Details for: PPP2R3B

Gene ID: 28227

Symbol: PPP2R3B

Ensembl ID: ENSG00000167393

Description: protein phosphatase 2 regulatory subunit B''beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 5.1530
    Cell Significance Index: 65.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0800
    Cell Significance Index: -9.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.9030
    Cell Significance Index: 60.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.6141
    Cell Significance Index: 23.8300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.5603
    Cell Significance Index: 38.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.2955
    Cell Significance Index: 27.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2107
    Cell Significance Index: 230.4000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.2079
    Cell Significance Index: 19.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1203
    Cell Significance Index: 50.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0836
    Cell Significance Index: 107.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0561
    Cell Significance Index: 81.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8245
    Cell Significance Index: 23.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6405
    Cell Significance Index: 17.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6256
    Cell Significance Index: 564.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6250
    Cell Significance Index: 124.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6246
    Cell Significance Index: 101.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6226
    Cell Significance Index: 67.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5255
    Cell Significance Index: 36.3400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5187
    Cell Significance Index: 4.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4934
    Cell Significance Index: 29.6200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4212
    Cell Significance Index: 3.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3942
    Cell Significance Index: 13.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3898
    Cell Significance Index: 10.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3733
    Cell Significance Index: 4.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3108
    Cell Significance Index: 4.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3008
    Cell Significance Index: 8.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2789
    Cell Significance Index: 50.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2483
    Cell Significance Index: 16.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2350
    Cell Significance Index: 103.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1819
    Cell Significance Index: 26.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1805
    Cell Significance Index: 98.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1681
    Cell Significance Index: 33.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1636
    Cell Significance Index: 20.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1631
    Cell Significance Index: 9.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1097
    Cell Significance Index: 7.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0975
    Cell Significance Index: 1.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0917
    Cell Significance Index: 12.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0764
    Cell Significance Index: 27.3900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0748
    Cell Significance Index: 1.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0730
    Cell Significance Index: 3.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0706
    Cell Significance Index: 1.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0654
    Cell Significance Index: 1.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0552
    Cell Significance Index: 1.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0510
    Cell Significance Index: 23.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0421
    Cell Significance Index: 4.9600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0263
    Cell Significance Index: 49.4300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0187
    Cell Significance Index: 0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0179
    Cell Significance Index: 32.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0159
    Cell Significance Index: 24.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0131
    Cell Significance Index: 8.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0116
    Cell Significance Index: 1.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0082
    Cell Significance Index: 11.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0051
    Cell Significance Index: 0.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0021
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0071
    Cell Significance Index: -2.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0075
    Cell Significance Index: -5.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0099
    Cell Significance Index: -7.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0117
    Cell Significance Index: -6.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0142
    Cell Significance Index: -8.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0144
    Cell Significance Index: -0.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0248
    Cell Significance Index: -3.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0285
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0286
    Cell Significance Index: -4.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0338
    Cell Significance Index: -3.4500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0359
    Cell Significance Index: -0.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0362
    Cell Significance Index: -0.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0373
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0395
    Cell Significance Index: -8.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0403
    Cell Significance Index: -1.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0565
    Cell Significance Index: -2.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0567
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0575
    Cell Significance Index: -6.5900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0577
    Cell Significance Index: -0.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0579
    Cell Significance Index: -1.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0708
    Cell Significance Index: -5.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0716
    Cell Significance Index: -7.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0755
    Cell Significance Index: -1.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0823
    Cell Significance Index: -4.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0870
    Cell Significance Index: -2.7900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0924
    Cell Significance Index: -0.8200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0929
    Cell Significance Index: -1.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0929
    Cell Significance Index: -4.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1048
    Cell Significance Index: -8.3000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1121
    Cell Significance Index: -1.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1188
    Cell Significance Index: -1.2300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1191
    Cell Significance Index: -2.0600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1302
    Cell Significance Index: -1.8700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1306
    Cell Significance Index: -1.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1374
    Cell Significance Index: -3.9400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1423
    Cell Significance Index: -1.7300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1564
    Cell Significance Index: -3.3800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.1566
    Cell Significance Index: -0.8900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1576
    Cell Significance Index: -5.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1616
    Cell Significance Index: -3.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1616
    Cell Significance Index: -5.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1631
    Cell Significance Index: -2.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1645
    Cell Significance Index: -5.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1759
    Cell Significance Index: -5.1800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1865
    Cell Significance Index: -3.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology**: PPP2R3B shares significant structural homology with other PP2A regulatory subunits, suggesting its functional conservation across different cell types. 2. **Cellular Expression**: PPP2R3B is widely expressed in various cell types, including cardiac muscle cells, enterocytes, and skeletal muscle cells. 3. **Regulatory Subunit**: PPP2R3B acts as a regulatory subunit of the PP2A complex, modulating its activity and substrate specificity. 4. **Phosphatase Activity**: PPP2R3B possesses phosphatase activity, enabling it to dephosphorylate and regulate various protein substrates. **Pathways and Functions:** 1. **Cell Cycle Regulation**: PPP2R3B plays a critical role in regulating the cell cycle, particularly during the G1/S transition and G2/M transition, by modulating the activity of key cyclin-dependent kinases (CDKs) and cyclins. 2. **Cyclin-Dependent Kinase (CDK) Regulation**: PPP2R3B interacts with CDKs and regulates their activity, influencing the progression of the cell cycle. 3. **DNA Replication**: PPP2R3B modulates the activity of E2F transcription factors, which regulate DNA replication and cell cycle progression. 4. **Apoptosis and Cell Survival**: PPP2R3B influences apoptosis and cell survival by regulating the activity of pro-apoptotic and anti-apoptotic proteins. **Clinical Significance:** 1. **Cancer**: Dysregulation of PPP2R3B has been implicated in various cancers, including colorectal, breast, and prostate cancer, highlighting its potential as a therapeutic target. 2. **Cardiovascular Disease**: PPP2R3B dysfunction has been linked to cardiac hypertrophy and heart failure, emphasizing its importance in cardiovascular disease. 3. **Neurological Disorders**: PPP2R3B has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, suggesting its potential as a therapeutic target. 4. **Inflammatory Diseases**: PPP2R3B modulates the activity of inflammatory transcription factors, such as NF-κB, which regulates immune responses and inflammation. In conclusion, PPP2R3B plays a crucial role in regulating cell cycle progression, DNA replication, and apoptosis, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the mechanisms by which PPP2R3B influences cellular processes and to explore its therapeutic potential in various diseases.

