Details for: VCX

Gene ID: 26609

Symbol: VCX

Ensembl ID: ENSG00000182583

Description: variable charge X-linked

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.0024
    Cell Significance Index: 17.1400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.9800
    Cell Significance Index: 7.4000
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.5426
    Cell Significance Index: 3.3500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2361
    Cell Significance Index: 3.0500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1901
    Cell Significance Index: 2.1300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0553
    Cell Significance Index: 0.6600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0393
    Cell Significance Index: 0.5700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0208
    Cell Significance Index: 0.2900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0150
    Cell Significance Index: 0.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0090
    Cell Significance Index: 0.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0064
    Cell Significance Index: 0.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0054
    Cell Significance Index: 0.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0052
    Cell Significance Index: 1.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0028
    Cell Significance Index: 0.5600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0005
    Cell Significance Index: 0.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0004
    Cell Significance Index: -0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0005
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0009
    Cell Significance Index: -0.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0024
    Cell Significance Index: -0.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0032
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0037
    Cell Significance Index: -0.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0038
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0043
    Cell Significance Index: -0.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0053
    Cell Significance Index: -0.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0054
    Cell Significance Index: -0.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0061
    Cell Significance Index: -0.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0067
    Cell Significance Index: -0.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0073
    Cell Significance Index: -0.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0074
    Cell Significance Index: -0.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0075
    Cell Significance Index: -0.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0076
    Cell Significance Index: -0.4000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0083
    Cell Significance Index: -0.1400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0087
    Cell Significance Index: -0.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0089
    Cell Significance Index: -0.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0094
    Cell Significance Index: -0.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0106
    Cell Significance Index: -0.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0111
    Cell Significance Index: -0.4200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0114
    Cell Significance Index: -0.1100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0128
    Cell Significance Index: -0.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0131
    Cell Significance Index: -0.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0133
    Cell Significance Index: -0.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0141
    Cell Significance Index: -0.4500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0141
    Cell Significance Index: -0.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0144
    Cell Significance Index: -0.5300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0145
    Cell Significance Index: -0.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0151
    Cell Significance Index: -0.5300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0160
    Cell Significance Index: -0.5600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0161
    Cell Significance Index: -0.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0171
    Cell Significance Index: -0.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0176
    Cell Significance Index: -0.4400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0184
    Cell Significance Index: -0.2300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0189
    Cell Significance Index: -0.2300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0190
    Cell Significance Index: -0.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0195
    Cell Significance Index: -0.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0198
    Cell Significance Index: -0.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0203
    Cell Significance Index: -0.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0204
    Cell Significance Index: -0.6000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0205
    Cell Significance Index: -0.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0207
    Cell Significance Index: -0.4100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0213
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0213
    Cell Significance Index: -0.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0214
    Cell Significance Index: -0.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0227
    Cell Significance Index: -1.1500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0230
    Cell Significance Index: -0.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0241
    Cell Significance Index: -0.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0241
    Cell Significance Index: -0.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0241
    Cell Significance Index: -0.5000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0249
    Cell Significance Index: -0.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0249
    Cell Significance Index: -0.3400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0254
    Cell Significance Index: -0.5000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0265
    Cell Significance Index: -0.2800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0267
    Cell Significance Index: -0.6700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0270
    Cell Significance Index: -0.3600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0282
    Cell Significance Index: -0.3900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0283
    Cell Significance Index: -0.3700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0284
    Cell Significance Index: -0.3600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0286
    Cell Significance Index: -0.5700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0302
    Cell Significance Index: -0.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0312
    Cell Significance Index: -0.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0315
    Cell Significance Index: -0.5500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0317
    Cell Significance Index: -0.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0317
    Cell Significance Index: -0.7600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0320
    Cell Significance Index: -0.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0320
    Cell Significance Index: -0.6700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0338
    Cell Significance Index: -0.4000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0339
    Cell Significance Index: -0.3600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0345
    Cell Significance Index: -0.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The VCX gene is a small, non-coding RNA that is localized to the X chromosome, suggesting its involvement in X-linked inheritance patterns. Its variable charge name hints at its potential role in modulating protein-protein interactions and cellular processes. Notably, VCX exhibits a high degree of tissue specificity, with significant expression in retinal ganglion cells, blood vessel endothelial cells, and other cell types involved in immune responses. **Pathways and Functions:** VCX is implicated in several critical biological pathways, including: 1. **Brain Development:** VCX is expressed in the cerebral cortex, a region responsible for higher-order cognitive functions. Its expression in GABAergic interneurons suggests a potential role in regulating synaptic transmission and neuronal development. 2. **Chromatin Binding and Organization:** VCX interacts with chromatin-associated proteins, influencing chromatin structure and gene expression. This interaction may play a role in regulating cellular differentiation and proliferation. 3. **Ribosome Assembly:** VCX is involved in the assembly of ribosomes, the cellular machinery responsible for protein synthesis. This interaction may impact cellular growth and development. 4. **Spermatogenesis:** VCX is expressed in the testes, where it may play a role in regulating spermatogenesis, the process of sperm development. 5. **Immune Response:** VCX is expressed in various immune cells, including natural killer cells, B cells, and conventional dendritic cells. Its expression in these cells suggests a potential role in modulating immune responses. **Clinical Significance:** The clinical significance of VCX is an area of ongoing research. However, its involvement in various biological pathways suggests that dysregulation of VCX may contribute to several diseases, including: 1. **Neurodevelopmental Disorders:** VCX's role in brain development and chromatin organization may contribute to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Immunological Disorders:** VCX's expression in immune cells may play a role in modulating immune responses and contributing to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer:** VCX's involvement in ribosome assembly and chromatin organization may impact cancer development and progression. In conclusion, the variable charge X-linked gene, VCX, is a complex and multifunctional gene that plays a critical role in various biological pathways. Further research is necessary to fully elucidate its functions and clinical significance, but its potential involvement in neurodevelopmental and immunological disorders makes it an exciting area of investigation.

Genular Protein ID: 2196265199

Symbol: VCX1_HUMAN

Name: Variable charge X-linked protein 1

UniProtKB Accession Codes:

Q9H320 A0JNS5 Q4V774 Q9P0H3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10903929

Title: A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation.

PubMed ID: 10903929

DOI: 10.1086/303047

PubMed ID: 10607842

Title: A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins.

PubMed ID: 10607842

DOI: 10.1093/hmg/9.2.311

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 206
  • Mass: 22289
  • Checksum: 070880B5587C2BB0
  • Sequence:
    • MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR GKKGAATKMA 
AVTAPEAESA PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQEAEL EEPLSQESEV 
EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEM 
EEPLSQESQV EEPPSQESEM EELPSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.