Details for: SRPX2

Gene ID: 27286

Symbol: SRPX2

Ensembl ID: ENSG00000102359

Description: sushi repeat containing protein X-linked 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 9.7218
    Cell Significance Index: 65.8700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.4224
    Cell Significance Index: 27.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8089
    Cell Significance Index: -15.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.6395
    Cell Significance Index: 189.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.4845
    Cell Significance Index: 48.4900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 2.0588
    Cell Significance Index: 25.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.4156
    Cell Significance Index: 86.7900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.3426
    Cell Significance Index: 19.2800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8550
    Cell Significance Index: 18.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.8421
    Cell Significance Index: 42.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6213
    Cell Significance Index: 17.8100
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.5708
    Cell Significance Index: 5.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5475
    Cell Significance Index: 7.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4704
    Cell Significance Index: 15.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3824
    Cell Significance Index: 72.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2160
    Cell Significance Index: 195.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1852
    Cell Significance Index: 18.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1419
    Cell Significance Index: 19.4800
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.1034
    Cell Significance Index: 0.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0864
    Cell Significance Index: 14.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0591
    Cell Significance Index: 7.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0583
    Cell Significance Index: 1.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0549
    Cell Significance Index: 84.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0511
    Cell Significance Index: 10.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0497
    Cell Significance Index: 31.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0402
    Cell Significance Index: 0.3700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0290
    Cell Significance Index: 0.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0248
    Cell Significance Index: 1.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0246
    Cell Significance Index: 4.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0190
    Cell Significance Index: 2.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0009
    Cell Significance Index: 0.0400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0024
    Cell Significance Index: -3.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0066
    Cell Significance Index: -0.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0068
    Cell Significance Index: -0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0070
    Cell Significance Index: -12.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0087
    Cell Significance Index: -6.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0094
    Cell Significance Index: -5.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0107
    Cell Significance Index: -7.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0139
    Cell Significance Index: -2.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0162
    Cell Significance Index: -7.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0172
    Cell Significance Index: -0.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0214
    Cell Significance Index: -16.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0220
    Cell Significance Index: -16.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0228
    Cell Significance Index: -14.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0263
    Cell Significance Index: -7.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0294
    Cell Significance Index: -16.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0331
    Cell Significance Index: -11.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0353
    Cell Significance Index: -6.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0496
    Cell Significance Index: -1.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0529
    Cell Significance Index: -3.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0700
    Cell Significance Index: -14.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0853
    Cell Significance Index: -10.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0889
    Cell Significance Index: -1.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0987
    Cell Significance Index: -14.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0988
    Cell Significance Index: -2.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0989
    Cell Significance Index: -11.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1199
    Cell Significance Index: -15.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1229
    Cell Significance Index: -14.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1322
    Cell Significance Index: -13.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1363
    Cell Significance Index: -13.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1529
    Cell Significance Index: -11.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1549
    Cell Significance Index: -9.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2035
    Cell Significance Index: -9.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2045
    Cell Significance Index: -9.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2072
    Cell Significance Index: -5.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2180
    Cell Significance Index: -14.6600
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2272
    Cell Significance Index: -2.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2295
    Cell Significance Index: -6.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2300
    Cell Significance Index: -3.8500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2366
    Cell Significance Index: -2.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2389
    Cell Significance Index: -3.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2521
    Cell Significance Index: -13.1300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2639
    Cell Significance Index: -3.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2841
    Cell Significance Index: -17.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2855
    Cell Significance Index: -16.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3174
    Cell Significance Index: -4.6900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.3196
    Cell Significance Index: -2.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3371
    Cell Significance Index: -17.7000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3574
    Cell Significance Index: -6.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3601
    Cell Significance Index: -15.9300
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.3627
    Cell Significance Index: -3.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3684
    Cell Significance Index: -9.4700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3992
    Cell Significance Index: -2.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4044
    Cell Significance Index: -11.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4146
    Cell Significance Index: -15.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4192
    Cell Significance Index: -15.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4249
    Cell Significance Index: -9.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4288
    Cell Significance Index: -15.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4367
    Cell Significance Index: -11.6600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4594
    Cell Significance Index: -11.4600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4657
    Cell Significance Index: -5.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4669
    Cell Significance Index: -11.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4703
    Cell Significance Index: -14.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4774
    Cell Significance Index: -16.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4841
    Cell Significance Index: -15.8500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4890
    Cell Significance Index: -7.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4962
    Cell Significance Index: -14.1600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5089
    Cell Significance Index: -12.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Sushi Repeat Domain:** SRPX2 possesses a distinctive sushi repeat domain, which is characterized by a conserved sequence of 15 amino acids. This domain is crucial for the protein's interactions with other molecules, influencing its regulatory functions. 2. **Cellular Localization:** SRPX2 is predominantly localized to the cytoplasm and cell surface, where it plays a crucial role in modulating cellular processes such as cell migration, angiogenesis, and synaptic assembly. 3. **Regulatory Functions:** SRPX2 acts as a positive regulator of cell migration involved in sprouting angiogenesis, synapse assembly, and positive regulation of phosphorylation. Its involvement in these processes highlights its potential as a therapeutic target in various diseases. **Pathways and Functions:** SRPX2 is intricately involved in various signaling pathways, including: 1. **Angiogenesis:** SRPX2 plays a critical role in the regulation of angiogenesis, a process essential for tissue development, wound healing, and cancer progression. 2. **Cell Migration:** SRPX2 modulates cell migration, which is a crucial process in developmental biology, tissue repair, and disease progression. 3. **Synaptic Assembly:** SRPX2 is involved in the regulation of synaptic assembly, a process essential for neuronal development and plasticity. 4. **Phosphorylation Regulation:** SRPX2 acts as a positive regulator of phosphorylation, influencing the activity of various signaling molecules. **Clinical Significance:** SRPX2 has been implicated in various diseases, including: 1. **Cancer:** SRPX2's involvement in angiogenesis and cell migration makes it a potential therapeutic target in cancer treatment. 2. **Neurological Disorders:** SRPX2's role in synaptic assembly and neuronal development highlights its potential as a therapeutic target in neurological disorders such as Alzheimer's disease and schizophrenia. 3. **Cardiovascular Diseases:** SRPX2's involvement in angiogenesis and vascular remodeling makes it a potential therapeutic target in cardiovascular diseases such as atherosclerosis. In conclusion, SRPX2 is a multifunctional protein that plays a critical role in various cellular processes, including angiogenesis, cell migration, and synaptic assembly. Its involvement in these processes highlights its potential as a therapeutic target in various diseases, and further research is necessary to fully elucidate its role in human physiology and disease.

