Details for: GALNT2

Gene ID: 2590

Symbol: GALNT2

Ensembl ID: ENSG00000143641

Description: polypeptide N-acetylgalactosaminyltransferase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.05
    Marker Score: 71,840
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.62
    Marker Score: 1,301
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.36
    Marker Score: 2,936
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.31
    Marker Score: 49,308
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.3
    Marker Score: 2,785
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.1
    Marker Score: 8,714
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.07
    Marker Score: 30,883
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.02
    Marker Score: 1,183
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.01
    Marker Score: 7,778
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.92
    Marker Score: 38,291
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.9
    Marker Score: 1,105
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.88
    Marker Score: 71,570
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.85
    Marker Score: 4,640
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.85
    Marker Score: 68,148
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.8
    Marker Score: 2,418
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.76
    Marker Score: 637
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.76
    Marker Score: 7,166
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.75
    Marker Score: 18,105
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.74
    Marker Score: 1,756
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.7
    Marker Score: 57,518
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.66
    Marker Score: 3,910
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.66
    Marker Score: 3,375
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.65
    Marker Score: 562
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.65
    Marker Score: 6,902
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.61
    Marker Score: 606
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.61
    Marker Score: 517
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.51
    Marker Score: 9,730
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.51
    Marker Score: 552
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.51
    Marker Score: 8,095
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.5
    Marker Score: 6,489
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.49
    Marker Score: 23,873
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.48
    Marker Score: 1,636
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.48
    Marker Score: 717
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.47
    Marker Score: 14,941
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.47
    Marker Score: 90,585
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.47
    Marker Score: 11,240
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.46
    Marker Score: 5,966
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.45
    Marker Score: 6,693
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.43
    Marker Score: 803
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.42
    Marker Score: 5,262
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.42
    Marker Score: 791
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.41
    Marker Score: 2,981
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.41
    Marker Score: 2,173
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.4
    Marker Score: 1,616
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.4
    Marker Score: 990
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.37
    Marker Score: 13,013
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.36
    Marker Score: 1,428
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.35
    Marker Score: 2,350
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.32
    Marker Score: 835
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.29
    Marker Score: 2,345
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 20,043
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.27
    Marker Score: 4,151
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.27
    Marker Score: 661
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.25
    Marker Score: 10,775
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.24
    Marker Score: 1,309
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.24
    Marker Score: 357
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.22
    Marker Score: 1,317
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.21
    Marker Score: 2,323
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.19
    Marker Score: 11,184
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.16
    Marker Score: 340
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.16
    Marker Score: 1,004
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.16
    Marker Score: 2,543
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.15
    Marker Score: 2,040
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.15
    Marker Score: 637
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.13
    Marker Score: 436
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.13
    Marker Score: 1,210
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.12
    Marker Score: 352
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.12
    Marker Score: 669
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.09
    Marker Score: 745
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.09
    Marker Score: 652
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.08
    Marker Score: 1,435
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.06
    Marker Score: 6,396
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.06
    Marker Score: 1,312
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.03
    Marker Score: 1,207
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.02
    Marker Score: 269
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.01
    Marker Score: 685
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.01
    Marker Score: 2,414
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.01
    Marker Score: 870
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,638
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,863
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.99
    Marker Score: 245
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.99
    Marker Score: 5,187
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.99
    Marker Score: 1,452
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.98
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,381
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.98
    Marker Score: 270
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.98
    Marker Score: 1,787
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.97
    Marker Score: 362
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.96
    Marker Score: 633
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.96
    Marker Score: 656
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.96
    Marker Score: 642
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.96
    Marker Score: 542
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.95
    Marker Score: 877
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.95
    Marker Score: 464
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,391
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.94
    Marker Score: 1,013
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.92
    Marker Score: 319
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.92
    Marker Score: 6,008

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GALNT2 is a type II transmembrane glycosyltransferase, consisting of 12 exons that encode a 1,013-amino acid protein. The enzyme exhibits a high degree of homology with other glycosyltransferases, including GALNT1, which shares 88% sequence identity. GALNT2 is predominantly expressed in the Golgi apparatus and is involved in the processing of various proteins, including mucins, which are essential components of the extracellular matrix and play roles in tissue architecture and function. **Pathways and Functions:** GALNT2 is uniquely positioned to participate in multiple cellular processes, including: 1. **O-Linked Glycosylation:** GALNT2 catalyzes the transfer of GalNAc to serine or threonine residues on target proteins, resulting in the formation of O-linked glycans. These glycans play a critical role in protein maturation, cell signaling, and cell-cell interactions. 2. **Protein Maturation:** GALNT2 is involved in the maturation of various proteins, including mucins, which are essential components of the extracellular matrix. 3. **Cell Signaling:** O-linked glycans formed by GALNT2 can serve as ligands for cell surface receptors, modulating cell signaling pathways. 4. **Cell-Cell Interactions:** Glycans formed by GALNT2 can facilitate cell-cell interactions, influencing cell adhesion, migration, and differentiation. **Clinical Significance:** Dysregulation of GALNT2 has been implicated in various diseases, including: 1. **Alzheimer's Disease:** Reduced GALNT2 expression has been observed in Alzheimer's disease brains, suggesting a potential link between GALNT2 dysfunction and disease progression. 2. **Cancer:** GALNT2 has been shown to be overexpressed in certain types of cancer, including colon and breast cancer, where it may contribute to tumor progression and metastasis. 3. **Neurological Disorders:** GALNT2 has been implicated in the pathogenesis of neurological disorders, including Parkinson's disease and amyotrophic lateral sclerosis (ALS). In conclusion, GALNT2 is a critical enzyme involved in the processing of glycosylated proteins and plays a vital role in various cellular processes, including O-linked glycosylation, protein maturation, cell signaling, and cell-cell interactions. Further research is needed to fully elucidate the functions of GALNT2 and its clinical significance in disease.

