Details for: FOXE3

Gene ID: 2301

Symbol: FOXE3

Ensembl ID: ENSG00000186790

Description: forkhead box E3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7669
    Cell Significance Index: 38.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.6783
    Cell Significance Index: 41.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.1606
    Cell Significance Index: 17.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.1445
    Cell Significance Index: 70.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4987
    Cell Significance Index: 10.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4529
    Cell Significance Index: 86.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3776
    Cell Significance Index: 37.3500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.3205
    Cell Significance Index: 4.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2853
    Cell Significance Index: 17.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2501
    Cell Significance Index: 27.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1962
    Cell Significance Index: 177.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1921
    Cell Significance Index: 31.2400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1121
    Cell Significance Index: 7.7600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0942
    Cell Significance Index: 1.3500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0938
    Cell Significance Index: 1.0800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0586
    Cell Significance Index: 0.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0377
    Cell Significance Index: 1.7100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0331
    Cell Significance Index: 0.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0207
    Cell Significance Index: 31.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0144
    Cell Significance Index: 0.3200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0101
    Cell Significance Index: 0.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0064
    Cell Significance Index: 11.8900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0050
    Cell Significance Index: 0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0020
    Cell Significance Index: 2.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0016
    Cell Significance Index: 0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0003
    Cell Significance Index: 0.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0007
    Cell Significance Index: -0.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0007
    Cell Significance Index: -0.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0009
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0009
    Cell Significance Index: -0.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0012
    Cell Significance Index: -0.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0016
    Cell Significance Index: -0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0019
    Cell Significance Index: -0.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0023
    Cell Significance Index: -0.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0024
    Cell Significance Index: -0.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0025
    Cell Significance Index: -0.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0030
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0040
    Cell Significance Index: -0.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0041
    Cell Significance Index: -0.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0049
    Cell Significance Index: -0.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0053
    Cell Significance Index: -0.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0053
    Cell Significance Index: -0.7300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0059
    Cell Significance Index: -0.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0062
    Cell Significance Index: -0.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0078
    Cell Significance Index: -0.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0120
    Cell Significance Index: -0.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0134
    Cell Significance Index: -0.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0136
    Cell Significance Index: -0.4800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0148
    Cell Significance Index: -0.1200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0163
    Cell Significance Index: -0.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0164
    Cell Significance Index: -0.9200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0173
    Cell Significance Index: -0.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0188
    Cell Significance Index: -0.6900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0190
    Cell Significance Index: -0.2400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0192
    Cell Significance Index: -0.2000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0193
    Cell Significance Index: -0.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0198
    Cell Significance Index: -0.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0206
    Cell Significance Index: -0.9100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0209
    Cell Significance Index: -0.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0215
    Cell Significance Index: -0.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0217
    Cell Significance Index: -0.6900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0221
    Cell Significance Index: -0.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0229
    Cell Significance Index: -0.4800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0233
    Cell Significance Index: -0.3200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0233
    Cell Significance Index: -0.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0235
    Cell Significance Index: -0.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0237
    Cell Significance Index: -0.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0240
    Cell Significance Index: -0.9100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0245
    Cell Significance Index: -0.3200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.0254
    Cell Significance Index: -0.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0258
    Cell Significance Index: -0.6900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0261
    Cell Significance Index: -0.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0262
    Cell Significance Index: -0.9100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0273
    Cell Significance Index: -0.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0277
    Cell Significance Index: -0.6900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0282
    Cell Significance Index: -0.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0285
    Cell Significance Index: -0.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0287
    Cell Significance Index: -0.8200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0287
    Cell Significance Index: -0.7000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0287
    Cell Significance Index: -0.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0295
    Cell Significance Index: -0.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0308
    Cell Significance Index: -0.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0315
    Cell Significance Index: -0.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0319
    Cell Significance Index: -0.9400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0328
    Cell Significance Index: -0.4600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0331
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0332
    Cell Significance Index: -0.3500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0333
    Cell Significance Index: -0.4600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0334
    Cell Significance Index: -0.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0335
    Cell Significance Index: -0.7100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0340
    Cell Significance Index: -0.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0342
    Cell Significance Index: -0.9000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0369
    Cell Significance Index: -0.6300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0374
    Cell Significance Index: -0.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOXE3 is a transcription factor that possesses a forkhead domain, a characteristic DNA-binding motif that allows it to regulate the expression of target genes. It is a member of the FOX family, which includes other transcription factors such as FOXO1, FOXO3, and FOXO4. FOXE3 is unique in its expression profile, with a high level of expression in cells involved in the immune system, such as T cells and plasma cells. Its expression is also notable in cells involved in epithelial development, such as goblet cells and intestinal stem cells. **Pathways and Functions** FOXE3 is involved in several key pathways, including: 1. **Apoptosis regulation**: FOXE3 acts as a negative regulator of the apoptotic process, preventing excessive cell death in developing tissues. 2. **Cell differentiation**: FOXE3 regulates the differentiation of lens epithelial cells and goblet cells, ensuring proper development of the lens and epithelial tissues. 3. **Cell cycle regulation**: FOXE3 regulates the cell cycle, promoting the proliferation of lens epithelial cells and goblet cells. 4. **Transcriptional regulation**: FOXE3 regulates the expression of target genes involved in various cellular processes, including epithelial development, immune system function, and cellular differentiation. **Clinical Significance** Dysregulation of FOXE3 has been implicated in several diseases, including: 1. **Corneal disorders**: Mutations in FOXE3 have been associated with corneal disorders, such as corneal dystrophies and keratoconus. 2. **Immune system disorders**: FOXE3 has been implicated in immune system disorders, such as autoimmune diseases and immunodeficiency syndromes. 3. **Cancer**: FOXE3 has been shown to inhibit cancer cell proliferation and survival, suggesting its potential as a tumor suppressor gene. 4. **Neurological disorders**: FOXE3 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, FOXE3 is a transcription factor gene that plays a crucial role in regulating gene expression in response to environmental cues and developmental signals. Its dysregulation has been implicated in several diseases, highlighting its importance as a potential therapeutic target for the treatment of various diseases. Further research is needed to fully understand the functions of FOXE3 and its role in human disease.

