Details for: NR5A2

Gene ID: 2494

Symbol: NR5A2

Ensembl ID: ENSG00000116833

Description: nuclear receptor subfamily 5 group A member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.9167
    Cell Significance Index: -6.0600
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 14.8742
    Cell Significance Index: 7.4700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.4616
    Cell Significance Index: 34.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7672
    Cell Significance Index: 549.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.4268
    Cell Significance Index: 40.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2086
    Cell Significance Index: 218.4800
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 2.1680
    Cell Significance Index: 16.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1612
    Cell Significance Index: 97.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.0155
    Cell Significance Index: 58.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.7100
    Cell Significance Index: 325.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6697
    Cell Significance Index: 100.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4968
    Cell Significance Index: 162.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4842
    Cell Significance Index: 22.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.4522
    Cell Significance Index: 36.3000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.3674
    Cell Significance Index: 5.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3137
    Cell Significance Index: 28.4600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.1850
    Cell Significance Index: 9.3600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.0289
    Cell Significance Index: 5.9300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9602
    Cell Significance Index: 13.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.7912
    Cell Significance Index: 4.7800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.7842
    Cell Significance Index: 4.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7764
    Cell Significance Index: 53.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7604
    Cell Significance Index: 39.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6240
    Cell Significance Index: 72.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6129
    Cell Significance Index: 553.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6074
    Cell Significance Index: 6.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4160
    Cell Significance Index: 8.8600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.3523
    Cell Significance Index: 2.5300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2486
    Cell Significance Index: 6.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2148
    Cell Significance Index: 6.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1820
    Cell Significance Index: 31.0700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1253
    Cell Significance Index: 1.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0962
    Cell Significance Index: 11.0300
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.0914
    Cell Significance Index: 0.6700
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.0851
    Cell Significance Index: 0.7200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0780
    Cell Significance Index: 0.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0690
    Cell Significance Index: 47.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0594
    Cell Significance Index: 0.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0589
    Cell Significance Index: 1.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0446
    Cell Significance Index: 0.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0168
    Cell Significance Index: 0.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0072
    Cell Significance Index: 1.4400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0054
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0019
    Cell Significance Index: -2.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0037
    Cell Significance Index: -2.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0075
    Cell Significance Index: -5.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0075
    Cell Significance Index: -5.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0077
    Cell Significance Index: -2.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0085
    Cell Significance Index: -5.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0092
    Cell Significance Index: -5.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0094
    Cell Significance Index: -6.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0112
    Cell Significance Index: -0.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0114
    Cell Significance Index: -5.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0155
    Cell Significance Index: -2.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0160
    Cell Significance Index: -4.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0264
    Cell Significance Index: -3.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0275
    Cell Significance Index: -5.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0317
    Cell Significance Index: -4.0700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0380
    Cell Significance Index: -0.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0405
    Cell Significance Index: -4.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0411
    Cell Significance Index: -0.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0441
    Cell Significance Index: -6.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0462
    Cell Significance Index: -2.0100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0482
    Cell Significance Index: -0.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0486
    Cell Significance Index: -2.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0506
    Cell Significance Index: -5.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0515
    Cell Significance Index: -1.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0547
    Cell Significance Index: -7.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0584
    Cell Significance Index: -3.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0607
    Cell Significance Index: -4.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0613
    Cell Significance Index: -7.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0619
    Cell Significance Index: -4.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0644
    Cell Significance Index: -3.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0652
    Cell Significance Index: -6.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0718
    Cell Significance Index: -4.6300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0903
    Cell Significance Index: -0.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0922
    Cell Significance Index: -6.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0993
    Cell Significance Index: -2.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1004
    Cell Significance Index: -6.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1055
    Cell Significance Index: -2.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1082
    Cell Significance Index: -6.0700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1085
    Cell Significance Index: -1.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1086
    Cell Significance Index: -2.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1137
    Cell Significance Index: -5.3000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1220
    Cell Significance Index: -2.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1253
    Cell Significance Index: -4.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1318
    Cell Significance Index: -6.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1381
    Cell Significance Index: -4.5200
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1399
    Cell Significance Index: -1.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1407
    Cell Significance Index: -4.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1407
    Cell Significance Index: -6.6200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1445
    Cell Significance Index: -2.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1463
    Cell Significance Index: -3.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1558
    Cell Significance Index: -4.1600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1611
    Cell Significance Index: -1.9800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1662
    Cell Significance Index: -1.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Nuclear Receptor**: NR5A2 is a nuclear receptor, a type of ligand-activated transcription factor that regulates gene expression in response to specific ligands. 2. **Developmental Regulation**: NR5A2 is involved in developmental processes, including embryonic development, pancreatic morphogenesis, and tissue development. 3. **Metabolic Regulation**: The gene is also involved in metabolic processes, such as cholesterol homeostasis, bile acid metabolic process, and protein metabolism. 4. **Hormone Regulation**: NR5A2 is regulated by hormones, including estrogen, and plays a role in estrogen-dependent gene expression. 5. **Cellular Signaling**: The gene is involved in various cellular signaling pathways, including calcineurin-mediated signaling, ER-mediated signaling, and phospholipid binding. **Pathways and Functions** NR5A2 is involved in several signaling pathways, including: 1. **Calcineurin-mediated Signaling**: NR5A2 regulates calcineurin-mediated signaling, which is involved in cellular processes such as cell proliferation and differentiation. 2. **Cholesterol Homeostasis**: The gene is involved in cholesterol homeostasis, regulating the expression of genes involved in cholesterol synthesis and degradation. 3. **Hormone-mediated Signaling**: NR5A2 is regulated by hormones, including estrogen, and plays a role in estrogen-dependent gene expression. 4. **Regulation of Gene Expression**: The gene regulates gene expression by binding to specific DNA sequences and recruiting transcriptional co-regulators. 5. **Protein Modification**: NR5A2 is involved in protein modification, regulating the expression of genes involved in protein synthesis and degradation. **Clinical Significance** NR5A2 has been implicated in various diseases, including: 1. **Pancreatic Disease**: The gene is involved in pancreatic development and function, and dysregulation of NR5A2 has been linked to pancreatic disease, including pancreatic cancer and diabetes. 2. **Hormone-Related Disorders**: NR5A2 is involved in hormone regulation, and dysregulation of the gene has been linked to hormone-related disorders, including polycystic ovary syndrome (PCOS) and breast cancer. 3. **Metabolic Disorders**: The gene is involved in metabolic processes, and dysregulation of NR5A2 has been linked to metabolic disorders, including obesity and type 2 diabetes. In conclusion, NR5A2 is a critical gene involved in various physiological processes, including development, metabolism, and hormone regulation. Its dysregulation has been linked to various diseases, highlighting the importance of further research into the gene's functions and clinical significance.

