Details for: FCGR2B

Gene ID: 2213

Symbol: FCGR2B

Ensembl ID: ENSG00000072694

Description: Fc gamma receptor IIb

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-HSA-198933)
  • Amyloid-beta binding
    (GO:0001540)
  • Antibody-dependent cellular cytotoxicity
    (GO:0001788)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ii
    (GO:0019886)
  • Cell body
    (GO:0044297)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to amyloid-beta
    (GO:1904646)
  • Cellular response to molecule of bacterial origin
    (GO:0071219)
  • Cerebellum development
    (GO:0021549)
  • Defense response
    (GO:0006952)
  • Dendritic spine
    (GO:0043197)
  • External side of plasma membrane
    (GO:0009897)
  • Fc-gamma receptor signaling pathway
    (GO:0038094)
  • Follicular b cell differentiation
    (GO:0002316)
  • Follicular dendritic cell activation
    (GO:0002266)
  • Igg binding
    (GO:0019864)
  • Igg receptor activity
    (GO:0019770)
  • Immune complex clearance by monocytes and macrophages
    (GO:0002436)
  • Immune effector process
    (GO:0002252)
  • Immunoglobulin mediated immune response
    (GO:0016064)
  • Inflammatory response
    (GO:0006954)
  • Low-affinity igg receptor activity
    (GO:0019772)
  • Mast cell activation
    (GO:0045576)
  • Mature b cell differentiation involved in immune response
    (GO:0002313)
  • Negative regulation of acute inflammatory response to antigenic stimulus
    (GO:0002865)
  • Negative regulation of antibody-dependent cellular cytotoxicity
    (GO:0001814)
  • Negative regulation of b cell activation
    (GO:0050869)
  • Negative regulation of b cell proliferation
    (GO:0030889)
  • Negative regulation of b cell receptor signaling pathway
    (GO:0050859)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of cytotoxic t cell degranulation
    (GO:0043318)
  • Negative regulation of dendritic cell antigen processing and presentation
    (GO:0002605)
  • Negative regulation of dendritic cell differentiation
    (GO:2001199)
  • Negative regulation of humoral immune response mediated by circulating immunoglobulin
    (GO:0002924)
  • Negative regulation of immune response
    (GO:0050777)
  • Negative regulation of immunoglobulin production
    (GO:0002638)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of macrophage activation
    (GO:0043031)
  • Negative regulation of neutrophil activation
    (GO:1902564)
  • Negative regulation of phagocytosis
    (GO:0050765)
  • Negative regulation of type i hypersensitivity
    (GO:0001811)
  • Phagocytosis
    (GO:0006909)
  • Phagocytosis, engulfment
    (GO:0006911)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of humoral immune response
    (GO:0002922)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of response to endoplasmic reticulum stress
    (GO:1905898)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Receptor-mediated endocytosis
    (GO:0006898)
  • Regulation of adaptive immune response
    (GO:0002819)
  • Regulation of b cell antigen processing and presentation
    (GO:0002622)
  • Regulation of dendritic spine maintenance
    (GO:1902950)
  • Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
    (GO:1903381)
  • Regulation of immune complex clearance by monocytes and macrophages
    (GO:0090264)
  • Regulation of innate immune response
    (GO:0045088)
  • Regulation of signaling receptor activity
    (GO:0010469)
  • Response to bacterium
    (GO:0009617)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.09
    Marker Score: 2395
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.62
    Marker Score: 4192
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.5
    Marker Score: 532
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.44
    Marker Score: 1357
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.41
    Marker Score: 1404
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.38
    Marker Score: 1477
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.37
    Marker Score: 1392
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.31
    Marker Score: 792
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4807
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.12
    Marker Score: 245
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 669
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.04
    Marker Score: 789
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.99
    Marker Score: 409
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.95
    Marker Score: 939
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5341.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.83
    Marker Score: 744
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.82
    Marker Score: 285
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.81
    Marker Score: 534
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.79
    Marker Score: 1548
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.76
    Marker Score: 1009
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 692
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.74
    Marker Score: 434
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.74
    Marker Score: 170
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.71
    Marker Score: 4289
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.67
    Marker Score: 1405
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.65
    Marker Score: 1135
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.64
    Marker Score: 697
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.62
    Marker Score: 7151
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1206
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.58
    Marker Score: 699
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.58
    Marker Score: 394
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 454
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.57
    Marker Score: 909
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.55
    Marker Score: 465
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.52
    Marker Score: 180
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.5
    Marker Score: 149
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.49
    Marker Score: 135
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.48
    Marker Score: 461
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.47
    Marker Score: 522
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 449
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.45
    Marker Score: 232
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 290
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.42
    Marker Score: 311
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.42
    Marker Score: 472
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.42
    Marker Score: 240
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.38
    Marker Score: 91
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.37
    Marker Score: 162
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.35
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.35
    Marker Score: 237
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.34
    Marker Score: 93
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.33
    Marker Score: 203
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.33
    Marker Score: 792
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.33
    Marker Score: 592
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.32
    Marker Score: 18153
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.31
    Marker Score: 921
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.31
    Marker Score: 588
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.31
    Marker Score: 85
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.31
    Marker Score: 397
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.3
    Marker Score: 71
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.29
    Marker Score: 164
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.28
    Marker Score: 244
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.27
    Marker Score: 163
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.27
    Marker Score: 239
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.27
    Marker Score: 1111
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.27
    Marker Score: 134
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.26
    Marker Score: 98
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.26
    Marker Score: 178
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.25
    Marker Score: 226
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.25
    Marker Score: 309
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.24
    Marker Score: 146
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.23
    Marker Score: 143
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.23
    Marker Score: 234
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.23
    Marker Score: 303
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.22
    Marker Score: 108
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.22
    Marker Score: 106
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2
    Marker Score: 2020