Genular Protein ID: 3771032147

Symbol: FOXE3_HUMAN

Name: Forkhead box protein E3

UniProtKB Accession Codes:

Q13461 Q5SVY9 Q9NQV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11159941

Title: Mutations in the human forkhead transcription factor FOXE3 associated with anterior segment ocular dysgenesis and cataracts.

PubMed ID: 11159941

DOI: 10.1093/hmg/10.3.231

PubMed ID: 11980846

Title: Foxe3 haploinsufficiency in mice: a model for Peters' anomaly.

PubMed ID: 11980846

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8825632

Title: Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12).

PubMed ID: 8825632

DOI: 10.1006/geno.1995.1266

PubMed ID: 22527307

Title: Growth inhibition of human lens epithelial cells by short hairpin RNA in transcription factor forkhead box E3 (FOXE3).

PubMed ID: 22527307

DOI: 10.1007/s00417-012-1944-5

PubMed ID: 25504734

Title: Functional analysis of FOXE3 mutations causing dominant and recessive ocular anterior segment disease.

PubMed ID: 25504734

DOI: 10.1002/humu.22741

PubMed ID: 16826526

Title: Homozygous nonsense mutation in the FOXE3 gene as a cause of congenital primary aphakia in humans.

PubMed ID: 16826526

DOI: 10.1086/505654

PubMed ID: 19708017

Title: Seeing clearly: the dominant and recessive nature of FOXE3 in eye developmental anomalies.

PubMed ID: 19708017

DOI: 10.1002/humu.21079

PubMed ID: 26854927

Title: FOXE3 mutations predispose to thoracic aortic aneurysms and dissections.

PubMed ID: 26854927

DOI: 10.1172/jci83778

PubMed ID: 27218149

Title: FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1.

PubMed ID: 27218149

DOI: 10.1038/ncomms10953

Sequence Information:

  • Length: 319
  • Mass: 33234
  • Checksum: E25A64457B7ECDF8
  • Sequence:
    • MAGRSDMDPP AAFSGFPALP AVAPSGPPPS PLAGAEPGRE PEEAAAGRGE AAPTPAPGPG 
RRRRRPLQRG KPPYSYIALI AMALAHAPGR RLTLAAIYRF ITERFAFYRD SPRKWQNSIR 
HNLTLNDCFV KVPREPGNPG KGNYWTLDPA AADMFDNGSF LRRRKRFKRA ELPAHAAAAP 
GPPLPFPYAP YAPAPGPALL VPPPSAGPGP SPPARLFSVD SLVNLQPELA GLGAPEPPCC 
AAPDAAAAAF PPCAAAASPP LYSQVPDRLV LPATRPGPGP LPAEPLLALA GPAAALGPLS 
PGEAYLRQPG FASGLERYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.