Genular Protein ID: 1313190343

Symbol: GALT2_HUMAN

Name: Polypeptide N-acetylgalactosaminyltransferase 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7592619

Title: Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase.

PubMed ID: 7592619

DOI: 10.1074/jbc.270.41.24156

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9295285

Title: Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.

PubMed ID: 9295285

DOI: 10.1074/jbc.272.38.23503

PubMed ID: 9394011

Title: Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus.

PubMed ID: 9394011

DOI: 10.1242/jcs.111.1.45

PubMed ID: 12438318

Title: Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2.

PubMed ID: 12438318

DOI: 10.1074/jbc.m211097200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

PubMed ID: 16434399

Title: Dynamic association between the catalytic and lectin domains of human UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-2.

PubMed ID: 16434399

DOI: 10.1074/jbc.m513590200

PubMed ID: 24954443

Title: Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase2.

PubMed ID: 24954443

DOI: 10.1002/anie.201402781

PubMed ID: 25939779

Title: Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation.

PubMed ID: 25939779

DOI: 10.1038/ncomms7937

PubMed ID: 27508872

Title: Loss of function of GALNT2 lowers high-density lipoproteins in humans, nonhuman primates, and rodents.

PubMed ID: 27508872

DOI: 10.1016/j.cmet.2016.07.012

PubMed ID: 32293671

Title: Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function.

PubMed ID: 32293671

DOI: 10.1093/brain/awaa063

Sequence Information:

  • Length: 571
  • Mass: 64733
  • Checksum: D9A0F5D17C55BAF2
  • Sequence:
  • MRRRSRMLLC FAFLWVLGIA YYMYSGGGSA LAGGAGGGAG RKEDWNEIDP IKKKDLHHSN 
    GEEKAQSMET LPPGKVRWPD FNQEAYVGGT MVRSGQDPYA RNKFNQVESD KLRMDRAIPD 
    TRHDQCQRKQ WRVDLPATSV VITFHNEARS ALLRTVVSVL KKSPPHLIKE IILVDDYSND 
    PEDGALLGKI EKVRVLRNDR REGLMRSRVR GADAAQAKVL TFLDSHCECN EHWLEPLLER 
    VAEDRTRVVS PIIDVINMDN FQYVGASADL KGGFDWNLVF KWDYMTPEQR RSRQGNPVAP 
    IKTPMIAGGL FVMDKFYFEE LGKYDMMMDV WGGENLEISF RVWQCGGSLE IIPCSRVGHV 
    FRKQHPYTFP GGSGTVFARN TRRAAEVWMD EYKNFYYAAV PSARNVPYGN IQSRLELRKK 
    LSCKPFKWYL ENVYPELRVP DHQDIAFGAL QQGTNCLDTL GHFADGVVGV YECHNAGGNQ 
    EWALTKEKSV KHMDLCLTVV DRAPGSLIKL QGCRENDSRQ KWEQIEGNSK LRHVGSNLCL 
    DSRTAKSGGL SVEVCGPALS QQWKFTLNLQ Q

Genular Protein ID: 336674727

Symbol: B7Z6K2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 533
  • Mass: 60826
  • Checksum: C8166676727BF4BF
  • Sequence:
  • MADREDWNEI DPIKKKDLHH SNGEEKAQSM ETLPPGKVRW PDFNQEAYVG GTMVRSGQDP 
    YARNKFNQVE SDKLRMDRAI PDTRHDQCQR KQWRVDLPAT SVVITFHNEA RSALLRTVVS 
    VLKKSPPHLI KEIILVDDYS NDPEDGALLG KIEKVRVLRN DRREGLMRSR VRGADAAQAK 
    VLTFLDSHCE CNEHWLEPLL ERVAEDRTRV VSPIIDVINM DNFQYVGASA DLKGGFDWNL 
    VFKWDYMTPE QRRSRQGNPV APIKTPMIAG GLFVMDKFYF EELGKYDMMM DVWGGENLEI 
    SFRVWQCGGS LEIIPCSRVG HVFRKQHPYT FPGGSGTVFA RNTRRAAEVW MDEYKNFYYA 
    AVPSARNVPY GNIQSRLELR KKLSCKPFKW YLENVYPELR VPDHQDIAFG ALQQGTNCLD 
    TLGHFADGVV GVYECHNAGG NQEWALTKEK SVKHMDLCLT VVDRAPGSLI KLQGCRENDS 
    RQKWEQIEGN SKLRHVGSNL CLDSRTAKSG GLSVEMCGPA LSQQWKFTLN LQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.