDDEDDSG DDTFGDDDSG PGPKDRQEGG NSRLGSDEDS DDTIQASEES APQGQDSAQD TTSESRELDN EDRVDSKPEG GDSTQESESE EHWVGGGSDG ESSHGDGSEL DDEGMQSDDP ESIRSERGNS RMNSAGMKSK ESGENSEQAN TQDSGGSQLL EHPSRKIFRK SRISEEDDRS ELDDNNTMEE VKSDSTENSN SRDTGLSQPR RDSKGDSQED SKENLSQEES QNVDGPSSES SQEANLSSQE NSSESQEEVV SESRGDNPDP TTSYVEDQED SDSSEEDSSH TLSHSKSESR EEQADSESSE SLNFSEESPE SPEDENSSSQ EGLQSHSSSA ESQSEESHSE EDDSDSQDSS RSKEDSNSTE SKSSSEEDGQ LKNIEIESRK LTVDAYHNKP IGDQDDNDCQ DGY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.