Details for: FCGR2B

Gene ID: 2213

Symbol: FCGR2B

Ensembl ID: ENSG00000072694

Description: Fc gamma receptor IIb

Associated with

  • Adaptive immune system
    (R-HSA-1280218)
  • Immune system
    (R-HSA-168256)
  • Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
    (R-HSA-198933)
  • Amyloid-beta binding
    (GO:0001540)
  • Antibody-dependent cellular cytotoxicity
    (GO:0001788)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ii
    (GO:0019886)
  • Cell body
    (GO:0044297)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to amyloid-beta
    (GO:1904646)
  • Cellular response to molecule of bacterial origin
    (GO:0071219)
  • Cerebellum development
    (GO:0021549)
  • Defense response
    (GO:0006952)
  • Dendritic spine
    (GO:0043197)
  • External side of plasma membrane
    (GO:0009897)
  • Fc-gamma receptor signaling pathway
    (GO:0038094)
  • Follicular b cell differentiation
    (GO:0002316)
  • Follicular dendritic cell activation
    (GO:0002266)
  • Igg binding
    (GO:0019864)
  • Igg receptor activity
    (GO:0019770)
  • Immune complex clearance by monocytes and macrophages
    (GO:0002436)
  • Immune effector process
    (GO:0002252)
  • Immunoglobulin mediated immune response
    (GO:0016064)
  • Inflammatory response
    (GO:0006954)
  • Low-affinity igg receptor activity
    (GO:0019772)
  • Mast cell activation
    (GO:0045576)
  • Mature b cell differentiation involved in immune response
    (GO:0002313)
  • Negative regulation of acute inflammatory response to antigenic stimulus
    (GO:0002865)
  • Negative regulation of antibody-dependent cellular cytotoxicity
    (GO:0001814)
  • Negative regulation of b cell activation
    (GO:0050869)
  • Negative regulation of b cell proliferation
    (GO:0030889)
  • Negative regulation of b cell receptor signaling pathway
    (GO:0050859)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of cytotoxic t cell degranulation
    (GO:0043318)
  • Negative regulation of dendritic cell antigen processing and presentation
    (GO:0002605)
  • Negative regulation of dendritic cell differentiation
    (GO:2001199)
  • Negative regulation of humoral immune response mediated by circulating immunoglobulin
    (GO:0002924)
  • Negative regulation of immune response
    (GO:0050777)
  • Negative regulation of immunoglobulin production
    (GO:0002638)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of macrophage activation
    (GO:0043031)
  • Negative regulation of neutrophil activation
    (GO:1902564)
  • Negative regulation of phagocytosis
    (GO:0050765)
  • Negative regulation of type i hypersensitivity
    (GO:0001811)
  • Phagocytosis
    (GO:0006909)
  • Phagocytosis, engulfment
    (GO:0006911)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of humoral immune response
    (GO:0002922)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of response to endoplasmic reticulum stress
    (GO:1905898)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Receptor-mediated endocytosis
    (GO:0006898)
  • Regulation of adaptive immune response
    (GO:0002819)
  • Regulation of b cell antigen processing and presentation
    (GO:0002622)
  • Regulation of dendritic spine maintenance
    (GO:1902950)
  • Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
    (GO:1903381)
  • Regulation of immune complex clearance by monocytes and macrophages
    (GO:0090264)
  • Regulation of innate immune response
    (GO:0045088)
  • Regulation of signaling receptor activity
    (GO:0010469)
  • Response to bacterium
    (GO:0009617)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 6.3367
    Cell Significance Index: 92.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.9555
    Cell Significance Index: 76.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.7698
    Cell Significance Index: 94.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6695
    Cell Significance Index: -9.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3668
    Cell Significance Index: -5.1800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.6789
    Cell Significance Index: 15.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3734
    Cell Significance Index: 62.2500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.1698
    Cell Significance Index: 9.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9302
    Cell Significance Index: 177.0300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8149
    Cell Significance Index: 10.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8041
    Cell Significance Index: 17.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7335
    Cell Significance Index: 72.5600
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.7040
    Cell Significance Index: 2.9300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.6405
    Cell Significance Index: 3.8700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.6293
    Cell Significance Index: 1.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6127
    Cell Significance Index: 553.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3005
    Cell Significance Index: 48.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2462
    Cell Significance Index: 26.7800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.2216
    Cell Significance Index: 3.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1807
    Cell Significance Index: 21.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1784
    Cell Significance Index: 3.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1307
    Cell Significance Index: 9.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1286
    Cell Significance Index: 3.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1236
    Cell Significance Index: 35.5800
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.0850
    Cell Significance Index: 0.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0151
    Cell Significance Index: 0.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0038
    Cell Significance Index: 0.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0011
    Cell Significance Index: 0.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0025
    Cell Significance Index: -0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0065
    Cell Significance Index: -10.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0142
    Cell Significance Index: -8.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0152
    Cell Significance Index: -9.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0158
    Cell Significance Index: -10.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0217
    Cell Significance Index: -9.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0236
    Cell Significance Index: -4.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0257
    Cell Significance Index: -9.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0377
    Cell Significance Index: -7.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0403
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0444
    Cell Significance Index: -9.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0470
    Cell Significance Index: -2.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0472
    Cell Significance Index: -9.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0491
    Cell Significance Index: -3.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0506
    Cell Significance Index: -9.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0519