Genular Protein ID: 1592372932

Symbol: SRPX2_HUMAN

Name: Sushi repeat-containing protein SRPX2

UniProtKB Accession Codes:

O60687 B3KQT3 Q8WW85

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9864177

Title: Two candidate downstream target genes for E2A-HLF.

PubMed ID: 9864177

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16497722

Title: SRPX2 mutations in disorders of language cortex and cognition.

PubMed ID: 16497722

DOI: 10.1093/hmg/ddl035

PubMed ID: 18718938

Title: Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.

PubMed ID: 18718938

DOI: 10.1093/hmg/ddn256

PubMed ID: 19065654

Title: SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion.

PubMed ID: 19065654

DOI: 10.1002/ijc.24065

PubMed ID: 22242148

Title: SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer.

PubMed ID: 22242148

DOI: 10.1371/journal.pone.0027922

PubMed ID: 24179158

Title: The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice.

PubMed ID: 24179158

DOI: 10.1126/science.1245079

Sequence Information:

  • Length: 465
  • Mass: 52972
  • Checksum: 4D752B187FF3EFB8
  • Sequence:
    • MASQLTQRGA LFLLFFLTPA VTPTWYAGSG YYPDESYNEV YAEEVPQAPA LDYRVPRWCY 
TLNIQDGEAT CYSPKGGNYH SSLGTRCELS CDRGFRLIGR RSVQCLPSRR WSGTAYCRQM 
RCHALPFITS GTYTCTNGVL LDSRCDYSCS SGYHLEGDRS RICMEDGRWS GGEPVCVDID 
PPKIRCPHSR EKMAEPEKLT ARVYWDPPLV KDSADGTITR VTLRGPEPGS HFPEGEHVIR 
YTAYDRAYNR ASCKFIVKVQ VRRCPTLKPP QHGYLTCTSA GDNYGATCEY HCDGGYDRQG 
TPSRVCQSSR QWSGSPPICA PMKINVNVNS AAGLLDQFYE KQRLLIISAP DPSNRYYKMQ 
ISMLQQSTCG LDLRHVTIIE LVGQPPQEVG RIREQQLSAN IIEELRQFQR LTRSYFNMVL 
IDKQGIDRDR YMEPVTPEEI FTFIDDYLLS NQELTQRREQ RDICE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.