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Other Information

**Key characteristics:** * FCGR2B is a cell surface receptor that is expressed on myeloid and epithelial cells. * It is a low-affinity receptor, meaning that it binds to a wide range of antigens with low affinity. * FCGR2B is involved in the regulation of the adaptive immune system, the regulation of antibody-dependent cellular cytotoxicity, and the regulation of inflammation. **Pathways and functions:** * FCGR2B is involved in the regulation of the adaptive immune system by interacting with antibodies. * It is expressed on myeloid and epithelial cells, which are important players in the immune system. * FCGR2B is involved in the recognition of antigens by antibodies. * It is also involved in the regulation of antibody-dependent cellular cytotoxicity, which is the process by which antibodies kill infected cells. * FCGR2B is also involved in the regulation of inflammation. **Clinical significance:** * Mutations in the FCGR2B gene have been linked to the development of several autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and multiple sclerosis. * FCGR2B is a potential target for therapeutic intervention in autoimmune diseases. **Additional notes:** * FCGR2B is a member of the immunoglobulin superfamily, which is a large family of cell surface receptors that are involved in a variety of immune responses. * FCGR2B is a low-affinity receptor, which means that it binds to a wide range of antigens with low affinity. This allows it to be expressed on a variety of cell types and to play a role in a variety of immune responses. * FCGR2B is a key regulator of the adaptive immune system. It is involved in the recognition of antigens by antibodies, the regulation of antibody-dependent cellular cytotoxicity, and the regulation of inflammation.

Genular Protein ID: 253327034

Symbol: FCG2B_HUMAN

Name: Low affinity immunoglobulin gamma Fc region receptor II-b

UniProtKB Accession Codes:

P31994 A6H8N3 O95649 Q53X85 Q5VXA9 Q8NIA1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 ELM 1 EMBL 29 Ensembl 3 EvolutionaryTrace 1 GO 56 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2531080

Title: Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.

PubMed ID: 2531080

DOI: 10.1002/j.1460-2075.1989.tb08540.x

PubMed ID: 2529342

Title: Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.

PubMed ID: 2529342

DOI: 10.1084/jem.170.4.1369

PubMed ID: 2142460

Title: Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II.

PubMed ID: 2142460

DOI: 10.1002/eji.1830200624

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12115230

Title: Fc gamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility.

PubMed ID: 12115230

DOI: 10.1002/art.10257

PubMed ID: 8327512

Title: Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

PubMed ID: 8327512

DOI: 10.1073/pnas.90.13.6305

PubMed ID: 8756631

Title: In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.

PubMed ID: 8756631

DOI: 10.1128/mcb.16.9.4735

PubMed ID: 9232445

Title: Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell.

PubMed ID: 9232445

DOI: 10.1016/s0165-2478(97)00055-2

PubMed ID: 15914856

Title: Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively.

PubMed ID: 15914856

DOI: 10.1099/vir.0.80791-0

PubMed ID: 10064577

Title: Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.

PubMed ID: 10064577

DOI: 10.1093/emboj/18.5.1095

PubMed ID: 8466861

Title: Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses.

PubMed ID: 8466861

DOI: 10.1093/intimm/5.3.239

PubMed ID: 17435165

Title: Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.

PubMed ID: 17435165

DOI: 10.1073/pnas.0608889104

PubMed ID: 20385827

Title: A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.

PubMed ID: 20385827

DOI: 10.1073/pnas.0915133107

Sequence Information:

  • Length: 310
  • Mass: 34044
  • Checksum: 2186F8538FF01F36
  • Sequence:
    • MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN 
VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL 
SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN 
FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA 
VVALIYCRKK RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA 
LEEPDDQNRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.