    Cell Significance Index: -6.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0546
    Cell Significance Index: -7.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0663
    Cell Significance Index: -9.6400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0691
    Cell Significance Index: -3.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0705
    Cell Significance Index: -8.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0732
    Cell Significance Index: -8.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0751
    Cell Significance Index: -9.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0787
    Cell Significance Index: -10.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0821
    Cell Significance Index: -4.1500
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.0878
    Cell Significance Index: -0.5300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1067
    Cell Significance Index: -1.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1072
    Cell Significance Index: -8.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1119
    Cell Significance Index: -5.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1222
    Cell Significance Index: -6.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1358
    Cell Significance Index: -10.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1414
    Cell Significance Index: -9.5100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1490
    Cell Significance Index: -2.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1497
    Cell Significance Index: -4.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1577
    Cell Significance Index: -7.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1679
    Cell Significance Index: -10.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1690
    Cell Significance Index: -4.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1811
    Cell Significance Index: -9.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1975
    Cell Significance Index: -5.5200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2137
    Cell Significance Index: -2.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2192
    Cell Significance Index: -9.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2196
    Cell Significance Index: -5.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2202
    Cell Significance Index: -5.8800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2266
    Cell Significance Index: -1.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2476
    Cell Significance Index: -9.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2540
    Cell Significance Index: -5.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2548
    Cell Significance Index: -9.6500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2729
    Cell Significance Index: -11.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2875
    Cell Significance Index: -10.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2905
    Cell Significance Index: -9.5100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2916
    Cell Significance Index: -3.0200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2958
    Cell Significance Index: -9.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2970
    Cell Significance Index: -9.4600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3262
    Cell Significance Index: -3.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3336
    Cell Significance Index: -9.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3362
    Cell Significance Index: -8.8400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3373
    Cell Significance Index: -8.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3387
    Cell Significance Index: -9.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3443
    Cell Significance Index: -10.1400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3473
    Cell Significance Index: -6.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3495
    Cell Significance Index: -10.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3593
    Cell Significance Index: -9.1800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3608
    Cell Significance Index: -5.1700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3625
    Cell Significance Index: -9.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3679
    Cell Significance Index: -7.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3684
    Cell Significance Index: -10.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3684
    Cell Significance Index: -7.1900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.3685
    Cell Significance Index: -3.9200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3716
    Cell Significance Index: -9.2700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3764
    Cell Significance Index: -3.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** * **Receptor function**: FCGR2B is a low-affinity receptor for IgG antibodies, mediating immune complex clearance and antigen presentation. * **Expression**: Primarily expressed on myeloid cells, such as macrophages and dendritic cells, and B cells. * **Signaling**: Activates various signaling pathways, including the JNK cascade, tumor necrosis factor production, and regulation of immune responses. * **Regulation**: Regulates immune complex clearance, antigen presentation, B cell activation, and proliferation. * **Disease associations**: Implicated in autoimmune disorders, cancer, and immune-related diseases. **Pathways and Functions** FCGR2B is involved in various immune-related pathways, including: 1. **Adaptive Immunity**: Regulates B cell activation, proliferation, and differentiation, as well as antigen presentation via MHC class II. 2. **Innate Immunity**: Mediates immune complex clearance and phagocytosis, regulating the innate immune response. 3. **Antibody-dependent Cellular Cytotoxicity (ADCC)**: Facilitates the removal of pathogens and tumor cells from the body. 4. **Immune Complex Clearance**: Regulates the clearance of immune complexes by monocytes and macrophages. 5. **Regulation of Immune Responses**: Inhibits or enhances immune responses, depending on the context, to prevent excessive inflammation or immune suppression. **Clinical Significance** Dysregulation of FCGR2B has been implicated in various disease processes, including: 1. **Autoimmune Disorders**: FCGR2B has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus, where it may contribute to immune complex formation and clearance. 2. **Cancer**: FCGR2B is overexpressed on certain cancer cells, where it may facilitate tumor growth and immune evasion. 3. **Infectious Diseases**: FCGR2B plays a role in the clearance of pathogens, such as bacteria and viruses, and may be involved in the development of infectious diseases. 4. **Immunodeficiency Disorders**: Mutations in the FCGR2B gene have been associated with immunodeficiency disorders, such as X-linked lymphoproliferative disease. In conclusion, FCGR2B is a crucial receptor in the immune system, regulating immune responses and mediating the clearance of immune complexes and pathogens. Dysregulation of FCGR2B has been implicated in various disease processes, highlighting the importance of this receptor in maintaining immune homeostasis. Further research is needed to fully understand the mechanisms of FCGR2B and its role in immune-related diseases.