Genular Protein ID: 2304210291

Symbol: P2R3B_HUMAN

Name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

UniProtKB Accession Codes:

Q9Y5P8 Q6P4G9 Q7RTT1 Q96H01

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10629059

Title: PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with cdc6 and modulates DNA replication in human cells.

PubMed ID: 10629059

DOI: 10.1128/mcb.20.3.1021-1029.2000

PubMed ID: 12605688

Title: Identification and characterization of B''-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues.

PubMed ID: 12605688

DOI: 10.1046/j.1432-1033.2003.03398.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 27812135

Title: Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.

PubMed ID: 27812135

DOI: 10.1371/journal.pone.0165420

Sequence Information:

  • Length: 575
  • Mass: 65061
  • Checksum: 9FDE046345C1F85F
  • Sequence:
    • MPPGKVLQPV LKMKVDELFL YWLSEASTQR MLQDCLRRIK APGRDQPTPG DGEQPGAWPT 
APLAAPRPSG LEPPGTPGPG PALPLGAASS PRNAPHVRGT RRSAGTRVVQ TRKEEPLPPA 
TSQSIPTFYF PRGRPQDSVN VDAVISKIES TFARFPHERA TMDDMGLVAK ACGCPLYWKG 
PLFYGAGGER TGSVSVHKFV AMWRKILQNC HDDAAKFVHL LMSPGCNYLV QEDFVPFLQD 
VVNTHPGLSF LKEASEFHSR YITTVIQRIF YAVNRSWSGR ITCAELRRSS FLQNVALLEE 
EADINQLTEF FSYEHFYVIY CKFWELDTDH DLLIDADDLA RHNDHALSTK MIDRIFSGAV 
TRGRKVQKEG KISYADFVWF LISEEDKKTP TSIEYWFRCM DLDGDGALSM FELEYFYEEQ 
CRRLDSMAIE ALPFQDCLCQ MLDLVKPRTE GKITLQDLKR CKLANVFFDT FFNIEKYLDH 
EQKEQISLLR DGDSGGPELS DWEKYAAEEY DILVAEETAG EPWEDGFEAE LSPVEQKLSA 
LRSPLAQRPF FEAPSPLGAV DLYEYACGDE DLEPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.