Genular Protein ID: 1113556127

Symbol: NR5A2_HUMAN

Name: Nuclear receptor subfamily 5 group A member 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9786908

Title: Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus.

PubMed ID: 9786908

DOI: 10.1074/jbc.273.44.29022

PubMed ID: 10359768

Title: CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene.

PubMed ID: 10359768

DOI: 10.1073/pnas.96.12.6660

PubMed ID: 11595170

Title: Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene.

PubMed ID: 11595170

DOI: 10.1016/s0378-1119(01)00586-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9858833

Title: Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization.

PubMed ID: 9858833

DOI: 10.1159/000015116

PubMed ID: 14728801

Title: LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication.

PubMed ID: 14728801

DOI: 10.1038/sj.cr.7290187

PubMed ID: 20159957

Title: GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.

PubMed ID: 20159957

DOI: 10.1101/gad.545110

PubMed ID: 15707893

Title: Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

PubMed ID: 15707893

DOI: 10.1016/j.cell.2005.01.024

PubMed ID: 16289203

Title: Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.

PubMed ID: 16289203

DOI: 10.1016/j.jmb.2005.10.009

PubMed ID: 15723037

Title: Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.

PubMed ID: 15723037

DOI: 10.1038/nsmb910

PubMed ID: 15897460

Title: The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.

PubMed ID: 15897460

DOI: 10.1073/pnas.0409482102

Sequence Information:

  • Length: 541
  • Mass: 61331
  • Checksum: 7B07170C075490FE
  • Sequence:
  • MSSNSDTGDL QESLKHGLTP IGAGLPDRHG SPIPARGRLV MLPKVETEAL GLARSHGEQG 
    QMPENMQVSQ FKMVNYSYDE DLEELCPVCG DKVSGYHYGL LTCESCKGFF KRTVQNNKRY 
    TCIENQNCQI DKTQRKRCPY CRFQKCLSVG MKLEAVRADR MRGGRNKFGP MYKRDRALKQ 
    QKKALIRANG LKLEAMSQVI QAMPSDLTIS SAIQNIHSAS KGLPLNHAAL PPTDYDRSPF 
    VTSPISMTMP PHGSLQGYQT YGHFPSRAIK SEYPDPYTSS PESIMGYSYM DSYQTSSPAS 
    IPHLILELLK CEPDEPQVQA KIMAYLQQEQ ANRSKHEKLS TFGLMCKMAD QTLFSIVEWA 
    RSSIFFRELK VDDQMKLLQN CWSELLILDH IYRQVVHGKE GSIFLVTGQQ VDYSIIASQA 
    GATLNNLMSH AQELVAKLRS LQFDQREFVC LKFLVLFSLD VKNLENFQLV EGVQEQVNAA 
    LLDYTMCNYP QQTEKFGQLL LRLPEIRAIS MQAEEYLYYK HLNGDVPYNN LLIEMLHAKR 
    A

Genular Protein ID: 1963924484

Symbol: F1D8R9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 495
  • Mass: 56459
  • Checksum: E73E60DCE9880855
  • Sequence:
  • MSSNSDTGDL QESLKHGLTP IVSQFKMVNY SYDEDLEELC PVCGDKVSGY HYGLLTCESC 
    KGFFKRTVQN NKRYTCIENQ NCQIDKTQRK RCPYCRFQKC LSVGMKLEAV RADRMRGGRN 
    KFGPMYKRDR ALKQQKKALI RANGLKLEAM SQVIQAMPSD LTISSAIQNI HSASKGLPLN 
    HAALPPTDYD RSPFVTSPIS MTMPPHGSLQ GYQTYGHFPS RAIKSEYPDP YTSSPESIMG 
    YSYMDSYQTS SPASIPHLIL ELLKCEPDEP QVQAKIMAYL QQEQANRSKH EKLSTFGLMC 
    KMADQTLFSI VEWARSSIFF RELKVDDQMK LLQNCWSELL ILDHIYRQVV HGKEGSIFLV 
    TGQQVDYSII ASQAGATLNN LMSHAQELVA KLRSLQFDQR EFVCLKFLVL FSLDVKNLEN 
    FQLVEGVQEQ VNAALLDYTM CNYPQQTEKF GQLLLRLPEI RAISMQAEEY LYYKHLNGDV 
    PYNNLLIEML HAKRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.