Details for: CT83

Gene ID: 203413

Symbol: CT83

Ensembl ID: ENSG00000204019

Description: cancer/testis antigen 83

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 1.9377
    Cell Significance Index: -1.8500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.2596
    Cell Significance Index: 1.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1388
    Cell Significance Index: 6.4700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0488
    Cell Significance Index: 0.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0126
    Cell Significance Index: -2.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0159
    Cell Significance Index: -2.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0189
    Cell Significance Index: -2.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0211
    Cell Significance Index: -0.5800
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0218
    Cell Significance Index: -0.1700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0230
    Cell Significance Index: -0.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0257
    Cell Significance Index: -1.3400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0288
    Cell Significance Index: -0.3300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0331
    Cell Significance Index: -0.3400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0427
    Cell Significance Index: -0.5900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0478
    Cell Significance Index: -0.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0541
    Cell Significance Index: -2.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0572
    Cell Significance Index: -2.6900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0585
    Cell Significance Index: -0.6700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0610
    Cell Significance Index: -0.6000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0616
    Cell Significance Index: -0.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0632
    Cell Significance Index: -0.6900
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0638
    Cell Significance Index: -0.6000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0706
    Cell Significance Index: -1.8000
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0739
    Cell Significance Index: -0.7900
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0792
    Cell Significance Index: -1.0100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0838
    Cell Significance Index: -1.0000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0856
    Cell Significance Index: -0.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0890
    Cell Significance Index: -2.3400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0906
    Cell Significance Index: -0.5600
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0920
    Cell Significance Index: -0.7100
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0982
    Cell Significance Index: -1.2200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0982
    Cell Significance Index: -0.6400
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.0995
    Cell Significance Index: -0.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1013
    Cell Significance Index: -1.7000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1093
    Cell Significance Index: -0.6700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1095
    Cell Significance Index: -3.1400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1128
    Cell Significance Index: -2.2500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1139
    Cell Significance Index: -0.6700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1149
    Cell Significance Index: -0.9500
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1184
    Cell Significance Index: -1.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1190
    Cell Significance Index: -4.3700
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.1205
    Cell Significance Index: -0.5600
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1215
    Cell Significance Index: -1.0800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1326
    Cell Significance Index: -1.7300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1365
    Cell Significance Index: -2.2500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1384
    Cell Significance Index: -1.6700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1397
    Cell Significance Index: -1.6600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1416
    Cell Significance Index: -2.4200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1461
    Cell Significance Index: -0.9700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1483
    Cell Significance Index: -1.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1508
    Cell Significance Index: -2.1600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1556
    Cell Significance Index: -1.9700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1563
    Cell Significance Index: -1.9000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1575
    Cell Significance Index: -1.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1618
    Cell Significance Index: -1.6800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1623
    Cell Significance Index: -1.6600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1638
    Cell Significance Index: -1.8300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1641
    Cell Significance Index: -1.9300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1660
    Cell Significance Index: -1.9100
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1669
    Cell Significance Index: -1.8400
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.1721
    Cell Significance Index: -0.8200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1725
    Cell Significance Index: -2.2700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1809
    Cell Significance Index: -1.9400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1814
    Cell Significance Index: -2.2300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1836
    Cell Significance Index: -2.1700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1838
    Cell Significance Index: -2.4000
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1845
    Cell Significance Index: -1.9500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1875
    Cell Significance Index: -2.4600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1918
    Cell Significance Index: -2.4200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1948
