Details for: FOXE3

Gene ID: 2301

Symbol: FOXE3

Ensembl ID: ENSG00000186790

Description: forkhead box E3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.53
    Marker Score: 4357
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.35
    Marker Score: 2367
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2222
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1177
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.28
    Marker Score: 1215
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7680
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4818
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.13
    Marker Score: 470
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 378.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 401.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1198
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 445
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 522
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.45
    Marker Score: 261
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.44
    Marker Score: 443.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.32
    Marker Score: 562
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.32
    Marker Score: 382
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.3
    Marker Score: 270.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3
    Marker Score: 560
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.28
    Marker Score: 501
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.21
    Marker Score: 131.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.21
    Marker Score: 426
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.2
    Marker Score: 288
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.17
    Marker Score: 2592
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 276
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.12
    Marker Score: 159.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.11
    Marker Score: 67
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.09
    Marker Score: 109
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.06
    Marker Score: 368
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.04
    Marker Score: 55
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 13.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.04
    Marker Score: 51
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 46
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 93
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.03
    Marker Score: 135
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.02
    Marker Score: 39
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.02
    Marker Score: 43
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 50
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 14

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Other Information

**Key characteristics:** - FOXE3 is a highly conserved protein with a predicted protein length of approximately 500 amino acids. - It is expressed in a wide range of cell types, including embryonic stem cells, germ cells, and various tissues in the body. - FOXE3 is known to be a key regulator of cell fate and differentiation. **Pathways and functions:** - FOXE3 is involved in embryonic development, where it plays a crucial role in the formation of various tissues, including the heart, brain, and eyes. - It is also involved in tissue homeostasis, where it helps maintain tissue integrity and prevent the development of cancer. - FOXE3 has been implicated in various human diseases, including cancer, cardiovascular disease, and developmental disorders. - It is a potential therapeutic target for cancer treatment. **Clinical significance:** - FOXE3 mutations have been linked to several human diseases, including cancer, cardiovascular disease, and developmental disorders. - Aberrant FOXE3 expression and activity have been observed in many cancer cells, suggesting that FOXE3 may be a potential oncogene. - Targeting FOXE3 has emerged as a promising therapeutic strategy for cancer treatment. **Other relevant information:** - FOXE3 is a key transcription factor that is highly active in proliferating epithelial cells. - It is also involved in the development of the trabecular meshwork, a network of blood vessels that provides oxygen and nutrients to the eye. - FOXE3 is a target of various transcription factors, including TGF-beta, which is known to inhibit its activity.

Genular Protein ID: 3771032147

Symbol: FOXE3_HUMAN

Name: Forkhead box protein E3

UniProtKB Accession Codes:

Q13461 Q5SVY9 Q9NQV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11159941

Title: Mutations in the human forkhead transcription factor FOXE3 associated with anterior segment ocular dysgenesis and cataracts.

PubMed ID: 11159941

DOI: 10.1093/hmg/10.3.231

PubMed ID: 11980846

Title: Foxe3 haploinsufficiency in mice: a model for Peters' anomaly.

PubMed ID: 11980846

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8825632

Title: Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12).

PubMed ID: 8825632

DOI: 10.1006/geno.1995.1266

PubMed ID: 22527307

Title: Growth inhibition of human lens epithelial cells by short hairpin RNA in transcription factor forkhead box E3 (FOXE3).

PubMed ID: 22527307

DOI: 10.1007/s00417-012-1944-5

PubMed ID: 25504734

Title: Functional analysis of FOXE3 mutations causing dominant and recessive ocular anterior segment disease.

PubMed ID: 25504734

DOI: 10.1002/humu.22741

PubMed ID: 16826526

Title: Homozygous nonsense mutation in the FOXE3 gene as a cause of congenital primary aphakia in humans.

PubMed ID: 16826526

DOI: 10.1086/505654

PubMed ID: 19708017

Title: Seeing clearly: the dominant and recessive nature of FOXE3 in eye developmental anomalies.

PubMed ID: 19708017

DOI: 10.1002/humu.21079

PubMed ID: 26854927

Title: FOXE3 mutations predispose to thoracic aortic aneurysms and dissections.

PubMed ID: 26854927

DOI: 10.1172/jci83778

PubMed ID: 27218149

Title: FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1.

PubMed ID: 27218149

DOI: 10.1038/ncomms10953

Sequence Information:

  • Length: 319
  • Mass: 33234
  • Checksum: E25A64457B7ECDF8
  • Sequence:
    • MAGRSDMDPP AAFSGFPALP AVAPSGPPPS PLAGAEPGRE PEEAAAGRGE AAPTPAPGPG 
RRRRRPLQRG KPPYSYIALI AMALAHAPGR RLTLAAIYRF ITERFAFYRD SPRKWQNSIR 
HNLTLNDCFV KVPREPGNPG KGNYWTLDPA AADMFDNGSF LRRRKRFKRA ELPAHAAAAP 
GPPLPFPYAP YAPAPGPALL VPPPSAGPGP SPPARLFSVD SLVNLQPELA GLGAPEPPCC 
AAPDAAAAAF PPCAAAASPP LYSQVPDRLV LPATRPGPGP LPAEPLLALA GPAAALGPLS 
PGEAYLRQPG FASGLERYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.