Details for: NR5A2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 14.9167
Cell Significance Index: -6.0600 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 14.8742
Cell Significance Index: 7.4700 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 3.4616
Cell Significance Index: 34.9200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.7672
Cell Significance Index: 549.1600 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.4268
Cell Significance Index: 40.8800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.2086
Cell Significance Index: 218.4800 - Cell Name: precursor cell (CL0011115)
Fold Change: 2.1680
Cell Significance Index: 16.4400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.1612
Cell Significance Index: 97.9600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.0155
Cell Significance Index: 58.0700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.7100
Cell Significance Index: 325.4300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.6697
Cell Significance Index: 100.2400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.4968
Cell Significance Index: 162.8100 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.4842
Cell Significance Index: 22.2400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.4522
Cell Significance Index: 36.3000 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 1.3674
Cell Significance Index: 5.1500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.3137
Cell Significance Index: 28.4600 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.1850
Cell Significance Index: 9.3600 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.0289
Cell Significance Index: 5.9300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.9602
Cell Significance Index: 13.8100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.7912
Cell Significance Index: 4.7800 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.7842
Cell Significance Index: 4.9100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.7764
Cell Significance Index: 53.6900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7604
Cell Significance Index: 39.6100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.6240
Cell Significance Index: 72.7200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6129
Cell Significance Index: 553.3800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.6074
Cell Significance Index: 6.9000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4160
Cell Significance Index: 8.8600 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.3523
Cell Significance Index: 2.5300 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.2486
Cell Significance Index: 6.2000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2148
Cell Significance Index: 6.8800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1820
Cell Significance Index: 31.0700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.1253
Cell Significance Index: 1.8500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0962
Cell Significance Index: 11.0300 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 0.0914
Cell Significance Index: 0.6700 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.0851
Cell Significance Index: 0.7200 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.0780
Cell Significance Index: 0.7700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0690
Cell Significance Index: 47.7000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0594
Cell Significance Index: 0.6200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0589
Cell Significance Index: 1.0100 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.0446
Cell Significance Index: 0.7500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0168
Cell Significance Index: 0.5900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0072
Cell Significance Index: 1.4400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.0054
Cell Significance Index: 0.1000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0002
Cell Significance Index: -0.4400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0007
Cell Significance Index: -1.1000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0013
Cell Significance Index: -2.4700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0019
Cell Significance Index: -2.5200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0037
Cell Significance Index: -2.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0075
Cell Significance Index: -5.5600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0075
Cell Significance Index: -5.6600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0077
Cell Significance Index: -2.7800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0085
Cell Significance Index: -5.3900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0088
Cell Significance Index: -4.9600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0092
Cell Significance Index: -5.7200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0094
Cell Significance Index: -6.8900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0112
Cell Significance Index: -0.1600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0114
Cell Significance Index: -5.1700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0155
Cell Significance Index: -2.7900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0160
Cell Significance Index: -4.5900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0264
Cell Significance Index: -3.8400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0275
Cell Significance Index: -5.8000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0317
Cell Significance Index: -4.0700 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0380
Cell Significance Index: -0.9200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0405
Cell Significance Index: -4.9800 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0411
Cell Significance Index: -0.6200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0441
Cell Significance Index: -6.0600 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0462
Cell Significance Index: -2.0100 - Cell Name: stem cell (CL0000034)
Fold Change: -0.0482
Cell Significance Index: -0.3500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0486
Cell Significance Index: -2.1500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0506
Cell Significance Index: -5.2700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0515
Cell Significance Index: -1.9500 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0547
Cell Significance Index: -7.0700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0584
Cell Significance Index: -3.6800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0607
Cell Significance Index: -4.6600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0613
Cell Significance Index: -7.2300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0619
Cell Significance Index: -4.1600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0644
Cell Significance Index: -3.9500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0652
Cell Significance Index: -6.6600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0718
Cell Significance Index: -4.6300 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.0903
Cell Significance Index: -0.5600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0922
Cell Significance Index: -6.8800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0993
Cell Significance Index: -2.6100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1004
Cell Significance Index: -6.1700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1055
Cell Significance Index: -2.0600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1082
Cell Significance Index: -6.0700 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.1085
Cell Significance Index: -1.4900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1086
Cell Significance Index: -2.9100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1137
Cell Significance Index: -5.3000 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.1220
Cell Significance Index: -2.0100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1253
Cell Significance Index: -4.3900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1318
Cell Significance Index: -6.9200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1381
Cell Significance Index: -4.5200 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.1399
Cell Significance Index: -1.5200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1407
Cell Significance Index: -4.4800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1407
Cell Significance Index: -6.6200 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1445
Cell Significance Index: -2.0700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1463
Cell Significance Index: -3.7600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1558
Cell Significance Index: -4.1600 - Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1611
Cell Significance Index: -1.9800 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: -0.1662
Cell Significance Index: -1.5800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1113556127
Symbol: NR5A2_HUMAN
Name: Nuclear receptor subfamily 5 group A member 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9786908
Title: Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus.