    Cell Significance Index: -2.2300
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1972
    Cell Significance Index: -2.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1973
    Cell Significance Index: -2.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2007
    Cell Significance Index: -2.3700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2008
    Cell Significance Index: -2.3900
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.2023
    Cell Significance Index: -2.2100
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.2027
    Cell Significance Index: -2.2300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.2027
    Cell Significance Index: -2.0000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.2065
    Cell Significance Index: -2.0200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.2068
    Cell Significance Index: -2.2100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2106
    Cell Significance Index: -2.2800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2119
    Cell Significance Index: -2.2000
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.2119
    Cell Significance Index: -2.3700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2120
    Cell Significance Index: -2.3100
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.2127
    Cell Significance Index: -2.1900
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.2137
    Cell Significance Index: -2.1200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.2158
    Cell Significance Index: -2.3400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2167
    Cell Significance Index: -2.4100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2209
    Cell Significance Index: -2.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2212
    Cell Significance Index: -2.4100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2218
    Cell Significance Index: -2.3600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2229
    Cell Significance Index: -1.6200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2259
    Cell Significance Index: -2.4000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2264
    Cell Significance Index: -2.4600
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.2285
    Cell Significance Index: -2.1700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2295
    Cell Significance Index: -1.9400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2318
    Cell Significance Index: -3.0800
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2323
    Cell Significance Index: -2.2300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2325
    Cell Significance Index: -2.1800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2329
    Cell Significance Index: -2.5800
  • Cell Name: brush cell of tracheobronchial tree (CL0002075)
    Fold Change: -0.2345
    Cell Significance Index: -2.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CT83 is a member of the cancer/testis antigen (CTA) family, a group of proteins that are exclusively expressed in cancer cells and are therefore attractive targets for cancer immunotherapy. The protein is characterized by its high expression in various types of cancer, including lung, colon, and breast cancer. Its expression is also significant in normal cells, such as goblet cells and intestinal epithelial cells, which highlights the complexity of its role in the human body. **Pathways and Functions** CT83 is involved in several cellular pathways, including the regulation of cell growth, differentiation, and survival. Its expression has been linked to the activation of various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. These pathways play a crucial role in the regulation of cell proliferation, survival, and apoptosis, making CT83 a potential target for cancer therapy. In addition to its role in cancer, CT83 has also been implicated in the regulation of immune responses. Its expression has been shown to modulate the activity of immune cells, including T cells and dendritic cells, which highlights the potential of CT83 as a target for immunotherapy. **Clinical Significance** The identification of CT83 as a potential target for cancer immunotherapy has significant clinical implications. Its high expression in various types of cancer makes it an attractive target for the development of novel cancer therapies. Moreover, its expression in normal cells highlights the need for careful consideration of its role in the human body, particularly in terms of its potential impact on normal tissues. The development of CT83-based therapies, such as monoclonal antibodies and cancer vaccines, holds great promise for the treatment of various types of cancer. Furthermore, the study of CT83's role in the regulation of immune responses has the potential to reveal new insights into the mechanisms of cancer immunology. In conclusion, CT83 is a complex protein that plays a multifaceted role in the human body, both in normal cells and in cancer cells. Its high expression in various types of cancer makes it an attractive target for cancer immunotherapy, while its role in the regulation of immune responses highlights its potential as a target for novel cancer therapies. Further research is needed to fully elucidate the mechanisms of CT83 and its potential applications in cancer therapy. **Recommendations** 1. Further research is needed to fully elucidate the mechanisms of CT83 and its potential applications in cancer therapy. 2. The development of CT83-based therapies, such as monoclonal antibodies and cancer vaccines, should be pursued with caution to minimize potential side effects on normal tissues. 3. The study of CT83's role in the regulation of immune responses has the potential to reveal new insights into the mechanisms of cancer immunology. By pursuing these recommendations, we can unlock the full potential of CT83 as a target for cancer immunotherapy and develop novel therapies that can improve patient outcomes.

Genular Protein ID: 3582712141

Symbol: KKLC1_HUMAN

Name: Kita-kyushu lung cancer antigen 1

UniProtKB Accession Codes:

Q5H943

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16651449

Title: Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma.

PubMed ID: 16651449

DOI: 10.1158/0008-5472.can-05-3840

Sequence Information:

  • Length: 113
  • Mass: 12784
  • Checksum: 7BC40E0AFFAC587A
  • Sequence:
    • MNFYLLLASS ILCALIVFWK YRRFQRNTGE MSSNSTALAL VRPSSSGLIN SNTDNNLAVY 
DLSRDILNNF PHSIARQKRI LVNLSMVENK LVELEHTLLS KGFRGASPHR KST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.