Genular Protein ID: 253327034

Symbol: FCG2B_HUMAN

Name: Low affinity immunoglobulin gamma Fc region receptor II-b

UniProtKB Accession Codes:

P31994 A6H8N3 O95649 Q53X85 Q5VXA9 Q8NIA1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 ELM 1 EMBL 29 Ensembl 3 EvolutionaryTrace 1 GO 57 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2531080

Title: Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.

PubMed ID: 2531080

DOI: 10.1002/j.1460-2075.1989.tb08540.x

PubMed ID: 2529342

Title: Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes.

PubMed ID: 2529342

DOI: 10.1084/jem.170.4.1369

PubMed ID: 2142460

Title: Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II.

PubMed ID: 2142460

DOI: 10.1002/eji.1830200624

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12115230

Title: Fc gamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility.

PubMed ID: 12115230

DOI: 10.1002/art.10257

PubMed ID: 8327512

Title: Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

PubMed ID: 8327512

DOI: 10.1073/pnas.90.13.6305

PubMed ID: 8756631

Title: In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.

PubMed ID: 8756631

DOI: 10.1128/mcb.16.9.4735

PubMed ID: 9232445

Title: Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell.

PubMed ID: 9232445

DOI: 10.1016/s0165-2478(97)00055-2

PubMed ID: 15914856

Title: Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively.

PubMed ID: 15914856

DOI: 10.1099/vir.0.80791-0

PubMed ID: 10064577

Title: Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.

PubMed ID: 10064577

DOI: 10.1093/emboj/18.5.1095

PubMed ID: 8466861

Title: Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses.

PubMed ID: 8466861

DOI: 10.1093/intimm/5.3.239

PubMed ID: 17435165

Title: Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.

PubMed ID: 17435165

DOI: 10.1073/pnas.0608889104

PubMed ID: 20385827

Title: A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.

PubMed ID: 20385827

DOI: 10.1073/pnas.0915133107

Sequence Information:

  • Length: 310
  • Mass: 34044
  • Checksum: 2186F8538FF01F36
  • Sequence:
    • MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN 
VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL 
SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN 
FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA 
VVALIYCRKK RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA 
LEEPDDQNRI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.