PubMed ID: 9786908
PubMed ID: 10359768
Title: CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene.
PubMed ID: 10359768
PubMed ID: 11595170
Title: Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene.
PubMed ID: 11595170
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9858833
Title: Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization.
PubMed ID: 9858833
DOI: 10.1159/000015116
PubMed ID: 14728801
Title: LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication.
PubMed ID: 14728801
PubMed ID: 20159957
Title: GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.
PubMed ID: 20159957
DOI: 10.1101/gad.545110
PubMed ID: 15707893
Title: Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
PubMed ID: 15707893
PubMed ID: 16289203
Title: Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity.
PubMed ID: 16289203
PubMed ID: 15723037
Title: Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.
PubMed ID: 15723037
DOI: 10.1038/nsmb910
PubMed ID: 15897460
Title: The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.
PubMed ID: 15897460
Sequence Information:
- Length: 541
- Mass: 61331
- Checksum: 7B07170C075490FE
- Sequence:
MSSNSDTGDL QESLKHGLTP IGAGLPDRHG SPIPARGRLV MLPKVETEAL GLARSHGEQG QMPENMQVSQ FKMVNYSYDE DLEELCPVCG DKVSGYHYGL LTCESCKGFF KRTVQNNKRY TCIENQNCQI DKTQRKRCPY CRFQKCLSVG MKLEAVRADR MRGGRNKFGP MYKRDRALKQ QKKALIRANG LKLEAMSQVI QAMPSDLTIS SAIQNIHSAS KGLPLNHAAL PPTDYDRSPF VTSPISMTMP PHGSLQGYQT YGHFPSRAIK SEYPDPYTSS PESIMGYSYM DSYQTSSPAS IPHLILELLK CEPDEPQVQA KIMAYLQQEQ ANRSKHEKLS TFGLMCKMAD QTLFSIVEWA RSSIFFRELK VDDQMKLLQN CWSELLILDH IYRQVVHGKE GSIFLVTGQQ VDYSIIASQA GATLNNLMSH AQELVAKLRS LQFDQREFVC LKFLVLFSLD VKNLENFQLV EGVQEQVNAA LLDYTMCNYP QQTEKFGQLL LRLPEIRAIS MQAEEYLYYK HLNGDVPYNN LLIEMLHAKR A
Genular Protein ID: 1963924484
Symbol: F1D8R9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 495
- Mass: 56459
- Checksum: E73E60DCE9880855
- Sequence:
MSSNSDTGDL QESLKHGLTP IVSQFKMVNY SYDEDLEELC PVCGDKVSGY HYGLLTCESC KGFFKRTVQN NKRYTCIENQ NCQIDKTQRK RCPYCRFQKC LSVGMKLEAV RADRMRGGRN KFGPMYKRDR ALKQQKKALI RANGLKLEAM SQVIQAMPSD LTISSAIQNI HSASKGLPLN HAALPPTDYD RSPFVTSPIS MTMPPHGSLQ GYQTYGHFPS RAIKSEYPDP YTSSPESIMG YSYMDSYQTS SPASIPHLIL ELLKCEPDEP QVQAKIMAYL QQEQANRSKH EKLSTFGLMC KMADQTLFSI VEWARSSIFF RELKVDDQMK LLQNCWSELL ILDHIYRQVV HGKEGSIFLV TGQQVDYSII ASQAGATLNN LMSHAQELVA KLRSLQFDQR EFVCLKFLVL FSLDVKNLEN FQLVEGVQEQ VNAALLDYTM CNYPQQTEKF GQLLLRLPEI RAISMQAEEY LYYKHLNGDV PYNNLLIEML HAKRA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.