Details for: STH

Gene ID: 246744

Symbol: STH

Ensembl ID: ENSG00000256762

Description: saitohin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.4516
    Cell Significance Index: 11.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1987
    Cell Significance Index: 4.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1407
    Cell Significance Index: 8.8700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0934
    Cell Significance Index: 0.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0532
    Cell Significance Index: 10.6700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0349
    Cell Significance Index: 0.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0320
    Cell Significance Index: 9.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0221
    Cell Significance Index: 7.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0129
    Cell Significance Index: 0.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0110
    Cell Significance Index: 0.3500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0093
    Cell Significance Index: 0.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0070
    Cell Significance Index: 0.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0058
    Cell Significance Index: 0.1900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.0034
    Cell Significance Index: 0.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0019
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0029
    Cell Significance Index: -0.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0032
    Cell Significance Index: -2.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0034
    Cell Significance Index: -0.1600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0057
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0066
    Cell Significance Index: -0.7600
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0067
    Cell Significance Index: -0.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0071
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0072
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0095
    Cell Significance Index: -2.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0100
    Cell Significance Index: -1.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0101
    Cell Significance Index: -0.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0105
    Cell Significance Index: -0.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0116
    Cell Significance Index: -0.2500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0118
    Cell Significance Index: -0.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0136
    Cell Significance Index: -1.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0149
    Cell Significance Index: -1.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0170
    Cell Significance Index: -0.4300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0182
    Cell Significance Index: -0.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0212
    Cell Significance Index: -0.4500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0335
    Cell Significance Index: -0.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0349
    Cell Significance Index: -3.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0349
    Cell Significance Index: -0.7000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0389
    Cell Significance Index: -0.4600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0401
    Cell Significance Index: -0.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0406
    Cell Significance Index: -0.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0426
    Cell Significance Index: -1.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0436
    Cell Significance Index: -1.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0454
    Cell Significance Index: -2.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0464
    Cell Significance Index: -1.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0506
    Cell Significance Index: -0.4800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0540
    Cell Significance Index: -0.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0547
    Cell Significance Index: -2.5700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0559
    Cell Significance Index: -0.6100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0619
    Cell Significance Index: -0.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0631
    Cell Significance Index: -1.8100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0640
    Cell Significance Index: -0.8700
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0745
    Cell Significance Index: -0.7000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0778
    Cell Significance Index: -1.0400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0779
    Cell Significance Index: -1.2500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0780
    Cell Significance Index: -1.0000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0846
    Cell Significance Index: -0.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0877
    Cell Significance Index: -1.8400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0882
    Cell Significance Index: -1.2200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0895
    Cell Significance Index: -0.9600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0934
    Cell Significance Index: -1.2600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0951
    Cell Significance Index: -1.1100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0987
    Cell Significance Index: -0.9100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0998
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.0998
    Cell Significance Index: -0.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0999
    Cell Significance Index: -1.9500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1023
    Cell Significance Index: -2.0400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1032
    Cell Significance Index: -0.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1055
    Cell Significance Index: -1.8700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1063
    Cell Significance Index: -1.1100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1110
    Cell Significance Index: -1.3500
