Details for: GABRA2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 4.4738
Cell Significance Index: 55.4900 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 3.6965
Cell Significance Index: 51.6900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.9638
Cell Significance Index: 1063.0600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.6897
Cell Significance Index: 539.5600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.5402
Cell Significance Index: 112.3600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.5259
Cell Significance Index: 72.0800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.5175
Cell Significance Index: 95.3300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.3838
Cell Significance Index: 146.5200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.3038
Cell Significance Index: 154.9100 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.9740
Cell Significance Index: 31.6700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.7521
Cell Significance Index: 42.0200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.3014
Cell Significance Index: 68.3300 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.1746
Cell Significance Index: 812.3800 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 1.1222
Cell Significance Index: 14.9700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7386
Cell Significance Index: 73.0600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7183
Cell Significance Index: 648.5600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4415
Cell Significance Index: 12.7200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4097
Cell Significance Index: 66.6300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3709
Cell Significance Index: 40.3500 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.3088
Cell Significance Index: 5.3400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2816
Cell Significance Index: 53.5900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2717
Cell Significance Index: 16.3100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2352
Cell Significance Index: 5.8800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1488
Cell Significance Index: 10.2900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1352
Cell Significance Index: 6.1300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1235
Cell Significance Index: 4.3400 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.0683
Cell Significance Index: 0.6500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0007
Cell Significance Index: -0.0800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0083
Cell Significance Index: -15.5400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0101
Cell Significance Index: -18.5700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0136
Cell Significance Index: -21.0100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0143
Cell Significance Index: -0.3100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0143
Cell Significance Index: -19.5000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0369
Cell Significance Index: -0.7300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0390
Cell Significance Index: -28.6100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0428
Cell Significance Index: -31.7000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0494
Cell Significance Index: -22.4400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0503
Cell Significance Index: -22.2400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0504
Cell Significance Index: -31.9900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0578
Cell Significance Index: -32.6100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0602
Cell Significance Index: -37.5600 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0826
Cell Significance Index: -0.9000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0878
Cell Significance Index: -25.2600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1168
Cell Significance Index: -23.1700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1222
Cell Significance Index: -12.7300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1274
Cell Significance Index: -3.5600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1282
Cell Significance Index: -17.6100 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1375
Cell Significance Index: -3.3300 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.1434
Cell Significance Index: -1.8600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1581
Cell Significance Index: -2.7100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1648
Cell Significance Index: -29.7100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1717
Cell Significance Index: -36.1600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1850
Cell Significance Index: -2.6500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1951
Cell Significance Index: -33.3100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2099
Cell Significance Index: -30.5100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2145
Cell Significance Index: -4.4500 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2202
Cell Significance Index: -4.4200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2284
Cell Significance Index: -6.0100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.2506
Cell Significance Index: -30.8100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2731
Cell Significance Index: -35.2800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3055
Cell Significance Index: -35.0000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3083
Cell Significance Index: -13.4100 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.3215
Cell Significance Index: -4.8100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3270
Cell Significance Index: -6.9400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3460
Cell Significance Index: -21.2100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3543
Cell Significance Index: -11.6000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3649
Cell Significance Index: -28.0000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3731
Cell Significance Index: -11.9500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3746
Cell Significance Index: -11.9300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4385
Cell Significance Index: -34.7300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4665
Cell Significance Index: -26.1800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4681
Cell Significance Index: -9.9700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4731
Cell Significance Index: -35.2600 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.5062
Cell Significance Index: -3.9700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5078
Cell Significance Index: -26.3800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5187
Cell Significance Index: -18.1700 - Cell Name: neural cell (CL0002319)
Fold Change: -0.5297
Cell Significance Index: -6.1800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5625
Cell Significance Index: -6.3900 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.5644
Cell Significance Index: -6.4600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5743
Cell Significance Index: -36.2000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.6034
Cell Significance Index: -31.4300 - Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: -0.6117
Cell Significance Index: -5.5300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.6378
Cell Significance Index: -13.7800 - Cell Name: granule cell (CL0000120)
Fold Change: -0.6381
Cell Significance Index: -7.2700 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.6411
Cell Significance Index: -9.1100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.6434
Cell Significance Index: -30.0000 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.6605
Cell Significance Index: -4.4800 - Cell Name: neuron (CL0000540)
Fold Change: -0.7026
Cell Significance Index: -6.6600 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.7049
Cell Significance Index: -8.7900 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.7180
Cell Significance Index: -9.0600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.7322
Cell Significance Index: -34.4200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7434
Cell Significance Index: -19.1100 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.7791
Cell Significance Index: -15.3400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.8349
Cell Significance Index: -30.6500 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.8462
Cell Significance Index: -11.2800 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.8654
Cell Significance Index: -18.9500 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.8779
Cell Significance Index: -21.9000 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.8856
Cell Significance Index: -17.6600 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.8981
Cell Significance Index: -10.7400 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.9295
Cell Significance Index: -19.4000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2123622260
Symbol: GBRA2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8391122
Title: Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.
PubMed ID: 8391122
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10449790
Title: Theta, a novel gamma-aminobutyric acid type A receptor subunit.
PubMed ID: 10449790
PubMed ID: 15024690
Title: Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.
PubMed ID: 15024690
DOI: 10.1086/383283
PubMed ID: 29961870
Title: De novo variants in GABRA2 and GABRA5 alter receptor function and contribute to early-onset epilepsy.
PubMed ID: 29961870
DOI: 10.1093/brain/awy171
PubMed ID: 29422393
Title: A de novo GABRA2 missense mutation in severe early-onset epileptic encephalopathy with a choreiform movement disorder.
PubMed ID: 29422393
PubMed ID: 31032849
Title: Novel GABRA2 variants in epileptic encephalopathy and intellectual disability with seizures.
PubMed ID: 31032849
DOI: 10.1093/brain/awz079
Sequence Information:
- Length: 451
- Mass: 51326
- Checksum: 43F9F708B5A00FFD
- Sequence:
MKTKLNIYNM QFLLFVFLVW DPARLVLANI QEDEAKNNIT IFTRILDRLL DGYDNRLRPG LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE RLKFKGPMNI LRLNNLMASK IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD DGTLLYTMRL TVQAECPMHL EDFPMDAHSC PLKFGSYAYT TSEVTYIWTY NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM TAHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV NDKKKEKASV MIQNNAYAVA VANYAPNLSK DPVLSTISKS ATTPEPNKKP ENKPAEAKKT FNSVSKIDRM SRIVFPVLFG TFNLVYWATY LNREPVLGVS P
Genular Protein ID: 1285142515
Symbol: E9PBQ7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
Sequence Information:
- Length: 511
- Mass: 58228
- Checksum: FEA49855AE25C20A
- Sequence:
MKTKLNIYNM QFLLFVFLVW DPARLVLANI QEDEAKNNIT IFTRILDRLL DGYDNRLRPG LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE RLKFKGPMNI LRLNNLMASK IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD DGTLLYTMRL TVQAECPMHL EDFPMDAHSC PLKFGSYAYT TSEVTYIWTY NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM TAHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV NDKSPSIKAE GITLTYNSVK AILQGAKLIW SKYIAFSWPS LFQEKTLEYL EKWMDCLTFK QSSKKEKASV MIQNNAYAVA VANYAPNLSK DPVLSTISKS ATTPEPNKKP ENKPAEAKKT FNSVSKIDRM SRIVFPVLFG TFNLVYWATY LNREPVLGVS P
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.