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1111
    Cell Significance Index: -0.8000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1114
    Cell Significance Index: -1.4800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1132
    Cell Significance Index: -1.7200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1142
    Cell Significance Index: -1.6700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1203
    Cell Significance Index: -1.5700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1211
    Cell Significance Index: -1.5200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1212
    Cell Significance Index: -1.7400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1226
    Cell Significance Index: -1.4900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1238
    Cell Significance Index: -2.4200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1246
    Cell Significance Index: -1.7700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1248
    Cell Significance Index: -1.4100
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.1255
    Cell Significance Index: -1.4400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1260
    Cell Significance Index: -1.1100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1271
    Cell Significance Index: -1.5200
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1274
    Cell Significance Index: -1.4800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1284
    Cell Significance Index: -1.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1314
    Cell Significance Index: -3.5200
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1322
    Cell Significance Index: -1.3200
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1331
    Cell Significance Index: -1.4900
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.1342
    Cell Significance Index: -1.4100
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: -0.1363
    Cell Significance Index: -1.4900
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.1363
    Cell Significance Index: -1.4700
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.1369
    Cell Significance Index: -1.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1371
    Cell Significance Index: -1.7000
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.1398
    Cell Significance Index: -1.4700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1398
    Cell Significance Index: -1.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1399
    Cell Significance Index: -4.1200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1413
    Cell Significance Index: -1.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Saitohin is a non-coding RNA gene, meaning it does not encode a protein but instead regulates gene expression through various mechanisms. It is primarily expressed in the cytosol and nucleus of cells, where it interacts with spliceosomal components to regulate mRNA splicing. The STH gene is highly conserved across species, suggesting its fundamental role in cellular processes. Its expression is widespread, with significant levels found in endothelial cells, stem cells, and neurons, highlighting its involvement in tissue development, maintenance, and function. **Pathways and Functions** The STH gene regulates mRNA splicing via the spliceosome, a complex molecular machine responsible for removing introns and joining exons to form a mature mRNA molecule. This process is essential for generating functional proteins and ensuring proper gene expression. Saitohin's role in regulating mRNA splicing has been implicated in various cellular processes, including: 1. **Cell differentiation**: STH's regulation of mRNA splicing is crucial for the development and differentiation of various cell types, including neurons and stem cells. 2. **Cell survival**: Dysregulation of STH's splicing activity has been linked to cancer, suggesting its importance in maintaining cellular homeostasis. 3. **Tissue development**: STH's expression in endothelial cells and stem cells highlights its role in vascular development and tissue morphogenesis. **Clinical Significance** Dysregulation of Saitohin's splicing activity has been implicated in various diseases, including: 1. **Cancer**: Aberrant expression of STH has been linked to cancer development and progression, highlighting its potential as a biomarker or therapeutic target. 2. **Neurological disorders**: STH's role in regulating mRNA splicing in neurons suggests its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Vascular diseases**: Dysregulation of STH's splicing activity has been linked to vascular diseases, including atherosclerosis and hypertension. In conclusion, Saitohin is a non-coding RNA gene that plays a critical role in regulating mRNA splicing, a fundamental process in gene expression. Its expression in various cell types and its involvement in cellular processes highlight its importance in tissue development, maintenance, and function. Dysregulation of STH's splicing activity has been implicated in various diseases, suggesting its potential as a therapeutic target or biomarker. Further research is necessary to fully elucidate the mechanisms by which Saitohin regulates mRNA splicing and its role in human disease.

Genular Protein ID: 2295826680

Symbol: STH_HUMAN

Name: Saitohin

UniProtKB Accession Codes:

Q8IWL8 A1L3X7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12032355

Title: A polymorphic gene nested within an intron of the tau gene: implications for Alzheimer's disease.

PubMed ID: 12032355

DOI: 10.1073/pnas.112194599

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16186110

Title: Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6.

PubMed ID: 16186110

DOI: 10.1074/jbc.m506116200

PubMed ID: 12402275

Title: No evidence for an association between Saitohin Q7R polymorphism and Alzheimer's disease.

PubMed ID: 12402275

DOI: 10.1002/ana.10362

PubMed ID: 12913211

Title: Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy.

PubMed ID: 12913211

DOI: 10.1212/01.wnl.0000073140.25533.90

Sequence Information:

  • Length: 128
  • Mass: 13652
  • Checksum: 6D14C8BE6C540F0D
  • Sequence:
    • MSEGGGQVSC IFAAPTRLCR WPALIECGVN LTQPLCEWMI QVARDRTLSL AWEVASLLTL 
SSSEVGLEGV GTIWPSSYSS EESSRNGAEQ GRQLSIEGPF QGQNCPSHPA AALPLPMRGE 
SQATSCQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.